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Protein

Calmodulin

Gene

CALM

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca2+. Among the enzymes to be stimulated by the calmodulin-Ca2+ complex are a number of protein kinases and phosphatases.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi21 – 321Add BLAST12
Calcium bindingi57 – 682Add BLAST12
Calcium bindingi94 – 1053Add BLAST12
Calcium bindingi130 – 1414Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: CAFA
  • CH domain binding Source: CAFA
  • disordered domain specific binding Source: CAFA
  • myosin binding Source: UniProtKB
  • protein C-terminus binding Source: CAFA

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-111932 CaMK IV-mediated phosphorylation of CREB
R-GGA-111933 Calmodulin induced events
R-GGA-111957 Cam-PDE 1 activation
R-GGA-114608 Platelet degranulation
R-GGA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-GGA-163615 PKA activation
R-GGA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-GGA-2025928 Calcineurin activates NFAT
R-GGA-203615 eNOS activation
R-GGA-2514859 Inactivation, recovery and regulation of the phototransduction cascade
R-GGA-2672351 Stimuli-sensing channels
R-GGA-2871809 FCERI mediated Ca+2 mobilization
R-GGA-4086398 Ca2+ pathway
R-GGA-418359 Reduction of cytosolic Ca++ levels
R-GGA-425561 Sodium/Calcium exchangers
R-GGA-442717 CREB phosphorylation through the activation of CaMKK
R-GGA-442729 CREB phosphorylation through the activation of CaMKII
R-GGA-442745 Activation of CaMK IV
R-GGA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-GGA-445355 Smooth Muscle Contraction
R-GGA-451308 Activation of Ca-permeable Kainate Receptor
R-GGA-5218920 VEGFR2 mediated vascular permeability
R-GGA-5578775 Ion homeostasis
R-GGA-5607763 CLEC7A (Dectin-1) induces NFAT activation
R-GGA-5626467 RHO GTPases activate IQGAPs
R-GGA-5627123 RHO GTPases activate PAKs
R-GGA-5673001 RAF/MAP kinase cascade
R-GGA-70221 Glycogen breakdown (glycogenolysis)
R-GGA-8876725 Protein methylation
R-GGA-936837 Ion transport by P-type ATPases

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin
Short name:
CaM
Gene namesi
Name:CALM
Synonyms:CAM
ORF Names:RCJMB04_24e7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componentsi: Chromosome 3, Chromosome 5

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001982302 – 149CalmodulinAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei116N6,N6,N6-trimethyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP62149
PRIDEiP62149

PTM databases

iPTMnetiP62149

Expressioni

Gene expression databases

BgeeiENSGALG00000010023
ExpressionAtlasiP62149 baseline and differential

Interactioni

GO - Molecular functioni

  • CH domain binding Source: CAFA
  • disordered domain specific binding Source: CAFA
  • myosin binding Source: UniProtKB
  • protein C-terminus binding Source: CAFA

Protein-protein interaction databases

DIPiDIP-29154N
ELMiP62149
IntActiP62149, 1 interactor
STRINGi9031.ENSGALP00000037503

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni2 – 4Combined sources3
Helixi7 – 20Combined sources14
Beta strandi25 – 28Combined sources4
Helixi30 – 39Combined sources10
Helixi46 – 56Combined sources11
Beta strandi61 – 65Combined sources5
Helixi66 – 74Combined sources9
Turni79 – 81Combined sources3
Helixi82 – 93Combined sources12
Beta strandi98 – 101Combined sources4
Helixi103 – 112Combined sources10
Helixi119 – 129Combined sources11
Beta strandi134 – 138Combined sources5
Helixi139 – 145Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AHRX-ray1.80A2-149[»]
1UP5X-ray1.90A/B2-149[»]
2BCXX-ray2.00A2-149[»]
2BKIX-ray2.90B/D2-149[»]
2KZ2NMR-A77-149[»]
2M3SNMR-A1-149[»]
2O5GX-ray1.08A2-149[»]
2O60X-ray1.55A2-149[»]
2VB6X-ray2.30B1-149[»]
3GOFX-ray1.45A/B2-149[»]
3GP2X-ray1.46A2-148[»]
4BYANMR-A77-149[»]
5HITX-ray2.85A2-148[»]
6BNVelectron microscopy4.60O/P/Q/R/S/T4-148[»]
ProteinModelPortaliP62149
SMRiP62149
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62149

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini81 – 116EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini117 – 149EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOVERGENiHBG012180
InParanoidiP62149
OrthoDBiEOG091G0V73
TreeFamiTF300912

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 2 hits
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62149-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ
60 70 80 90 100
DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY
110 120 130 140
ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Length:149
Mass (Da):16,838
Last modified:January 23, 2007 - v2
Checksum:i6B4BC3FCDE10727B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00101
, L00096, L00097, L00098, L00099, L00100 Genomic DNA Translation: AAA48653.1
M36167 mRNA Translation: AAA48650.1
AJ720728 mRNA Translation: CAG32387.1
PIRiA92394 MCCH
UniGeneiGga.11685

Genome annotation databases

EnsembliENSGALT00000045488; ENSGALP00000042446; ENSGALG00000026445
ENSGALT00000080380; ENSGALP00000044697; ENSGALG00000010023

Similar proteinsi

Entry informationi

Entry nameiCALM_CHICK
AccessioniPrimary (citable) accession number: P62149
Secondary accession number(s): P02593
, P70667, P99014, Q5ZIQ6, Q61379, Q61380
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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