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P62241

- RS8_HUMAN

UniProt

P62241 - RS8_HUMAN

Protein

40S ribosomal protein S8

Gene

RPS8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. structural constituent of ribosome Source: RefGenome

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. gene expression Source: Reactome
    3. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: RefGenome
    4. mRNA metabolic process Source: Reactome
    5. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
    6. RNA metabolic process Source: Reactome
    7. SRP-dependent cotranslational protein targeting to membrane Source: Reactome
    8. translation Source: UniProtKB
    9. translational elongation Source: Reactome
    10. translational initiation Source: Reactome
    11. translational termination Source: Reactome
    12. viral life cycle Source: Reactome
    13. viral process Source: Reactome
    14. viral transcription Source: Reactome

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    ReactomeiREACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    40S ribosomal protein S8
    Gene namesi
    Name:RPS8
    ORF Names:OK/SW-cl.83
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10441. RPS8.

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. cytosol Source: Reactome
    3. cytosolic small ribosomal subunit Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt
    5. membrane Source: UniProtKB
    6. nucleus Source: UniProt
    7. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34856.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 20820740S ribosomal protein S8PRO_0000122240Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371N6-acetyllysineBy similarity
    Modified residuei128 – 1281N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP62241.
    PaxDbiP62241.
    PeptideAtlasiP62241.
    PRIDEiP62241.

    PTM databases

    PhosphoSiteiP62241.

    Miscellaneous databases

    PMAP-CutDBP62241.

    Expressioni

    Gene expression databases

    BgeeiP62241.
    CleanExiHS_RPS8.
    GenevestigatoriP62241.

    Organism-specific databases

    HPAiHPA029266.

    Interactioni

    Subunit structurei

    Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NDRG1Q925971EBI-351811,EBI-716486

    Protein-protein interaction databases

    BioGridi112116. 155 interactions.
    IntActiP62241. 25 interactions.
    MINTiMINT-1141293.
    STRINGi9606.ENSP00000379888.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3J3Aelectron microscopy5.00I1-208[»]
    ProteinModelPortaliP62241.
    SMRiP62241. Positions 2-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S8e family.Curated

    Phylogenomic databases

    eggNOGiCOG2007.
    HOGENOMiHOG000211544.
    HOVERGENiHBG030738.
    InParanoidiP62241.
    KOiK02995.
    OMAiWASEQTT.
    PhylomeDBiP62241.
    TreeFamiTF300041.

    Family and domain databases

    InterProiIPR001047. Ribosomal_S8e.
    IPR022309. Ribosomal_S8e/biogenesis_NSA2.
    IPR018283. Ribosomal_S8e_CS.
    [Graphical view]
    PANTHERiPTHR10394. PTHR10394. 1 hit.
    PfamiPF01201. Ribosomal_S8e. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00307. S8e. 1 hit.
    PROSITEiPS01193. RIBOSOMAL_S8E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62241-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG    50
    GNKKYRALRL DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC 100
    IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD 150
    ERKKNAKISS LLEEQFQQGK LLACIASRPG QCGRADGYVL EGKELEFYLR 200
    KIKARKGK 208
    Length:208
    Mass (Da):24,205
    Last modified:January 23, 2007 - v2
    Checksum:i407FDF59171F7422
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti110 – 1101R → G.
    Corresponds to variant rs11537870 [ dbSNP | Ensembl ].
    VAR_051861

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67247 Genomic DNA. Translation: CAA47670.1.
    AB062401 mRNA. Translation: BAB93488.1.
    BC070875 mRNA. Translation: AAH70875.1.
    CCDSiCCDS513.1.
    PIRiS25022.
    RefSeqiNP_001003.1. NM_001012.1.
    UniGeneiHs.512675.

    Genome annotation databases

    EnsembliENST00000396651; ENSP00000379888; ENSG00000142937.
    GeneIDi6202.
    KEGGihsa:6202.
    UCSCiuc001cmi.3. human.

