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P62079

- TSN5_HUMAN

UniProt

P62079 - TSN5_HUMAN

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Protein

Tetraspanin-5

Gene
TSPAN5, TM4SF9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. enzyme binding Source: UniProt

GO - Biological processi

  1. establishment of protein localization to plasma membrane Source: UniProt
  2. positive regulation of Notch signaling pathway Source: UniProt
  3. protein maturation Source: UniProt
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-5
Short name:
Tspan-5
Alternative name(s):
Tetraspan NET-4
Transmembrane 4 superfamily member 9
Gene namesi
Name:TSPAN5
Synonyms:TM4SF9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:17753. TSPAN5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1717Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei18 – 3821Helical; Reviewed predictionAdd
BLAST
Topological domaini39 – 6123Extracellular Reviewed predictionAdd
BLAST
Transmembranei62 – 8221Helical; Reviewed predictionAdd
BLAST
Topological domaini83 – 9210Cytoplasmic Reviewed prediction
Transmembranei93 – 11321Helical; Reviewed predictionAdd
BLAST
Topological domaini114 – 232119Extracellular Reviewed predictionAdd
BLAST
Transmembranei233 – 25321Helical; Reviewed predictionAdd
BLAST
Topological domaini254 – 26815Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134864098.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Tetraspanin-5PRO_0000219243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP62079.
PaxDbiP62079.
PRIDEiP62079.

PTM databases

PhosphoSiteiP62079.

Expressioni

Gene expression databases

ArrayExpressiP62079.
BgeeiP62079.
CleanExiHS_TSPAN5.
GenevestigatoriP62079.

Interactioni

Protein-protein interaction databases

BioGridi115405. 2 interactions.
STRINGi9606.ENSP00000307701.

Structurei

3D structure databases

ProteinModelPortaliP62079.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG312878.
HOGENOMiHOG000230652.
HOVERGENiHBG108605.
InParanoidiP62079.
KOiK17345.
OMAiIYIKGCV.
PhylomeDBiP62079.
TreeFamiTF313002.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62079-1 [UniParc]FASTAAdd to Basket

« Hide

MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI    50
SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI 100
IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY 150
WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC 200
GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG 250
ICLAQNLVSD IEAVRASW 268
Length:268
Mass (Da):30,337
Last modified:June 21, 2004 - v1
Checksum:i7F4480BD0FA6192D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 944Missing in AAC69712. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053455 Genomic DNA. Translation: AAC69712.1.
AF065389 mRNA. Translation: AAC17120.1.
CR541809 mRNA. Translation: CAG46608.1.
AK315723 mRNA. Translation: BAG38079.1.
CH471057 Genomic DNA. Translation: EAX06074.1.
BC009704 mRNA. Translation: AAH09704.1.
CCDSiCCDS3646.1.
PIRiA59261.
RefSeqiNP_005714.2. NM_005723.3.
UniGeneiHs.118118.

Genome annotation databases

EnsembliENST00000305798; ENSP00000307701; ENSG00000168785.
GeneIDi10098.
KEGGihsa:10098.
UCSCiuc003hub.3. human.

Polymorphism databases

DMDMi49065848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF053455 Genomic DNA. Translation: AAC69712.1 .
AF065389 mRNA. Translation: AAC17120.1 .
CR541809 mRNA. Translation: CAG46608.1 .
AK315723 mRNA. Translation: BAG38079.1 .
CH471057 Genomic DNA. Translation: EAX06074.1 .
BC009704 mRNA. Translation: AAH09704.1 .
CCDSi CCDS3646.1.
PIRi A59261.
RefSeqi NP_005714.2. NM_005723.3.
UniGenei Hs.118118.

3D structure databases

ProteinModelPortali P62079.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115405. 2 interactions.
STRINGi 9606.ENSP00000307701.

PTM databases

PhosphoSitei P62079.

Polymorphism databases

DMDMi 49065848.

Proteomic databases

MaxQBi P62079.
PaxDbi P62079.
PRIDEi P62079.

Protocols and materials databases

DNASUi 10098.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305798 ; ENSP00000307701 ; ENSG00000168785 .
GeneIDi 10098.
KEGGi hsa:10098.
UCSCi uc003hub.3. human.

Organism-specific databases

CTDi 10098.
GeneCardsi GC04M099391.
HGNCi HGNC:17753. TSPAN5.
MIMi 613136. gene.
neXtProti NX_P62079.
PharmGKBi PA134864098.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG312878.
HOGENOMi HOG000230652.
HOVERGENi HBG108605.
InParanoidi P62079.
KOi K17345.
OMAi IYIKGCV.
PhylomeDBi P62079.
TreeFami TF313002.

Miscellaneous databases

GenomeRNAii 10098.
NextBioi 38195.
PROi P62079.
SOURCEi Search...

Gene expression databases

ArrayExpressi P62079.
Bgeei P62079.
CleanExi HS_TSPAN5.
Genevestigatori P62079.

Family and domain databases

InterProi IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view ]
Pfami PF00335. Tetraspannin. 1 hit.
[Graphical view ]
PIRSFi PIRSF002419. Tetraspanin. 1 hit.
PRINTSi PR00259. TMFOUR.
SUPFAMi SSF48652. SSF48652. 1 hit.
PROSITEi PS00421. TM4_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
    Todd S.C., Doctor V.S., Levy S.
    Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "New tetraspans identified in the EST database."
    Rubinstein E., Serru V., Boucheix C.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiTSN5_HUMAN
AccessioniPrimary (citable) accession number: P62079
Secondary accession number(s): B2RDY2
, O60628, O60746, Q6FHE5, Q9JLY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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