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P61968 (LMO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
LIM domain transcription factor LMO4
Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name=LMO-4
Gene names
Name:LMO4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probable transcriptional factor By similarity.

Subunit structure

Interacts strongly with LDBS. Interacts with DEAF1; LMO4 blocks export from nucleus. Interacts with CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity By similarity.

Sequence similarities

Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   DomainLIM domain
Repeat
   LigandMetal-binding
Zinc
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of protein complex assembly

Inferred from electronic annotation. Source: Ensembl

neural tube closure

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of cell activation

Inferred from electronic annotation. Source: Ensembl

regulation of cell fate specification

Inferred from electronic annotation. Source: Ensembl

spinal cord association neuron differentiation

Inferred from electronic annotation. Source: Ensembl

spinal cord motor neuron differentiation

Inferred from electronic annotation. Source: Ensembl

thymus development

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

ventral spinal cord interneuron differentiation

Inferred from electronic annotation. Source: Ensembl

ventricular septum development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componenttranscription factor complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionenhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: UniProtKB

transcription factor binding

Inferred from sequence or structural similarity. Source: UniProtKB

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165LIM domain transcription factor LMO4
PRO_0000075820

Regions

Domain23 – 8361LIM zinc-binding 1
Domain87 – 14761LIM zinc-binding 2

Secondary structure

................ 165
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P61968 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: C8AC295144AD7787

FASTA16517,994
        10         20         30         40         50         60 
MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI 

        70         80         90        100        110        120 
GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN 

       130        140        150        160 
RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of LMO4, a new human LIM domain gene."
Racevskis J., Dill A., Sparano J.A., Ruan H.
Biochim. Biophys. Acta 1445:148-153(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary tumor.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye, Lung and PNS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U24576 mRNA. Translation: AAB51073.1.
CH471097 Genomic DNA. Translation: EAW73168.1.
CH471097 Genomic DNA. Translation: EAW73169.1.
BC003600 mRNA. Translation: AAH03600.1.
BC017673 mRNA. Translation: AAH17673.1.
BC065818 mRNA. Translation: AAH65818.1.
CCDSCCDS713.1.
RefSeqNP_006760.1. NM_006769.3.
XP_005271348.1. XM_005271291.1.
UniGeneHs.436792.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2L4ZNMR-A16-82[»]
ProteinModelPortalP61968.
SMRP61968. Positions 19-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114113. 27 interactions.
IntActP61968. 21 interactions.
MINTMINT-265427.
STRING9606.ENSP00000359573.

Proteomic databases

MaxQBP61968.
PaxDbP61968.
PRIDEP61968.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370542; ENSP00000359573; ENSG00000143013.
ENST00000370544; ENSP00000359575; ENSG00000143013.
GeneID8543.
KEGGhsa:8543.
UCSCuc001dmi.3. human.

Organism-specific databases

CTD8543.
GeneCardsGC01P087794.
HGNCHGNC:6644. LMO4.
HPACAB022345.
MIM603129. gene.
neXtProtNX_P61968.
PharmGKBPA30410.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG314117.
HOGENOMHOG000232175.
HOVERGENHBG054231.
InParanoidP61968.
OMADRYWHTG.
OrthoDBEOG75J0PF.
PhylomeDBP61968.
TreeFamTF351071.

Gene expression databases

BgeeP61968.
CleanExHS_LMO4.
GenevestigatorP61968.

Family and domain databases

Gene3D2.10.110.10. 2 hits.
InterProIPR001781. Znf_LIM.
[Graphical view]
PfamPF00412. LIM. 2 hits.
[Graphical view]
SMARTSM00132. LIM. 2 hits.
[Graphical view]
PROSITEPS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLMO4. human.
EvolutionaryTraceP61968.
GeneWikiLMO4.
GenomeRNAi8543.
NextBio32002.
PROP61968.
SOURCESearch...

Entry information

Entry nameLMO4_HUMAN
AccessionPrimary (citable) accession number: P61968
Secondary accession number(s): D3DT23, O00158, O88894
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM