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Protein

Calmodulin

Gene

PF14_0323

Organism
Plasmodium falciparum (isolate 3D7)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-PFA-114608. Platelet degranulation.
R-PFA-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-PFA-203615. eNOS activation.
R-PFA-2871809. FCERI mediated Ca+2 mobilization.
R-PFA-4086398. Ca2+ pathway.
R-PFA-5218920. VEGFR2 mediated vascular permeability.
R-PFA-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
ORF Names:PF14_0323
OrganismiPlasmodium falciparum (isolate 3D7)
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1434200.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001982652 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Interactioni

Protein-protein interaction databases

BioGridi1207263. 10 interactors.
IntActiP62203. 7 interactors.
MINTiMINT-1546362.

Structurei

3D structure databases

ProteinModelPortaliP62203.
SMRiP62203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000233018.
InParanoidiP62203.
KOiK02183.
OMAiHRISGKA.
PhylomeDBiP62203.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKLTEEQI SEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEIDTDG NGTIDFPEFL TLMARKLKDT DTEEELIEAF RVFDRDGDGY
110 120 130 140
ISADELRHVM TNLGEKLTNE EVDEMIREAD IDGDGQINYE EFVKMMIAK
Length:149
Mass (Da):16,931
Last modified:January 23, 2007 - v2
Checksum:i30D806FDA42BC173
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36936.1.
RefSeqiXP_001348497.1. XM_001348461.1.

Genome annotation databases

EnsemblProtistsiAAN36936; AAN36936; PF14_0323.
GeneDBiPF3D7_1434200.1:pep.
GeneIDi811905.
KEGGipfa:PF14_0323.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014187 Genomic DNA. Translation: AAN36936.1.
RefSeqiXP_001348497.1. XM_001348461.1.

3D structure databases

ProteinModelPortaliP62203.
SMRiP62203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1207263. 10 interactors.
IntActiP62203. 7 interactors.
MINTiMINT-1546362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiAAN36936; AAN36936; PF14_0323.
GeneDBiPF3D7_1434200.1:pep.
GeneIDi811905.
KEGGipfa:PF14_0323.

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1434200.

Phylogenomic databases

HOGENOMiHOG000233018.
InParanoidiP62203.
KOiK02183.
OMAiHRISGKA.
PhylomeDBiP62203.

Enzyme and pathway databases

ReactomeiR-PFA-114608. Platelet degranulation.
R-PFA-1474151. Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.
R-PFA-203615. eNOS activation.
R-PFA-2871809. FCERI mediated Ca+2 mobilization.
R-PFA-4086398. Ca2+ pathway.
R-PFA-5218920. VEGFR2 mediated vascular permeability.
R-PFA-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM_PLAF7
AccessioniPrimary (citable) accession number: P62203
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

Calmodulin is not involved in the mechanism of chloroquine resistance.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.