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P61968

- LMO4_HUMAN

UniProt

P61968 - LMO4_HUMAN

Protein

LIM domain transcription factor LMO4

Gene

LMO4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Probable transcriptional factor.By similarity

    GO - Molecular functioni

    1. enhancer sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    3. transcription factor binding Source: UniProtKB
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of protein complex assembly Source: Ensembl
    2. neural tube closure Source: UniProtKB
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. regulation of cell activation Source: Ensembl
    5. regulation of cell fate specification Source: Ensembl
    6. spinal cord association neuron differentiation Source: Ensembl
    7. spinal cord motor neuron differentiation Source: Ensembl
    8. thymus development Source: Ensembl
    9. transcription from RNA polymerase II promoter Source: UniProtKB
    10. ventral spinal cord interneuron differentiation Source: Ensembl
    11. ventricular septum development Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LIM domain transcription factor LMO4
    Alternative name(s):
    Breast tumor autoantigen
    LIM domain only protein 4
    Short name:
    LMO-4
    Gene namesi
    Name:LMO4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6644. LMO4.

    Subcellular locationi

    GO - Cellular componenti

    1. transcription factor complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30410.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165LIM domain transcription factor LMO4PRO_0000075820Add
    BLAST

    Proteomic databases

    MaxQBiP61968.
    PaxDbiP61968.
    PRIDEiP61968.

    Expressioni

    Gene expression databases

    BgeeiP61968.
    CleanExiHS_LMO4.
    GenevestigatoriP61968.

    Organism-specific databases

    HPAiCAB022345.

    Interactioni

    Subunit structurei

    Interacts strongly with LDBS. Interacts with DEAF1; LMO4 blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity By similarity.By similarity

    Protein-protein interaction databases

    BioGridi114113. 27 interactions.
    IntActiP61968. 21 interactions.
    MINTiMINT-265427.
    STRINGi9606.ENSP00000359573.

    Structurei

    Secondary structure

    1
    165
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 299
    Beta strandi32 – 387
    Beta strandi41 – 444
    Turni45 – 473
    Turni51 – 533
    Helixi57 – 593
    Beta strandi67 – 693
    Helixi74 – 807

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L4ZNMR-A16-82[»]
    ProteinModelPortaliP61968.
    SMRiP61968. Positions 19-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61968.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 8361LIM zinc-binding 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini87 – 14761LIM zinc-binding 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 LIM zinc-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    LIM domain, Repeat

    Phylogenomic databases

    eggNOGiNOG314117.
    HOGENOMiHOG000232175.
    HOVERGENiHBG054231.
    InParanoidiP61968.
    OMAiDRYWHTG.
    OrthoDBiEOG75J0PF.
    PhylomeDBiP61968.
    TreeFamiTF351071.

    Family and domain databases

    Gene3Di2.10.110.10. 2 hits.
    InterProiIPR001781. Znf_LIM.
    [Graphical view]
    PfamiPF00412. LIM. 2 hits.
    [Graphical view]
    SMARTiSM00132. LIM. 2 hits.
    [Graphical view]
    PROSITEiPS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61968-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC    50
    SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV 100
    MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL 150
    NSLQSNPLLP DQKVC 165
    Length:165
    Mass (Da):17,994
    Last modified:June 7, 2004 - v1
    Checksum:iC8AC295144AD7787
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24576 mRNA. Translation: AAB51073.1.
    CH471097 Genomic DNA. Translation: EAW73168.1.
    CH471097 Genomic DNA. Translation: EAW73169.1.
    BC003600 mRNA. Translation: AAH03600.1.
    BC017673 mRNA. Translation: AAH17673.1.
    BC065818 mRNA. Translation: AAH65818.1.
    CCDSiCCDS713.1.
    RefSeqiNP_006760.1. NM_006769.3.
    XP_005271348.1. XM_005271291.1.
    UniGeneiHs.436792.

    Genome annotation databases

    EnsembliENST00000370542; ENSP00000359573; ENSG00000143013.
    ENST00000370544; ENSP00000359575; ENSG00000143013.
    GeneIDi8543.
    KEGGihsa:8543.
    UCSCiuc001dmi.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24576 mRNA. Translation: AAB51073.1 .
    CH471097 Genomic DNA. Translation: EAW73168.1 .
    CH471097 Genomic DNA. Translation: EAW73169.1 .
    BC003600 mRNA. Translation: AAH03600.1 .
    BC017673 mRNA. Translation: AAH17673.1 .
    BC065818 mRNA. Translation: AAH65818.1 .
    CCDSi CCDS713.1.
    RefSeqi NP_006760.1. NM_006769.3.
    XP_005271348.1. XM_005271291.1.
    UniGenei Hs.436792.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L4Z NMR - A 16-82 [» ]
    ProteinModelPortali P61968.
    SMRi P61968. Positions 19-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114113. 27 interactions.
    IntActi P61968. 21 interactions.
    MINTi MINT-265427.
    STRINGi 9606.ENSP00000359573.

    Proteomic databases

    MaxQBi P61968.
    PaxDbi P61968.
    PRIDEi P61968.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370542 ; ENSP00000359573 ; ENSG00000143013 .
    ENST00000370544 ; ENSP00000359575 ; ENSG00000143013 .
    GeneIDi 8543.
    KEGGi hsa:8543.
    UCSCi uc001dmi.3. human.

    Organism-specific databases

    CTDi 8543.
    GeneCardsi GC01P087794.
    HGNCi HGNC:6644. LMO4.
    HPAi CAB022345.
    MIMi 603129. gene.
    neXtProti NX_P61968.
    PharmGKBi PA30410.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG314117.
    HOGENOMi HOG000232175.
    HOVERGENi HBG054231.
    InParanoidi P61968.
    OMAi DRYWHTG.
    OrthoDBi EOG75J0PF.
    PhylomeDBi P61968.
    TreeFami TF351071.

    Miscellaneous databases

    ChiTaRSi LMO4. human.
    EvolutionaryTracei P61968.
    GeneWikii LMO4.
    GenomeRNAii 8543.
    NextBioi 32002.
    PROi P61968.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61968.
    CleanExi HS_LMO4.
    Genevestigatori P61968.

    Family and domain databases

    Gene3Di 2.10.110.10. 2 hits.
    InterProi IPR001781. Znf_LIM.
    [Graphical view ]
    Pfami PF00412. LIM. 2 hits.
    [Graphical view ]
    SMARTi SM00132. LIM. 2 hits.
    [Graphical view ]
    PROSITEi PS00478. LIM_DOMAIN_1. 2 hits.
    PS50023. LIM_DOMAIN_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of LMO4, a new human LIM domain gene."
      Racevskis J., Dill A., Sparano J.A., Ruan H.
      Biochim. Biophys. Acta 1445:148-153(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary tumor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye, Lung and PNS.

    Entry informationi

    Entry nameiLMO4_HUMAN
    AccessioniPrimary (citable) accession number: P61968
    Secondary accession number(s): D3DT23, O00158, O88894
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3