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P62031

- GCSPB_TREDE

UniProt

P62031 - GCSPB_TREDE

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (21 Jun 2004)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciTDEN243275:GJ7G-1650-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:TDE_1624
    OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
    Taxonomic identifieri243275 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
    ProteomesiUP000008212: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167024Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi243275.TDE1624.

    Structurei

    3D structure databases

    ProteinModelPortaliP62031.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00283.
    OMAiIFERRIK.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P62031-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELIFEKSV KGHKFAEAKL TVPEYKLDSK YLRASDAKLP EVSELEFVRH    50
    YMELSKRTHG VDNGFYPLGS CTMKYNPKLN EEVADLPNFT NIHPLQPEHT 100
    MKGCIEAMGD LGKKLGEITG MDAFSLQPSA GAHGEFTALL VIRAYHEKRG 150
    DHARNKILVP DSAHGTNPAS AAMVGCEIVN IPSDKDGNVD IEELKKTVGN 200
    DTAALMLTNP NTLGLFETHI KEIAEIVHKA GGLLYYDGAN LNAIMGRLRP 250
    GDMGYDIVHL NLHKTFSTPH GGGGPGSGPI GCKKFLEEFL PVPVVTGSDG 300
    SYKLDYNRPD SIGRVRNFYG NFLVFLRAYA YILTLGSEGI RESSGYAVLN 350
    ANYLKKKLEK EYDVAFDRIC MHEFVLTLEK IKEETGVSAL DIAKGLIDDG 400
    IHPPTMYFPL IVHEALMFEP TETESKSTLD FTAEVMIKLK KEAYSNPEKL 450
    HGYPYTRPIG RVDETKAARE PVLRYKACCC CK 482
    Length:482
    Mass (Da):53,417
    Last modified:June 21, 2004 - v1
    Checksum:i122CC637802FC530
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS12141.1.
    RefSeqiNP_972230.1. NC_002967.9.

    Genome annotation databases

    EnsemblBacteriaiAAS12141; AAS12141; TDE_1624.
    GeneIDi2740865.
    KEGGitde:TDE1624.
    PATRICi20525408. VBITreDen445_1552.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017226 Genomic DNA. Translation: AAS12141.1 .
    RefSeqi NP_972230.1. NC_002967.9.

    3D structure databases

    ProteinModelPortali P62031.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243275.TDE1624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS12141 ; AAS12141 ; TDE_1624 .
    GeneIDi 2740865.
    KEGGi tde:TDE1624.
    PATRICi 20525408. VBITreDen445_1552.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00283.
    OMAi IFERRIK.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci TDEN243275:GJ7G-1650-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35405 / CIP 103919 / DSM 14222.

    Entry informationi

    Entry nameiGCSPB_TREDE
    AccessioniPrimary (citable) accession number: P62031
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2004
    Last sequence update: June 21, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3