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Protein

Nuclear transport factor 2

Gene

Nutf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).By similarity

GO - Molecular functioni

  • protein transporter activity Source: MGI
  • Ran GTPase binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transport factor 2
Short name:
NTF-2
Gene namesi
Name:Nutf2
Synonyms:Ntf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 19, Chromosome 8

Organism-specific databases

MGIiMGI:1915301. Nutf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Nuclear transport factor 2PRO_0000194776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61971.
MaxQBiP61971.
PaxDbiP61971.
PeptideAtlasiP61971.
PRIDEiP61971.

PTM databases

iPTMnetiP61971.
PhosphoSiteiP61971.

Expressioni

Gene expression databases

BgeeiP61971.
CleanExiMM_NUTF2.
GenevisibleiP61971. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with NUP58.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212629. 4 interactions.
IntActiP61971. 2 interactions.
MINTiMINT-4153278.
STRINGi10090.ENSMUSP00000131850.

Structurei

3D structure databases

ProteinModelPortaliP61971.
SMRiP61971. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 121112NTF2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 NTF2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61971.
OMAiFYYQQFD.
OrthoDBiEOG7TQV2N.
PhylomeDBiP61971.
TreeFamiTF314422.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA
60 70 80 90 100
AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH
110 120
QMFLLKNIND AWVCTNDMFR LALHNFG
Length:127
Mass (Da):14,478
Last modified:June 7, 2004 - v1
Checksum:i817752F20E262FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002461 mRNA. Translation: BAB22117.1.
AK012500 mRNA. Translation: BAB28283.1.
AK020512 mRNA. Translation: BAB32122.1.
AK028410 mRNA. Translation: BAC25936.1.
AK051049 mRNA. Translation: BAC34511.1.
AK168026 mRNA. Translation: BAE40011.1.
BC003955 mRNA. Translation: AAH03955.1.
BC083165 mRNA. Translation: AAH83165.1.
BC086773 mRNA. Translation: AAH86773.1.
CCDSiCCDS22617.1.
RefSeqiNP_080808.1. NM_026532.3.
XP_001474007.1. XM_001473957.5.
XP_006531388.1. XM_006531325.2.
XP_006543465.1. XM_006543402.2.
UniGeneiMm.455474.

Genome annotation databases

EnsembliENSMUST00000008594; ENSMUSP00000008594; ENSMUSG00000008450.
ENSMUST00000095978; ENSMUSP00000131850; ENSMUSG00000071497.
GeneIDi621832.
68051.
KEGGimmu:621832.
mmu:68051.
UCSCiuc009nej.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002461 mRNA. Translation: BAB22117.1.
AK012500 mRNA. Translation: BAB28283.1.
AK020512 mRNA. Translation: BAB32122.1.
AK028410 mRNA. Translation: BAC25936.1.
AK051049 mRNA. Translation: BAC34511.1.
AK168026 mRNA. Translation: BAE40011.1.
BC003955 mRNA. Translation: AAH03955.1.
BC083165 mRNA. Translation: AAH83165.1.
BC086773 mRNA. Translation: AAH86773.1.
CCDSiCCDS22617.1.
RefSeqiNP_080808.1. NM_026532.3.
XP_001474007.1. XM_001473957.5.
XP_006531388.1. XM_006531325.2.
XP_006543465.1. XM_006543402.2.
UniGeneiMm.455474.

3D structure databases

ProteinModelPortaliP61971.
SMRiP61971. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212629. 4 interactions.
IntActiP61971. 2 interactions.
MINTiMINT-4153278.
STRINGi10090.ENSMUSP00000131850.

PTM databases

iPTMnetiP61971.
PhosphoSiteiP61971.

Proteomic databases

EPDiP61971.
MaxQBiP61971.
PaxDbiP61971.
PeptideAtlasiP61971.
PRIDEiP61971.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000008594; ENSMUSP00000008594; ENSMUSG00000008450.
ENSMUST00000095978; ENSMUSP00000131850; ENSMUSG00000071497.
GeneIDi621832.
68051.
KEGGimmu:621832.
mmu:68051.
UCSCiuc009nej.1. mouse.

Organism-specific databases

CTDi10204.
621832.
MGIiMGI:1915301. Nutf2.

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61971.
OMAiFYYQQFD.
OrthoDBiEOG7TQV2N.
PhylomeDBiP61971.
TreeFamiTF314422.

Miscellaneous databases

PROiP61971.
SOURCEiSearch...

Gene expression databases

BgeeiP61971.
CleanExiMM_NUTF2.
GenevisibleiP61971. MM.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNTF2_MOUSE
AccessioniPrimary (citable) accession number: P61971
Secondary accession number(s): P13662, Q3TI35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 6, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.