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Protein

HTH-type transcriptional regulator GlnR

Gene

glnR

Organism
Bacillus anthracis
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transcription repressor during nitrogen excess. On the contrary of the MerR members, which require longer DNA sites for high-affinity binding, GlnR requires a DNA sequence of 17 nucleotides as minimal binding site.By similarity

Enzyme regulationi

Under conditions of nitrogen excess, the DNA binding activity of GlnR is activated by a transient interaction with feedback-inhibited GlnA. Under conditions of nitrogen-limited, GlnR is autoinhibited by its C-terminal region.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 32H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

  • glutamine biosynthetic process Source: TIGR
  • regulation of transcription, DNA-templated Source: TIGR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator GlnRBy similarity
Gene namesi
Name:glnRBy similarity
Ordered Locus Names:BA_3834, GBAA_3834, BAS3550
OrganismiBacillus anthracis
Taxonomic identifieri1392 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000000594 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000981191 – 129HTH-type transcriptional regulator GlnRAdd BLAST129

Expressioni

Inductioni

Under conditions of nitrogen-limited growth, repressed by TnrA.By similarity

Interactioni

Subunit structurei

Homodimer under conditions of nitrogen excess. Monomer under conditions of nitrogen-limited. Interacts with feedback-inhibited GlnA in order to stabilizes GlnR-DNA complex.By similarity

Protein-protein interaction databases

STRINGi198094.BA_3834.

Structurei

3D structure databases

ProteinModelPortaliP62172.
SMRiP62172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 78HTH merR-typePROSITE-ProRule annotationAdd BLAST69

Phylogenomic databases

eggNOGiENOG4105KV4. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266082.
KOiK03713.
OMAiYEEQELV.

Family and domain databases

InterProiView protein in InterPro
IPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
PfamiView protein in Pfam
PF13411. MerR_1. 1 hit.
SMARTiView protein in SMART
SM00422. HTH_MERR. 1 hit.
SUPFAMiSSF46955. SSF46955. 1 hit.
PROSITEiView protein in PROSITE
PS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P62172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDRRSAPL FPIGIVMDLT QLSARQIRYY EEHNLVSPTR TKGNRRLFSF
60 70 80 90 100
NDVDKLLEIK DLLDQGLNMA GIKQVLLMKE NQTEAVKVKE ETKEISKTEL
110 120
RKILRDELQH TGRFNRTSLR QGDISRFFH
Length:129
Mass (Da):15,173
Last modified:June 21, 2004 - v1
Checksum:iBA363083892C6802
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27571.1.
AE017334 Genomic DNA. Translation: AAT32943.1.
AE017225 Genomic DNA. Translation: AAT55855.1.
RefSeqiNP_846085.1. NC_003997.3.
WP_000656783.1. NZ_MLJX01000004.1.
YP_029804.1. NC_005945.1.

Genome annotation databases

EnsemblBacteriaiAAP27571; AAP27571; BA_3834.
AAT32943; AAT32943; GBAA_3834.
AAT55855; AAT55855; BAS3550.
GeneIDi1084985.
23125415.
2848381.
KEGGiban:BA_3834.
bar:GBAA_3834.
bat:BAS3550.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016879 Genomic DNA. Translation: AAP27571.1.
AE017334 Genomic DNA. Translation: AAT32943.1.
AE017225 Genomic DNA. Translation: AAT55855.1.
RefSeqiNP_846085.1. NC_003997.3.
WP_000656783.1. NZ_MLJX01000004.1.
YP_029804.1. NC_005945.1.

3D structure databases

ProteinModelPortaliP62172.
SMRiP62172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198094.BA_3834.

Protocols and materials databases

DNASUi1084985.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAP27571; AAP27571; BA_3834.
AAT32943; AAT32943; GBAA_3834.
AAT55855; AAT55855; BAS3550.
GeneIDi1084985.
23125415.
2848381.
KEGGiban:BA_3834.
bar:GBAA_3834.
bat:BAS3550.

Phylogenomic databases

eggNOGiENOG4105KV4. Bacteria.
COG0789. LUCA.
HOGENOMiHOG000266082.
KOiK03713.
OMAiYEEQELV.

Family and domain databases

InterProiView protein in InterPro
IPR009061. DNA-bd_dom_put.
IPR000551. MerR-type_HTH_dom.
PfamiView protein in Pfam
PF13411. MerR_1. 1 hit.
SMARTiView protein in SMART
SM00422. HTH_MERR. 1 hit.
SUPFAMiSSF46955. SSF46955. 1 hit.
PROSITEiView protein in PROSITE
PS00552. HTH_MERR_1. 1 hit.
PS50937. HTH_MERR_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLNR_BACAN
AccessioniPrimary (citable) accession number: P62172
Secondary accession number(s): P19083, Q6HV34, Q6KPA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: March 15, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The amino acid sequences of the N-terminal DNA binding domains of TnrA and GlnR are highly similar, and both proteins bind to DNA sequences with a common consensus sequence. In contrast, the C-terminal signal transduction domains of TnrA and GlnR have no homology.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.