Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HTH-type transcriptional regulator GlnR

Gene

glnR

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription repressor during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site.By similarity

Miscellaneous

The amino acid sequences of the N-terminal DNA binding domains of TnrA and GlnR are highly similar, and both proteins bind to DNA sequences with a common consensus sequence. In contrast, the C-terminal signal transduction domains of TnrA and GlnR have no homology.By similarity

Enzyme regulationi

Under conditions of nitrogen excess, the DNA binding activity of GlnR is activated by a transient interaction with feedback-inhibited GlnA. Under conditions of nitrogen-limited, GlnR is autoinhibited by its C-terminal region.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 32H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • glutamine biosynthetic process Source: TIGR
  • regulation of transcription, DNA-templated Source: TIGR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GlnRBy similarity
Gene namesi
Name:glnRBy similarity
Ordered Locus Names:BA_3834, GBAA_3834, BAS3550
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome
  • UP000000427 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981191 – 129HTH-type transcriptional regulator GlnRAdd BLAST129

Expressioni

Inductioni

Under conditions of nitrogen-limited growth, repressed by TnrA.By similarity

Interactioni

Subunit structurei

Homodimer under conditions of nitrogen excess. Monomer under conditions of nitrogen-limited. Interacts with feedback-inhibited GlnA in order to stabilizes GlnR-DNA complex.By similarity

Protein-protein interaction databases

STRINGi260799.BAS3550

Structurei

3D structure databases

ProteinModelPortaliP62172
SMRiP62172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 78HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4105KV4 Bacteria
COG0789 LUCA
HOGENOMiHOG000266082
KOiK03713
OMAiMYSLNDV

Family and domain databases

InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR000551 MerR-type_HTH_dom
PfamiView protein in Pfam
PF13411 MerR_1, 1 hit
SMARTiView protein in SMART
SM00422 HTH_MERR, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
PROSITEiView protein in PROSITE
PS00552 HTH_MERR_1, 1 hit
PS50937 HTH_MERR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P62172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDRRSAPL FPIGIVMDLT QLSARQIRYY EEHNLVSPTR TKGNRRLFSF
60 70 80 90 100
NDVDKLLEIK DLLDQGLNMA GIKQVLLMKE NQTEAVKVKE ETKEISKTEL
110 120
RKILRDELQH TGRFNRTSLR QGDISRFFH
Length:129
Mass (Da):15,173
Last modified:June 21, 2004 - v1
Checksum:iBA363083892C6802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA Translation: AAP27571.1
AE017334 Genomic DNA Translation: AAT32943.1
AE017225 Genomic DNA Translation: AAT55855.1
RefSeqiNP_846085.1, NC_003997.3
WP_000656783.1, NZ_PPES01000004.1
YP_029804.1, NC_005945.1

Genome annotation databases

EnsemblBacteriaiAAP27571; AAP27571; BA_3834
AAT32943; AAT32943; GBAA_3834
AAT55855; AAT55855; BAS3550
GeneIDi1084985
2848381
31628840
KEGGiban:BA_3834
bar:GBAA_3834
bat:BAS3550
PATRICifig|198094.11.peg.3802

Similar proteinsi

Entry informationi

Entry nameiGLNR_BACAN
AccessioniPrimary (citable) accession number: P62172
Secondary accession number(s): P19083, Q6HV34, Q6KPA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health