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P62030

- GCSPB_THET2

UniProt

P62030 - GCSPB_THET2

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, TT_C0151
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-155-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:TT_C0151
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_0000167023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi262724.TTC0151.

Structurei

3D structure databases

ProteinModelPortaliP62030.
SMRiP62030. Positions 2-473.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiIFERRIK.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

P62030-1 [UniParc]FASTAAdd to Basket

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MSFPLIFERS RKGRRGLKLV KAVPKAEDLI PKEHLREVPP RLPEVDELTL    50
VRHYTGLSRR QVGVDTTFYP LGSCTMKYNP KLHEEAARLF ADLHPYQDPR 100
TAQGALRLMW ELGEYLKALT GMDAITLEPA AGAHGELTGI LIIRAYHEDR 150
GEGRTRRVVL VPDSAHGSNP ATASMAGYQV REIPSGPEGE VDLEALKREL 200
GPHVAALMLT NPNTLGLFER RILEISRLCK EAGVQLYYDG ANLNAIMGWA 250
RPGDMGFDVV HLNLHKTFTV PHGGGGPGSG PVGVKAHLAP YLPVPLVERG 300
EEGFYLDFDR PKSIGRVRSF YGNFLALVRA WAYIRTLGLE GLKKAAALAV 350
LNARYLKELL KEKGYRVPYD GPSMHEFVAQ PPQGFRALDL AKGLLELGFH 400
PPTVYFPLIV KEALMVEPTE TEAKETLEAF AEAMGALLKK PKEWLENAPY 450
STPVRRLDEL RANRSPKLTY FDE 473
Length:473
Mass (Da):52,629
Last modified:June 21, 2004 - v1
Checksum:iA8E95DFB002D4987
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS80499.1.
RefSeqiWP_011172606.1. NC_005835.1.
YP_004126.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS80499; AAS80499; TT_C0151.
GeneIDi2774496.
KEGGitth:TTC0151.
PATRICi23950693. VBITheThe54392_0151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS80499.1 .
RefSeqi WP_011172606.1. NC_005835.1.
YP_004126.1. NC_005835.1.

3D structure databases

ProteinModelPortali P62030.
SMRi P62030. Positions 2-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 262724.TTC0151.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS80499 ; AAS80499 ; TT_C0151 .
GeneIDi 2774496.
KEGGi tth:TTC0151.
PATRICi 23950693. VBITheThe54392_0151.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi IFERRIK.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-155-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiGCSPB_THET2
AccessioniPrimary (citable) accession number: P62030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 21, 2004
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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