    Polymorphism databases

    DMDMi50403622.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X67247 Genomic DNA. Translation: CAA47670.1 .
    AB062401 mRNA. Translation: BAB93488.1 .
    BC070875 mRNA. Translation: AAH70875.1 .
    CCDSi CCDS513.1.
    PIRi S25022.
    RefSeqi NP_001003.1. NM_001012.1.
    UniGenei Hs.512675.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3J3A electron microscopy 5.00 I 1-208 [» ]
    ProteinModelPortali P62241.
    SMRi P62241. Positions 2-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112116. 155 interactions.
    IntActi P62241. 25 interactions.
    MINTi MINT-1141293.
    STRINGi 9606.ENSP00000379888.

    PTM databases

    PhosphoSitei P62241.

    Polymorphism databases

    DMDMi 50403622.

    Proteomic databases

    MaxQBi P62241.
    PaxDbi P62241.
    PeptideAtlasi P62241.
    PRIDEi P62241.

    Protocols and materials databases

    DNASUi 6202.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000396651 ; ENSP00000379888 ; ENSG00000142937 .
    GeneIDi 6202.
    KEGGi hsa:6202.
    UCSCi uc001cmi.3. human.

    Organism-specific databases

    CTDi 6202.
    GeneCardsi GC01P045240.
    HGNCi HGNC:10441. RPS8.
    HPAi HPA029266.
    MIMi 600357. gene.
    neXtProti NX_P62241.
    PharmGKBi PA34856.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2007.
    HOGENOMi HOG000211544.
    HOVERGENi HBG030738.
    InParanoidi P62241.
    KOi K02995.
    OMAi WASEQTT.
    PhylomeDBi P62241.
    TreeFami TF300041.

    Enzyme and pathway databases

    Reactomei REACT_1079. Formation of the ternary complex, and subsequently, the 43S complex.
    REACT_115902. SRP-dependent cotranslational protein targeting to membrane.
    REACT_1404. Peptide chain elongation.
    REACT_1797. Formation of a pool of free 40S subunits.
    REACT_1979. Translation initiation complex formation.
    REACT_1986. Eukaryotic Translation Termination.
    REACT_2085. GTP hydrolysis and joining of the 60S ribosomal subunit.
    REACT_75768. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_75822. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_79. L13a-mediated translational silencing of Ceruloplasmin expression.
    REACT_931. Ribosomal scanning and start codon recognition.
    REACT_9491. Viral mRNA Translation.

    Miscellaneous databases

    ChiTaRSi RPS8. human.
    GeneWikii RPS8.
    GenomeRNAii 6202.
    NextBioi 24087.
    PMAP-CutDB P62241.
    PROi P62241.
    SOURCEi Search...

    Gene expression databases

    Bgeei P62241.
    CleanExi HS_RPS8.
    Genevestigatori P62241.

    Family and domain databases

    InterProi IPR001047. Ribosomal_S8e.
    IPR022309. Ribosomal_S8e/biogenesis_NSA2.
    IPR018283. Ribosomal_S8e_CS.
    [Graphical view ]
    PANTHERi PTHR10394. PTHR10394. 1 hit.
    Pfami PF01201. Ribosomal_S8e. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00307. S8e. 1 hit.
    PROSITEi PS01193. RIBOSOMAL_S8E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The structure of the human intron-containing S8 ribosomal protein gene and determination of its chromosomal location at 1p32-p34.1."
      Davies B., Fried M.
      Genomics 15:68-75(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
      Shichijo S., Itoh K.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon adenocarcinoma.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    4. "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry."
      Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A.
      Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE.
      Tissue: Placenta.
    5. Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: STRUCTURE BY ELECTRON MICROSCOPY (5.0 ANGSTROMS).

    Entry informationi

    Entry nameiRS8_HUMAN
    AccessioniPrimary (citable) accession number: P62241
    Secondary accession number(s): P09058, Q6IRL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Ribosomal proteins
      Ribosomal proteins families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3