ID LMO4_HUMAN Reviewed; 165 AA. AC P61968; D3DT23; O00158; O88894; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 07-JUN-2004, sequence version 1. DT 24-JAN-2024, entry version 162. DE RecName: Full=LIM domain transcription factor LMO4; DE AltName: Full=Breast tumor autoantigen; DE AltName: Full=LIM domain only protein 4; DE Short=LMO-4; GN Name=LMO4; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Mammary tumor; RX PubMed=10209267; DOI=10.1016/s0167-4781(99)00037-8; RA Racevskis J., Dill A., Sparano J.A., Ruan H.; RT "Molecular cloning of LMO4, a new human LIM domain gene."; RL Biochim. Biophys. Acta 1445:148-153(1999). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye, Lung, and PNS; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP INTERACTION WITH RPPB8. RX PubMed=23353824; DOI=10.1016/j.jmb.2013.01.017; RA Stokes P.H., Liew C.W., Kwan A.H., Foo P., Barker H.E., Djamirze A., RA O'Reilly V., Visvader J.E., Mackay J.P., Matthews J.M.; RT "Structural basis of the interaction of the breast cancer oncogene LMO4 RT with the tumour suppressor CtIP/RBBP8."; RL J. Mol. Biol. 425:1101-1110(2013). CC -!- FUNCTION: Transcription cofactor. Plays a role in establishing motor CC neuron identity, in concert with MNX1, acting, at least in part, to CC disrupt LDB1-LHX3 complexes thereby negatively modulating interneuron CC genes in motor neurons. {ECO:0000250|UniProtKB:P61969}. CC -!- SUBUNIT: Interacts strongly with LDBS. Interacts with LDB2 and LDB1. CC Interaction with complexes consisting of at least LDB1 and LHX3, acts CC to disassemble the complex; may preferentially disassemble LDB1-LHX3 CC complexes rather than complexes consisting of LDB1, LHX3 and ISL1. CC Interacts (via the LIM zinc-binding domain 1) with RBBP8 CC (PubMed:23353824). Interacts with both RPPB8 and LDB1 through the same CC face and cannot bind to both proteins simultaneously (By similarity). CC Interacts with BRCA1 (via the BRCT domains); the interaction represses CC BRCA1 transcriptional activity. Interacts with DEAF1; LMO4 blocks CC export from nucleus. {ECO:0000250|UniProtKB:P61969, CC ECO:0000269|PubMed:23353824}. CC -!- INTERACTION: CC P61968; Q4LEZ3: AARD; NbExp=3; IntAct=EBI-2798728, EBI-5463075; CC P61968; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-2798728, EBI-11096309; CC P61968; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-2798728, EBI-10173507; CC P61968; Q4VCS5-2: AMOT; NbExp=3; IntAct=EBI-2798728, EBI-3891843; CC P61968; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-2798728, EBI-10187270; CC P61968; Q9HBZ2: ARNT2; NbExp=3; IntAct=EBI-2798728, EBI-765971; CC P61968; Q8N9N5: BANP; NbExp=3; IntAct=EBI-2798728, EBI-744695; CC P61968; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-2798728, EBI-11524452; CC P61968; Q9BXC9: BBS2; NbExp=3; IntAct=EBI-2798728, EBI-748297; CC P61968; O75934: BCAS2; NbExp=3; IntAct=EBI-2798728, EBI-1050106; CC P61968; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-2798728, EBI-517623; CC P61968; Q86WS4: C12orf40; NbExp=3; IntAct=EBI-2798728, EBI-10286004; CC P61968; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-2798728, EBI-739580; CC P61968; Q68D86: CCDC102B; NbExp=6; IntAct=EBI-2798728, EBI-10171570; CC P61968; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-2798728, EBI-744556; CC P61968; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-2798728, EBI-743488; CC P61968; Q9Y2V7: COG6; NbExp=3; IntAct=EBI-2798728, EBI-3866319; CC P61968; Q9UBG3: CRNN; NbExp=3; IntAct=EBI-2798728, EBI-3197866; CC P61968; P43320: CRYBB2; NbExp=3; IntAct=EBI-2798728, EBI-974082; CC P61968; P56545-3: CTBP2; NbExp=3; IntAct=EBI-2798728, EBI-10171902; CC