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Protein

Nuclear transport factor 2

Gene

NUTF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.2 Publications

GO - Molecular functioni

  • protein transmembrane transporter activity Source: UniProtKB
  • Ran GTPase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102898-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transport factor 21 Publication
Short name:
NTF-2
Alternative name(s):
Placental protein 151 Publication
Short name:
PP151 Publication
Gene namesi
Name:NUTF2Imported
Synonyms:NTF21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13722. NUTF2.

Subcellular locationi

  • Cytoplasmcytosol 2 Publications
  • Nucleus outer membrane By similarity
  • Nucleusnuclear pore complex By similarity
  • Nucleus inner membrane By similarity
  • Nucleusnucleoplasm 1 Publication

  • Note: At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci.1 Publication

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nuclear inner membrane Source: UniProtKB-SubCell
  • nuclear membrane Source: UniProtKB
  • nuclear outer membrane Source: UniProtKB-SubCell
  • nuclear pore central transport channel Source: Ensembl
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nuclear pore complex, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi42E → K: No effect on localization to the nucleoplasm. 1 Publication1
Mutagenesisi124Missing : No effect on localization to the nucleoplasm. 1 Publication1

Organism-specific databases

DisGeNETi10204.
OpenTargetsiENSG00000102898.
PharmGKBiPA38365.

Polymorphism and mutation databases

BioMutaiNUTF2.
DMDMi48429030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001947751 – 127Nuclear transport factor 2Add BLAST127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61970.
MaxQBiP61970.
PaxDbiP61970.
PeptideAtlasiP61970.
PRIDEiP61970.
TopDownProteomicsiP61970.

2D gel databases

OGPiP61970.

PTM databases

iPTMnetiP61970.
PhosphoSitePlusiP61970.

Expressioni

Gene expression databases

BgeeiENSG00000102898.
CleanExiHS_NUTF2.
ExpressionAtlasiP61970. baseline and differential.
GenevisibleiP61970. HS.

Organism-specific databases

HPAiHPA040915.
HPA040956.

Interactioni

Subunit structurei

Homodimer (PubMed:7744965). Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import (PubMed:10679025). Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import (PubMed:7744965). Interacts with CAPG; mediates its nuclear import (PubMed:18266911).3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371985EBI-591778,EBI-347978
RANP628264EBI-591778,EBI-286642

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115499. 34 interactors.
DIPiDIP-6057N.
IntActiP61970. 9 interactors.
MINTiMINT-5004387.
STRINGi9606.ENSP00000219169.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 24Combined sources19
Helixi26 – 32Combined sources7
Beta strandi33 – 41Combined sources9
Beta strandi44 – 48Combined sources5
Helixi49 – 57Combined sources9
Beta strandi62 – 75Combined sources14
Beta strandi81 – 94Combined sources14
Beta strandi97 – 108Combined sources12
Beta strandi111 – 124Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GY5X-ray2.30A/B1-127[»]
ProteinModelPortaliP61970.
SMRiP61970.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61970.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 121NTF2PROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Contains 1 NTF2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61970.
OMAiLSLHDCD.
OrthoDBiEOG091G0SZN.
PhylomeDBiP61970.
TreeFamiTF314422.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA
60 70 80 90 100
AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH
110 120
QMFLLKNIND AWVCTNDMFR LALHNFG
Length:127
Mass (Da):14,478
Last modified:June 7, 2004 - v1
Checksum:i817752F20E262FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07315 mRNA. Translation: CAA30278.1.
U43939 mRNA. Translation: AAA85905.1.
CR456937 mRNA. Translation: CAG33218.1.
AK311822 mRNA. Translation: BAG34764.1.
CH471092 Genomic DNA. Translation: EAW83181.1.
BC002348 mRNA. Translation: AAH02348.1.
CCDSiCCDS10848.1.
PIRiS00751.
RefSeqiNP_001308967.1. NM_001322038.1.
NP_001308968.1. NM_001322039.1.
NP_001308969.1. NM_001322040.1.
NP_001308970.1. NM_001322041.1.
NP_005787.1. NM_005796.2.
UniGeneiHs.356630.

Genome annotation databases

EnsembliENST00000219169; ENSP00000219169; ENSG00000102898.
ENST00000568396; ENSP00000457022; ENSG00000102898.
ENST00000569436; ENSP00000457989; ENSG00000102898.
GeneIDi10204.
KEGGihsa:10204.
UCSCiuc002eup.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07315 mRNA. Translation: CAA30278.1.
U43939 mRNA. Translation: AAA85905.1.
CR456937 mRNA. Translation: CAG33218.1.
AK311822 mRNA. Translation: BAG34764.1.
CH471092 Genomic DNA. Translation: EAW83181.1.
BC002348 mRNA. Translation: AAH02348.1.
CCDSiCCDS10848.1.
PIRiS00751.
RefSeqiNP_001308967.1. NM_001322038.1.
NP_001308968.1. NM_001322039.1.
NP_001308969.1. NM_001322040.1.
NP_001308970.1. NM_001322041.1.
NP_005787.1. NM_005796.2.
UniGeneiHs.356630.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1GY5X-ray2.30A/B1-127[»]
ProteinModelPortaliP61970.
SMRiP61970.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115499. 34 interactors.
DIPiDIP-6057N.
IntActiP61970. 9 interactors.
MINTiMINT-5004387.
STRINGi9606.ENSP00000219169.

PTM databases

iPTMnetiP61970.
PhosphoSitePlusiP61970.

Polymorphism and mutation databases

BioMutaiNUTF2.
DMDMi48429030.

2D gel databases

OGPiP61970.

Proteomic databases

EPDiP61970.
MaxQBiP61970.
PaxDbiP61970.
PeptideAtlasiP61970.
PRIDEiP61970.
TopDownProteomicsiP61970.

Protocols and materials databases

DNASUi10204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219169; ENSP00000219169; ENSG00000102898.
ENST00000568396; ENSP00000457022; ENSG00000102898.
ENST00000569436; ENSP00000457989; ENSG00000102898.
GeneIDi10204.
KEGGihsa:10204.
UCSCiuc002eup.4. human.

Organism-specific databases

CTDi10204.
DisGeNETi10204.
GeneCardsiNUTF2.
HGNCiHGNC:13722. NUTF2.
HPAiHPA040915.
HPA040956.
MIMi605813. gene.
neXtProtiNX_P61970.
OpenTargetsiENSG00000102898.
PharmGKBiPA38365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61970.
OMAiLSLHDCD.
OrthoDBiEOG091G0SZN.
PhylomeDBiP61970.
TreeFamiTF314422.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000102898-MONOMER.

Miscellaneous databases

ChiTaRSiNUTF2. human.
EvolutionaryTraceiP61970.
GeneWikiiNUTF2.
GenomeRNAii10204.
PROiP61970.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102898.
CleanExiHS_NUTF2.
ExpressionAtlasiP61970. baseline and differential.
GenevisibleiP61970. HS.

Family and domain databases

CDDicd00780. NTF2. 1 hit.
Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTF2_HUMAN
AccessioniPrimary (citable) accession number: P61970
Secondary accession number(s): B2R4G7, P13662, Q6IB67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.