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Protein

Transcription initiation factor IIB

Gene

tfb

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7Zinc1
Metal bindingi10Zinc1
Metal bindingi26Zinc1
Metal bindingi29Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 34TFIIB-typeUniRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor IIBUniRule annotation
Short name:
TFIIBUniRule annotation
Gene namesi
Name:tfbUniRule annotation
Ordered Locus Names:PF1377
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001193271 – 300Transcription initiation factor IIBAdd BLAST300

Proteomic databases

PRIDEiP61998

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP61998, 1 interactor
MINTiP61998
STRINGi186497.PF1377

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni8 – 10Combined sources3
Beta strandi15 – 18Combined sources4
Turni19 – 22Combined sources4
Beta strandi23 – 29Combined sources7
Beta strandi42 – 45Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PFTNMR-A1-49[»]
ProteinModelPortaliP61998
SMRiP61998
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61998

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati114 – 1971Add BLAST84
Repeati210 – 2912Add BLAST82

Sequence similaritiesi

Belongs to the TFIIB family.UniRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri2 – 34TFIIB-typeUniRule annotationAdd BLAST33

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiarCOG01981 Archaea
COG1405 LUCA
HOGENOMiHOG000108633
KOiK03124
OMAiNDDQGND
OrthoDBiPOG093Z07LX

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
HAMAPiMF_00383 TF2B_arch, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR000812 TFIIB
IPR023484 TFIIB_arc
IPR023486 TFIIB_CS
IPR013150 TFIIB_cyclin
IPR013137 Znf_TFIIB
PANTHERiPTHR11618 PTHR11618, 1 hit
PfamiView protein in Pfam
PF08271 TF_Zn_Ribbon, 1 hit
PF00382 TFIIB, 2 hits
PRINTSiPR00685 TIFACTORIIB
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00782 TFIIB, 2 hits
PS51134 ZF_TFIIB, 1 hit

Sequencei

Sequence statusi: Complete.

P61998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKQKVCPAC ESAELIYDPE RGEIVCAKCG YVIEENIIDM GPEWRAFDAS
60 70 80 90 100
QRERRSRTGA PESILLHDKG LSTEIGIDRS LSGLMREKMY RLRKWQSRLR
110 120 130 140 150
VSDAAERNLA FALSELDRIT AQLKLPRHVE EEAARLYREA VRKGLIRGRS
160 170 180 190 200
IESVMAACVY AACRLLKVPR TLDEIADIAR VDKKEIGRSY RFIARNLNLT
210 220 230 240 250
PKKLFVKPTD YVNKFADELG LSEKVRRRAI EILDEAYKRG LTSGKSPAGL
260 270 280 290 300
VAAALYIASL LEGEKRTQRE VAEVARVTEV TVRNRYKELV EKLKIKVPIA
Length:300
Mass (Da):34,106
Last modified:June 7, 2004 - v1
Checksum:i476D7CA32B2ED4C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48391 Genomic DNA Translation: AAC43724.1
AE009950 Genomic DNA Translation: AAL81501.1
PIRiT46883
RefSeqiWP_011012524.1, NC_003413.1

Genome annotation databases

EnsemblBacteriaiAAL81501; AAL81501; PF1377
GeneIDi1469253
KEGGipfu:PF1377
PATRICifig|186497.12.peg.1440

Similar proteinsi

Entry informationi

Entry nameiTF2B_PYRFU
AccessioniPrimary (citable) accession number: P61998
Secondary accession number(s): P29095, Q51731
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health