Calmodulin - Gallus gallus (Chicken)

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P62149 (CALM_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calmodulin
Short name=CaM

Gene names

Name:	CALM
Synonyms:	CAM
ORF Names:	RCJMB04_24e7

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca²⁺. Among the enzymes to be stimulated by the calmodulin-Ca²⁺ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Sequence similarities

Belongs to the calmodulin family.

Contains 4 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Acetylation Methylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of cytokinesis Inferred from electronic annotation. Source: Compara response to calcium ion Inferred from electronic annotation. Source: Compara
Cellular_component	centrosome Inferred from electronic annotation. Source: Compara spindle microtubule Inferred from electronic annotation. Source: Compara spindle pole Inferred from electronic annotation. Source: Compara
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 149

148

Calmodulin

PRO_0000198230

Regions

Domain

8 – 43

EF-hand 1

Domain

44 – 79

EF-hand 2

Domain

81 – 116

EF-hand 3

Domain

117 – 149

EF-hand 4

Calcium binding

Calcium binding

Calcium binding

Calcium binding

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

116

N6,N6,N6-trimethyllysine By similarity

Secondary structure

149

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P62149 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 6B4BC3FCDE10727B
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FASTA

149

16,838

        10         20         30         40         50         60 
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG 

        70         80         90        100        110        120 
NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE 

       130        140 
EVDEMIREAD IDGDGQVNYE EFVQMMTAK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone." Putkey J.A., Ts'Ui K.F., Tanaka T., Lagace L., Stein J.P., Lai E.C., Means A.R. J. Biol. Chem. 258:11864-11870(1983) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The structural organization of the chicken calmodulin gene." Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R. J. Biol. Chem. 260:907-912(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Erratum Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R. J. Biol. Chem. 262:4928-4929(1987)
[4]	"cDNA sequences and molecular evolution of calmodulin genes of chicken and eel." Iida Y. Bull. Chem. Soc. Jpn. 57:2667-2668(1984) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.
[6]	"The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding." Tabernero L., Taylor D.A., Chandross R.J., VanBerkum M.F.A., Means A.R., Quiocho F.A., Sack J.S. Structure 5:613-622(1997) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L00101

L00100 Genomic DNA. Translation: AAA48653.1.
M36167 mRNA. Translation: AAA48650.1.
AJ720728 mRNA. Translation: CAG32387.1.

IPI

IPI00823322.

PIR

MCCH. A92394.

UniGene

Gga.11685.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AHR	X-ray	1.80	A	2-147	[»]
1UP5	X-ray	1.90	A/B	2-149	[»]
2BCX	X-ray	2.00	A	2-148	[»]
2BKI	X-ray	2.90	B/D	2-148	[»]
2KZ2	NMR	-	A	77-149	[»]
2O5G	X-ray	1.08	A	2-149	[»]
2O60	X-ray	1.55	A	2-149	[»]
2VB6	X-ray	2.30	B	1-147	[»]
3GOF	X-ray	1.45	A/B	2-149	[»]
3GP2	X-ray	1.46	A	2-148	[»]

ProteinModelPortal

P62149.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-29154N.

STRING

9031.ENSGALP00000037503.

Proteomic databases

PaxDb

P62149.

PRIDE

P62149.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSGALT00000038297; ENSGALP00000037503; ENSGALG00000010023.

Phylogenomic databases

eggNOG

COG5126.

GeneTree

ENSGT00690000101867.

HOVERGEN

HBG012180.

InParanoid

P62149.

OMA

ELEDMIN.

OrthoDB

EOG4001KK.

Gene expression databases

ArrayExpress

P62149.

Family and domain databases

Gene3D

1.10.238.10. 2 hits.

InterPro

IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001125. Recoverin.
[Graphical view]

Pfam

PF13499. EF_hand_5. 2 hits.
[Graphical view]

PRINTS

PR00450. RECOVERIN.

SMART

SM00054. EFh. 4 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

P62149.

EvolutionaryTrace

P62149.

Entry information

Entry name

CALM_CHICK

Accession

Primary (citable) accession number: P62149
Secondary accession number(s): P02593

Q61380

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents