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Protein

Calmodulin

Gene

CALM

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • myosin binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:CALM
Synonyms:CAM
ORF Names:RCJMB04_24e7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001982302 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP62149.

PTM databases

iPTMnetiP62149.

Expressioni

Gene expression databases

BgeeiENSGALG00000010023.

Interactioni

GO - Molecular functioni

  • myosin binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-29154N.
STRINGi9031.ENSGALP00000037503.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni2 – 4Combined sources3
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 56Combined sources11
Beta strandi61 – 65Combined sources5
Helixi66 – 74Combined sources9
Turni79 – 81Combined sources3
Helixi82 – 93Combined sources12
Beta strandi98 – 101Combined sources4
Helixi103 – 112Combined sources10
Helixi119 – 129Combined sources11
Beta strandi134 – 138Combined sources5
Helixi139 – 145Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHRX-ray1.80A2-149[»]
1UP5X-ray1.90A/B2-149[»]
2BCXX-ray2.00A2-149[»]
2BKIX-ray2.90B/D2-149[»]
2KZ2NMR-A77-149[»]
2M3SNMR-A1-149[»]
2O5GX-ray1.08A2-149[»]
2O60X-ray1.55A2-149[»]
2VB6X-ray2.30B1-149[»]
3GOFX-ray1.45A/B2-149[»]
3GP2X-ray1.46A2-148[»]
4BYANMR-A77-149[»]
5HITX-ray2.85A2-148[»]
ProteinModelPortaliP62149.
SMRiP62149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOVERGENiHBG012180.
InParanoidiP62149.
OrthoDBiEOG091G0V73.
TreeFamiTF300912.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,838
Last modified:January 23, 2007 - v2
Checksum:i6B4BC3FCDE10727B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00101
, L00096, L00097, L00098, L00099, L00100 Genomic DNA. Translation: AAA48653.1.
M36167 mRNA. Translation: AAA48650.1.
AJ720728 mRNA. Translation: CAG32387.1.
PIRiA92394. MCCH.
UniGeneiGga.11685.

Genome annotation databases

EnsembliENSGALT00000045488; ENSGALP00000042446; ENSGALG00000026445.
ENSGALT00000080380; ENSGALP00000044697; ENSGALG00000010023.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00101
, L00096, L00097, L00098, L00099, L00100 Genomic DNA. Translation: AAA48653.1.
M36167 mRNA. Translation: AAA48650.1.
AJ720728 mRNA. Translation: CAG32387.1.
PIRiA92394. MCCH.
UniGeneiGga.11685.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHRX-ray1.80A2-149[»]
1UP5X-ray1.90A/B2-149[»]
2BCXX-ray2.00A2-149[»]
2BKIX-ray2.90B/D2-149[»]
2KZ2NMR-A77-149[»]
2M3SNMR-A1-149[»]
2O5GX-ray1.08A2-149[»]
2O60X-ray1.55A2-149[»]
2VB6X-ray2.30B1-149[»]
3GOFX-ray1.45A/B2-149[»]
3GP2X-ray1.46A2-148[»]
4BYANMR-A77-149[»]
5HITX-ray2.85A2-148[»]
ProteinModelPortaliP62149.
SMRiP62149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29154N.
STRINGi9031.ENSGALP00000037503.

PTM databases

iPTMnetiP62149.

Proteomic databases

PaxDbiP62149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045488; ENSGALP00000042446; ENSGALG00000026445.
ENSGALT00000080380; ENSGALP00000044697; ENSGALG00000010023.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOVERGENiHBG012180.
InParanoidiP62149.
OrthoDBiEOG091G0V73.
TreeFamiTF300912.

Miscellaneous databases

EvolutionaryTraceiP62149.

Gene expression databases

BgeeiENSGALG00000010023.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALM_CHICK
AccessioniPrimary (citable) accession number: P62149
Secondary accession number(s): P02593
, P70667, P99014, Q5ZIQ6, Q61379, Q61380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.