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Protein

Tetraspanin-5

Gene

Tspan5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulates ADAM10 maturation and trafficking to the cell surface (PubMed:23035126). Promotes ADAM10-mediated cleavage of CD44 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-5
Short name:
Tspan-5
Alternative name(s):
Tetraspan NET-4
Transmembrane 4 superfamily member 9
Gene namesi
Name:Tspan5
Synonyms:Tm4sf9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1928096. Tspan5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularSequence analysisAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 92CytoplasmicSequence analysis10
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 232ExtracellularSequence analysisAdd BLAST119
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 268CytoplasmicSequence analysisAdd BLAST15

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192441 – 268Tetraspanin-5Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Glycosylationi169N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP62080.
PRIDEiP62080.

PTM databases

PhosphoSitePlusiP62080.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028152.
CleanExiMM_TSPAN5.
ExpressionAtlasiP62080. baseline and differential.
GenevisibleiP62080. MM.

Interactioni

Subunit structurei

Interacts with ADAM10.2 Publications

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029800.

Structurei

3D structure databases

ProteinModelPortaliP62080.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiP62080.
KOiK17345.
OMAiIYIKGCV.
OrthoDBiEOG091G0CHZ.
PhylomeDBiP62080.
TreeFamiTF313002.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62080-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI
60 70 80 90 100
SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI
110 120 130 140 150
IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY
160 170 180 190 200
WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC
210 220 230 240 250
GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG
260
ICLAQNLVSD IEAVRASW
Length:268
Mass (Da):30,337
Last modified:June 21, 2004 - v1
Checksum:i7F4480BD0FA6192D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30G → E in AAH58695 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121344 mRNA. Translation: AAF28869.1.
BC058695 mRNA. Translation: AAH58695.1.
CCDSiCCDS17870.1.
RefSeqiNP_062517.1. NM_019571.5.
UniGeneiMm.31927.

Genome annotation databases

EnsembliENSMUST00000029800; ENSMUSP00000029800; ENSMUSG00000028152.
GeneIDi56224.
KEGGimmu:56224.
UCSCiuc008rnp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121344 mRNA. Translation: AAF28869.1.
BC058695 mRNA. Translation: AAH58695.1.
CCDSiCCDS17870.1.
RefSeqiNP_062517.1. NM_019571.5.
UniGeneiMm.31927.

3D structure databases

ProteinModelPortaliP62080.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029800.

PTM databases

PhosphoSitePlusiP62080.

Proteomic databases

PaxDbiP62080.
PRIDEiP62080.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029800; ENSMUSP00000029800; ENSMUSG00000028152.
GeneIDi56224.
KEGGimmu:56224.
UCSCiuc008rnp.2. mouse.

Organism-specific databases

CTDi10098.
MGIiMGI:1928096. Tspan5.

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118875.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiP62080.
KOiK17345.
OMAiIYIKGCV.
OrthoDBiEOG091G0CHZ.
PhylomeDBiP62080.
TreeFamiTF313002.

Miscellaneous databases

ChiTaRSiTspan5. mouse.
PROiP62080.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028152.
CleanExiMM_TSPAN5.
ExpressionAtlasiP62080. baseline and differential.
GenevisibleiP62080. MM.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSN5_MOUSE
AccessioniPrimary (citable) accession number: P62080
Secondary accession number(s): O60628, O60746, Q9JLY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.