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Protein

LIM domain transcription factor LMO4

Gene

Lmo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional factor.

GO - Molecular functioni

  • enhancer sequence-specific DNA binding Source: MGI
  • transcription factor binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • negative regulation of protein complex assembly Source: MGI
  • neural tube closure Source: UniProtKB
  • positive regulation of kinase activity Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell activation Source: MGI
  • regulation of cell fate specification Source: MGI
  • regulation of cell migration Source: UniProtKB
  • spinal cord association neuron differentiation Source: MGI
  • spinal cord motor neuron differentiation Source: MGI
  • thymus development Source: MGI
  • transcription from RNA polymerase II promoter Source: MGI
  • ventral spinal cord interneuron differentiation Source: MGI
  • ventricular septum development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain transcription factor LMO4
Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name:
LMO-4
Gene namesi
Name:Lmo4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:109360. Lmo4.

Subcellular locationi

GO - Cellular componenti

  • cell leading edge Source: UniProtKB
  • transcription factor complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758211 – 165LIM domain transcription factor LMO4Add BLAST165

Proteomic databases

PaxDbiP61969.
PeptideAtlasiP61969.
PRIDEiP61969.

PTM databases

iPTMnetiP61969.
PhosphoSitePlusiP61969.

Expressioni

Tissue specificityi

Expressed in a wide variety of tissues.

Gene expression databases

BgeeiENSMUSG00000028266.
CleanExiMM_LMO4.
ExpressionAtlasiP61969. baseline and differential.
GenevisibleiP61969. MM.

Interactioni

Subunit structurei

Interacts strongly with LDBS. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity. Interacts with DEAF1; LMO4 blocks export from nucleus.5 Publications

GO - Molecular functioni

  • transcription factor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi201180. 4 interactors.
STRINGi10090.ENSMUSP00000113513.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni24 – 26Combined sources3
Beta strandi33 – 38Combined sources6
Beta strandi41 – 43Combined sources3
Helixi45 – 47Combined sources3
Turni51 – 53Combined sources3
Helixi57 – 60Combined sources4
Beta strandi62 – 67Combined sources6
Beta strandi70 – 72Combined sources3
Helixi74 – 81Combined sources8
Turni88 – 90Combined sources3
Beta strandi98 – 103Combined sources6
Beta strandi106 – 109Combined sources4
Helixi110 – 112Combined sources3
Turni116 – 118Combined sources3
Beta strandi127 – 131Combined sources5
Beta strandi134 – 137Combined sources4
Helixi138 – 140Combined sources3
Turni143 – 145Combined sources3
Beta strandi158 – 160Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M3VNMR-A16-86[»]
1RUTX-ray1.30X16-152[»]
2DFYX-ray1.65C/X18-161[»]
2MBVNMR-A77-147[»]
ProteinModelPortaliP61969.
SMRiP61969.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61969.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini87 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP61969.
OMAiTIPANDY.
OrthoDBiEOG091G0LKW.
PhylomeDBiP61969.
TreeFamiTF351071.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC
60 70 80 90 100
SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV
110 120 130 140 150
MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL
160
NSLQSNPLLP DQKVC
Length:165
Mass (Da):17,994
Last modified:June 7, 2004 - v1
Checksum:iC8AC295144AD7787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074600 mRNA. Translation: AAC62958.1.
AF102817 mRNA. Translation: AAC98510.1.
AF096996 mRNA. Translation: AAC83789.1.
BC003488 mRNA. Translation: AAH03488.1.
BC004661 mRNA. No translation available.
BC010278 mRNA. Translation: AAH10278.3.
CCDSiCCDS51085.1.
RefSeqiNP_001155241.1. NM_001161769.1.
NP_001155242.1. NM_001161770.1.
NP_034853.1. NM_010723.3.
UniGeneiMm.29187.

Genome annotation databases

EnsembliENSMUST00000120539; ENSMUSP00000113840; ENSMUSG00000028266.
ENSMUST00000121112; ENSMUSP00000113865; ENSMUSG00000028266.
ENSMUST00000121796; ENSMUSP00000113513; ENSMUSG00000028266.
GeneIDi16911.
KEGGimmu:16911.
UCSCiuc008rpl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074600 mRNA. Translation: AAC62958.1.
AF102817 mRNA. Translation: AAC98510.1.
AF096996 mRNA. Translation: AAC83789.1.
BC003488 mRNA. Translation: AAH03488.1.
BC004661 mRNA. No translation available.
BC010278 mRNA. Translation: AAH10278.3.
CCDSiCCDS51085.1.
RefSeqiNP_001155241.1. NM_001161769.1.
NP_001155242.1. NM_001161770.1.
NP_034853.1. NM_010723.3.
UniGeneiMm.29187.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M3VNMR-A16-86[»]
1RUTX-ray1.30X16-152[»]
2DFYX-ray1.65C/X18-161[»]
2MBVNMR-A77-147[»]
ProteinModelPortaliP61969.
SMRiP61969.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201180. 4 interactors.
STRINGi10090.ENSMUSP00000113513.

PTM databases

iPTMnetiP61969.
PhosphoSitePlusiP61969.

Proteomic databases

PaxDbiP61969.
PeptideAtlasiP61969.
PRIDEiP61969.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000120539; ENSMUSP00000113840; ENSMUSG00000028266.
ENSMUST00000121112; ENSMUSP00000113865; ENSMUSG00000028266.
ENSMUST00000121796; ENSMUSP00000113513; ENSMUSG00000028266.
GeneIDi16911.
KEGGimmu:16911.
UCSCiuc008rpl.2. mouse.

Organism-specific databases

CTDi8543.
MGIiMGI:109360. Lmo4.

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP61969.
OMAiTIPANDY.
OrthoDBiEOG091G0LKW.
PhylomeDBiP61969.
TreeFamiTF351071.

Miscellaneous databases

ChiTaRSiLmo4. mouse.
EvolutionaryTraceiP61969.
PROiP61969.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028266.
CleanExiMM_LMO4.
ExpressionAtlasiP61969. baseline and differential.
GenevisibleiP61969. MM.

Family and domain databases

Gene3Di2.10.110.10. 2 hits.
InterProiIPR001781. Znf_LIM.
[Graphical view]
PfamiPF00412. LIM. 2 hits.
[Graphical view]
SMARTiSM00132. LIM. 2 hits.
[Graphical view]
PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLMO4_MOUSE
AccessioniPrimary (citable) accession number: P61969
Secondary accession number(s): O00158, O88894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.