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Protein

40S ribosomal protein S8

Gene

Rps8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:Rps8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi61910. Rps8.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: RGD
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 20820740S ribosomal protein S8PRO_0000122242Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei37 – 371N6-acetyllysineBy similarity
Modified residuei128 – 1281N6-acetyllysineBy similarity
Modified residuei130 – 1301PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP62243.
PRIDEiP62243.

PTM databases

iPTMnetiP62243.
PhosphoSiteiP62243.

Expressioni

Gene expression databases

GenevisibleiP62243. RN.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.By similarity

Protein-protein interaction databases

BioGridi249257. 2 interactions.
IntActiP62243. 2 interactions.
MINTiMINT-4578289.
STRINGi10116.ENSRNOP00000025796.

Structurei

3D structure databases

ProteinModelPortaliP62243.
SMRiP62243. Positions 2-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8e family.Curated

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62243.
KOiK02995.
OMAiNYSWASE.
OrthoDBiEOG7V1FRW.
PhylomeDBiP62243.
TreeFamiTF300041.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62243-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG
60 70 80 90 100
GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC
110 120 130 140 150
IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD
160 170 180 190 200
ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR

KIKARKGK
Length:208
Mass (Da):24,205
Last modified:January 23, 2007 - v2
Checksum:i407FDF59171F7422
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06423 mRNA. Translation: CAA29732.1.
BC082802 mRNA. Translation: AAH82802.1.
PIRiS01609. R3RT8.
RefSeqiNP_113894.1. NM_031706.1.
UniGeneiRn.3198.

Genome annotation databases

EnsembliENSRNOT00000081747; ENSRNOP00000074753; ENSRNOG00000054626.
GeneIDi65136.
KEGGirno:65136.
UCSCiRGD:61910. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06423 mRNA. Translation: CAA29732.1.
BC082802 mRNA. Translation: AAH82802.1.
PIRiS01609. R3RT8.
RefSeqiNP_113894.1. NM_031706.1.
UniGeneiRn.3198.

3D structure databases

ProteinModelPortaliP62243.
SMRiP62243. Positions 2-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249257. 2 interactions.
IntActiP62243. 2 interactions.
MINTiMINT-4578289.
STRINGi10116.ENSRNOP00000025796.

PTM databases

iPTMnetiP62243.
PhosphoSiteiP62243.

Proteomic databases

PaxDbiP62243.
PRIDEiP62243.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000081747; ENSRNOP00000074753; ENSRNOG00000054626.
GeneIDi65136.
KEGGirno:65136.
UCSCiRGD:61910. rat.

Organism-specific databases

CTDi6202.
RGDi61910. Rps8.

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62243.
KOiK02995.
OMAiNYSWASE.
OrthoDBiEOG7V1FRW.
PhylomeDBiP62243.
TreeFamiTF300041.

Miscellaneous databases

NextBioi613951.
PROiP62243.

Gene expression databases

GenevisibleiP62243. RN.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of rat ribosomal protein S8."
    Chan Y.-L., Lin A., Paz V., Wool I.G.
    Nucleic Acids Res. 15:9451-9459(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 205-208.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  3. "Sequence of the amino-terminal region of rat liver ribosomal proteins S4, S6, S8, L6, L7a, L18, L27, L30, L37, L37a, and L39."
    Wittmann-Liebold B., Geissler A.W., Lin A., Wool I.G.
    J. Supramol. Struct. 12:425-433(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.

Entry informationi

Entry nameiRS8_RAT
AccessioniPrimary (citable) accession number: P62243
Secondary accession number(s): P09058
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.