P62241 (RS8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
40S ribosomal protein S8

Gene names

Name:	RPS8
ORF Names:	OK/SW-cl.83

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Ref.5
Subcellular location	Cytoplasm. Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Ref.5
Sequence similarities	Belongs to the ribosomal protein S8e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Inferred from Biological aspect of Ancestor. Source: RefGenome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic small ribosomal subunit Inferred from direct assay PubMed 15883184Ref.4. Source: UniProtKB
Molecular_function	structural constituent of ribosome Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NDRG1	Q92597	1	EBI-351811,EBI-716486

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 208	208	40S ribosomal protein S8		PRO_0000122240
Amino acid modifications
	Modified residue	160	1	Phosphoserine By similarity
Natural variations
	Natural variant	110	1	R → G. Corresponds to variant rs11537870 [ dbSNP | Ensembl ].		VAR_051861

Sequences

	Sequence		Length	Mass (Da)
	P62241 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 407FDF59171F7422	FASTA	208	24,205
	10 20 30 40 50 60 MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL 70 80 90 100 110 120 DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP 130 140 150 160 170 180 LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS LLEEQFQQGK LLACIASRPG 190 200 QCGRADGYVL EGKELEFYLR KIKARKGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1." Davies B., Fried M. Genomics 15:68-75(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S., Itoh K. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon adenocarcinoma.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-17. Tissue: Placenta.
[5]	"Molecular composition of IMP1 ribonucleoprotein granules." Joeson L., Vikesaa J., Krogh A., Nielsen L.K., Hansen T., Borup R., Johnsen A.H., Christiansen J., Nielsen F.C. Mol. Cell. Proteomics 6:798-811(2007) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X67247 Genomic DNA. Translation: CAA47670.1. AB062401 mRNA. Translation: BAB93488.1. BC070875 mRNA. Translation: AAH70875.1.
IPI	IPI00216587.
PIR	S25022.
RefSeq	NP_001003.1. NM_001012.1.
UniGene	Hs.512675.
3D structure databases
ProteinModelPortal	P62241.
ModBase	Search...
Protein-protein interaction databases
IntAct	P62241. 18 interactions.
MINT	MINT-1141293.
STRING	9606.ENSP00000379888.
PTM databases
PhosphoSite	P62241.
Polymorphism databases
DMDM	50403622.
Proteomic databases
PaxDb	P62241.
PeptideAtlas	P62241.
PRIDE	P62241.
Protocols and materials databases
DNASU	6202.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000396651; ENSP00000379888; ENSG00000142937.
GeneID	6202.
KEGG	hsa:6202.
UCSC	uc001cmi.3. human.
Organism-specific databases
CTD	6202.
GeneCards	GC01P045240.
HGNC	HGNC:10441. RPS8.
HPA	HPA029266.
MIM	600357. gene.
neXtProt	NX_P62241.
PharmGKB	PA34856.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2007.
HOGENOM	HOG000211544.
HOVERGEN	HBG030738.
InParanoid	P62241.
KO	K02995.
OMA	KNCIVLV.
OrthoDB	EOG402WT3.
PhylomeDB	P62241.
Enzyme and pathway databases
Reactome	REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	P62241.
Bgee	P62241.
CleanEx	HS_RPS8.
Genevestigator	P62241.
GermOnline	ENSG00000142937. Homo sapiens.
Family and domain databases
InterPro	IPR001047. Ribosomal_S8e. IPR022309. Ribosomal_S8e/biogenesis_NSA2. IPR018283. Ribosomal_S8e_CS. [Graphical view]
PANTHER	PTHR10394. PTHR10394. 1 hit.
Pfam	PF01201. Ribosomal_S8e. 1 hit. [Graphical view]
TIGRFAMs	TIGR00307. S8e. 1 hit.
PROSITE	PS01193. RIBOSOMAL_S8E. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RPS8. human.
GenomeRNAi	6202.
NextBio	24087.
PMAP-CutDB	P62241.
SOURCE	Search...

Entry information

Entry name

RS8_HUMAN

Accession

Primary (citable) accession number: P62241
Secondary accession number(s): P09058, Q6IRL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 93 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.