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Protein

Nuclear transport factor 2

Gene

Nutf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transport factor 2Curated
Short name:
NTF-2
Gene namesi
Name:Nutf2Imported
Synonyms:Ntf2By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componentsi: Chromosome 19, Chromosome 8

Organism-specific databases

MGIiMGI:1915301 Nutf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947761 – 127Nuclear transport factor 2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61971
MaxQBiP61971
PaxDbiP61971
PeptideAtlasiP61971
PRIDEiP61971

PTM databases

iPTMnetiP61971
PhosphoSitePlusiP61971

Expressioni

Gene expression databases

BgeeiENSMUSG00000008450
CleanExiMM_NUTF2
ExpressionAtlasiP61971 baseline and differential
GenevisibleiP61971 MM

Interactioni

Subunit structurei

Homodimer. Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import. Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear import.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212629, 4 interactors
IntActiP61971, 2 interactors
MINTiP61971
STRINGi10090.ENSMUSP00000131850

Structurei

3D structure databases

ProteinModelPortaliP61971
SMRiP61971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 121NTF2PROSITE-ProRule annotationAdd BLAST112

Phylogenomic databases

eggNOGiKOG2104 Eukaryota
ENOG4111QUX LUCA
GeneTreeiENSGT00510000047030
HOGENOMiHOG000197024
HOVERGENiHBG025070
InParanoidiP61971
OMAiQFTDFYY
OrthoDBiEOG091G0SZN
PhylomeDBiP61971
TreeFamiTF314422

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P61971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA
60 70 80 90 100
AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH
110 120
QMFLLKNIND AWVCTNDMFR LALHNFG
Length:127
Mass (Da):14,478
Last modified:June 7, 2004 - v1
Checksum:i817752F20E262FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002461 mRNA Translation: BAB22117.1
AK012500 mRNA Translation: BAB28283.1
AK020512 mRNA Translation: BAB32122.1
AK028410 mRNA Translation: BAC25936.1
AK051049 mRNA Translation: BAC34511.1
AK168026 mRNA Translation: BAE40011.1
BC003955 mRNA Translation: AAH03955.1
BC083165 mRNA Translation: AAH83165.1
BC086773 mRNA Translation: AAH86773.1
CCDSiCCDS22617.1
RefSeqiNP_080808.1, NM_026532.3
XP_001474007.1, XM_001473957.5
XP_006531388.1, XM_006531325.3
UniGeneiMm.455474

Genome annotation databases

EnsembliENSMUST00000008594; ENSMUSP00000008594; ENSMUSG00000008450
ENSMUST00000095978; ENSMUSP00000131850; ENSMUSG00000071497
ENSMUST00000212042; ENSMUSP00000148713; ENSMUSG00000008450
GeneIDi621832
68051
KEGGimmu:621832
mmu:68051
UCSCiuc009nej.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNTF2_MOUSE
AccessioniPrimary (citable) accession number: P61971
Secondary accession number(s): P13662, Q3TI35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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