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P61973

- MDH_BDEBA

UniProt

P61973 - MDH_BDEBA

Protein

Malate dehydrogenase

Gene

mdh

Organism
Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei107 – 1071NADUniRule annotation
    Binding sitei114 – 1141NADUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Active sitei192 – 1921Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 177NADUniRule annotation
    Nucleotide bindingi131 – 1333NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:Bd0928
    OrganismiBdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    Taxonomic identifieri264462 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaBdellovibrionalesBdellovibrionaceaeBdellovibrio
    ProteomesiUP000008080: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Malate dehydrogenasePRO_0000113348Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi264462.Bd0928.

    Structurei

    3D structure databases

    ProteinModelPortaliP61973.
    SMRiP61973. Positions 2-335.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P61973-1 [UniParc]FASTAAdd to Basket

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    MKAPVRVAVT GAAGQIGYAL LFRIASGAML GADQPVILQL LEIPDEKAQK    50
    ALKGVMMELE DCAFPLLHSM IATGDPAVAF KDADVALLVG ARPRGPGMER 100
    KDLLTANGQI FTVQGEAIGK YANPNVKVLV VGNPANTNAY IAMKSAMKHG 150
    RVKAKNFTAM LRLDHNRALS QLATKTGKPV ASFKKVAVWG NHSPTMYPDV 200
    RFATADGAKV PELLKLGTAE GDAWNKDTFI PTVGKRGAAI IEARGLSSAA 250
    SAASAAVDHI RDWWLGTNGE WVTMGIPSDG SYDIPEGIMY GFPVTCKNGE 300
    YEIVKGLEID AFSREKMNNT LKELNEEKDA VASML 335
    Length:335
    Mass (Da):35,799
    Last modified:June 7, 2004 - v1
    Checksum:iF27B09F07ACD8EC7
    GO

    Sequence cautioni

    The sequence CAE78869.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842648 Genomic DNA. Translation: CAE78869.1. Different initiation.
    RefSeqiNP_967876.2. NC_005363.1.

    Genome annotation databases

    EnsemblBacteriaiCAE78869; CAE78869; Bd0928.
    GeneIDi2733201.
    KEGGibba:Bd0928.
    PATRICi21076530. VBIBdeBac73187_0847.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX842648 Genomic DNA. Translation: CAE78869.1 . Different initiation.
    RefSeqi NP_967876.2. NC_005363.1.

    3D structure databases

    ProteinModelPortali P61973.
    SMRi P61973. Positions 2-335.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264462.Bd0928.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAE78869 ; CAE78869 ; Bd0928 .
    GeneIDi 2733201.
    KEGGi bba:Bd0928.
    PATRICi 21076530. VBIBdeBac73187_0847.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OrthoDBi EOG6PP9Q2.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective."
      Rendulic S., Jagtap P., Rosinus A., Eppinger M., Baar C., Lanz C., Keller H., Lambert C., Evans K.J., Goesmann A., Meyer F., Sockett R.E., Schuster S.C.
      Science 303:689-692(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15356 / DSM 50701 / NCIB 9529 / HD100.

    Entry informationi

    Entry nameiMDH_BDEBA
    AccessioniPrimary (citable) accession number: P61973
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3