P61961 (UFM1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-fold modifier 1

Gene names

Name:

Ufm1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1 By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity. Note: Predominantly nuclear. Also expressed diffusely in the cytoplasm By similarity.
Sequence similarities	Belongs to the UFM1 family.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
PTM	Isopeptide bond
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein ufmylation Inferred from direct assay PubMed 20018847. Source: UniProtKB
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 83

83

Ubiquitin-fold modifier 1

PRO_0000042126

Propeptide

84 – 85

2

Removed in mature form By similarity

PRO_0000042127

Amino acid modifications

Cross-link

83

Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) Potential

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

85

Helix Strand Turn

Details...

Beta strand

3 – 10

8

Beta strand

18 – 24

7

Helix

29 – 39

11

Beta strand

44 – 50

7

Beta strand

60 – 62

3

Helix

63 – 69

7

Beta strand

72 – 78

7

Sequences

	Sequence		Length	Mass (Da)
	P61961 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: EDB2412E5E5836D8	FASTA	85	9,118
	10 20 30 40 50 60 MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA 70 80 QTAGNVFLKH GSELRIIPRD RVGSC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: BALB/c and C57BL/6J. Tissue: Mammary gland, Pancreas, Placenta and Small intestine.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Solution structure of mouse hypothetical 9.1 kDa protein, a ubiquitin-like fold." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2002) to the PDB data bank Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK007788 mRNA. Translation: BAB25255.1.
AK008280 mRNA. Translation: BAB25572.1.
AK089948 mRNA. Translation: BAC41011.1.
AK148146 mRNA. Translation: BAE28374.1.
AK166332 mRNA. Translation: BAE38712.1.
AK167301 mRNA. Translation: BAE39406.1.
AK167321 mRNA. Translation: BAE39423.1.
BC061065 mRNA. Translation: AAH61065.1.

IPI

IPI00139378.

RefSeq

NP_080711.1. NM_026435.5.

UniGene

Mm.23067.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1J0G	NMR	-	A	1-85	[»]

ProteinModelPortal

P61961.

ModBase

Search...

PTM databases

PhosphoSite

P61961.

Proteomic databases

PaxDb

P61961.

PRIDE

P61961.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000146598; ENSMUSP00000118478; ENSMUSG00000027746.

GeneID

67890.

KEGG

mmu:67890.

UCSC

uc008pfa.2. mouse.

Organism-specific databases

CTD

51569.

MGI

MGI:1915140. Ufm1.

Phylogenomic databases

eggNOG

NOG249065.

GeneTree

ENSGT00390000010391.

HOGENOM

HOG000185753.

HOVERGEN

HBG094129.

InParanoid

P61961.

KO

K12162.

Gene expression databases

ArrayExpress

P61961.

Bgee

P61961.

CleanEx

MM_UFM1.

Genevestigator

P61961.

GermOnline

ENSMUSG00000027746. Mus musculus.

Family and domain databases

InterPro

IPR005375. UFM1.
[Graphical view]

Pfam

PF03671. Ufm1. 1 hit.
[Graphical view]

PIRSF

PIRSF038027. Ubiquitin-like_Ufm1. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P61961.

NextBio

325858.

SOURCE

Search...

Entry information

Entry name

UFM1_MOUSE

Accession

Primary (citable) accession number: P61961
Secondary accession number(s): Q14346 , Q3TLT0, Q542A7, Q9CPX2, Q9NZF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program