Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TATA-box-binding protein

Gene

tbp

Organism
Pyrococcus woesei
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
Box A-binding protein
Short name:
BAP
TATA sequence-binding protein
Short name:
TBP
TATA-box factor
Gene namesi
Name:tbp
OrganismiPyrococcus woesei
Taxonomic identifieri2262 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001540231 – 191TATA-box-binding proteinAdd BLAST191

Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi8 – 19Combined sources12
Helixi26 – 29Combined sources4
Turni30 – 32Combined sources3
Beta strandi34 – 39Combined sources6
Turni40 – 42Combined sources3
Beta strandi44 – 49Combined sources6
Beta strandi51 – 53Combined sources3
Beta strandi56 – 59Combined sources4
Beta strandi63 – 72Combined sources10
Helixi73 – 89Combined sources17
Beta strandi95 – 97Combined sources3
Beta strandi99 – 110Combined sources12
Helixi117 – 123Combined sources7
Beta strandi127 – 130Combined sources4
Turni131 – 133Combined sources3
Beta strandi135 – 141Combined sources7
Turni142 – 145Combined sources4
Beta strandi146 – 150Combined sources5
Beta strandi154 – 163Combined sources10
Helixi164 – 178Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AISX-ray2.10A1-181[»]
1D3UX-ray2.40A1-181[»]
1PCZX-ray2.20A/B1-191[»]
ProteinModelPortaliP62001.
SMRiP62001.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62001.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati11 – 871Add BLAST77
Repeati102 – 1782Add BLAST77

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Family and domain databases

CDDicd04518. TBP_archaea. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR033711. TBP_archaea.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDMSKVKLR IENIVASVDL FAQLDLEKVL DLCPNSKYNP EEFPGIICHL
60 70 80 90 100
DDPKVALLIF SSGKLVVTGA KSVQDIERAV AKLAQKLKSI GVKFKRAPQI
110 120 130 140 150
DVQNMVFSGD IGREFNLDVV ALTLPNCEYE PEQFPGVIYR VKEPKSVILL
160 170 180 190
FSSGKIVCSG AKSEADAWEA VRKLLRELDK YGLLEEEEEE L
Length:191
Mass (Da):21,312
Last modified:June 7, 2004 - v1
Checksum:iB371491BF9282972
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10285 Unassigned DNA. Translation: AAA73447.1.
PIRiA54275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10285 Unassigned DNA. Translation: AAA73447.1.
PIRiA54275.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AISX-ray2.10A1-181[»]
1D3UX-ray2.40A1-181[»]
1PCZX-ray2.20A/B1-191[»]
ProteinModelPortaliP62001.
SMRiP62001.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP62001.

Family and domain databases

CDDicd04518. TBP_archaea. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR033711. TBP_archaea.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP_PYRWO
AccessioniPrimary (citable) accession number: P62001
Secondary accession number(s): Q57050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.