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Protein

Nuclear transport factor 2

Gene

NUTF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • nuclear import signal receptor activity Source: Ensembl
  • Ran GTPase binding Source: UniProtKB
  • structural constituent of nuclear pore Source: GO_Central

GO - Biological processi

Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transport factor 21 Publication
Short name:
NTF-2
Alternative name(s):
Placental protein 151 Publication
Short name:
PP151 Publication
Gene namesi
Name:NUTF2Imported
Synonyms:NTF21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102898.11
HGNCiHGNC:13722 NUTF2
MIMi605813 gene
neXtProtiNX_P61970

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42E → K: No effect on localization to the nucleoplasm. 1 Publication1
Mutagenesisi124Missing : No effect on localization to the nucleoplasm. 1 Publication1

Organism-specific databases

DisGeNETi10204
OpenTargetsiENSG00000102898
PharmGKBiPA38365

Polymorphism and mutation databases

BioMutaiNUTF2
DMDMi48429030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947751 – 127Nuclear transport factor 2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61970
MaxQBiP61970
PaxDbiP61970
PeptideAtlasiP61970
PRIDEiP61970
TopDownProteomicsiP61970

2D gel databases

OGPiP61970

PTM databases

iPTMnetiP61970
PhosphoSitePlusiP61970

Expressioni

Gene expression databases

BgeeiENSG00000102898
CleanExiHS_NUTF2
ExpressionAtlasiP61970 baseline and differential
GenevisibleiP61970 HS

Organism-specific databases

HPAiHPA040915
HPA040956

Interactioni

Subunit structurei

Homodimer (PubMed:7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:7744965). Interacts with CAPG; mediates its nuclear import (PubMed:18266911).3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • Ran GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115499, 35 interactors
DIPiDIP-6057N
IntActiP61970, 22 interactors
STRINGi9606.ENSP00000219169

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 24Combined sources19
Helixi26 – 32Combined sources7
Beta strandi33 – 41Combined sources9
Beta strandi44 – 48Combined sources5
Helixi49 – 57Combined sources9
Beta strandi62 – 75Combined sources14
Beta strandi81 – 94Combined sources14
Beta strandi97 – 108Combined sources12
Beta strandi111 – 124Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GY5X-ray2.30A/B1-127[»]
ProteinModelPortaliP61970
SMRiP61970
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61970

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 121NTF2PROSITE-ProRule annotationAdd BLAST112

Phylogenomic databases

eggNOGiKOG2104 Eukaryota
ENOG4111QUX LUCA
GeneTreeiENSGT00510000047030
HOGENOMiHOG000197024
HOVERGENiHBG025070
InParanoidiP61970
OMAiQFTDFYY
OrthoDBiEOG091G0SZN
PhylomeDBiP61970
TreeFamiTF314422

Family and domain databases

CDDicd00780 NTF2, 1 hit
InterProiView protein in InterPro
IPR002075 NTF2
IPR032710 NTF2-like_dom_sf
IPR018222 Nuclear_transport_factor_2_euk
PfamiView protein in Pfam
PF02136 NTF2, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
PROSITEiView protein in PROSITE
PS50177 NTF2_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

P61970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA
60 70 80 90 100
AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH
110 120
QMFLLKNIND AWVCTNDMFR LALHNFG
Length:127
Mass (Da):14,478
Last modified:June 7, 2004 - v1
Checksum:i817752F20E262FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07315 mRNA Translation: CAA30278.1
U43939 mRNA Translation: AAA85905.1
CR456937 mRNA Translation: CAG33218.1
AK311822 mRNA Translation: BAG34764.1
CH471092 Genomic DNA Translation: EAW83181.1
BC002348 mRNA Translation: AAH02348.1
CCDSiCCDS10848.1
PIRiS00751
RefSeqiNP_001308967.1, NM_001322038.1
NP_001308968.1, NM_001322039.1
NP_001308969.1, NM_001322040.1
NP_001308970.1, NM_001322041.1
NP_005787.1, NM_005796.2
UniGeneiHs.356630

Genome annotation databases

EnsembliENST00000219169; ENSP00000219169; ENSG00000102898
ENST00000568396; ENSP00000457022; ENSG00000102898
ENST00000569436; ENSP00000457989; ENSG00000102898
GeneIDi10204
KEGGihsa:10204
UCSCiuc002eup.4 human

Similar proteinsi

Entry informationi

Entry nameiNTF2_HUMAN
AccessioniPrimary (citable) accession number: P61970
Secondary accession number(s): B2R4G7, P13662, Q6IB67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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