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Protein

Nuclear transport factor 2

Gene

NUTF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates protein transport into the nucleus. Interacts with the nucleoporin p62 and with Ran. Acts at a relatively late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB
  • transporter activity Source: ProtInc

GO - Biological processi

  • negative regulation of vascular endothelial growth factor production Source: Ensembl
  • positive regulation of protein import into nucleus Source: Ensembl
  • protein export from nucleus Source: BHF-UCL
  • protein import into nucleus, translocation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transport factor 2
Short name:
NTF-2
Alternative name(s):
Placental protein 15
Short name:
PP15
Gene namesi
Name:NUTF2
Synonyms:NTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:13722. NUTF2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: ProtInc
  • extracellular exosome Source: UniProtKB
  • nuclear outer membrane Source: Ensembl
  • nuclear pore Source: ProtInc
  • nuclear pore central transport channel Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38365.

Polymorphism and mutation databases

BioMutaiNUTF2.
DMDMi48429030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Nuclear transport factor 2PRO_0000194775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41N6-acetyllysineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP61970.
MaxQBiP61970.
PaxDbiP61970.
PeptideAtlasiP61970.
PRIDEiP61970.
TopDownProteomicsiP61970.

2D gel databases

OGPiP61970.

PTM databases

iPTMnetiP61970.
PhosphoSiteiP61970.

Expressioni

Gene expression databases

BgeeiP61970.
CleanExiHS_NUTF2.
ExpressionAtlasiP61970. baseline and differential.
GenevisibleiP61970. HS.

Organism-specific databases

HPAiHPA040915.
HPA040956.

Interactioni

Subunit structurei

Homodimer (PubMed:7744965). Interacts with NUP58.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371983EBI-591778,EBI-347978
RANP628264EBI-591778,EBI-286642

GO - Molecular functioni

  • Ran GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115499. 34 interactions.
DIPiDIP-6057N.
IntActiP61970. 6 interactions.
MINTiMINT-5004387.
STRINGi9606.ENSP00000219169.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2419Combined sources
Helixi26 – 327Combined sources
Beta strandi33 – 419Combined sources
Beta strandi44 – 485Combined sources
Helixi49 – 579Combined sources
Beta strandi62 – 7514Combined sources
Beta strandi81 – 9414Combined sources
Beta strandi97 – 10812Combined sources
Beta strandi111 – 12414Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GY5X-ray2.30A/B1-127[»]
ProteinModelPortaliP61970.
SMRiP61970. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61970.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 121112NTF2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 NTF2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61970.
OMAiFYYQQFD.
OrthoDBiEOG7TQV2N.
PhylomeDBiP61970.
TreeFamiTF314422.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61970-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPIWEQI GSSFIQHYYQ LFDNDRTQLG AIYIDASCLT WEGQQFQGKA
60 70 80 90 100
AIVEKLSSLP FQKIQHSITA QDHQPTPDSC IISMVVGQLK ADEDPIMGFH
110 120
QMFLLKNIND AWVCTNDMFR LALHNFG
Length:127
Mass (Da):14,478
Last modified:June 7, 2004 - v1
Checksum:i817752F20E262FD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07315 mRNA. Translation: CAA30278.1.
U43939 mRNA. Translation: AAA85905.1.
CR456937 mRNA. Translation: CAG33218.1.
AK311822 mRNA. Translation: BAG34764.1.
CH471092 Genomic DNA. Translation: EAW83181.1.
BC002348 mRNA. Translation: AAH02348.1.
CCDSiCCDS10848.1.
PIRiS00751.
RefSeqiNP_005787.1. NM_005796.1.
XP_005255828.1. XM_005255771.1.
UniGeneiHs.356630.

Genome annotation databases

EnsembliENST00000219169; ENSP00000219169; ENSG00000102898.
ENST00000568396; ENSP00000457022; ENSG00000102898.
ENST00000569436; ENSP00000457989; ENSG00000102898.
GeneIDi10204.
KEGGihsa:10204.
UCSCiuc002eup.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07315 mRNA. Translation: CAA30278.1.
U43939 mRNA. Translation: AAA85905.1.
CR456937 mRNA. Translation: CAG33218.1.
AK311822 mRNA. Translation: BAG34764.1.
CH471092 Genomic DNA. Translation: EAW83181.1.
BC002348 mRNA. Translation: AAH02348.1.
CCDSiCCDS10848.1.
PIRiS00751.
RefSeqiNP_005787.1. NM_005796.1.
XP_005255828.1. XM_005255771.1.
UniGeneiHs.356630.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GY5X-ray2.30A/B1-127[»]
ProteinModelPortaliP61970.
SMRiP61970. Positions 3-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115499. 34 interactions.
DIPiDIP-6057N.
IntActiP61970. 6 interactions.
MINTiMINT-5004387.
STRINGi9606.ENSP00000219169.

PTM databases

iPTMnetiP61970.
PhosphoSiteiP61970.

Polymorphism and mutation databases

BioMutaiNUTF2.
DMDMi48429030.

2D gel databases

OGPiP61970.

Proteomic databases

EPDiP61970.
MaxQBiP61970.
PaxDbiP61970.
PeptideAtlasiP61970.
PRIDEiP61970.
TopDownProteomicsiP61970.

Protocols and materials databases

DNASUi10204.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219169; ENSP00000219169; ENSG00000102898.
ENST00000568396; ENSP00000457022; ENSG00000102898.
ENST00000569436; ENSP00000457989; ENSG00000102898.
GeneIDi10204.
KEGGihsa:10204.
UCSCiuc002eup.4. human.

Organism-specific databases

CTDi10204.
GeneCardsiNUTF2.
HGNCiHGNC:13722. NUTF2.
HPAiHPA040915.
HPA040956.
MIMi605813. gene.
neXtProtiNX_P61970.
PharmGKBiPA38365.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2104. Eukaryota.
ENOG4111QUX. LUCA.
GeneTreeiENSGT00510000047030.
HOGENOMiHOG000197024.
HOVERGENiHBG025070.
InParanoidiP61970.
OMAiFYYQQFD.
OrthoDBiEOG7TQV2N.
PhylomeDBiP61970.
TreeFamiTF314422.

Miscellaneous databases

ChiTaRSiNUTF2. human.
EvolutionaryTraceiP61970.
GeneWikiiNUTF2.
GenomeRNAii10204.
NextBioi38624.
PROiP61970.
SOURCEiSearch...

Gene expression databases

BgeeiP61970.
CleanExiHS_NUTF2.
ExpressionAtlasiP61970. baseline and differential.
GenevisibleiP61970. HS.

Family and domain databases

Gene3Di3.10.450.50. 1 hit.
InterProiIPR002075. NTF2.
IPR032710. NTF2-like_dom.
IPR018222. Nuclear_transport_factor_2_euk.
[Graphical view]
PfamiPF02136. NTF2. 1 hit.
[Graphical view]
SUPFAMiSSF54427. SSF54427. 1 hit.
PROSITEiPS50177. NTF2_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA coding for the placental protein 15 (PP15)."
    Grundmann U., Nerlich C., Rein T., Lottspeich F., Kuepper H.A.
    Nucleic Acids Res. 16:4721-4721(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62."
    Paschal B.M., Gerace L.
    J. Cell Biol. 129:925-937(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, CHARACTERIZATION, SUBUNIT.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNTF2_HUMAN
AccessioniPrimary (citable) accession number: P61970
Secondary accession number(s): B2R4G7, P13662, Q6IB67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 11, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.