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P62079

- TSN5_HUMAN

UniProt

P62079 - TSN5_HUMAN

Protein

Tetraspanin-5

Gene

TSPAN5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (21 Jun 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. enzyme binding Source: UniProt

    GO - Biological processi

    1. establishment of protein localization to plasma membrane Source: UniProt
    2. positive regulation of Notch signaling pathway Source: UniProt
    3. protein maturation Source: UniProt

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraspanin-5
    Short name:
    Tspan-5
    Alternative name(s):
    Tetraspan NET-4
    Transmembrane 4 superfamily member 9
    Gene namesi
    Name:TSPAN5
    Synonyms:TM4SF9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:17753. TSPAN5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProt

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134864098.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268Tetraspanin-5PRO_0000219243Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP62079.
    PaxDbiP62079.
    PRIDEiP62079.

    PTM databases

    PhosphoSiteiP62079.

    Expressioni

    Gene expression databases

    ArrayExpressiP62079.
    BgeeiP62079.
    CleanExiHS_TSPAN5.
    GenevestigatoriP62079.

    Interactioni

    Protein-protein interaction databases

    BioGridi115405. 2 interactions.
    STRINGi9606.ENSP00000307701.

    Structurei

    3D structure databases

    ProteinModelPortaliP62079.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini39 – 6123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini83 – 9210CytoplasmicSequence Analysis
    Topological domaini114 – 232119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26815CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei18 – 3821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei62 – 8221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei93 – 11321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tetraspanin (TM4SF) family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG312878.
    HOGENOMiHOG000230652.
    HOVERGENiHBG108605.
    InParanoidiP62079.
    KOiK17345.
    OMAiIYIKGCV.
    PhylomeDBiP62079.
    TreeFamiTF313002.

    Family and domain databases

    InterProiIPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view]
    PfamiPF00335. Tetraspannin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002419. Tetraspanin. 1 hit.
    PRINTSiPR00259. TMFOUR.
    SUPFAMiSSF48652. SSF48652. 1 hit.
    PROSITEiPS00421. TM4_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P62079-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGKHYKGPE VSCCIKYFIF GFNVIFWFLG ITFLGIGLWA WNEKGVLSNI    50
    SSITDLGGFD PVWLFLVVGG VMFILGFAGC IGALRENTFL LKFFSVFLGI 100
    IFFLELTAGV LAFVFKDWIK DQLYFFINNN IRAYRDDIDL QNLIDFTQEY 150
    WQCCGAFGAD DWNLNIYFNC TDSNASRERC GVPFSCCTKD PAEDVINTQC 200
    GYDARQKPEV DQQIVIYTKG CVPQFEKWLQ DNLTIVAGIF IGIALLQIFG 250
    ICLAQNLVSD IEAVRASW 268
    Length:268
    Mass (Da):30,337
    Last modified:June 21, 2004 - v1
    Checksum:i7F4480BD0FA6192D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti91 – 944Missing in AAC69712. (PubMed:9714763)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053455 Genomic DNA. Translation: AAC69712.1.
    AF065389 mRNA. Translation: AAC17120.1.
    CR541809 mRNA. Translation: CAG46608.1.
    AK315723 mRNA. Translation: BAG38079.1.
    CH471057 Genomic DNA. Translation: EAX06074.1.
    BC009704 mRNA. Translation: AAH09704.1.
    CCDSiCCDS3646.1.
    PIRiA59261.
    RefSeqiNP_005714.2. NM_005723.3.
    UniGeneiHs.118118.

    Genome annotation databases

    EnsembliENST00000305798; ENSP00000307701; ENSG00000168785.
    GeneIDi10098.
    KEGGihsa:10098.
    UCSCiuc003hub.3. human.

    Polymorphism databases

    DMDMi49065848.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF053455 Genomic DNA. Translation: AAC69712.1 .
    AF065389 mRNA. Translation: AAC17120.1 .
    CR541809 mRNA. Translation: CAG46608.1 .
    AK315723 mRNA. Translation: BAG38079.1 .
    CH471057 Genomic DNA. Translation: EAX06074.1 .
    BC009704 mRNA. Translation: AAH09704.1 .
    CCDSi CCDS3646.1.
    PIRi A59261.
    RefSeqi NP_005714.2. NM_005723.3.
    UniGenei Hs.118118.

    3D structure databases

    ProteinModelPortali P62079.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115405. 2 interactions.
    STRINGi 9606.ENSP00000307701.

    PTM databases

    PhosphoSitei P62079.

    Polymorphism databases

    DMDMi 49065848.

    Proteomic databases

    MaxQBi P62079.
    PaxDbi P62079.
    PRIDEi P62079.

    Protocols and materials databases

    DNASUi 10098.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000305798 ; ENSP00000307701 ; ENSG00000168785 .
    GeneIDi 10098.
    KEGGi hsa:10098.
    UCSCi uc003hub.3. human.

    Organism-specific databases

    CTDi 10098.
    GeneCardsi GC04M099391.
    HGNCi HGNC:17753. TSPAN5.
    MIMi 613136. gene.
    neXtProti NX_P62079.
    PharmGKBi PA134864098.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG312878.
    HOGENOMi HOG000230652.
    HOVERGENi HBG108605.
    InParanoidi P62079.
    KOi K17345.
    OMAi IYIKGCV.
    PhylomeDBi P62079.
    TreeFami TF313002.

    Miscellaneous databases

    GenomeRNAii 10098.
    NextBioi 38195.
    PROi P62079.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P62079.
    Bgeei P62079.
    CleanExi HS_TSPAN5.
    Genevestigatori P62079.

    Family and domain databases

    InterProi IPR000301. Tetraspanin.
    IPR018499. Tetraspanin/Peripherin.
    IPR018503. Tetraspanin_CS.
    IPR008952. Tetraspanin_EC2.
    [Graphical view ]
    Pfami PF00335. Tetraspannin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002419. Tetraspanin. 1 hit.
    PRINTSi PR00259. TMFOUR.
    SUPFAMi SSF48652. SSF48652. 1 hit.
    PROSITEi PS00421. TM4_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequences and expression of six new members of the tetraspanin/TM4SF family."
      Todd S.C., Doctor V.S., Levy S.
      Biochim. Biophys. Acta 1399:101-104(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "New tetraspans identified in the EST database."
      Rubinstein E., Serru V., Boucheix C.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiTSN5_HUMAN
    AccessioniPrimary (citable) accession number: P62079
    Secondary accession number(s): B2RDY2
    , O60628, O60746, Q6FHE5, Q9JLY1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2004
    Last sequence update: June 21, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3