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P62149

- CALM_CHICK

UniProt

P62149 - CALM_CHICK

Protein

Calmodulin

Gene

CALM

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi21 – 32121Add
    BLAST
    Calcium bindingi57 – 68122Add
    BLAST
    Calcium bindingi94 – 105123Add
    BLAST
    Calcium bindingi130 – 141124Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. myosin binding Source: UniProtKB
    3. protein phosphatase activator activity Source: Ensembl

    GO - Biological processi

    1. detection of calcium ion Source: Ensembl
    2. positive regulation of cyclic nucleotide metabolic process Source: Ensembl
    3. positive regulation of cyclic-nucleotide phosphodiesterase activity Source: Ensembl
    4. positive regulation of phosphoprotein phosphatase activity Source: Ensembl
    5. positive regulation of protein dephosphorylation Source: Ensembl
    6. positive regulation of ryanodine-sensitive calcium-release channel activity Source: Ensembl
    7. regulation of cardiac muscle contraction Source: Ensembl
    8. regulation of cytokinesis Source: Ensembl
    9. regulation of heart rate Source: Ensembl
    10. regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calmodulin
    Short name:
    CaM
    Gene namesi
    Name:CALM
    Synonyms:CAM
    ORF Names:RCJMB04_24e7
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. calcium channel complex Source: Ensembl
    2. centrosome Source: Ensembl
    3. sarcomere Source: Ensembl
    4. spindle microtubule Source: Ensembl
    5. spindle pole Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 149148CalmodulinPRO_0000198230Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei116 – 1161N6,N6,N6-trimethyllysineBy similarity

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    PaxDbiP62149.
    PRIDEiP62149.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-29154N.
    STRINGi9031.ENSGALP00000037503.

    Structurei

    Secondary structure

    1
    149
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni2 – 43
    Helixi7 – 2014
    Beta strandi25 – 284
    Helixi30 – 3910
    Helixi46 – 5611
    Beta strandi61 – 655
    Helixi66 – 749
    Turni79 – 813
    Helixi82 – 9312
    Beta strandi98 – 1014
    Helixi103 – 11210
    Helixi119 – 12911
    Beta strandi134 – 1385
    Helixi139 – 1457

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AHRX-ray1.80A2-149[»]
    1UP5X-ray1.90A/B2-149[»]
    2BCXX-ray2.00A2-149[»]
    2BKIX-ray2.90B/D2-149[»]
    2KZ2NMR-A77-149[»]
    2M3SNMR-A1-149[»]
    2O5GX-ray1.08A2-149[»]
    2O60X-ray1.55A2-149[»]
    2VB6X-ray2.30B1-149[»]
    3GOFX-ray1.45A/B2-149[»]
    3GP2X-ray1.46A2-148[»]
    ProteinModelPortaliP62149.
    SMRiP62149. Positions 1-149.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP62149.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini81 – 11636EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini117 – 14933EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the calmodulin family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOVERGENiHBG012180.
    InParanoidiP62149.
    OMAiTEQISEF.
    OrthoDBiEOG7F7WBV.
    TreeFamiTF300912.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P62149-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ    50
    DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY 100
    ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK 149
    Length:149
    Mass (Da):16,838
    Last modified:January 23, 2007 - v2
    Checksum:i6B4BC3FCDE10727B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00101
    , L00096, L00097, L00098, L00099, L00100 Genomic DNA. Translation: AAA48653.1.
    M36167 mRNA. Translation: AAA48650.1.
    AJ720728 mRNA. Translation: CAG32387.1.
    PIRiA92394. MCCH.
    UniGeneiGga.11685.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L00101
    , L00096 , L00097 , L00098 , L00099 , L00100 Genomic DNA. Translation: AAA48653.1 .
    M36167 mRNA. Translation: AAA48650.1 .
    AJ720728 mRNA. Translation: CAG32387.1 .
    PIRi A92394. MCCH.
    UniGenei Gga.11685.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AHR X-ray 1.80 A 2-149 [» ]
    1UP5 X-ray 1.90 A/B 2-149 [» ]
    2BCX X-ray 2.00 A 2-149 [» ]
    2BKI X-ray 2.90 B/D 2-149 [» ]
    2KZ2 NMR - A 77-149 [» ]
    2M3S NMR - A 1-149 [» ]
    2O5G X-ray 1.08 A 2-149 [» ]
    2O60 X-ray 1.55 A 2-149 [» ]
    2VB6 X-ray 2.30 B 1-149 [» ]
    3GOF X-ray 1.45 A/B 2-149 [» ]
    3GP2 X-ray 1.46 A 2-148 [» ]
    ProteinModelPortali P62149.
    SMRi P62149. Positions 1-149.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-29154N.
    STRINGi 9031.ENSGALP00000037503.

    Chemistry

    BindingDBi P62149.

    Proteomic databases

    PaxDbi P62149.
    PRIDEi P62149.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOVERGENi HBG012180.
    InParanoidi P62149.
    OMAi TEQISEF.
    OrthoDBi EOG7F7WBV.
    TreeFami TF300912.

    Miscellaneous databases

    EvolutionaryTracei P62149.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone."
      Putkey J.A., Ts'Ui K.F., Tanaka T., Lagace L., Stein J.P., Lai E.C., Means A.R.
      J. Biol. Chem. 258:11864-11870(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The structural organization of the chicken calmodulin gene."
      Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R.
      J. Biol. Chem. 260:907-912(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Erratum
      Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R.
      J. Biol. Chem. 262:4928-4929(1987)
    4. "cDNA sequences and molecular evolution of calmodulin genes of chicken and eel."
      Iida Y.
      Bull. Chem. Soc. Jpn. 57:2667-2668(1984)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.
    6. "The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding."
      Tabernero L., Taylor D.A., Chandross R.J., VanBerkum M.F.A., Means A.R., Quiocho F.A., Sack J.S.
      Structure 5:613-622(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

    Entry informationi

    Entry nameiCALM_CHICK
    AccessioniPrimary (citable) accession number: P62149
    Secondary accession number(s): P02593
    , P70667, P99014, Q5ZIQ6, Q61379, Q61380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    This protein has four functional calcium-binding sites.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3