Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear transport factor 2

Gene

Nutf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).By similarity

GO - Molecular functioni

  • protein transporter activity Source: MGI
  • Ran GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transport factor 2
Short name:
NTF-2
Gene namesi
Name:Nutf2
Synonyms:Ntf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 19, Chromosome 8

Organism-specific databases

MGIiMGI:1915301. Nutf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Nuclear transport factor 2PRO_0000194776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61971.
MaxQBiP61971.
PaxDbiP61971.
PeptideAtlasiP61971.
PRIDEiP61971.

PTM databases

iPTMnetiP61971.
PhosphoSiteiP61971.

Expressioni

Gene expression databases

BgeeiENSMUSG00000008450.
CleanExiMM_NUTF2.
GenevisibleiP61971. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with NUP58.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212629. 4 interactions.
IntActiP61971. 2 interactions.
MINTiMINT-4153278.
STRINGi10090.ENSMUSP00000131850.

Structurei

3D structure databases

ProteinModelPortaliP61971.
SMRiP61971. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 121112NTF2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 NTF2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61971.
OMAiLSLHDCD.
OrthoDBiEOG091G0SZN.
PhylomeDBiP61971.
TreeFamiTF314422.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA
60 70 80 90 100
AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH
110 120
QMFLLKNIND AWVCTNDMFR LALHNFG
Length:127
Mass (Da):14,478
Last modified:June 7, 2004 - v1
Checksum:i817752F20E262FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002461 mRNA. Translation: BAB22117.1.
AK012500 mRNA. Translation: BAB28283.1.
AK020512 mRNA. Translation: BAB32122.1.
AK028410 mRNA. Translation: BAC25936.1.
AK051049 mRNA. Translation: BAC34511.1.
AK168026 mRNA. Translation: BAE40011.1.
BC003955 mRNA. Translation: AAH03955.1.
BC083165 mRNA. Translation: AAH83165.1.
BC086773 mRNA. Translation: AAH86773.1.
CCDSiCCDS22617.1.
RefSeqiNP_080808.1. NM_026532.3.
XP_001474007.1. XM_001473957.5.
XP_006531388.1. XM_006531325.2.
XP_006543465.1. XM_006543402.2.
UniGeneiMm.455474.

Genome annotation databases

EnsembliENSMUST00000008594; ENSMUSP00000008594; ENSMUSG00000008450.
ENSMUST00000095978; ENSMUSP00000131850; ENSMUSG00000071497.
GeneIDi621832.
68051.
KEGGimmu:621832.
mmu:68051.
UCSCiuc009nej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002461 mRNA. Translation: BAB22117.1.
AK012500 mRNA. Translation: BAB28283.1.
AK020512 mRNA. Translation: BAB32122.1.
AK028410 mRNA. Translation: BAC25936.1.
AK051049 mRNA. Translation: BAC34511.1.
AK168026 mRNA. Translation: BAE40011.1.
BC003955 mRNA. Translation: AAH03955.1.
BC083165 mRNA. Translation: AAH83165.1.
BC086773 mRNA. Translation: AAH86773.1.
CCDSiCCDS22617.1.
RefSeqiNP_080808.1. NM_026532.3.
XP_001474007.1. XM_001473957.5.
XP_006531388.1. XM_006531325.2.
XP_006543465.1. XM_006543402.2.
UniGeneiMm.455474.

3D structure databases

ProteinModelPortaliP61971.
SMRiP61971. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212629. 4 interactions.
IntActiP61971. 2 interactions.
MINTiMINT-4153278.
STRINGi10090.ENSMUSP00000131850.

PTM databases

iPTMnetiP61971.
PhosphoSiteiP61971.

Proteomic databases

EPDiP61971.
MaxQBiP61971.
PaxDbiP61971.
PeptideAtlasiP61971.
PRIDEiP61971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008594; ENSMUSP00000008594; ENSMUSG00000008450.
ENSMUST00000095978; ENSMUSP00000131850; ENSMUSG00000071497.
GeneIDi621832.
68051.
KEGGimmu:621832.
mmu:68051.
UCSCiuc009nej.1. mouse.

Organism-specific databases

CTDi10204.
621832.
MGIiMGI:1915301. Nutf2.

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61971.
OMAiLSLHDCD.
OrthoDBiEOG091G0SZN.
PhylomeDBiP61971.
TreeFamiTF314422.

Miscellaneous databases

PROiP61971.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000008450.
CleanExiMM_NUTF2.
GenevisibleiP61971. MM.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTF2_MOUSE
AccessioniPrimary (citable) accession number: P61971
Secondary accession number(s): P13662, Q3TI35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.