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Protein

40S ribosomal protein S8

Gene

Rps8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:Rps8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:98166. Rps8.

Subcellular locationi

  • Cytoplasm By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001222412 – 20840S ribosomal protein S8Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei37N6-acetyllysineCombined sources1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei160PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP62242.
PaxDbiP62242.
PeptideAtlasiP62242.
PRIDEiP62242.
TopDownProteomicsiP62242.

PTM databases

iPTMnetiP62242.
PhosphoSitePlusiP62242.
SwissPalmiP62242.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047675.
CleanExiMM_RPS8.
ExpressionAtlasiP62242. baseline and differential.
GenevisibleiP62242. MM.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.By similarity

Protein-protein interaction databases

BioGridi203017. 2 interactors.
IntActiP62242. 6 interactors.
MINTiMINT-1857514.
STRINGi10090.ENSMUSP00000099757.

Structurei

3D structure databases

ProteinModelPortaliP62242.
SMRiP62242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8e family.Curated

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62242.
KOiK02995.
OMAiPFFLAFY.
OrthoDBiEOG091G0MF7.
PhylomeDBiP62242.
TreeFamiTF300041.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62242-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG
60 70 80 90 100
GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC
110 120 130 140 150
IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD
160 170 180 190 200
ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR

KIKARKGK
Length:208
Mass (Da):24,205
Last modified:January 23, 2007 - v2
Checksum:i407FDF59171F7422
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70E → V in BAC40485 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73829 mRNA. Translation: CAA52050.1.
AK009023 mRNA. Translation: BAB26032.1.
AK010650 mRNA. Translation: BAB27090.1.
AK011048 mRNA. Translation: BAB27359.1.
AK011058 mRNA. Translation: BAB27366.1.
AK011642 mRNA. Translation: BAB27754.1.
AK012435 mRNA. Translation: BAB28236.1.
AK012665 mRNA. Translation: BAB28394.1.
AK088660 mRNA. Translation: BAC40485.1.
BC027217 mRNA. Translation: AAH27217.1.
BC051446 mRNA. Translation: AAH51446.1.
BC081465 mRNA. Translation: AAH81465.1.
CCDSiCCDS18530.1.
PIRiS42110.
RefSeqiNP_033124.1. NM_009098.2.
UniGeneiMm.260904.
Mm.338718.

Genome annotation databases

EnsembliENSMUST00000102696; ENSMUSP00000099757; ENSMUSG00000047675.
GeneIDi20116.
KEGGimmu:20116.
UCSCiuc008uic.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73829 mRNA. Translation: CAA52050.1.
AK009023 mRNA. Translation: BAB26032.1.
AK010650 mRNA. Translation: BAB27090.1.
AK011048 mRNA. Translation: BAB27359.1.
AK011058 mRNA. Translation: BAB27366.1.
AK011642 mRNA. Translation: BAB27754.1.
AK012435 mRNA. Translation: BAB28236.1.
AK012665 mRNA. Translation: BAB28394.1.
AK088660 mRNA. Translation: BAC40485.1.
BC027217 mRNA. Translation: AAH27217.1.
BC051446 mRNA. Translation: AAH51446.1.
BC081465 mRNA. Translation: AAH81465.1.
CCDSiCCDS18530.1.
PIRiS42110.
RefSeqiNP_033124.1. NM_009098.2.
UniGeneiMm.260904.
Mm.338718.

3D structure databases

ProteinModelPortaliP62242.
SMRiP62242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203017. 2 interactors.
IntActiP62242. 6 interactors.
MINTiMINT-1857514.
STRINGi10090.ENSMUSP00000099757.

PTM databases

iPTMnetiP62242.
PhosphoSitePlusiP62242.
SwissPalmiP62242.

Proteomic databases

EPDiP62242.
PaxDbiP62242.
PeptideAtlasiP62242.
PRIDEiP62242.
TopDownProteomicsiP62242.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102696; ENSMUSP00000099757; ENSMUSG00000047675.
GeneIDi20116.
KEGGimmu:20116.
UCSCiuc008uic.1. mouse.

Organism-specific databases

CTDi6202.
MGIiMGI:98166. Rps8.

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62242.
KOiK02995.
OMAiPFFLAFY.
OrthoDBiEOG091G0MF7.
PhylomeDBiP62242.
TreeFamiTF300041.

Enzyme and pathway databases

ReactomeiR-MMU-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72649. Translation initiation complex formation.
R-MMU-72689. Formation of a pool of free 40S subunits.
R-MMU-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-MMU-72702. Ribosomal scanning and start codon recognition.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP62242.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047675.
CleanExiMM_RPS8.
ExpressionAtlasiP62242. baseline and differential.
GenevisibleiP62242. MM.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS8_MOUSE
AccessioniPrimary (citable) accession number: P62242
Secondary accession number(s): P09058, Q8C2G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.