##gff-version 3 P61964 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 P61964 UniProtKB Chain 2 334 . . . ID=PRO_0000051350;Note=WD repeat-containing protein 5 P61964 UniProtKB Repeat 43 82 . . . Note=WD 1 P61964 UniProtKB Repeat 85 126 . . . Note=WD 2 P61964 UniProtKB Repeat 128 168 . . . Note=WD 3 P61964 UniProtKB Repeat 169 208 . . . Note=WD 4 P61964 UniProtKB Repeat 212 253 . . . Note=WD 5 P61964 UniProtKB Repeat 256 296 . . . Note=WD 6 P61964 UniProtKB Repeat 299 333 . . . Note=WD 7 P61964 UniProtKB Region 1 31 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61964 UniProtKB Compositional bias 14 31 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P61964 UniProtKB Site 107 107 . . . Note=Important for interaction with histone H3 P61964 UniProtKB Site 133 133 . . . Note=Important for interaction with histone H3 P61964 UniProtKB Site 263 263 . . . Note=Important for interaction with histone H3 P61964 UniProtKB Site 322 322 . . . Note=Important for interaction with histone H3 P61964 UniProtKB Modified residue 2 2 . . . Note=N-acetylalanine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22814378;Dbxref=PMID:22814378 P61964 UniProtKB Modified residue 112 112 . . . Note=N6-acetyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19608861;Dbxref=PMID:19608861 P61964 UniProtKB Cross-link 7 7 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P61964 UniProtKB Cross-link 27 27 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P61964 UniProtKB Cross-link 46 46 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 P61964 UniProtKB Natural variant 208 208 . . . ID=VAR_081531;Note=Found in a patient with childhood apraxia of speech%3B uncertain significance. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:29463886;Dbxref=PMID:29463886 P61964 UniProtKB Mutagenesis 47 47 . . . Note=Strongly reduced affinity for histone H3. A->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16600877;Dbxref=PMID:16600877 P61964 UniProtKB Mutagenesis 91 91 . . . Note=Strongly reduced affinity for histone H3. S->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16600877;Dbxref=PMID:16600877 P61964 UniProtKB Mutagenesis 107 107 . . . Note=Strongly reduced affinity for histone H3. Significant decrease in interaction with KMT2A. D->A;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16600877,ECO:0000269|PubMed:16829960,ECO:0000269|PubMed:18840606;Dbxref=PMID:16600877,PMID:16829960,PMID:18840606 P61964 UniProtKB Mutagenesis 107 107 . . . Note=Strongly reduced affinity for histone H3. D->N;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16829960;Dbxref=PMID:16829960 P61964 UniProtKB Mutagenesis 133 133 . . . Note=Strongly reduced affinity for histone H3. Significant decrease in interaction with KMT2A. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16829960,ECO:0000269|PubMed:18840606;Dbxref=PMID:16829960,PMID:18840606 P61964 UniProtKB Mutagenesis 133 133 . . . Note=Strongly reduced affinity for histone H3. F->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16600877;Dbxref=PMID:16600877 P61964 UniProtKB Mutagenesis 133 133 . . . Note=Strongly reduced affinity for histone H3. F->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16829960;Dbxref=PMID:16829960 P61964 UniProtKB Mutagenesis 149 149 . . . Note=Significant decrease in interaction with KMT2A. F->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18840606;Dbxref=PMID:18840606 P61964 UniProtKB Mutagenesis 225 225 . . . Note=Loss of interaction with RBBP5 and reduced ability to stimulate KMT2A methyltransferase activity in association with RBBP5 and ASH2L. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220120;Dbxref=PMID:21220120 P61964 UniProtKB Mutagenesis 240 240 . . . Note=Loss of interaction with RBBP5 and reduced ability to stimulate KMT2A methyltransferase activity in association with RBBP5 and ASH2L. L->K;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220120;Dbxref=PMID:21220120 P61964 UniProtKB Mutagenesis 263 263 . . . Note=Strongly reduced affinity for histone H3. Significant decrease in interaction with KMT2A. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16829960,ECO:0000269|PubMed:18840606;Dbxref=PMID:16829960,PMID:18840606 P61964 UniProtKB Mutagenesis 263 263 . . . Note=Strongly reduced affinity for histone H3. F->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16829960;Dbxref=PMID:16829960 P61964 UniProtKB Mutagenesis 289 289 . . . Note=Reduced interaction with RBBP5 and reduced ability to stimulate KMT2A methyltransferase activity in association with RBBP5 and ASH2L. Q->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:21220120;Dbxref=PMID:21220120 P61964 UniProtKB Mutagenesis 321 321 . . . Note=Abolishes histone H3 binding. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16829960;Dbxref=PMID:16829960 P61964 UniProtKB Mutagenesis 322 322 . . . Note=Strongly reduced affinity for histone H3. No effect on interaction with KMT2A. E->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:16600877,ECO:0000269|PubMed:18840606;Dbxref=PMID:16600877,PMID:18840606 P61964 UniProtKB Helix 13 15 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7BED P61964 UniProtKB Beta strand 25 27 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:5EAP P61964 UniProtKB Beta strand 31 33 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:8Q1N P61964 UniProtKB Beta strand 36 41 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 48 53 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 57 64 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 67 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 74 76 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 79 84 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 90 95 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 99 106 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 109 115 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 116 118 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 121 126 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 132 137 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 141 148 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 153 157 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 158 160 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 163 167 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 174 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 183 190 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 193 199 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 200 202 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 205 211 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 213 215 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 217 222 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 226 233 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 234 236 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 237 242 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 243 246 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 247 252 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 258 260 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 264 267 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 269 271 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 273 276 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 279 281 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2G9A P61964 UniProtKB Beta strand 283 287 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 288 290 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 293 297 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 304 309 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 311 320 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Turn 322 324 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z P61964 UniProtKB Beta strand 327 331 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6E1Z