P61968; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-2798728, EBI-3867333; CC P61968; P17661: DES; NbExp=3; IntAct=EBI-2798728, EBI-1055572; CC P61968; Q16610: ECM1; NbExp=3; IntAct=EBI-2798728, EBI-947964; CC P61968; Q2NKX8: ERCC6L; NbExp=3; IntAct=EBI-2798728, EBI-1042535; CC P61968; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-2798728, EBI-371922; CC P61968; Q86W67: FAM228A; NbExp=3; IntAct=EBI-2798728, EBI-12958227; CC P61968; Q13643: FHL3; NbExp=3; IntAct=EBI-2798728, EBI-741101; CC P61968; Q06547: GABPB1; NbExp=6; IntAct=EBI-2798728, EBI-618165; CC P61968; Q08379: GOLGA2; NbExp=6; IntAct=EBI-2798728, EBI-618309; CC P61968; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-2798728, EBI-5916454; CC P61968; Q6ISB3: GRHL2; NbExp=7; IntAct=EBI-2798728, EBI-10219092; CC P61968; A0A087WSW0: HELT; NbExp=3; IntAct=EBI-2798728, EBI-12057631; CC P61968; O14964: HGS; NbExp=3; IntAct=EBI-2798728, EBI-740220; CC P61968; O75031: HSF2BP; NbExp=3; IntAct=EBI-2798728, EBI-7116203; CC P61968; Q02535: ID3; NbExp=3; IntAct=EBI-2798728, EBI-1387094; CC P61968; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-2798728, EBI-11522367; CC P61968; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-2798728, EBI-747204; CC P61968; Q15811: ITSN1; NbExp=3; IntAct=EBI-2798728, EBI-602041; CC P61968; Q63ZY3: KANK2; NbExp=6; IntAct=EBI-2798728, EBI-2556193; CC P61968; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-2798728, EBI-715394; CC P61968; Q8N8K9: KIAA1958; NbExp=6; IntAct=EBI-2798728, EBI-10181113; CC P61968; P19012: KRT15; NbExp=6; IntAct=EBI-2798728, EBI-739566; CC P61968; Q15323: KRT31; NbExp=6; IntAct=EBI-2798728, EBI-948001; CC P61968; Q14525: KRT33B; NbExp=3; IntAct=EBI-2798728, EBI-1049638; CC P61968; O76011: KRT34; NbExp=5; IntAct=EBI-2798728, EBI-1047093; CC P61968; O76015: KRT38; NbExp=3; IntAct=EBI-2798728, EBI-1047263; CC P61968; Q6A163: KRT39; NbExp=3; IntAct=EBI-2798728, EBI-11958242; CC P61968; Q6A162: KRT40; NbExp=3; IntAct=EBI-2798728, EBI-10171697; CC P61968; Q7RTS7: KRT74; NbExp=3; IntAct=EBI-2798728, EBI-968660; CC P61968; O95678: KRT75; NbExp=3; IntAct=EBI-2798728, EBI-2949715; CC P61968; Q01546: KRT76; NbExp=3; IntAct=EBI-2798728, EBI-2952745; CC P61968; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-2798728, EBI-1052037; CC P61968; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-2798728, EBI-9996449; CC P61968; Q16719-2: KYNU; NbExp=3; IntAct=EBI-2798728, EBI-12351611; CC P61968; Q96JM7-2: L3MBTL3; NbExp=3; IntAct=EBI-2798728, EBI-11985629; CC P61968; Q14847-2: LASP1; NbExp=3; IntAct=EBI-2798728, EBI-9088686; CC P61968; Q86U70: LDB1; NbExp=6; IntAct=EBI-2798728, EBI-677177; CC P61968; Q86U70-2: LDB1; NbExp=8; IntAct=EBI-2798728, EBI-11979761; CC P61968; O43679: LDB2; NbExp=6; IntAct=EBI-2798728, EBI-2865580; CC P61968; P25791-3: LMO2; NbExp=3; IntAct=EBI-2798728, EBI-11959475; CC P61968; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-2798728, EBI-1216080; CC P61968; P59942: MCCD1; NbExp=3; IntAct=EBI-2798728, EBI-11987923; CC P61968; Q8N6F8: METTL27; NbExp=3; IntAct=EBI-2798728, EBI-8487781; CC P61968; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-2798728, EBI-10172526; CC P61968; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-2798728, EBI-11522433; CC P61968; P15172: MYOD1; NbExp=3; IntAct=EBI-2798728, EBI-488878; CC P61968; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-2798728, EBI-5662487; CC P61968; O15049: N4BP3; NbExp=3; IntAct=EBI-2798728, EBI-2512055; CC P61968; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-2798728, EBI-10271199; CC P61968; Q13952-2: NFYC; NbExp=3; IntAct=EBI-2798728, EBI-11956831; CC P61968; O00746: