SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P62241

- RS8_HUMAN

UniProt

P62241 - RS8_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
40S ribosomal protein S8
Gene
RPS8, OK/SW-cl.83
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. structural constituent of ribosome Source: RefGenome

GO - Biological processi

  1. RNA metabolic process Source: Reactome
  2. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  3. cellular protein metabolic process Source: Reactome
  4. gene expression Source: Reactome
  5. mRNA metabolic process Source: Reactome
  6. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: RefGenome
  7. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  8. translation Source: UniProtKB
  9. translational elongation Source: Reactome
  10. translational initiation Source: Reactome
  11. translational termination Source: Reactome
  12. viral life cycle Source: Reactome
  13. viral process Source: Reactome
  14. viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:RPS8
ORF Names:OK/SW-cl.83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10441. RPS8.

Subcellular locationi

Cytoplasm
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: HPA
  2. cytosol Source: Reactome
  3. cytosolic small ribosomal subunit Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProt
  5. nucleus Source: UniProt
  6. ribonucleoprotein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34856.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 20820740S ribosomal protein S8
PRO_0000122240Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371N6-acetyllysine By similarity
Modified residuei128 – 1281N6-acetyllysine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP62241.
PaxDbiP62241.
PeptideAtlasiP62241.
PRIDEiP62241.

PTM databases

PhosphoSiteiP62241.

Miscellaneous databases

PMAP-CutDBP62241.

Expressioni

Gene expression databases

BgeeiP62241.
CleanExiHS_RPS8.
GenevestigatoriP62241.

Organism-specific databases

HPAiHPA029266.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NDRG1Q925971EBI-351811,EBI-716486

Protein-protein interaction databases

BioGridi112116. 155 interactions.
IntActiP62241. 24 interactions.
MINTiMINT-1141293.
STRINGi9606.ENSP00000379888.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J3Aelectron microscopy5.00I1-208[»]
ProteinModelPortaliP62241.
SMRiP62241. Positions 2-207.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2007.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62241.
KOiK02995.
OMAiWASEQTT.
PhylomeDBiP62241.
TreeFamiTF300041.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. S8e. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62241-1 [UniParc]FASTAAdd to Basket

« Hide

MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG    50
GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC 100
IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD 150
ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR 200
KIKARKGK 208
Length:208
Mass (Da):24,205
Last modified:January 23, 2007 - v2
Checksum:i407FDF59171F7422
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti110 – 1101R → G.
Corresponds to variant rs11537870 [ dbSNP | Ensembl ].
VAR_051861

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67247 Genomic DNA. Translation: CAA47670.1.
AB062401 mRNA. Translation: BAB93488.1.
BC070875 mRNA. Translation: AAH70875.1.
CCDSiCCDS513.1.
PIRiS25022.
RefSeqiNP_001003.1. NM_001012.1.
UniGeneiHs.512675.

Genome annotation databases

EnsembliENST00000396651; ENSP00000379888; ENSG00000142937.
GeneIDi6202.
KEGGihsa:6202.
UCSCiuc001cmi.3. human.

Polymorphism databases

DMDMi50403622.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X67247 Genomic DNA. Translation: CAA47670.1 .
AB062401 mRNA. Translation: BAB93488.1 .
BC070875 mRNA. Translation: AAH70875.1 .
CCDSi CCDS513.1.
PIRi S25022.
RefSeqi NP_001003.1. NM_001012.1.
UniGenei Hs.512675.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3J3A electron microscopy 5.00 I 1-208 [» ]
ProteinModelPortali P62241.
SMRi P62241. Positions 2-207.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112116. 155 interactions.
IntActi P62241. 24 interactions.
MINTi MINT-1141293.
STRINGi 9606.ENSP00000379888.

PTM databases

PhosphoSitei P62241.

Polymorphism databases

DMDMi 50403622.

Proteomic databases

MaxQBi P62241.
PaxDbi P62241.
PeptideAtlasi P62241.
PRIDEi P62241.

Protocols and materials databases

DNASUi 6202.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000396651 ; ENSP00000379888 ; ENSG00000142937 .
GeneIDi 6202.
KEGGi hsa:6202.
UCSCi uc001cmi.3. human.

Organism-specific databases

CTDi 6202.
GeneCardsi GC01P045240.
HGNCi HGNC:10441. RPS8.
HPAi HPA029266.
MIMi 600357. gene.
neXtProti NX_P62241.
PharmGKBi PA34856.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2007.
HOGENOMi HOG000211544.
HOVERGENi HBG030738.
InParanoidi P62241.
KOi K02995.
OMAi WASEQTT.
PhylomeDBi P62241.
TreeFami TF300041.

Enzyme and pathway databases

Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
REACT_1404. Peptide chain elongation.
REACT_1797. Formation of a pool of free 40S subunits.
REACT_1979. Translation initiation complex formation.
REACT_1986. Eukaryotic Translation Termination.
REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_931. Ribosomal scanning and start codon recognition.
REACT_9491. Viral mRNA Translation.

Miscellaneous databases

ChiTaRSi RPS8. human.
GeneWikii RPS8.
GenomeRNAii 6202.
NextBioi 24087.
PMAP-CutDB P62241.
PROi P62241.
SOURCEi Search...

Gene expression databases

Bgeei P62241.
CleanExi HS_RPS8.
Genevestigatori P62241.

Family and domain databases

InterProi IPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view ]
PANTHERi PTHR10394. PTHR10394. 1 hit.
Pfami PF01201. Ribosomal_S8e. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00307. S8e. 1 hit.
PROSITEi PS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1."
    Davies B., Fried M.
    Genomics 15:68-75(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
    Shichijo S., Itoh K.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon adenocarcinoma.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
    Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
    Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE.
    Tissue: Placenta.
  5. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

Entry informationi

Entry nameiRS8_HUMAN
AccessioniPrimary (citable) accession number: P62241
Secondary accession number(s): P09058, Q6IRL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi