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Protein

Ras-related protein R-Ras2

Gene

Rras2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi127 – 130GTPBy similarity4
Nucleotide bindingi157 – 159GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

  • cellular process Source: MGI
  • osteoblast differentiation Source: MGI
  • positive regulation of cell migration Source: MGI
  • Ras protein signal transduction Source: MGI
  • regulation of neuron death Source: MGI
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein R-Ras2
Gene namesi
Name:Rras2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1914172. Rras2.

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

  • Note: Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • focal adhesion Source: MGI
  • intracellular Source: MGI
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000826532 – 201Ras-related protein R-Ras2Add BLAST200
PropeptideiPRO_0000281303202 – 204Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei186PhosphoserineCombined sources1
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei201Cysteine methyl esterBy similarity1
Lipidationi201S-farnesyl cysteineBy similarity1

Post-translational modificationi

May be post-translationally modified by both palmitoylation and polyisoprenylation.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

EPDiP62071.
MaxQBiP62071.
PaxDbiP62071.
PeptideAtlasiP62071.
PRIDEiP62071.

PTM databases

iPTMnetiP62071.
PhosphoSitePlusiP62071.
SwissPalmiP62071.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055723.
CleanExiMM_RRAS2.
GenevisibleiP62071. MM.

Interactioni

Protein-protein interaction databases

BioGridi211811. 6 interactors.
IntActiP62071. 1 interactor.
MINTiMINT-86673.
STRINGi10090.ENSMUSP00000069752.

Structurei

3D structure databases

ProteinModelPortaliP62071.
SMRiP62071.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi43 – 51Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP62071.
KOiK07830.
OMAiCSAKLRI.
OrthoDBiEOG091G0UAU.
PhylomeDBiP62071.
TreeFamiTF312796.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62071-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAGWRDGS GQEKYRLVVV GGGGVGKSAL TIQFIQSYFV TDYDPTIEDS
60 70 80 90 100
YTKQCVIDDR AARLDILDTA GQEEFGAMRE QYMRTGEGFL LVFSVTDRGS
110 120 130 140 150
FEEIYKFQRQ ILRVKDRDEF PMILIGNKAD LDHQRQVTQE EGQQLARQLK
160 170 180 190 200
VTYMEASAKI RMNVDQAFHE LVRVIRKFQE QECPPSPEPT RKEKDKKGCH

CVIF
Length:204
Mass (Da):23,400
Last modified:June 21, 2004 - v1
Checksum:iBA7D4759DC49446F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → D in BAC37432 (PubMed:16141072).Curated1
Sequence conflicti96T → R in BAB27607 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011419 mRNA. Translation: BAB27607.1.
AK078870 mRNA. Translation: BAC37432.1.
AK172037 mRNA. Translation: BAE42790.1.
BC003871 mRNA. Translation: AAH03871.1.
CCDSiCCDS21758.1.
RefSeqiNP_080122.2. NM_025846.2.
UniGeneiMm.276572.

Genome annotation databases

EnsembliENSMUST00000069449; ENSMUSP00000069752; ENSMUSG00000055723.
GeneIDi66922.
KEGGimmu:66922.
UCSCiuc009jhw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011419 mRNA. Translation: BAB27607.1.
AK078870 mRNA. Translation: BAC37432.1.
AK172037 mRNA. Translation: BAE42790.1.
BC003871 mRNA. Translation: AAH03871.1.
CCDSiCCDS21758.1.
RefSeqiNP_080122.2. NM_025846.2.
UniGeneiMm.276572.

3D structure databases

ProteinModelPortaliP62071.
SMRiP62071.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211811. 6 interactors.
IntActiP62071. 1 interactor.
MINTiMINT-86673.
STRINGi10090.ENSMUSP00000069752.

PTM databases

iPTMnetiP62071.
PhosphoSitePlusiP62071.
SwissPalmiP62071.

Proteomic databases

EPDiP62071.
MaxQBiP62071.
PaxDbiP62071.
PeptideAtlasiP62071.
PRIDEiP62071.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000069449; ENSMUSP00000069752; ENSMUSG00000055723.
GeneIDi66922.
KEGGimmu:66922.
UCSCiuc009jhw.2. mouse.

Organism-specific databases

CTDi22800.
MGIiMGI:1914172. Rras2.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133672.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiP62071.
KOiK07830.
OMAiCSAKLRI.
OrthoDBiEOG091G0UAU.
PhylomeDBiP62071.
TreeFamiTF312796.

Miscellaneous databases

ChiTaRSiRras2. mouse.
PROiP62071.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055723.
CleanExiMM_RRAS2.
GenevisibleiP62071. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRRAS2_MOUSE
AccessioniPrimary (citable) accession number: P62071
Secondary accession number(s): P17082
, Q3TA79, Q8C5D1, Q9D0H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.