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Protein

40S ribosomal protein S8

Gene

RPS8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142937-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S8
Gene namesi
Name:RPS8
ORF Names:OK/SW-cl.83
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:10441. RPS8.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6202.
OpenTargetsiENSG00000142937.
PharmGKBiPA34856.

Polymorphism and mutation databases

BioMutaiRPS8.
DMDMi50403622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001222402 – 20840S ribosomal protein S8Add BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei37N6-acetyllysineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei160PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP62241.
PaxDbiP62241.
PeptideAtlasiP62241.
PRIDEiP62241.
TopDownProteomicsiP62241.

PTM databases

iPTMnetiP62241.
PhosphoSitePlusiP62241.
SwissPalmiP62241.

Miscellaneous databases

PMAP-CutDBP62241.

Expressioni

Gene expression databases

BgeeiENSG00000142937.
CleanExiHS_RPS8.
ExpressionAtlasiP62241. baseline and differential.
GenevisibleiP62241. HS.

Organism-specific databases

HPAiHPA029266.

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

Protein-protein interaction databases

BioGridi112116. 288 interactors.
IntActiP62241. 42 interactors.
MINTiMINT-1141293.
STRINGi9606.ENSP00000379888.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SI1-208[»]
4V6Xelectron microscopy5.00AI1-208[»]
5A2Qelectron microscopy3.90I1-208[»]
5AJ0electron microscopy3.50BI1-208[»]
5FLXelectron microscopy3.90I1-208[»]
ProteinModelPortaliP62241.
SMRiP62241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S8e family.Curated

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62241.
KOiK02995.
OMAiPFFLAFY.
OrthoDBiEOG091G0MF7.
PhylomeDBiP62241.
TreeFamiTF300041.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG
60 70 80 90 100
GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC
110 120 130 140 150
IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD
160 170 180 190 200
ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR

KIKARKGK
Length:208
Mass (Da):24,205
Last modified:January 23, 2007 - v2
Checksum:i407FDF59171F7422
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051861110R → G.Corresponds to variant rs11537870dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67247 Genomic DNA. Translation: CAA47670.1.
AB062401 mRNA. Translation: BAB93488.1.
BC070875 mRNA. Translation: AAH70875.1.
CCDSiCCDS513.1.
PIRiS25022.
RefSeqiNP_001003.1. NM_001012.1.
UniGeneiHs.512675.

Genome annotation databases

EnsembliENST00000396651; ENSP00000379888; ENSG00000142937.
GeneIDi6202.
KEGGihsa:6202.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X67247 Genomic DNA. Translation: CAA47670.1.
AB062401 mRNA. Translation: BAB93488.1.
BC070875 mRNA. Translation: AAH70875.1.
CCDSiCCDS513.1.
PIRiS25022.
RefSeqiNP_001003.1. NM_001012.1.
UniGeneiHs.512675.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SI1-208[»]
4V6Xelectron microscopy5.00AI1-208[»]
5A2Qelectron microscopy3.90I1-208[»]
5AJ0electron microscopy3.50BI1-208[»]
5FLXelectron microscopy3.90I1-208[»]
ProteinModelPortaliP62241.
SMRiP62241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112116. 288 interactors.
IntActiP62241. 42 interactors.
MINTiMINT-1141293.
STRINGi9606.ENSP00000379888.

PTM databases

iPTMnetiP62241.
PhosphoSitePlusiP62241.
SwissPalmiP62241.

Polymorphism and mutation databases

BioMutaiRPS8.
DMDMi50403622.

Proteomic databases

EPDiP62241.
PaxDbiP62241.
PeptideAtlasiP62241.
PRIDEiP62241.
TopDownProteomicsiP62241.

Protocols and materials databases

DNASUi6202.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396651; ENSP00000379888; ENSG00000142937.
GeneIDi6202.
KEGGihsa:6202.

Organism-specific databases

CTDi6202.
DisGeNETi6202.
GeneCardsiRPS8.
HGNCiHGNC:10441. RPS8.
HPAiHPA029266.
MIMi600357. gene.
neXtProtiNX_P62241.
OpenTargetsiENSG00000142937.
PharmGKBiPA34856.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3283. Eukaryota.
COG2007. LUCA.
GeneTreeiENSGT00390000012433.
HOGENOMiHOG000211544.
HOVERGENiHBG030738.
InParanoidiP62241.
KOiK02995.
OMAiPFFLAFY.
OrthoDBiEOG091G0MF7.
PhylomeDBiP62241.
TreeFamiTF300041.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000142937-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS8. human.
GeneWikiiRPS8.
GenomeRNAii6202.
PMAP-CutDBP62241.
PROiP62241.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142937.
CleanExiHS_RPS8.
ExpressionAtlasiP62241. baseline and differential.
GenevisibleiP62241. HS.

Family and domain databases

InterProiIPR001047. Ribosomal_S8e.
IPR022309. Ribosomal_S8e/biogenesis_NSA2.
IPR018283. Ribosomal_S8e_CS.
[Graphical view]
PANTHERiPTHR10394. PTHR10394. 1 hit.
PfamiPF01201. Ribosomal_S8e. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00307. eS8. 1 hit.
PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS8_HUMAN
AccessioniPrimary (citable) accession number: P62241
Secondary accession number(s): P09058, Q6IRL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.