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Protein

AP-1 complex subunit sigma-1A

Gene

Ap1s1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Molecular functioni

  • protein transporter activity Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: UniProtKB
  • response to virus Source: Ensembl
  • retrograde transport, endosome to Golgi Source: MGI
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit sigma-1A
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1A
Adaptor-related protein complex 1 subunit sigma-1A
Clathrin assembly protein complex 1 sigma-1A small chain
Clathrin coat assembly protein AP19
Golgi adaptor HA1/AP1 adaptin sigma-1A subunit
HA1 19 kDa subunit
Sigma 1a subunit of AP-1 clathrin
Sigma-adaptin 1A
Sigma1A-adaptin
Gene namesi
Name:Ap1s1
Synonyms:Ap19
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1098244. Ap1s1.

Subcellular locationi

GO - Cellular componenti

  • AP-1 adaptor complex Source: UniProtKB
  • clathrin-coated pit Source: UniProtKB-SubCell
  • cytosol Source: GOC
  • extracellular exosome Source: MGI
  • Golgi apparatus Source: MGI
  • intracellular membrane-bounded organelle Source: MGI
  • membrane Source: MGI
  • terminal bouton Source: MGI
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158AP-1 complex subunit sigma-1APRO_0000193798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP61967.
MaxQBiP61967.
PaxDbiP61967.
PeptideAtlasiP61967.
PRIDEiP61967.

PTM databases

iPTMnetiP61967.
PhosphoSiteiP61967.

Expressioni

Tissue specificityi

Detected in brain and embryonic stem cells.

Gene expression databases

BgeeiENSMUSG00000004849.
CleanExiMM_AP1S1.
ExpressionAtlasiP61967. baseline and differential.
GenevisibleiP61967. MM.

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

Protein-protein interaction databases

IntActiP61967. 3 interactions.
MINTiMINT-1870317.
STRINGi10090.ENSMUSP00000106709.

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 87
Beta strandi10 – 123
Beta strandi14 – 218
Helixi25 – 4016
Beta strandi44 – 463
Beta strandi48 – 525
Beta strandi55 – 628
Beta strandi65 – 717
Beta strandi73 – 753
Helixi77 – 9519
Helixi100 – 11516
Beta strandi122 – 1243
Helixi128 – 14619

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W63X-ray4.00Q/S/T/U/W/X1-158[»]
ProteinModelPortaliP61967.
SMRiP61967. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61967.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0934. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00530000062839.
HOGENOMiHOG000185227.
HOVERGENiHBG050517.
InParanoidiP61967.
KOiK12394.
OMAiCCAVEEQ.
PhylomeDBiP61967.
TreeFamiTF312921.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61967-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMRFMLLFSR QGKLRLQKWY LATSDKERKK MVRELMQVVL ARKPKMCSFL
60 70 80 90 100
EWRDLKVVYK RYASLYFCCA IEGQDNELIT LELIHRYVEL LDKYFGSVCE
110 120 130 140 150
LDIIFNFEKA YFILDEFLMG GDVQDTSKKS VLKAIEQADL LQEEDESPRS

VLEEMGLA
Length:158
Mass (Da):18,733
Last modified:June 7, 2004 - v1
Checksum:iE461937790406D8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62418 mRNA. Translation: AAA37243.1.
AK002225 mRNA. Translation: BAB21947.1.
BC052692 mRNA. Translation: AAH52692.1.
CCDSiCCDS39330.1.
PIRiA40535.
RefSeqiNP_031483.1. NM_007457.2.
UniGeneiMm.833.

Genome annotation databases

EnsembliENSMUST00000111080; ENSMUSP00000106709; ENSMUSG00000004849.
GeneIDi11769.
KEGGimmu:11769.
UCSCiuc009abm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62418 mRNA. Translation: AAA37243.1.
AK002225 mRNA. Translation: BAB21947.1.
BC052692 mRNA. Translation: AAH52692.1.
CCDSiCCDS39330.1.
PIRiA40535.
RefSeqiNP_031483.1. NM_007457.2.
UniGeneiMm.833.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W63X-ray4.00Q/S/T/U/W/X1-158[»]
ProteinModelPortaliP61967.
SMRiP61967. Positions 1-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP61967. 3 interactions.
MINTiMINT-1870317.
STRINGi10090.ENSMUSP00000106709.

PTM databases

iPTMnetiP61967.
PhosphoSiteiP61967.

Proteomic databases

EPDiP61967.
MaxQBiP61967.
PaxDbiP61967.
PeptideAtlasiP61967.
PRIDEiP61967.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111080; ENSMUSP00000106709; ENSMUSG00000004849.
GeneIDi11769.
KEGGimmu:11769.
UCSCiuc009abm.1. mouse.

Organism-specific databases

CTDi1174.
MGIiMGI:1098244. Ap1s1.

Phylogenomic databases

eggNOGiKOG0934. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00530000062839.
HOGENOMiHOG000185227.
HOVERGENiHBG050517.
InParanoidiP61967.
KOiK12394.
OMAiCCAVEEQ.
PhylomeDBiP61967.
TreeFamiTF312921.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

EvolutionaryTraceiP61967.
PROiP61967.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004849.
CleanExiMM_AP1S1.
ExpressionAtlasiP61967. baseline and differential.
GenevisibleiP61967. MM.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP1S1_MOUSE
AccessioniPrimary (citable) accession number: P61967
Secondary accession number(s): P82267
, Q00382, Q9BTN4, Q9UDW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.