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Protein

TATA-box-binding protein

Gene

tbp

Organism
Pyrococcus woesei
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
Box A-binding protein
Short name:
BAP
TATA sequence-binding protein
Short name:
TBP
TATA-box factor
Gene namesi
Name:tbp
OrganismiPyrococcus woesei
Taxonomic identifieri2262 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 191191TATA-box-binding proteinPRO_0000154023Add
BLAST

Proteomic databases

PRIDEiP62001.

Structurei

Secondary structure

1
191
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 63Combined sources
Beta strandi8 – 1912Combined sources
Helixi26 – 294Combined sources
Turni30 – 323Combined sources
Beta strandi34 – 396Combined sources
Turni40 – 423Combined sources
Beta strandi44 – 496Combined sources
Beta strandi51 – 533Combined sources
Beta strandi56 – 594Combined sources
Beta strandi63 – 7210Combined sources
Helixi73 – 8917Combined sources
Beta strandi95 – 973Combined sources
Beta strandi99 – 11012Combined sources
Helixi117 – 1237Combined sources
Beta strandi127 – 1304Combined sources
Turni131 – 1333Combined sources
Beta strandi135 – 1417Combined sources
Turni142 – 1454Combined sources
Beta strandi146 – 1505Combined sources
Beta strandi154 – 16310Combined sources
Helixi164 – 17815Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AISX-ray2.10A1-181[»]
1D3UX-ray2.40A1-181[»]
1PCZX-ray2.20A/B1-191[»]
ProteinModelPortaliP62001.
SMRiP62001. Positions 2-184.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP62001.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 87771Add
BLAST
Repeati102 – 178772Add
BLAST

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P62001-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDMSKVKLR IENIVASVDL FAQLDLEKVL DLCPNSKYNP EEFPGIICHL
60 70 80 90 100
DDPKVALLIF SSGKLVVTGA KSVQDIERAV AKLAQKLKSI GVKFKRAPQI
110 120 130 140 150
DVQNMVFSGD IGREFNLDVV ALTLPNCEYE PEQFPGVIYR VKEPKSVILL
160 170 180 190
FSSGKIVCSG AKSEADAWEA VRKLLRELDK YGLLEEEEEE L
Length:191
Mass (Da):21,312
Last modified:June 7, 2004 - v1
Checksum:iB371491BF9282972
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10285 Unassigned DNA. Translation: AAA73447.1.
PIRiA54275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10285 Unassigned DNA. Translation: AAA73447.1.
PIRiA54275.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AISX-ray2.10A1-181[»]
1D3UX-ray2.40A1-181[»]
1PCZX-ray2.20A/B1-191[»]
ProteinModelPortaliP62001.
SMRiP62001. Positions 2-184.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP62001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP62001.

Family and domain databases

Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria."
    Rowlands T.M., Baumann P., Jackson S.P.
    Science 264:1326-1329(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The crystal structure of a hyperthermophilic archaeal TATA-box binding protein."
    DeDecker B.S., O'Brien R., Fleming P.J., Geiger J.H., Jackson S.P., Sigler P.B.
    J. Mol. Biol. 264:1072-1084(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiTBP_PYRWO
AccessioniPrimary (citable) accession number: P62001
Secondary accession number(s): Q57050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 14, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.