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P61967

- AP1S1_MOUSE

UniProt

P61967 - AP1S1_MOUSE

Protein

AP-1 complex subunit sigma-1A

Gene

Ap1s1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. protein transporter activity Source: UniProtKB

    GO - Biological processi

    1. intracellular protein transport Source: UniProtKB
    2. response to virus Source: Ensembl
    3. vesicle-mediated transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AP-1 complex subunit sigma-1A
    Alternative name(s):
    Adaptor protein complex AP-1 subunit sigma-1A
    Adaptor-related protein complex 1 subunit sigma-1A
    Clathrin assembly protein complex 1 sigma-1A small chain
    Clathrin coat assembly protein AP19
    Golgi adaptor HA1/AP1 adaptin sigma-1A subunit
    HA1 19 kDa subunit
    Sigma 1a subunit of AP-1 clathrin
    Sigma-adaptin 1A
    Sigma1A-adaptin
    Gene namesi
    Name:Ap1s1
    Synonyms:Ap19
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1098244. Ap1s1.

    Subcellular locationi

    Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membraneclathrin-coated pit
    Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

    GO - Cellular componenti

    1. AP-1 adaptor complex Source: UniProtKB
    2. coated pit Source: UniProtKB-SubCell
    3. trans-Golgi network Source: UniProtKB

    Keywords - Cellular componenti

    Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 158158AP-1 complex subunit sigma-1APRO_0000193798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP61967.
    PaxDbiP61967.
    PRIDEiP61967.

    PTM databases

    PhosphoSiteiP61967.

    Expressioni

    Tissue specificityi

    Detected in brain and embryonic stem cells.

    Gene expression databases

    ArrayExpressiP61967.
    BgeeiP61967.
    CleanExiMM_AP1S1.
    GenevestigatoriP61967.

    Interactioni

    Subunit structurei

    Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

    Protein-protein interaction databases

    IntActiP61967. 3 interactions.
    MINTiMINT-1870317.

    Structurei

    Secondary structure

    1
    158
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 87
    Beta strandi10 – 123
    Beta strandi14 – 218
    Helixi25 – 4016
    Beta strandi44 – 463
    Beta strandi48 – 525
    Beta strandi55 – 628
    Beta strandi65 – 717
    Beta strandi73 – 753
    Helixi77 – 9519
    Helixi100 – 11516
    Beta strandi122 – 1243
    Helixi128 – 14619

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1W63X-ray4.00Q/S/T/U/W/X1-158[»]
    ProteinModelPortaliP61967.
    SMRiP61967. Positions 1-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61967.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5030.
    GeneTreeiENSGT00530000062839.
    HOGENOMiHOG000185227.
    HOVERGENiHBG050517.
    InParanoidiP61967.
    KOiK12394.
    OMAiIGSGDNE.
    OrthoDBiEOG7S7SGC.
    PhylomeDBiP61967.
    TreeFamiTF312921.

    Family and domain databases

    InterProiIPR016635. AP_complex_ssu.
    IPR022775. AP_mu_sigma_su.
    IPR000804. Clathrin_sm-chain_CS.
    IPR011012. Longin-like_dom.
    [Graphical view]
    PANTHERiPTHR11753. PTHR11753. 1 hit.
    PfamiPF01217. Clat_adaptor_s. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
    SUPFAMiSSF64356. SSF64356. 1 hit.
    PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P61967-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL    50
    EWRDLKVVYK RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE 100
    LDIIFNFEKA YFILDEFLMG GDVQDTSKKS VLKAIEQADL LQEEDESPRS 150
    VLEEMGLA 158
    Length:158
    Mass (Da):18,733
    Last modified:June 7, 2004 - v1
    Checksum:iE461937790406D8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62418 mRNA. Translation: AAA37243.1.
    AK002225 mRNA. Translation: BAB21947.1.
    BC052692 mRNA. Translation: AAH52692.1.
    CCDSiCCDS39330.1.
    PIRiA40535.
    RefSeqiNP_031483.1. NM_007457.2.
    UniGeneiMm.833.

    Genome annotation databases

    EnsembliENSMUST00000111080; ENSMUSP00000106709; ENSMUSG00000004849.
    GeneIDi11769.
    KEGGimmu:11769.
    UCSCiuc009abm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62418 mRNA. Translation: AAA37243.1 .
    AK002225 mRNA. Translation: BAB21947.1 .
    BC052692 mRNA. Translation: AAH52692.1 .
    CCDSi CCDS39330.1.
    PIRi A40535.
    RefSeqi NP_031483.1. NM_007457.2.
    UniGenei Mm.833.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1W63 X-ray 4.00 Q/S/T/U/W/X 1-158 [» ]
    ProteinModelPortali P61967.
    SMRi P61967. Positions 1-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P61967. 3 interactions.
    MINTi MINT-1870317.

    PTM databases

    PhosphoSitei P61967.

    Proteomic databases

    MaxQBi P61967.
    PaxDbi P61967.
    PRIDEi P61967.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111080 ; ENSMUSP00000106709 ; ENSMUSG00000004849 .
    GeneIDi 11769.
    KEGGi mmu:11769.
    UCSCi uc009abm.1. mouse.

    Organism-specific databases

    CTDi 1174.
    MGIi MGI:1098244. Ap1s1.

    Phylogenomic databases

    eggNOGi COG5030.
    GeneTreei ENSGT00530000062839.
    HOGENOMi HOG000185227.
    HOVERGENi HBG050517.
    InParanoidi P61967.
    KOi K12394.
    OMAi IGSGDNE.
    OrthoDBi EOG7S7SGC.
    PhylomeDBi P61967.
    TreeFami TF312921.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.

    Miscellaneous databases

    EvolutionaryTracei P61967.
    NextBioi 279541.
    PROi P61967.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61967.
    Bgeei P61967.
    CleanExi MM_AP1S1.
    Genevestigatori P61967.

    Family and domain databases

    InterProi IPR016635. AP_complex_ssu.
    IPR022775. AP_mu_sigma_su.
    IPR000804. Clathrin_sm-chain_CS.
    IPR011012. Longin-like_dom.
    [Graphical view ]
    PANTHERi PTHR11753. PTHR11753. 1 hit.
    Pfami PF01217. Clat_adaptor_s. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015588. AP_complex_sigma. 1 hit.
    SUPFAMi SSF64356. SSF64356. 1 hit.
    PROSITEi PS00989. CLAT_ADAPTOR_S. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast."
      Kirchhausen T., Davis A.C., Frucht S., O'Brine Greco B., Payne G.S., Tubb B.
      J. Biol. Chem. 266:11153-11157(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
    4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiAP1S1_MOUSE
    AccessioniPrimary (citable) accession number: P61967
    Secondary accession number(s): P82267
    , Q00382, Q9BTN4, Q9UDW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3