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Protein

40S ribosomal protein S8

Gene

RPS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Alternative name(s):
Small ribosomal subunit protein eS81 Publication
Gene namesi
Name:RPS8
ORF Names:OK/SW-cl.83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142937.11
HGNCiHGNC:10441 RPS8
MIMi600357 gene
neXtProtiNX_P62241

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6202
OpenTargetsiENSG00000142937
PharmGKBiPA34856

Polymorphism and mutation databases

BioMutaiRPS8
DMDMi50403622

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001222402 – 20840S ribosomal protein S8Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei37N6-acetyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Cross-linki170Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Lipoprotein, Myristate, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP62241
PaxDbiP62241
PeptideAtlasiP62241
PRIDEiP62241
TopDownProteomicsiP62241

PTM databases

iPTMnetiP62241
PhosphoSitePlusiP62241
SwissPalmiP62241

Miscellaneous databases

PMAP-CutDBP62241

Expressioni

Gene expression databases

BgeeiENSG00000142937
CleanExiHS_RPS8
ExpressionAtlasiP62241 baseline and differential
GenevisibleiP62241 HS

Organism-specific databases

HPAiHPA029266

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

BioGridi112116, 300 interactors
CORUMiP62241
IntActiP62241, 47 interactors
MINTiP62241
STRINGi9606.ENSP00000379888

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SI1-208[»]
4V6Xelectron microscopy5.00AI1-208[»]
5A2Qelectron microscopy3.90I1-208[»]
5AJ0electron microscopy3.50BI1-208[»]
5FLXelectron microscopy3.90I1-208[»]
5LKSelectron microscopy3.60SI1-208[»]
5OA3electron microscopy4.30I1-208[»]
5T2Celectron microscopy3.60Au1-208[»]
5VYCX-ray6.00I1/I2/I3/I4/I5/I61-208[»]
6EK0electron microscopy2.90SI1-208[»]
6FECelectron microscopy6.30o2-207[»]
ProteinModelPortaliP62241
SMRiP62241
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3283 Eukaryota
COG2007 LUCA
GeneTreeiENSGT00390000012433
HOGENOMiHOG000211544
HOVERGENiHBG030738
InParanoidiP62241
KOiK02995
OMAiAWGSEHV
OrthoDBiEOG091G0MF7
PhylomeDBiP62241
TreeFamiTF300041

Family and domain databases

InterProiView protein in InterPro
IPR001047 Ribosomal_S8e
IPR022309 Ribosomal_S8e/biogenesis_NSA2
IPR018283 Ribosomal_S8e_CS
PANTHERiPTHR10394 PTHR10394, 1 hit
PfamiView protein in Pfam
PF01201 Ribosomal_S8e, 1 hit
TIGRFAMsiTIGR00307 eS8, 1 hit
PROSITEiView protein in PROSITE
PS01193 RIBOSOMAL_S8E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG
60 70 80 90 100
GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC
110 120 130 140 150
IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD
160 170 180 190 200
ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR

KIKARKGK
Length:208
Mass (Da):24,205
Last modified:January 23, 2007 - v2
Checksum:i407FDF59171F7422
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051861110R → G. Corresponds to variant dbSNP:rs11537870Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67247 Genomic DNA Translation: CAA47670.1
AB062401 mRNA Translation: BAB93488.1
BC070875 mRNA Translation: AAH70875.1
CCDSiCCDS513.1
PIRiS25022
RefSeqiNP_001003.1, NM_001012.1
UniGeneiHs.512675

Genome annotation databases

EnsembliENST00000396651; ENSP00000379888; ENSG00000142937
GeneIDi6202
KEGGihsa:6202

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRS8_HUMAN
AccessioniPrimary (citable) accession number: P62241
Secondary accession number(s): P09058, Q6IRL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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