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P61982

- 1433G_MOUSE

UniProt

P61982 - 1433G_MOUSE

Protein

14-3-3 protein gamma

Gene

Ywhag

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei57 – 571Interaction with phosphoserine on interacting proteinBy similarity
    Sitei132 – 1321Interaction with phosphoserine on interacting proteinBy similarity

    GO - Molecular functioni

    1. actin binding Source: UniProtKB
    2. insulin-like growth factor receptor binding Source: UniProtKB
    3. protein binding Source: IntAct
    4. protein domain specific binding Source: MGI
    5. protein kinase C binding Source: UniProtKB

    GO - Biological processi

    1. protein targeting Source: MGI
    2. regulation of neuron differentiation Source: UniProtKB
    3. regulation of synaptic plasticity Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.
    REACT_199054. Translocation of GLUT4 to the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    14-3-3 protein gamma
    Cleaved into the following chain:
    Gene namesi
    Name:Ywhag
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:108109. Ywhag.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: Reactome
    2. cytosol Source: Reactome
    3. extracellular vesicular exosome Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 24724714-3-3 protein gammaPRO_0000367908Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 24724614-3-3 protein gamma, N-terminally processedPRO_0000058607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylvaline; in 14-3-3 protein gamma, N-terminally processedBy similarity
    Modified residuei145 – 1451PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated by various PKC isozymes.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP61982.
    PaxDbiP61982.
    PRIDEiP61982.

    2D gel databases

    REPRODUCTION-2DPAGEP61982.
    UCD-2DPAGEP61982.

    PTM databases

    PhosphoSiteiP61982.

    Expressioni

    Gene expression databases

    ArrayExpressiP61982.
    BgeeiP61982.
    GenevestigatoriP61982.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with PKA-phosphorylated AANAT and SIRT2 By similarity. Interacts with SAMSN1.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Kcnma1Q084604EBI-359843,EBI-1633915
    Lrrk2Q5S0067EBI-359843,EBI-2693710

    Protein-protein interaction databases

    BioGridi204620. 16 interactions.
    IntActiP61982. 17 interactions.
    MINTiMINT-1869483.

    Structurei

    3D structure databases

    ProteinModelPortaliP61982.
    SMRiP61982. Positions 1-235.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the 14-3-3 family.Curated

    Phylogenomic databases

    eggNOGiCOG5040.
    GeneTreeiENSGT00730000110613.
    HOVERGENiHBG050423.
    InParanoidiP61982.
    KOiK16198.
    OMAiCSETQHE.
    OrthoDBiEOG7HHWT3.
    PhylomeDBiP61982.
    TreeFamiTF102003.

    Family and domain databases

    Gene3Di1.20.190.20. 1 hit.
    InterProiIPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view]
    PANTHERiPTHR18860. PTHR18860. 1 hit.
    PfamiPF00244. 14-3-3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000868. 14-3-3. 1 hit.
    PRINTSiPR00305. 1433ZETA.
    SMARTiSM00101. 14_3_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48445. SSF48445. 1 hit.
    PROSITEiPS00796. 1433_1. 1 hit.
    PS00797. 1433_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61982-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK    50
    NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV 100
    LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS 150
    EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA 200
    FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN 247
    Length:247
    Mass (Da):28,303
    Last modified:January 23, 2007 - v2
    Checksum:iB0D16C6DE1F4455D
    GO

    Sequence cautioni

    The sequence BAE28625.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501S → F in AAC14345. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058799 mRNA. Translation: AAC14345.1.
    CT010208 mRNA. Translation: CAJ18416.1.
    AK088847 mRNA. Translation: BAC40609.1.
    AK148618 mRNA. Translation: BAE28625.1. Different initiation.
    AK153307 mRNA. Translation: BAE31888.1.
    AK164356 mRNA. Translation: BAE37756.1.
    BC008129 mRNA. Translation: AAH08129.1.
    CCDSiCCDS19748.1.
    RefSeqiNP_061359.2. NM_018871.3.
    UniGeneiMm.233813.

    Genome annotation databases

    EnsembliENSMUST00000055808; ENSMUSP00000051223; ENSMUSG00000051391.
    GeneIDi22628.
    KEGGimmu:22628.
    UCSCiuc008zzf.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF058799 mRNA. Translation: AAC14345.1 .
    CT010208 mRNA. Translation: CAJ18416.1 .
    AK088847 mRNA. Translation: BAC40609.1 .
    AK148618 mRNA. Translation: BAE28625.1 . Different initiation.
    AK153307 mRNA. Translation: BAE31888.1 .
    AK164356 mRNA. Translation: BAE37756.1 .
    BC008129 mRNA. Translation: AAH08129.1 .
    CCDSi CCDS19748.1.
    RefSeqi NP_061359.2. NM_018871.3.
    UniGenei Mm.233813.

    3D structure databases

    ProteinModelPortali P61982.
    SMRi P61982. Positions 1-235.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204620. 16 interactions.
    IntActi P61982. 17 interactions.
    MINTi MINT-1869483.

    Chemistry

    BindingDBi P61982.

    PTM databases

    PhosphoSitei P61982.

    2D gel databases

    REPRODUCTION-2DPAGE P61982.
    UCD-2DPAGE P61982.

    Proteomic databases

    MaxQBi P61982.
    PaxDbi P61982.
    PRIDEi P61982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055808 ; ENSMUSP00000051223 ; ENSMUSG00000051391 .
    GeneIDi 22628.
    KEGGi mmu:22628.
    UCSCi uc008zzf.2. mouse.

    Organism-specific databases

    CTDi 7532.
    MGIi MGI:108109. Ywhag.

    Phylogenomic databases

    eggNOGi COG5040.
    GeneTreei ENSGT00730000110613.
    HOVERGENi HBG050423.
    InParanoidi P61982.
    KOi K16198.
    OMAi CSETQHE.
    OrthoDBi EOG7HHWT3.
    PhylomeDBi P61982.
    TreeFami TF102003.

    Enzyme and pathway databases

    Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.
    REACT_199054. Translocation of GLUT4 to the plasma membrane.

    Miscellaneous databases

    ChiTaRSi YWHAG. mouse.
    NextBioi 302991.
    PROi P61982.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61982.
    Bgeei P61982.
    Genevestigatori P61982.

    Family and domain databases

    Gene3Di 1.20.190.20. 1 hit.
    InterProi IPR000308. 14-3-3.
    IPR023409. 14-3-3_CS.
    IPR023410. 14-3-3_domain.
    [Graphical view ]
    PANTHERi PTHR18860. PTHR18860. 1 hit.
    Pfami PF00244. 14-3-3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000868. 14-3-3. 1 hit.
    PRINTSi PR00305. 1433ZETA.
    SMARTi SM00101. 14_3_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48445. SSF48445. 1 hit.
    PROSITEi PS00796. 1433_1. 1 hit.
    PS00797. 1433_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Karpitskiy V.V., Shaw A.S.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    2. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Thymus.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    5. Lubec G., Kang S.U., Klug S., Friebe K., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 13-50; 43-56; 62-69; 78-83; 92-120 AND 133-247, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.
    6. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    7. Cited for: INTERACTION WITH SAMSN1.

    Entry informationi

    Entry namei1433G_MOUSE
    AccessioniPrimary (citable) accession number: P61982
    Secondary accession number(s): O70457
    , P35214, Q3UFD6, Q4FK44, Q9UDP2, Q9UN99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3