P61968 (LMO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
LIM domain transcription factor LMO4

Alternative name(s):
Breast tumor autoantigen
LIM domain only protein 4
Short name=LMO-4

Gene names

Name:

LMO4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable transcriptional factor By similarity.
Subunit structure	Interacts strongly with LDBS. Interacts with DEAF1, CLIM1 and CLIM2. Interacts (via the LIM zinc-binding domain 1) with RBBP8. Interacts with BRCA1 (via the BRCT domains); the interaction represses BRCA1 transcriptional activity By similarity.
Sequence similarities	Contains 2 LIM zinc-binding domains.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Domain	LIM domain Repeat
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of protein complex assembly Inferred from electronic annotation. Source: Compara neural tube closure Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of cell activation Inferred from electronic annotation. Source: Compara regulation of cell fate specification Inferred from electronic annotation. Source: Compara spinal cord association neuron differentiation Inferred from electronic annotation. Source: Compara spinal cord motor neuron differentiation Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB ventral spinal cord interneuron differentiation Inferred from electronic annotation. Source: Compara ventricular septum development Inferred from electronic annotation. Source: Compara
Cellular_component	transcription factor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	enhancer sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Traceable author statement Ref.1. Source: UniProtKB transcription factor binding Inferred from sequence or structural similarity. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 165

165

LIM domain transcription factor LMO4

PRO_0000075820

Regions

Domain

23 – 83

61

LIM zinc-binding 1

Domain

87 – 147

61

LIM zinc-binding 2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

165

Helix Strand Turn

Details...

Beta strand

21 – 29

9

Beta strand

32 – 38

7

Beta strand

41 – 44

4

Turn

45 – 47

3

Turn

51 – 53

3

Helix

57 – 59

3

Beta strand

67 – 69

3

Helix

74 – 80

7

Sequences

	Sequence		Length	Mass (Da)
	P61968 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: C8AC295144AD7787	FASTA	165	17,994
	10 20 30 40 50 60 MVNPGSSSQP PPVTAGSLSW KRCAGCGGKI ADRFLLYAMD SYWHSRCLKC SCCQAQLGDI 70 80 90 100 110 120 GTSCYTKSGM ILCRNDYIRL FGNSGACSAC GQSIPASELV MRAQGNVYHL KCFTCSTCRN 130 140 150 160 RLVPGDRFHY INGSLFCEHD RPTALINGHL NSLQSNPLLP DQKVC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of LMO4, a new human LIM domain gene." Racevskis J., Dill A., Sparano J.A., Ruan H. Biochim. Biophys. Acta 1445:148-153(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary tumor.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye, Lung and PNS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U24576 mRNA. Translation: AAB51073.1.
CH471097 Genomic DNA. Translation: EAW73168.1.
CH471097 Genomic DNA. Translation: EAW73169.1.
BC003600 mRNA. Translation: AAH03600.1.
BC017673 mRNA. Translation: AAH17673.1.
BC065818 mRNA. Translation: AAH65818.1.

IPI

IPI00297604.

RefSeq

NP_006760.1. NM_006769.3.

UniGene

Hs.436792.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2L4Z	NMR	-	A	18-82	[»]

ProteinModelPortal

P61968.

ModBase

Search...

Protein-protein interaction databases

IntAct

P61968. 2 interactions.

MINT

MINT-265427.

STRING

9606.ENSP00000359573.

Polymorphism databases

DMDM

48428992.

Proteomic databases

PaxDb

P61968.

PRIDE

P61968.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000370542; ENSP00000359573; ENSG00000143013.
ENST00000370544; ENSP00000359575; ENSG00000143013.

GeneID

8543.

KEGG

hsa:8543.

UCSC

uc001dmi.3. human.

Organism-specific databases

CTD

8543.

GeneCards

GC01P087794.

HGNC

HGNC:6644. LMO4.

HPA

CAB022345.

MIM

603129. gene.

neXtProt

NX_P61968.

PharmGKB

PA30410.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG314117.

HOGENOM

HOG000232175.

HOVERGEN

HBG054231.

InParanoid

P61968.

OMA

ALSWKRC.

OrthoDB

EOG4XKV82.

PhylomeDB

P61968.

Enzyme and pathway databases

Pathway_Interaction_DB

il6_7pathway. IL6-mediated signaling events.

Gene expression databases

Bgee

P61968.

CleanEx

HS_LMO4.

Genevestigator

P61968.

GermOnline

ENSG00000143013. Homo sapiens.

Family and domain databases

Gene3D

2.10.110.10. 2 hits.

InterPro

IPR001781. Znf_LIM.
[Graphical view]

Pfam

PF00412. LIM. 2 hits.
[Graphical view]

SMART

SM00132. LIM. 2 hits.
[Graphical view]

PROSITE

PS00478. LIM_DOMAIN_1. 2 hits.
PS50023. LIM_DOMAIN_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

LMO4. human.

EvolutionaryTrace

P61968.

GenomeRNAi

8543.

NextBio

32002.

SOURCE

Search...

Entry information

Entry name

LMO4_HUMAN

Accession

Primary (citable) accession number: P61968
Secondary accession number(s): D3DT23, O00158, O88894

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.