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P62149

- CALM_CHICK

UniProt

P62149 - CALM_CHICK

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Protein

Calmodulin

Gene

CALM

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi21 – 32121Add
BLAST
Calcium bindingi57 – 68122Add
BLAST
Calcium bindingi94 – 105123Add
BLAST
Calcium bindingi130 – 141124Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. myosin binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:CALM
Synonyms:CAM
ORF Names:RCJMB04_24e7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 149148CalmodulinPRO_0000198230Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei116 – 1161N6,N6,N6-trimethyllysineBy similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP62149.
PRIDEiP62149.

Expressioni

Gene expression databases

ExpressionAtlasiP62149. baseline.

Interactioni

Protein-protein interaction databases

DIPiDIP-29154N.
STRINGi9031.ENSGALP00000037503.

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni2 – 43Combined sources
Helixi7 – 2014Combined sources
Beta strandi25 – 284Combined sources
Helixi30 – 3910Combined sources
Helixi46 – 5611Combined sources
Beta strandi61 – 655Combined sources
Helixi66 – 749Combined sources
Turni79 – 813Combined sources
Helixi82 – 9312Combined sources
Beta strandi98 – 1014Combined sources
Helixi103 – 11210Combined sources
Helixi119 – 12911Combined sources
Beta strandi134 – 1385Combined sources
Helixi139 – 1457Combined sources

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AHRX-ray1.80A2-149[»]
1UP5X-ray1.90A/B2-149[»]
2BCXX-ray2.00A2-149[»]
2BKIX-ray2.90B/D2-149[»]
2KZ2NMR-A77-149[»]
2M3SNMR-A1-149[»]
2O5GX-ray1.08A2-149[»]
2O60X-ray1.55A2-149[»]
2VB6X-ray2.30B1-149[»]
3GOFX-ray1.45A/B2-149[»]
3GP2X-ray1.46A2-148[»]
4BYANMR-A77-149[»]
ProteinModelPortaliP62149.
SMRiP62149. Positions 2-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62149.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini81 – 11636EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 14933EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOVERGENiHBG012180.
InParanoidiP62149.
OMAiTEQISEF.
OrthoDBiEOG7F7WBV.
TreeFamiTF300912.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62149-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,838
Last modified:January 23, 2007 - v2
Checksum:i6B4BC3FCDE10727B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00101
, L00096, L00097, L00098, L00099, L00100 Genomic DNA. Translation: AAA48653.1.
M36167 mRNA. Translation: AAA48650.1.
AJ720728 mRNA. Translation: CAG32387.1.
PIRiA92394. MCCH.
UniGeneiGga.11685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L00101
, L00096 , L00097 , L00098 , L00099 , L00100 Genomic DNA. Translation: AAA48653.1 .
M36167 mRNA. Translation: AAA48650.1 .
AJ720728 mRNA. Translation: CAG32387.1 .
PIRi A92394. MCCH.
UniGenei Gga.11685.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AHR X-ray 1.80 A 2-149 [» ]
1UP5 X-ray 1.90 A/B 2-149 [» ]
2BCX X-ray 2.00 A 2-149 [» ]
2BKI X-ray 2.90 B/D 2-149 [» ]
2KZ2 NMR - A 77-149 [» ]
2M3S NMR - A 1-149 [» ]
2O5G X-ray 1.08 A 2-149 [» ]
2O60 X-ray 1.55 A 2-149 [» ]
2VB6 X-ray 2.30 B 1-149 [» ]
3GOF X-ray 1.45 A/B 2-149 [» ]
3GP2 X-ray 1.46 A 2-148 [» ]
4BYA NMR - A 77-149 [» ]
ProteinModelPortali P62149.
SMRi P62149. Positions 2-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29154N.
STRINGi 9031.ENSGALP00000037503.

Chemistry

BindingDBi P62149.

Proteomic databases

PaxDbi P62149.
PRIDEi P62149.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5126.
HOVERGENi HBG012180.
InParanoidi P62149.
OMAi TEQISEF.
OrthoDBi EOG7F7WBV.
TreeFami TF300912.

Miscellaneous databases

EvolutionaryTracei P62149.

Gene expression databases

ExpressionAtlasi P62149. baseline.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone."
    Putkey J.A., Ts'Ui K.F., Tanaka T., Lagace L., Stein J.P., Lai E.C., Means A.R.
    J. Biol. Chem. 258:11864-11870(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The structural organization of the chicken calmodulin gene."
    Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R.
    J. Biol. Chem. 260:907-912(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Erratum
    Simmen R.C.M., Tanaka T., Ts'Ui K.F., Putkey J.A., Scott M.J., Lai E.C., Means A.R.
    J. Biol. Chem. 262:4928-4929(1987)
  4. "cDNA sequences and molecular evolution of calmodulin genes of chicken and eel."
    Iida Y.
    Bull. Chem. Soc. Jpn. 57:2667-2668(1984)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.
  6. "The structure of a calmodulin mutant with a deletion in the central helix: implications for molecular recognition and protein binding."
    Tabernero L., Taylor D.A., Chandross R.J., VanBerkum M.F.A., Means A.R., Quiocho F.A., Sack J.S.
    Structure 5:613-622(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS).

Entry informationi

Entry nameiCALM_CHICK
AccessioniPrimary (citable) accession number: P62149
Secondary accession number(s): P02593
, P70667, P99014, Q5ZIQ6, Q61379, Q61380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3