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Protein

LIM domain transcription factor LMO4

Gene

LMO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transcriptional factor.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
LIM domain transcription factor LMO4
Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name:
LMO-4
Gene namesi
Name:LMO4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143013.12.
HGNCiHGNC:6644. LMO4.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi8543.
OpenTargetsiENSG00000143013.
PharmGKBiPA30410.

Polymorphism and mutation databases

BioMutaiLMO4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000758201 – 165LIM domain transcription factor LMO4Add BLAST165

Proteomic databases

EPDiP61968.
MaxQBiP61968.
PaxDbiP61968.
PeptideAtlasiP61968.
PRIDEiP61968.

PTM databases

iPTMnetiP61968.
PhosphoSitePlusiP61968.

Expressioni

Gene expression databases

BgeeiENSG00000143013.
CleanExiHS_LMO4.
GenevisibleiP61968. HS.

Organism-specific databases

HPAiCAB022345.
HPA045877.
HPA061638.

Interactioni

Subunit structurei

Interacts strongly with LDBS. Interacts with DEAF1; LMO4 blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114113. 60 interactors.
CORUMiP61968.
DIPiDIP-41414N.
IntActiP61968. 120 interactors.
MINTiMINT-265427.
STRINGi9606.ENSP00000359573.

Structurei

Secondary structure

1165
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 29Combined sources9
Beta strandi32 – 38Combined sources7
Beta strandi41 – 44Combined sources4
Turni45 – 47Combined sources3
Turni51 – 53Combined sources3
Helixi57 – 59Combined sources3
Beta strandi67 – 69Combined sources3
Helixi74 – 80Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4ZNMR-A16-82[»]
ProteinModelPortaliP61968.
SMRiP61968.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61968.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 83LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST61
Domaini87 – 147LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00720000108603.
HOGENOMiHOG000232175.
HOVERGENiHBG054231.
InParanoidiP61968.
OMAiICENDYS.
OrthoDBiEOG091G0LKW.
PhylomeDBiP61968.
TreeFamiTF351071.

Family and domain databases

InterProiView protein in InterPro
IPR001781. Znf_LIM.
PfamiView protein in Pfam
PF00412. LIM. 2 hits.
SMARTiView protein in SMART
SM00132. LIM. 2 hits.
PROSITEiView protein in PROSITE
PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P61968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC
60 70 80 90 100
SCCQAQLGDI GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV
110 120 130 140 150
MRAQGNVYHL KCFTCSTCRN RLVPGDRFHY INGSLFCEHD RPTALINGHL
160
NSLQSNPLLP DQKVC
Length:165
Mass (Da):17,994
Last modified:June 7, 2004 - v1
Checksum:iC8AC295144AD7787
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24576 mRNA. Translation: AAB51073.1.
CH471097 Genomic DNA. Translation: EAW73168.1.
CH471097 Genomic DNA. Translation: EAW73169.1.
BC003600 mRNA. Translation: AAH03600.1.
BC017673 mRNA. Translation: AAH17673.1.
BC065818 mRNA. Translation: AAH65818.1.
CCDSiCCDS713.1.
RefSeqiNP_006760.1. NM_006769.3.
XP_005271348.1. XM_005271291.3.
UniGeneiHs.436792.

Genome annotation databases

EnsembliENST00000370542; ENSP00000359573; ENSG00000143013.
ENST00000370544; ENSP00000359575; ENSG00000143013.
GeneIDi8543.
KEGGihsa:8543.
UCSCiuc001dmi.4. human.

Similar proteinsi

Entry informationi

Entry nameiLMO4_HUMAN
AccessioniPrimary (citable) accession number: P61968
Secondary accession number(s): D3DT23, O00158, O88894
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 27, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references