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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Enzyme regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16NAD; via amide nitrogenUniRule annotation1
Binding sitei37NADUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei90SubstrateUniRule annotation1
Binding sitei145NADUniRule annotation1
Binding sitei155Allosteric activatorUniRule annotation1
Binding sitei170Allosteric activatorUniRule annotation1
Active sitei177Proton acceptorUniRule annotation1
Binding sitei233SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi81 – 82NADUniRule annotation2
Nucleotide bindingi120 – 122NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciTDEN243275:G1G0Q-358-MONOMER
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Ordered Locus Names:TDE_0351
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
Proteomesi
  • UP000008212 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001684091 – 315L-lactate dehydrogenaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei224PhosphotyrosineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP62056

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243275.TDE0351

Structurei

3D structure databases

ProteinModelPortaliP62056
SMRiP62056
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni122 – 125Substrate bindingUniRule annotation4
Regioni150 – 153Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00016
OMAiMDLMQTA
OrthoDBiPOG091H02EQ

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

P62056-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEKKRKVTV VGAGAVGSTF AYALAQSGYA DEIAITDMNK NFAEGQALDL
60 70 80 90 100
VQGLPFLPQV DIHAGDKTDY ADSDIVVVTA GAKQQSGETR IDLLKRNASI
110 120 130 140 150
ITGIAKDIAE SGCSGVMLIV SNPVDILTRA ALKASGWERG RVIGSGTVLD
160 170 180 190 200
TARFRYTLSK ECGVDARNIH GYILGEHGDS EFAAWSMTSV AGRRIDEYCS
210 220 230 240 250
GGVCSSGPHF DKAKILEEVR NSAYHIIDYK GSTYFAVGLA LTRIAGAILR
260 270 280 290 300
NEHSILSVSM TLDGEFGLKD VCLSVPCIVG RSGAERVIES DLPADEQAAL
310
EASAKRLKEA FTEMN
Length:315
Mass (Da):33,603
Last modified:June 21, 2004 - v1
Checksum:i60F90E68BA73B192
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA Translation: AAS10846.1
RefSeqiNP_970965.1, NC_002967.9
WP_002684979.1, NC_002967.9

Genome annotation databases

EnsemblBacteriaiAAS10846; AAS10846; TDE_0351
GeneIDi2740158
KEGGitde:TDE0351
PATRICifig|243275.7.peg.340

Similar proteinsi

Entry informationi

Entry nameiLDH_TREDE
AccessioniPrimary (citable) accession number: P62056
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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