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P62031 (GCSPB_TREDE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:TDE_1624
OrganismTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222) [Complete proteome] [HAMAP]
Taxonomic identifier243275 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167024

Amino acid modifications

Modified residue2641N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P62031 [UniParc].

Last modified June 21, 2004. Version 1.
Checksum: 122CC637802FC530

FASTA48253,417
        10         20         30         40         50         60 
MSELIFEKSV KGHKFAEAKL TVPEYKLDSK YLRASDAKLP EVSELEFVRH YMELSKRTHG 

        70         80         90        100        110        120 
VDNGFYPLGS CTMKYNPKLN EEVADLPNFT NIHPLQPEHT MKGCIEAMGD LGKKLGEITG 

       130        140        150        160        170        180 
MDAFSLQPSA GAHGEFTALL VIRAYHEKRG DHARNKILVP DSAHGTNPAS AAMVGCEIVN 

       190        200        210        220        230        240 
IPSDKDGNVD IEELKKTVGN DTAALMLTNP NTLGLFETHI KEIAEIVHKA GGLLYYDGAN 

       250        260        270        280        290        300 
LNAIMGRLRP GDMGYDIVHL NLHKTFSTPH GGGGPGSGPI GCKKFLEEFL PVPVVTGSDG 

       310        320        330        340        350        360 
SYKLDYNRPD SIGRVRNFYG NFLVFLRAYA YILTLGSEGI RESSGYAVLN ANYLKKKLEK 

       370        380        390        400        410        420 
EYDVAFDRIC MHEFVLTLEK IKEETGVSAL DIAKGLIDDG IHPPTMYFPL IVHEALMFEP 

       430        440        450        460        470        480 
TETESKSTLD FTAEVMIKLK KEAYSNPEKL HGYPYTRPIG RVDETKAARE PVLRYKACCC 


CK 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017226 Genomic DNA. Translation: AAS12141.1.
RefSeqNP_972230.1. NC_002967.9.

3D structure databases

ProteinModelPortalP62031.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243275.TDE1624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS12141; AAS12141; TDE_1624.
GeneID2740865.
KEGGtde:TDE1624.
PATRIC20525408. VBITreDen445_1552.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00283.
OMAIFERRIK.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycTDEN243275:GJ7G-1650-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_TREDE
AccessionPrimary (citable) accession number: P62031
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families