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Protein

L-lactate dehydrogenase 2

Gene

ldh2

Organism
Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 1 (ldh1), L-lactate dehydrogenase 2 (ldh2)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14NAD; via amide nitrogenUniRule annotation1
Binding sitei35NADUniRule annotation1
Binding sitei65NADUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei101NADUniRule annotation1
Binding sitei143NADUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1
Binding sitei225SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi79 – 80NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciLJOH257314:G1G0M-1212-MONOMER
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 2UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 2UniRule annotation
Gene namesi
Name:ldh2UniRule annotation
Ordered Locus Names:LJ_1403
OrganismiLactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533)
Taxonomic identifieri257314 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000000581 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683501 – 308L-lactate dehydrogenase 2Add BLAST308

Proteomic databases

PRIDEiP62053

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi257314.LJ1403

Structurei

3D structure databases

ProteinModelPortaliP62053
SMRiP62053
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 123Substrate bindingUniRule annotation4
Regioni148 – 151Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
KOiK00016
OMAiQICKAIL

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

P62053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRRKVFLVG DGRVGSTFAN DLLQNVRIDE LVICDVVKKI TEGDALDLED
60 70 80 90 100
LAPFVGQCTV KSGDYSDAKD ADIAVITAGA ARKPGMTRLD LVKTNVKILE
110 120 130 140 150
SIIKPIVESG FNGIFVVSAN PVDILTTLTQ KLSGFPKNKV IGTGTSLDTA
160 170 180 190 200
RLRVALSHKT GVNVDHIDAY VLGEHGDTSF ENFDEAIIDH KPLRSYKELD
210 220 230 240 250
EETLVELETD VRKKGGKIIA NKGATFYGVA MCLTQICKAI LENKALVMPL
260 270 280 290 300
SAPMTGEYGI HDLYIGSPAV VTANGISDVI ELHLSEDENK KMAYSAAKMK

EVVDGIDL
Length:308
Mass (Da):33,283
Last modified:June 21, 2004 - v1
Checksum:iA610A15C82E85C0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017198 Genomic DNA Translation: AAS09169.1
RefSeqiWP_011162161.1, NC_005362.1

Genome annotation databases

EnsemblBacteriaiAAS09169; AAS09169; LJ_1403
KEGGiljo:LJ_1403
PATRICifig|257314.6.peg.1217

Similar proteinsi

Entry informationi

Entry nameiLDH2_LACJO
AccessioniPrimary (citable) accession number: P62053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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