Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

40S ribosomal protein S7

Gene

RPS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for rRNA maturation.1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: InterPro

GO - Biological processi

  • cell differentiation Source: Ensembl
  • neural tube closure Source: Ensembl
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: Reactome
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S7
Gene namesi
Name:RPS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:10440. RPS7.

Subcellular locationi

GO - Cellular componenti

  • 90S preribosome Source: GO_Central
  • cytoplasm Source: HPA
  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • intracellular ribonucleoprotein complex Source: MGI
  • membrane Source: UniProtKB
  • microtubule organizing center Source: UniProtKB-SubCell
  • nucleolus Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • ribosome Source: UniProtKB
  • small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 8 (DBA8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:612563

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

MalaCardsiRPS7.
MIMi612563. phenotype.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34855.

Polymorphism and mutation databases

BioMutaiRPS7.
DMDMi49065831.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19419440S ribosomal protein S7PRO_0000174190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineCombined sources
Modified residuei74 – 741N6-acetyllysineCombined sources

Post-translational modificationi

Phosphorylated by NEK6.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP62081.
PaxDbiP62081.
PeptideAtlasiP62081.
PRIDEiP62081.
TopDownProteomicsiP62081.

PTM databases

iPTMnetiP62081.
PhosphoSiteiP62081.
SwissPalmiP62081.

Miscellaneous databases

PMAP-CutDBP62081.

Expressioni

Gene expression databases

BgeeiENSG00000171863.
CleanExiHS_RPS7.
ExpressionAtlasiP62081. baseline and differential.
GenevisibleiP62081. HS.

Organism-specific databases

HPAiHPA056586.

Interactioni

Subunit structurei

Binds IPO9 with high affinity. Interacts with NEK6.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q0098715EBI-354360,EBI-389668
NEDD8Q158432EBI-354360,EBI-716247
ZBTB14O438293EBI-354360,EBI-10176632

Protein-protein interaction databases

BioGridi112115. 172 interactions.
IntActiP62081. 34 interactions.
MINTiMINT-5001160.
STRINGi9606.ENSP00000339095.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SH1-194[»]
4V6Xelectron microscopy5.00AH1-194[»]
5A2Qelectron microscopy3.90H1-194[»]
5AJ0electron microscopy3.50BH1-194[»]
5FLXelectron microscopy3.90H1-194[»]
ProteinModelPortaliP62081.
SMRiP62081. Positions 5-194.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 12023Arg/Lys-rich (basic)Add
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S7e family.Curated

Phylogenomic databases

eggNOGiKOG3320. Eukaryota.
ENOG410ZYKB. LUCA.
GeneTreeiENSGT00390000014122.
HOGENOMiHOG000197237.
HOVERGENiHBG001698.
InParanoidiP62081.
KOiK02993.
OMAiKRIRVKM.
OrthoDBiEOG091G0L94.
PhylomeDBiP62081.
TreeFamiTF343364.

Family and domain databases

InterProiIPR000554. Ribosomal_S7e.
[Graphical view]
PANTHERiPTHR11278. PTHR11278. 1 hit.
PfamiPF01251. Ribosomal_S7e. 1 hit.
[Graphical view]
PROSITEiPS00948. RIBOSOMAL_S7E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62081-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSSSAKIVK PNGEKPDEFE SGISQALLEL EMNSDLKAQL RELNITAAKE
60 70 80 90 100
IEVGGGRKAI IIFVPVPQLK SFQKIQVRLV RELEKKFSGK HVVFIAQRRI
110 120 130 140 150
LPKPTRKSRT KNKQKRPRSR TLTAVHDAIL EDLVFPSEIV GKRIRVKLDG
160 170 180 190
SRLIKVHLDK AQQNNVEHKV ETFSGVYKKL TGKDVNFEFP EFQL
Length:194
Mass (Da):22,127
Last modified:June 21, 2004 - v1
Checksum:iE21089929CC061E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77233 mRNA. Translation: AAB00969.1.
Z25749 Genomic DNA. Translation: CAA81022.1.
AK311794 mRNA. Translation: BAG34737.1.
AC108488 Genomic DNA. Translation: AAX82027.1.
CH471053 Genomic DNA. Translation: EAX01057.1.
CH471053 Genomic DNA. Translation: EAX01058.1.
CH471053 Genomic DNA. Translation: EAX01059.1.
BC002866 mRNA. Translation: AAH02866.1.
BC061901 mRNA. Translation: AAH61901.1.
BC071919 mRNA. Translation: AAH71919.1.
CCDSiCCDS1648.1.
PIRiJC4388.
RefSeqiNP_001002.1. NM_001011.3.
UniGeneiHs.534346.
Hs.546287.
Hs.646582.

