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Protein

40S ribosomal protein S7

Gene

Rps7

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for rRNA maturation.By similarity

GO - Molecular functioni

  • poly(U) RNA binding Source: RGD
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S7
Alternative name(s):
S8
Gene namesi
Name:Rps7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi61907. Rps7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001741921 – 19440S ribosomal protein S7Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei74N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylated by NEK6.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP62083.
PRIDEiP62083.

PTM databases

iPTMnetiP62083.
PhosphoSitePlusiP62083.
SwissPalmiP62083.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008551.
ExpressionAtlasiP62083. differential.
GenevisibleiP62083. RN.

Interactioni

Subunit structurei

Binds IPO9 with high affinity. Interacts with NEK6.By similarity

Protein-protein interaction databases

BioGridi247931. 1 interactor.
IntActiP62083. 2 interactors.
MINTiMINT-4133247.
STRINGi10116.ENSRNOP00000011545.

Structurei

3D structure databases

ProteinModelPortaliP62083.
SMRiP62083.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi98 – 120Arg/Lys-rich (basic)Add BLAST23

Sequence similaritiesi

Belongs to the ribosomal protein S7e family.Curated

Phylogenomic databases

eggNOGiKOG3320. Eukaryota.
ENOG410ZYKB. LUCA.
GeneTreeiENSGT00390000014122.
HOGENOMiHOG000197237.
HOVERGENiHBG001698.
InParanoidiP62083.
KOiK02993.
OMAiKRIRVKM.
OrthoDBiEOG091G0L94.
PhylomeDBiP62083.
TreeFamiTF343364.

Family and domain databases

InterProiIPR000554. Ribosomal_S7e.
[Graphical view]
PANTHERiPTHR11278. PTHR11278. 1 hit.
PfamiPF01251. Ribosomal_S7e. 1 hit.
[Graphical view]
PROSITEiPS00948. RIBOSOMAL_S7E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62083-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE
60 70 80 90 100
IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI
110 120 130 140 150
LPKPTRKSRT KNKQKRPRSR TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG
160 170 180 190
SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL TGKDVNFEFP EFQL
Length:194
Mass (Da):22,127
Last modified:June 21, 2004 - v1
Checksum:iE21089929CC061E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2F → S in CAA40177 (PubMed:2030949).Curated1
Sequence conflicti14 – 16EKP → KKR in CAA40177 (PubMed:2030949).Curated3
Sequence conflicti35D → E in CAA40177 (PubMed:2030949).Curated1
Sequence conflicti38A → T in CAA40177 (PubMed:2030949).Curated1
Sequence conflicti41R → W in CAA40177 (PubMed:2030949).Curated1
Sequence conflicti75 – 79IQVRL → MAKSGK in CAA40177 (PubMed:2030949).Curated5
Sequence conflicti149D → V in CAA40177 (PubMed:2030949).Curated1
Sequence conflicti180 – 181LT → PL in CAA40177 (PubMed:2030949).Curated2
Sequence conflicti192 – 194FQL → VSV in CAA40177 (PubMed:2030949).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53377 mRNA. Translation: CAA37457.1.
X56846 mRNA. Translation: CAA40177.1.
BC060557 mRNA. Translation: AAH60557.1.
PIRiS12862. R3RT7.
RefSeqiNP_113758.2. NM_031570.2.
XP_002726666.2. XM_002726620.5.
XP_002729622.2. XM_002729576.5.
UniGeneiRn.107039.
Rn.224475.

Genome annotation databases

EnsembliENSRNOT00000011333; ENSRNOP00000011333; ENSRNOG00000008551.
ENSRNOT00000092867; ENSRNOP00000075995; ENSRNOG00000008551.
GeneIDi100362830.
29258.
KEGGirno:100362830.
rno:29258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53377 mRNA. Translation: CAA37457.1.
X56846 mRNA. Translation: CAA40177.1.
BC060557 mRNA. Translation: AAH60557.1.
PIRiS12862. R3RT7.
RefSeqiNP_113758.2. NM_031570.2.
XP_002726666.2. XM_002726620.5.
XP_002729622.2. XM_002729576.5.
UniGeneiRn.107039.
Rn.224475.

3D structure databases

ProteinModelPortaliP62083.
SMRiP62083.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247931. 1 interactor.
IntActiP62083. 2 interactors.
MINTiMINT-4133247.
STRINGi10116.ENSRNOP00000011545.

PTM databases

iPTMnetiP62083.
PhosphoSitePlusiP62083.
SwissPalmiP62083.

Proteomic databases

PaxDbiP62083.
PRIDEiP62083.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011333; ENSRNOP00000011333; ENSRNOG00000008551.
ENSRNOT00000092867; ENSRNOP00000075995; ENSRNOG00000008551.
GeneIDi100362830.
29258.
KEGGirno:100362830.
rno:29258.

Organism-specific databases

CTDi6201.
RGDi61907. Rps7.

Phylogenomic databases

eggNOGiKOG3320. Eukaryota.
ENOG410ZYKB. LUCA.
GeneTreeiENSGT00390000014122.
HOGENOMiHOG000197237.
HOVERGENiHBG001698.
InParanoidiP62083.
KOiK02993.
OMAiKRIRVKM.
OrthoDBiEOG091G0L94.
PhylomeDBiP62083.
TreeFamiTF343364.

Enzyme and pathway databases

ReactomeiR-RNO-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-RNO-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-RNO-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-RNO-72649. Translation initiation complex formation.
R-RNO-72689. Formation of a pool of free 40S subunits.
R-RNO-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-RNO-72702. Ribosomal scanning and start codon recognition.
R-RNO-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-RNO-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-RNO-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP62083.

Gene expression databases

BgeeiENSRNOG00000008551.
ExpressionAtlasiP62083. differential.
GenevisibleiP62083. RN.

Family and domain databases

InterProiIPR000554. Ribosomal_S7e.
[Graphical view]
PANTHERiPTHR11278. PTHR11278. 1 hit.
PfamiPF01251. Ribosomal_S7e. 1 hit.
[Graphical view]
PROSITEiPS00948. RIBOSOMAL_S7E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS7_RAT
AccessioniPrimary (citable) accession number: P62083
Secondary accession number(s): P23821, P24818
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.