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Protein

Tetraspanin-5

Gene

TSPAN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

GO - Biological processi

  • positive regulation of Notch signaling pathway Source: UniProtKB
  • protein localization to plasma membrane Source: UniProtKB
  • protein maturation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-5
Short name:
Tspan-5
Alternative name(s):
Tetraspan NET-4
Transmembrane 4 superfamily member 9
Gene namesi
Name:TSPAN5
Synonyms:TM4SF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168785.7
HGNCiHGNC:17753 TSPAN5
MIMi613136 gene
neXtProtiNX_P62079

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38HelicalSequence analysisAdd BLAST21
Topological domaini39 – 61ExtracellularSequence analysisAdd BLAST23
Transmembranei62 – 82HelicalSequence analysisAdd BLAST21
Topological domaini83 – 92CytoplasmicSequence analysis10
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 232ExtracellularSequence analysisAdd BLAST119
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 268CytoplasmicSequence analysisAdd BLAST15

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10098
OpenTargetsiENSG00000168785
PharmGKBiPA134864098

Polymorphism and mutation databases

BioMutaiTSPAN5
DMDMi49065848

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002192431 – 268Tetraspanin-5Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi232N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP62079
PaxDbiP62079
PeptideAtlasiP62079
PRIDEiP62079
ProteomicsDBi57363

PTM databases

iPTMnetiP62079
PhosphoSitePlusiP62079
SwissPalmiP62079

Expressioni

Gene expression databases

BgeeiENSG00000168785
CleanExiHS_TSPAN5
ExpressionAtlasiP62079 baseline and differential
GenevisibleiP62079 HS

Interactioni

Subunit structurei

Interacts with ADAM10.1 Publication

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115405, 63 interactors
STRINGi9606.ENSP00000307701

Structurei

3D structure databases

ProteinModelPortaliP62079
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882 Eukaryota
ENOG4111IRY LUCA
GeneTreeiENSGT00880000137851
HOGENOMiHOG000230652
HOVERGENiHBG108605
InParanoidiP62079
KOiK17345
OMAiFNIIFWF
OrthoDBiEOG091G0CHZ
PhylomeDBiP62079
TreeFamiTF313002

Family and domain databases

Gene3Di1.10.1450.10, 1 hit
InterProiView protein in InterPro
IPR000301 Tetraspanin
IPR018499 Tetraspanin/Peripherin
IPR018503 Tetraspanin_CS
IPR008952 Tetraspanin_EC2_sf
PfamiView protein in Pfam
PF00335 Tetraspannin, 1 hit
PIRSFiPIRSF002419 Tetraspanin, 1 hit
PRINTSiPR00259 TMFOUR
SUPFAMiSSF48652 SSF48652, 1 hit
PROSITEiView protein in PROSITE
PS00421 TM4_1, 1 hit

Sequencei

Sequence statusi: Complete.

P62079-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI
60 70 80 90 100
SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI
110 120 130 140 150
IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY
160 170 180 190 200
WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC
210 220 230 240 250
GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG
260
ICLAQNLVSD IEAVRASW
Length:268
Mass (Da):30,337
Last modified:June 21, 2004 - v1
Checksum:i7F4480BD0FA6192D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91 – 94Missing in AAC69712 (PubMed:9714763).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF053455 Genomic DNA Translation: AAC69712.1
AF065389 mRNA Translation: AAC17120.1
CR541809 mRNA Translation: CAG46608.1
AK315723 mRNA Translation: BAG38079.1
CH471057 Genomic DNA Translation: EAX06074.1
BC009704 mRNA Translation: AAH09704.1
CCDSiCCDS3646.1
PIRiA59261
RefSeqiNP_005714.2, NM_005723.3
UniGeneiHs.118118

Genome annotation databases

EnsembliENST00000305798; ENSP00000307701; ENSG00000168785
GeneIDi10098
KEGGihsa:10098
UCSCiuc003hub.4 human

Similar proteinsi

Entry informationi

Entry nameiTSN5_HUMAN
AccessioniPrimary (citable) accession number: P62079
Secondary accession number(s): B2RDY2
, O60628, O60746, Q6FHE5, Q9JLY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: June 20, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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