Genome annotation databases

EnsembliENST00000304921; ENSP00000339095; ENSG00000171863.
ENST00000403564; ENSP00000385018; ENSG00000171863.
ENST00000406376; ENSP00000385286; ENSG00000171863.
GeneIDi6201.
KEGGihsa:6201.
UCSCiuc002qxw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77233 mRNA. Translation: AAB00969.1.
Z25749 Genomic DNA. Translation: CAA81022.1.
AK311794 mRNA. Translation: BAG34737.1.
AC108488 Genomic DNA. Translation: AAX82027.1.
CH471053 Genomic DNA. Translation: EAX01057.1.
CH471053 Genomic DNA. Translation: EAX01058.1.
CH471053 Genomic DNA. Translation: EAX01059.1.
BC002866 mRNA. Translation: AAH02866.1.
BC061901 mRNA. Translation: AAH61901.1.
BC071919 mRNA. Translation: AAH71919.1.
CCDSiCCDS1648.1.
PIRiJC4388.
RefSeqiNP_001002.1. NM_001011.3.
UniGeneiHs.534346.
Hs.546287.
Hs.646582.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SH1-194[»]
4V6Xelectron microscopy5.00AH1-194[»]
5A2Qelectron microscopy3.90H1-194[»]
5AJ0electron microscopy3.50BH1-194[»]
5FLXelectron microscopy3.90H1-194[»]
ProteinModelPortaliP62081.
SMRiP62081. Positions 5-194.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112115. 172 interactions.
IntActiP62081. 34 interactions.
MINTiMINT-5001160.
STRINGi9606.ENSP00000339095.

PTM databases

iPTMnetiP62081.
PhosphoSiteiP62081.
SwissPalmiP62081.

Polymorphism and mutation databases

BioMutaiRPS7.
DMDMi49065831.

Proteomic databases

EPDiP62081.
PaxDbiP62081.
PeptideAtlasiP62081.
PRIDEiP62081.
TopDownProteomicsiP62081.

Protocols and materials databases

DNASUi6201.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304921; ENSP00000339095; ENSG00000171863.
ENST00000403564; ENSP00000385018; ENSG00000171863.
ENST00000406376; ENSP00000385286; ENSG00000171863.
GeneIDi6201.
KEGGihsa:6201.
UCSCiuc002qxw.4. human.

Organism-specific databases

CTDi6201.
GeneCardsiRPS7.
GeneReviewsiRPS7.
HGNCiHGNC:10440. RPS7.
HPAiHPA056586.
MalaCardsiRPS7.
MIMi603658. gene.
612563. phenotype.
neXtProtiNX_P62081.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34855.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3320. Eukaryota.
ENOG410ZYKB. LUCA.
GeneTreeiENSGT00390000014122.
HOGENOMiHOG000197237.
HOVERGENiHBG001698.
InParanoidiP62081.
KOiK02993.
OMAiKRIRVKM.
OrthoDBiEOG091G0L94.
PhylomeDBiP62081.
TreeFamiTF343364.

Enzyme and pathway databases

ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS7. human.
GeneWikiiRPS7.
GenomeRNAii6201.
PMAP-CutDBP62081.
PROiP62081.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171863.
CleanExiHS_RPS7.
ExpressionAtlasiP62081. baseline and differential.
GenevisibleiP62081. HS.

Family and domain databases

InterProiIPR000554. Ribosomal_S7e.
[Graphical view]
PANTHERiPTHR11278. PTHR11278. 1 hit.
PfamiPF01251. Ribosomal_S7e. 1 hit.
[Graphical view]
PROSITEiPS00948. RIBOSOMAL_S7E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS7_HUMAN
AccessioniPrimary (citable) accession number: P62081
Secondary accession number(s): P23821
, P24818, Q57Z92, Q6IPH1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: September 7, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.