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P62149

- CALM_CHICK

UniProt

P62149 - CALM_CHICK

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Protein
Calmodulin
Gene
CALM, CAM, RCJMB04_24e7
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121
Add
BLAST
Calcium bindingi57 – 68122
Add
BLAST
Calcium bindingi94 – 105123
Add
BLAST
Calcium bindingi130 – 141124
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. myosin binding Source: UniProtKB
  3. protein phosphatase activator activity Source: Ensembl

GO - Biological processi

  1. detection of calcium ion Source: Ensembl
  2. positive regulation of cyclic nucleotide metabolic process Source: Ensembl
  3. positive regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
  4. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
  5. positive regulation of protein dephosphorylation Source: Ensembl
  6. positive regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
  7. regulation of cardiac muscle contraction Source: Ensembl
  8. regulation of cytokinesis Source: Ensembl
  9. regulation of heart rate Source: Ensembl
  10. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:CALM
Synonyms:CAM
ORF Names:RCJMB04_24e7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. calcium channel complex Source: Ensembl
  2. centrosome Source: Ensembl
  3. sarcomere Source: Ensembl
  4. spindle microtubule Source: Ensembl
  5. spindle pole Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 149148Calmodulin
PRO_0000198230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei116 – 1161N6,N6,N6-trimethyllysine By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP62149.
PRIDEiP62149.

Interactioni

Protein-protein interaction databases

DIPiDIP-29154N.
STRINGi9031.ENSGALP00000037503.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2 – 43
Helixi7 – 2014
Beta strandi25 – 284
Helixi30 – 3910
Helixi46 – 5611
Beta strandi61 – 655
Helixi66 – 749
Turni79 – 813
Helixi82 – 9312
Beta strandi98 – 1014
Helixi103 – 11210
Helixi119 – 12911
Beta strandi134 – 1385
Helixi139 – 1457

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHRX-ray1.80A2-149[»]
1UP5X-ray1.90A/B2-149[»]
2BCXX-ray2.00A2-149[»]
2BKIX-ray2.90B/D2-149[»]
2KZ2NMR-A77-149[»]
2M3SNMR-A1-149[»]
2O5GX-ray1.08A2-149[»]
2O60X-ray1.55A2-149[»]
2VB6X-ray2.30B1-149[»]
3GOFX-ray1.45A/B2-149[»]
3GP2X-ray1.46A2-148[»]
ProteinModelPortaliP62149.
SMRiP62149. Positions 1-149.

Miscellaneous databases

EvolutionaryTraceiP62149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1
Add
BLAST
Domaini44 – 7936EF-hand 2
Add
BLAST
Domaini81 – 11636EF-hand 3
Add
BLAST
Domaini117 – 14933EF-hand 4
Add
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.
Contains 4 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOVERGENiHBG012180.
InParanoidiP62149.
OMAiTEQISEF.
OrthoDBiEOG7F7WBV.
TreeFamiTF300912.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62149-1 [UniParc]FASTAAdd to Basket

« Hide

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ    50
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY 100
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK 149
Length:149
Mass (Da):16,838
Last modified:January 23, 2007 - v2
Checksum:i6B4BC3FCDE10727B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00101
, L00096, L00097, L00098, L00099, L00100 Genomic DNA. Translation: AAA48653.1.
M36167 mRNA. Translation: AAA48650.1.
AJ720728 mRNA. Translation: CAG32387.1.
PIRiA92394. MCCH.
UniGeneiGga.11685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00101
, L00096 , L00097 , L00098 , L00099 , L00100 Genomic DNA. Translation: AAA48653.1 .
M36167 mRNA. Translation: AAA48650.1 .
AJ720728 mRNA. Translation: CAG32387.1 .
PIRi A92394. MCCH.
UniGenei Gga.11685.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AHR X-ray 1.80 A 2-149 [» ]
1UP5 X-ray 1.90 A/B 2-149 [» ]
2BCX X-ray 2.00 A 2-149 [» ]
2BKI X-ray 2.90 B/D 2-149 [» ]
2KZ2 NMR - A 77-149 [» ]
2M3S NMR - A 1-149 [» ]
2O5G X-ray 1.08 A 2-149 [» ]
2O60 X-ray 1.55 A 2-149 [» ]
2VB6 X-ray 2.30 B 1-149 [» ]
3GOF X-ray 1.45 A/B 2-149 [» ]
3GP2 X-ray 1.46 A 2-148 [» ]
ProteinModelPortali P62149.
SMRi P62149. Positions 1-149.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29154N.
STRINGi 9031.ENSGALP00000037503.

Chemistry

BindingDBi P62149.

Proteomic databases

PaxDbi P62149.
PRIDEi P62149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5126.
HOVERGENi HBG012180.
InParanoidi P62149.
OMAi TEQISEF.
OrthoDBi EOG7F7WBV.
TreeFami TF300912.

Miscellaneous databases

EvolutionaryTracei P62149.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone."
    Putkey J.A., Ts'Ui K.F., Tanaka T., Lagace L., Stein J.P., Lai E.C., Means A.R.
    J. Biol. Chem. 258:11864-11870(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The structural organization of the chicken calmodulin gene."
    Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R.
    J. Biol. Chem. 260:907-912(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Erratum
    Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R.
    J. Biol. Chem. 262:4928-4929(1987)
  4. "cDNA sequences and molecular evolution of calmodulin genes of chicken and eel."
    Iida Y.
    Bull. Chem. Soc. Jpn. 57:2667-2668(1984)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  6. "The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding."
    Tabernero L., Taylor D.A., Chandross R.J., VanBerkum M.F.A., Means A.R., Quiocho F.A., Sack J.S.
    Structure 5:613-622(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Entry informationi

Entry nameiCALM_CHICK
AccessioniPrimary (citable) accession number: P62149
Secondary accession number(s): P02593
, P70667, P99014, Q5ZIQ6, Q61379, Q61380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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