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Protein

Mitochondrial import inner membrane translocase subunit Tim10

Gene

Timm10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Translocation, Transport
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit Tim10
Gene namesi
Name:Timm10
Synonyms:Tim10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353429 Timm10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001936131 – 90Mitochondrial import inner membrane translocase subunit Tim10Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 54By similarity
Disulfide bondi33 ↔ 50By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP62073
MaxQBiP62073
PaxDbiP62073
PeptideAtlasiP62073
PRIDEiP62073

PTM databases

iPTMnetiP62073
PhosphoSitePlusiP62073

Expressioni

Gene expression databases

BgeeiENSMUSG00000027076
GenevisibleiP62073 MM

Interactioni

Subunit structurei

Heterohexamer; composed of 3 copies of TIMM9 and 3 copies of TIMM10/TIM10A, named soluble 70 kDa complex. The complex forms a 6-bladed alpha-propeller structure and associates with the TIMM22 component of the TIM22 complex. Interacts with multi-pass transmembrane proteins in transit. Also forms a complex composed of TIMM9, TIMM10/TIM10A and FXC1/TIM10B (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP62073, 1 interactor
STRINGi10090.ENSMUSP00000028470

Structurei

3D structure databases

ProteinModelPortaliP62073
SMRiP62073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi29 – 54Twin CX3C motifAdd BLAST26

Domaini

The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIMM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity).By similarity

Sequence similaritiesi

Belongs to the small Tim family.Curated

Phylogenomic databases

eggNOGiKOG3480 Eukaryota
ENOG4112539 LUCA
GeneTreeiENSGT00390000003068
HOGENOMiHOG000211421
HOVERGENiHBG055029
InParanoidiP62073
KOiK17778
OMAiLEIEMMS
OrthoDBiEOG091G15XZ
PhylomeDBiP62073
TreeFamiTF106193

Family and domain databases

Gene3Di1.10.287.810, 1 hit
InterProiView protein in InterPro
IPR027100 Tim10
IPR004217 Tim10-like
IPR035427 Tim10-like_dom_sf
IPR037376 Tim10/12
PANTHERiPTHR11038 PTHR11038, 1 hit
PTHR11038:SF16 PTHR11038:SF16, 1 hit
PfamiView protein in Pfam
PF02953 zf-Tim10_DDP, 1 hit
SUPFAMiSSF144122 SSF144122, 1 hit

Sequencei

Sequence statusi: Complete.

P62073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPLRAQQLA AELEVEMMAD MYNRMTSACH RKCVPPHYKE AELSKGESVC
60 70 80 90
LDRCVSKYLD IHERMGKKLT ELSMQDEELM KRVQQSSGPA
Length:90
Mass (Da):10,333
Last modified:June 21, 2004 - v1
Checksum:iD20EFAE694D14BAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12 – 13EL → DV in AAD39996 (PubMed:10611480).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF150090 mRNA Translation: AAD39996.1
AK008088 mRNA Translation: BAB25452.1
BC031448 mRNA Translation: AAH31448.1
CCDSiCCDS38161.1
RefSeqiNP_038927.2, NM_013899.2
UniGeneiMm.21826

Genome annotation databases

EnsembliENSMUST00000028470; ENSMUSP00000028470; ENSMUSG00000027076
ENSMUST00000111631; ENSMUSP00000107258; ENSMUSG00000027076
GeneIDi30059
KEGGimmu:30059
UCSCiuc008kjh.2 mouse

Entry informationi

Entry nameiTIM10_MOUSE
AccessioniPrimary (citable) accession number: P62073
Secondary accession number(s): Q9WV99, Q9WVA0, Q9Y5J8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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