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Protein

HTH-type transcriptional regulator GlnR

Gene

glnR

Organism
Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription repressor during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site.By similarity

Miscellaneous

The amino acid sequences of the N-terminal DNA binding domains of TnrA and GlnR are highly similar, and both proteins bind to DNA sequences with a common consensus sequence. In contrast, the C-terminal signal transduction domains of TnrA and GlnR have no homology.By similarity

Enzyme regulationi

Under conditions of nitrogen excess, the DNA binding activity of GlnR is activated by a transient interaction with feedback-inhibited GlnA. Under conditions of nitrogen-limited, GlnR is autoinhibited by its C-terminal region.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 32H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GlnRBy similarity
Gene namesi
Name:glnRBy similarity
Ordered Locus Names:BC_3706
OrganismiBacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NRRL B-3711)
Taxonomic identifieri226900 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000001417 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981211 – 129HTH-type transcriptional regulator GlnRAdd BLAST129

Expressioni

Inductioni

Under conditions of nitrogen-limited growth, repressed by TnrA.By similarity

Interactioni

Subunit structurei

Homodimer under conditions of nitrogen excess. Monomer under conditions of nitrogen-limited. Interacts with feedback-inhibited GlnA in order to stabilizes GlnR-DNA complex.By similarity

Protein-protein interaction databases

STRINGi226900.BC3706

Structurei

3D structure databases

ProteinModelPortaliP62174
SMRiP62174
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 78HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiCOG0789 LUCA
KOiK03713
OMAiMYSLNDV

Family and domain databases

InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P62174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDRRSAPL FPIGIVMDLT QLSARQIRYY EEHNLVSPTR TKGNRRLFSF
60 70 80 90 100
NDVDKLLEIK DLLDQGLNMA GIKQVLLMKE NQTEAVKVKE ETKEISKTEL
110 120
RKILRDELQH TGRFNRTSLR QGDISRFFH
Length:129
Mass (Da):15,173
Last modified:June 21, 2004 - v1
Checksum:iBA363083892C6802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016877 Genomic DNA Translation: AAP10634.1
RefSeqiNP_833433.1, NC_004722.1
WP_000656783.1, NC_004722.1

Genome annotation databases

EnsemblBacteriaiAAP10634; AAP10634; BC_3706
GeneIDi1206051
31628840
KEGGibce:BC3706
PATRICifig|226900.8.peg.3815

Similar proteinsi

Entry informationi

Entry nameiGLNR_BACCR
AccessioniPrimary (citable) accession number: P62174
Secondary accession number(s): P19083
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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