Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P62194 (PRS8_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
26S protease regulatory subunit 8
Alternative name(s):
26S proteasome AAA-ATPase subunit RPT6
Proteasome 26S subunit ATPase 5
Proteasome subunit p45
p45/SUG
Gene names
Name:PSMC5
Synonyms:SUG1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.

Subunit structure

Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR). Interacts with NDC80. Interacts with PAAF1 By similarity. Interacts with TRIM5. Component of a complex with USP49 and RUVBL1 By similarity.

Subcellular location

Cytoplasm Potential. Nucleus Potential.

Sequence similarities

Belongs to the AAA ATPase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 40640526S protease regulatory subunit 8
PRO_0000084720

Regions

Nucleotide binding190 – 1978ATP Potential

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue2221N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62194 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 29C6410C4A85A7F7

FASTA40645,626
        10         20         30         40         50         60 
MALDGPEQME LEEGKAGSGL RQYYLSKIEE LQLIVNDKSQ NLRRLQAQRN ELNAKVRLLR 

        70         80         90        100        110        120 
EELQLLQEQG SYVGEVVRAM DKKKVLVKVH PEGKFVVDVD KNIDINDVTP NCRVALRNDS 

       130        140        150        160        170        180 
YTLHKILPNK VDPLVSLMMV EKVPDSTYEM IGGLDKQIKE IKEVIELPVK HPELFEALGI 

       190        200        210        220        230        240 
AQPKGVLLYG PPGTGKTLLA RAVAHHTDCT FIRVSGSELV QKFIGEGARM VRELFVMARE 

       250        260        270        280        290        300 
HAPSIIFMDE IDSIGSSRLE GGSGGDSEVQ RTMLELLNQL DGFEATKNIK VIMATNRIDI 

       310        320        330        340        350        360 
LDSALLRPGR IDRKIEFPPP NEEARLDILK IHSRKMNLTR GINLRKIAEL MPGASGAEVK 

       370        380        390        400 
GVCTEAGMYA LRERRVHVTQ EDFEMAVAKV MQKDSEKNMS IKKLWK 

« Hide

References

« Hide 'large scale' references
[1]"Interaction of phosducin and phosducin isoforms with a 26S proteasomal subunit, SUG1."
Zhu X., Craft C.M.
Mol. Vis. 4:13-13(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]NIH - Mammalian Gene Collection (MGC) project
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Brain cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF069053 mRNA. Translation: AAC19266.1.
BC146195 mRNA. Translation: AAI46196.1.
RefSeqNP_776866.1. NM_174441.2.
UniGeneBt.8062.

3D structure databases

ProteinModelPortalP62194.
SMRP62194. Positions 27-396.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid159304. 1 interaction.

Proteomic databases

PaxDbP62194.
PRIDEP62194.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000028048; ENSBTAP00000028048; ENSBTAG00000021061.
GeneID282015.
KEGGbta:282015.

Organism-specific databases

CTD5705.

Phylogenomic databases

eggNOGCOG1222.
GeneTreeENSGT00550000074947.
HOGENOMHOG000225143.
HOVERGENHBG000109.
InParanoidP62194.
KOK03066.
OMAVMGTKKV.
OrthoDBEOG7TF78Z.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR005937. 26S_Psome_P45.
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00004. AAA. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR01242. 26Sp45. 1 hit.
PROSITEPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805880.

Entry information

Entry namePRS8_BOVIN
AccessionPrimary (citable) accession number: P62194
Secondary accession number(s): A6H7C5 expand/collapse secondary AC list , O35051, P47210, P52915, P52916
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families