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Protein

L-lactate dehydrogenase 2

Gene

ldh2

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 1 (ldh1), L-lactate dehydrogenase 2 (ldh2)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88SubstrateUniRule annotation1
Binding sitei120NAD or substrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1
Binding sitei225SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 40NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 2UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 2UniRule annotation
Gene namesi
Name:ldh2UniRule annotation
Ordered Locus Names:LJ_1403
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000581 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683501 – 308L-lactate dehydrogenase 2Add BLAST308

Proteomic databases

PRIDEiP62053.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi257314.LJ1403.

Structurei

3D structure databases

ProteinModelPortaliP62053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
KOiK00016.
OMAiQICKAIL.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

P62053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKVFLVG DGRVGSTFAN DLLQNVRIDE LVICDVVKKI TEGDALDLED
60 70 80 90 100
LAPFVGQCTV KSGDYSDAKD ADIAVITAGA ARKPGMTRLD LVKTNVKILE
110 120 130 140 150
SIIKPIVESG FNGIFVVSAN PVDILTTLTQ KLSGFPKNKV IGTGTSLDTA
160 170 180 190 200
RLRVALSHKT GVNVDHIDAY VLGEHGDTSF ENFDEAIIDH KPLRSYKELD
210 220 230 240 250
EETLVELETD VRKKGGKIIA NKGATFYGVA MCLTQICKAI LENKALVMPL
260 270 280 290 300
SAPMTGEYGI HDLYIGSPAV VTANGISDVI ELHLSEDENK KMAYSAAKMK

EVVDGIDL
Length:308
Mass (Da):33,283
Last modified:June 21, 2004 - v1
Checksum:iA610A15C82E85C0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA. Translation: AAS09169.1.
RefSeqiWP_011162161.1. NC_005362.1.

Genome annotation databases

EnsemblBacteriaiAAS09169; AAS09169; LJ_1403.
KEGGiljo:LJ_1403.
PATRICifig|257314.6.peg.1217.

Similar proteinsi

Entry informationi

Entry nameiLDH2_LACJO
AccessioniPrimary (citable) accession number: P62053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families