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P62031

- GCSPB_TREDE

UniProt

P62031 - GCSPB_TREDE

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-1650-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:TDE_1624
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000008212: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi243275.TDE1624.

Structurei

3D structure databases

ProteinModelPortaliP62031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiIFERRIK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P62031-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELIFEKSV KGHKFAEAKL TVPEYKLDSK YLRASDAKLP EVSELEFVRH
60 70 80 90 100
YMELSKRTHG VDNGFYPLGS CTMKYNPKLN EEVADLPNFT NIHPLQPEHT
110 120 130 140 150
MKGCIEAMGD LGKKLGEITG MDAFSLQPSA GAHGEFTALL VIRAYHEKRG
160 170 180 190 200
DHARNKILVP DSAHGTNPAS AAMVGCEIVN IPSDKDGNVD IEELKKTVGN
210 220 230 240 250
DTAALMLTNP NTLGLFETHI KEIAEIVHKA GGLLYYDGAN LNAIMGRLRP
260 270 280 290 300
GDMGYDIVHL NLHKTFSTPH GGGGPGSGPI GCKKFLEEFL PVPVVTGSDG
310 320 330 340 350
SYKLDYNRPD SIGRVRNFYG NFLVFLRAYA YILTLGSEGI RESSGYAVLN
360 370 380 390 400
ANYLKKKLEK EYDVAFDRIC MHEFVLTLEK IKEETGVSAL DIAKGLIDDG
410 420 430 440 450
IHPPTMYFPL IVHEALMFEP TETESKSTLD FTAEVMIKLK KEAYSNPEKL
460 470 480
HGYPYTRPIG RVDETKAARE PVLRYKACCC CK
Length:482
Mass (Da):53,417
Last modified:June 21, 2004 - v1
Checksum:i122CC637802FC530
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS12141.1.
RefSeqiNP_972230.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS12141; AAS12141; TDE_1624.
GeneIDi2740865.
KEGGitde:TDE1624.
PATRICi20525408. VBITreDen445_1552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017226 Genomic DNA. Translation: AAS12141.1 .
RefSeqi NP_972230.1. NC_002967.9.

3D structure databases

ProteinModelPortali P62031.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243275.TDE1624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS12141 ; AAS12141 ; TDE_1624 .
GeneIDi 2740865.
KEGGi tde:TDE1624.
PATRICi 20525408. VBITreDen445_1552.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi IFERRIK.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TDEN243275:GJ7G-1650-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Entry informationi

Entry nameiGCSPB_TREDE
AccessioniPrimary (citable) accession number: P62031
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3