NME4; NbExp=3; IntAct=EBI-2798728, EBI-744871; CC P61968; Q15233-2: NONO; NbExp=3; IntAct=EBI-2798728, EBI-10203843; CC P61968; Q16656-4: NRF1; NbExp=3; IntAct=EBI-2798728, EBI-11742836; CC P61968; Q5VU43: PDE4DIP; NbExp=4; IntAct=EBI-2798728, EBI-1105124; CC P61968; Q9BRX2: PELO; NbExp=3; IntAct=EBI-2798728, EBI-1043580; CC P61968; O15055: PER2; NbExp=3; IntAct=EBI-2798728, EBI-1054296; CC P61968; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-2798728, EBI-2798044; CC P61968; Q9NYW8: RBAK; NbExp=3; IntAct=EBI-2798728, EBI-1210429; CC P61968; Q99708-2: RBBP8; NbExp=3; IntAct=EBI-2798728, EBI-10203615; CC P61968; Q93062: RBPMS; NbExp=3; IntAct=EBI-2798728, EBI-740322; CC P61968; Q15293: RCN1; NbExp=3; IntAct=EBI-2798728, EBI-948278; CC P61968; O76064: RNF8; NbExp=3; IntAct=EBI-2798728, EBI-373337; CC P61968; Q9HAT0: ROPN1; NbExp=3; IntAct=EBI-2798728, EBI-1378139; CC P61968; Q9H0K4: RSPH6A; NbExp=3; IntAct=EBI-2798728, EBI-12169267; CC P61968; Q7Z5V6-2: SAXO4; NbExp=3; IntAct=EBI-2798728, EBI-12000762; CC P61968; Q16348: SLC15A2; NbExp=3; IntAct=EBI-2798728, EBI-12806032; CC P61968; Q13485: SMAD4; NbExp=8; IntAct=EBI-2798728, EBI-347263; CC P61968; P51692: STAT5B; NbExp=3; IntAct=EBI-2798728, EBI-1186119; CC P61968; P51687: SUOX; NbExp=3; IntAct=EBI-2798728, EBI-3921347; CC P61968; P15884: TCF4; NbExp=3; IntAct=EBI-2798728, EBI-533224; CC P61968; P15884-3: TCF4; NbExp=3; IntAct=EBI-2798728, EBI-13636688; CC P61968; Q8IWB6: TEX14; NbExp=3; IntAct=EBI-2798728, EBI-6674697; CC P61968; Q9UBB9: TFIP11; NbExp=6; IntAct=EBI-2798728, EBI-1105213; CC P61968; Q08117: TLE5; NbExp=3; IntAct=EBI-2798728, EBI-717810; CC P61968; Q08117-2: TLE5; NbExp=3; IntAct=EBI-2798728, EBI-11741437; CC P61968; Q13625-3: TP53BP2; NbExp=3; IntAct=EBI-2798728, EBI-10175039; CC P61968; O00463: TRAF5; NbExp=3; IntAct=EBI-2798728, EBI-523498; CC P61968; P14373: TRIM27; NbExp=3; IntAct=EBI-2798728, EBI-719493; CC P61968; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-2798728, EBI-2130429; CC P61968; Q6ZT98-3: TTLL7; NbExp=3; IntAct=EBI-2798728, EBI-13339851; CC P61968; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-2798728, EBI-947187; CC P61968; Q2NL98: VMAC; NbExp=3; IntAct=EBI-2798728, EBI-2803134; CC P61968; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-2798728, EBI-2799833; CC P61968; O43298: ZBTB43; NbExp=3; IntAct=EBI-2798728, EBI-740718; CC P61968; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-2798728, EBI-12030590; CC P61968; P52742: ZNF135; NbExp=3; IntAct=EBI-2798728, EBI-7101455; CC P61968; O95125: ZNF202; NbExp=4; IntAct=EBI-2798728, EBI-751960; CC P61968; O14771: ZNF213; NbExp=3; IntAct=EBI-2798728, EBI-12838388; CC P61968; Q8NF99: ZNF397; NbExp=3; IntAct=EBI-2798728, EBI-10213894; CC P61968; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-2798728, EBI-11741890; CC P61968; Q7Z7K2: ZNF467; NbExp=3; IntAct=EBI-2798728, EBI-11986485; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U24576; AAB51073.1; -; mRNA. DR EMBL; CH471097; EAW73168.1; -; Genomic_DNA. DR EMBL; CH471097; EAW73169.1; -; Genomic_DNA. DR EMBL; BC003600; AAH03600.1; -; mRNA. DR EMBL; BC017673; AAH17673.1; -; mRNA. DR EMBL; BC065818; AAH65818.1; -; mRNA. DR CCDS; CCDS713.1; -. DR RefSeq; NP_006760.1; NM_006769.3. DR RefSeq; XP_005271348.1; XM_005271291.3. DR AlphaFoldDB; P61968; -. DR BMRB; P61968; -. DR SMR; P61968; -. DR BioGRID; 114113; 148. DR CORUM; P61968; -. DR DIP; DIP-41414N; -. DR IntAct; P61968; 136. DR MINT; P61968; -. DR STRING; 9606.ENSP00000359575; -. DR iPTMnet; P61968; -. DR PhosphoSitePlus; P61968; -. DR BioMuta; LMO4; -. DR EPD; P61968; -. DR jPOST; P61968; -. DR MassIVE; P61968; -. DR