P62001 (TBP_PYRWO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
TATA-box-binding protein

Alternative name(s):
Box A-binding protein
Short name=BAP
TATA sequence-binding protein
Short name=TBP
TATA-box factor

Gene names

Name:

tbp

Organism

Pyrococcus woesei

Taxonomic identifier

2262 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	191 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. HAMAP MF_00408
Sequence similarities	Belongs to the TBP family.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Domain	Repeat
Ligand	DNA-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription initiation from RNA polymerase II promoter Inferred from electronic annotation. Source: InterPro
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 191

191

TATA-box-binding protein HAMAP MF_00408

PRO_0000154023

Regions

Repeat

11 – 87

77

1 HAMAP MF_00408

Repeat

102 – 178

77

2 HAMAP MF_00408

Secondary structure

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191

Helix Strand Turn

Details...

Beta strand

8 – 19

12

Helix

26 – 29

4

Turn

30 – 32

3

Turn

40 – 42

3

Beta strand

44 – 49

6

Beta strand

51 – 53

3

Beta strand

56 – 59

4

Beta strand

63 – 72

10

Helix

73 – 89

17

Beta strand

95 – 97

3

Beta strand

99 – 110

12

Helix

117 – 123

7

Turn

131 – 133

3

Beta strand

135 – 141

7

Turn

142 – 145

4

Beta strand

146 – 150

5

Beta strand

154 – 163

10

Helix

164 – 178

15

Sequences

	Sequence		Length	Mass (Da)
	P62001 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: B371491BF9282972	FASTA	191	21,312
	10 20 30 40 50 60 MVDMSKVKLR IENIVASVDL FAQLDLEKVL DLCPNSKYNP EEFPGIICHL DDPKVALLIF 70 80 90 100 110 120 SSGKLVVTGA KSVQDIERAV AKLAQKLKSI GVKFKRAPQI DVQNMVFSGD IGREFNLDVV 130 140 150 160 170 180 ALTLPNCEYE PEQFPGVIYR VKEPKSVILL FSSGKIVCSG AKSEADAWEA VRKLLRELDK 190 YGLLEEEEEE L

References

[1]	"The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria." Rowlands T.M., Baumann P., Jackson S.P. Science 264:1326-1329(1994) [PubMed: 8191287] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The crystal structure of a hyperthermophilic archaeal TATA-box binding protein." DeDecker B.S., O'Brien R., Fleming P.J., Geiger J.H., Jackson S.P., Sigler P.B. J. Mol. Biol. 264:1072-1084(1996) [PubMed: 9000631] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U10285 Unassigned DNA. Translation: AAA73447.1.

PIR

A54275.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1AIS	X-ray	2.10	A	1-181	[»]
1D3U	X-ray	2.40	A	1-181	[»]
1PCZ	X-ray	2.20	A/B	1-191	[»]

ProteinModelPortal

P62001.

SMR

P62001. Positions 2-184.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

HAMAP

MF_00408. TATA_bind_prot_arch.
[Tree]

InterPro

IPR000814. TBP.
IPR012294. TFIID_C/glycos_N.
[Graphical view]

PANTHER

PTHR10126. TBP. 1 hit.

Pfam

PF00352. TBP. 2 hits.
[Graphical view]

PRINTS

PR00686. TIFACTORIID.

SUPFAM

SSF55945. TFIID_C/glycos_N. 2 hits.

PROSITE

PS00351. TFIID. 2 hits.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

TBP_PYRWO

Accession

Primary (citable) accession number: P62001
Secondary accession number(s): Q57050

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program