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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96ElectrophileUniRule annotation1
Active sitei144Proton acceptorUniRule annotation1
Binding sitei149Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei184Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Synonyms:tpi
Ordered Locus Names:PF1920
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000903412 – 228Triosephosphate isomeraseAdd BLAST227

Proteomic databases

PRIDEiP62002

Interactioni

Subunit structurei

Homotetramer; dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi186497.PF1920

Structurei

3D structure databases

ProteinModelPortaliP62002
SMRiP62002
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 14Substrate bindingUniRule annotation3
Regioni205 – 206Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01087 Archaea
COG0149 LUCA
HOGENOMiHOG000223030
KOiK01803
OMAiIPVYAQH
OrthoDBiPOG093Z0G5K

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_A TIM_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033983 Thiazole_synthase_ThiG
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR022891 Triosephosphate_isomerase_arc
IPR020861 Triosephosphate_isomerase_AS
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF05690 ThiG, 1 hit
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS00171 TIM_1, 1 hit
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P62002-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLKEPIIA INFKTYIEAT GKRALEIAKA AEKVYKETGV TIVVAPQLVD
60 70 80 90 100
LRMIAESVEI PVFAQHIDPI KPGSHTGHVL PEAVKEAGAV GTLLNHSENR
110 120 130 140 150
MILADLEAAI RRAEEVGLMT MVCSNNPAVS AAVAALNPDY VAVEPPELIG
160 170 180 190 200
TGIPVSKAKP EVITNTVELV KKVNPEVKVL CGAGISTGED VKKAIELGTV
210 220
GVLLASGVTK AKDPEKAIWD LVSGIIKE
Length:228
Mass (Da):24,066
Last modified:January 23, 2007 - v2
Checksum:i1F24C7A2D71BB6F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA Translation: AAL82044.1
PIRiA44632
RefSeqiWP_011013060.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL82044; AAL82044; PF1920
GeneIDi1469800
KEGGipfu:PF1920
PATRICifig|186497.12.peg.1991

Entry informationi

Entry nameiTPIS_PYRFU
AccessioniPrimary (citable) accession number: P62002
Secondary accession number(s): P95583
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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