MaxQB; P61968; -. DR PaxDb; 9606-ENSP00000359575; -. DR PeptideAtlas; P61968; -. DR ProteomicsDB; 57350; -. DR Pumba; P61968; -. DR Antibodypedia; 33592; 331 antibodies from 34 providers. DR DNASU; 8543; -. DR Ensembl; ENST00000370542.1; ENSP00000359573.1; ENSG00000143013.13. DR Ensembl; ENST00000370544.10; ENSP00000359575.4; ENSG00000143013.13. DR GeneID; 8543; -. DR KEGG; hsa:8543; -. DR MANE-Select; ENST00000370544.10; ENSP00000359575.4; NM_006769.4; NP_006760.1. DR UCSC; uc001dmi.4; human. DR AGR; HGNC:6644; -. DR CTD; 8543; -. DR DisGeNET; 8543; -. DR GeneCards; LMO4; -. DR HGNC; HGNC:6644; LMO4. DR HPA; ENSG00000143013; Tissue enhanced (brain). DR MIM; 603129; gene. DR neXtProt; NX_P61968; -. DR OpenTargets; ENSG00000143013; -. DR PharmGKB; PA30410; -. DR VEuPathDB; HostDB:ENSG00000143013; -. DR eggNOG; KOG0490; Eukaryota. DR GeneTree; ENSGT00940000157730; -. DR HOGENOM; CLU_001357_7_1_1; -. DR InParanoid; P61968; -. DR OMA; WINGITP; -. DR OrthoDB; 2875464at2759; -. DR PhylomeDB; P61968; -. DR TreeFam; TF351071; -. DR PathwayCommons; P61968; -. DR SignaLink; P61968; -. DR BioGRID-ORCS; 8543; 27 hits in 1163 CRISPR screens. DR ChiTaRS; LMO4; human. DR EvolutionaryTrace; P61968; -. DR GeneWiki; LMO4; -. DR GenomeRNAi; 8543; -. DR Pharos; P61968; Tbio. DR PRO; PR:P61968; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; P61968; Protein. DR Bgee; ENSG00000143013; Expressed in dorsolateral prefrontal cortex and 213 other cell types or tissues. DR GO; GO:0031252; C:cell leading edge; ISS:UniProtKB. DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl. DR GO; GO:0005667; C:transcription regulator complex; ISS:UniProtKB. DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISS:UniProtKB. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl. DR GO; GO:0008045; P:motor neuron axon guidance; IEA:Ensembl. DR GO; GO:0031333; P:negative regulation of protein-containing complex assembly; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0001843; P:neural tube closure; ISS:UniProtKB. DR GO; GO:0033674; P:positive regulation of kinase activity; ISS:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0050865; P:regulation of cell activation; IEA:Ensembl. DR GO; GO:0042659; P:regulation of cell fate specification; IEA:Ensembl. DR GO; GO:0030334; P:regulation of cell migration; ISS:UniProtKB. DR GO; GO:0021527; P:spinal cord association neuron differentiation; IEA:Ensembl. DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Ensembl. DR GO; GO:0048538; P:thymus development; IEA:Ensembl. DR GO; GO:0021514; P:ventral spinal cord interneuron differentiation; IEA:Ensembl. DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl. DR CDD; cd09386; LIM1_LMO4; 1. DR CDD; cd09387; LIM2_LMO4; 1. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2. DR IDEAL; IID00310; -. DR InterPro; IPR001781; Znf_LIM. DR PANTHER; PTHR45787; LD11652P; 1. DR PANTHER; PTHR45787:SF5; LIM DOMAIN TRANSCRIPTION FACTOR LMO4; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 4. DR PROSITE; PS00478; LIM_DOMAIN_1; 2. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. DR Genevisible; P61968; HS. PE 1: Evidence at protein level; KW LIM domain; Metal-binding; Reference proteome; Repeat; Transcription; KW Transcription regulation; Zinc. FT CHAIN 1..165 FT /note="LIM domain transcription factor LMO4" FT /id="PRO_0000075820" FT DOMAIN 23..83 FT /note="LIM zinc-binding 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125" FT DOMAIN 87..147 FT /note="LIM zinc-binding 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125" SQ SEQUENCE 165 AA; 17994 MW; C8AC295144AD7787 CRC64; MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC //