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P61961

- UFM1_MOUSE

UniProt

P61961 - UFM1_MOUSE

Protein

Ubiquitin-fold modifier 1

Gene

Ufm1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1.By similarity

    GO - Biological processi

    1. protein ufmylation Source: UniProtKB
    2. response to endoplasmic reticulum stress Source: MGI

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-fold modifier 1
    Gene namesi
    Name:Ufm1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915140. Ufm1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity
    Note: Predominantly nuclear. Also expressed diffusely in the cytoplasm By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 8383Ubiquitin-fold modifier 1PRO_0000042126Add
    BLAST
    Propeptidei84 – 852Removed in mature formBy similarityPRO_0000042127

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki83 – 83Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)Sequence Analysis

    Keywords - PTMi

    Isopeptide bond

    Proteomic databases

    MaxQBiP61961.
    PaxDbiP61961.
    PRIDEiP61961.

    PTM databases

    PhosphoSiteiP61961.

    Expressioni

    Gene expression databases

    ArrayExpressiP61961.
    BgeeiP61961.
    CleanExiMM_UFM1.
    GenevestigatoriP61961.

    Structurei

    Secondary structure

    1
    85
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 108
    Beta strandi18 – 247
    Helixi29 – 3911
    Beta strandi44 – 507
    Beta strandi60 – 623
    Helixi63 – 697
    Beta strandi72 – 787

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1J0GNMR-A1-85[»]
    ProteinModelPortaliP61961.
    SMRiP61961. Positions 1-85.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61961.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UFM1 family.Curated

    Phylogenomic databases

    eggNOGiNOG249065.
    GeneTreeiENSGT00390000010391.
    HOGENOMiHOG000185753.
    HOVERGENiHBG094129.
    InParanoidiP61961.
    KOiK12162.
    OrthoDBiEOG7Q8CQW.
    PhylomeDBiP61961.
    TreeFamiTF312934.

    Family and domain databases

    InterProiIPR029071. Ubiquitin-rel_dom.
    IPR005375. UFM1.
    [Graphical view]
    PfamiPF03671. Ufm1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038027. Ubiquitin-like_Ufm1. 1 hit.
    SUPFAMiSSF54236. SSF54236. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61961-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII   50
    TNDGIGINPA QTAGNVFLKH GSELRIIPRD RVGSC 85
    Length:85
    Mass (Da):9,118
    Last modified:June 7, 2004 - v1
    Checksum:iEDB2412E5E5836D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007788 mRNA. Translation: BAB25255.1.
    AK008280 mRNA. Translation: BAB25572.1.
    AK089948 mRNA. Translation: BAC41011.1.
    AK148146 mRNA. Translation: BAE28374.1.
    AK166332 mRNA. Translation: BAE38712.1.
    AK167301 mRNA. Translation: BAE39406.1.
    AK167321 mRNA. Translation: BAE39423.1.
    BC061065 mRNA. Translation: AAH61065.1.
    CCDSiCCDS38430.1.
    RefSeqiNP_080711.1. NM_026435.5.
    UniGeneiMm.23067.

    Genome annotation databases

    EnsembliENSMUST00000146598; ENSMUSP00000118478; ENSMUSG00000027746.
    GeneIDi67890.
    KEGGimmu:67890.
    UCSCiuc008pfa.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK007788 mRNA. Translation: BAB25255.1 .
    AK008280 mRNA. Translation: BAB25572.1 .
    AK089948 mRNA. Translation: BAC41011.1 .
    AK148146 mRNA. Translation: BAE28374.1 .
    AK166332 mRNA. Translation: BAE38712.1 .
    AK167301 mRNA. Translation: BAE39406.1 .
    AK167321 mRNA. Translation: BAE39423.1 .
    BC061065 mRNA. Translation: AAH61065.1 .
    CCDSi CCDS38430.1.
    RefSeqi NP_080711.1. NM_026435.5.
    UniGenei Mm.23067.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1J0G NMR - A 1-85 [» ]
    ProteinModelPortali P61961.
    SMRi P61961. Positions 1-85.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P61961.

    Proteomic databases

    MaxQBi P61961.
    PaxDbi P61961.
    PRIDEi P61961.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000146598 ; ENSMUSP00000118478 ; ENSMUSG00000027746 .
    GeneIDi 67890.
    KEGGi mmu:67890.
    UCSCi uc008pfa.2. mouse.

    Organism-specific databases

    CTDi 51569.
    MGIi MGI:1915140. Ufm1.

    Phylogenomic databases

    eggNOGi NOG249065.
    GeneTreei ENSGT00390000010391.
    HOGENOMi HOG000185753.
    HOVERGENi HBG094129.
    InParanoidi P61961.
    KOi K12162.
    OrthoDBi EOG7Q8CQW.
    PhylomeDBi P61961.
    TreeFami TF312934.

    Miscellaneous databases

    EvolutionaryTracei P61961.
    NextBioi 325858.
    PROi P61961.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P61961.
    Bgeei P61961.
    CleanExi MM_UFM1.
    Genevestigatori P61961.

    Family and domain databases

    InterProi IPR029071. Ubiquitin-rel_dom.
    IPR005375. UFM1.
    [Graphical view ]
    Pfami PF03671. Ufm1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038027. Ubiquitin-like_Ufm1. 1 hit.
    SUPFAMi SSF54236. SSF54236. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c and C57BL/6J.
      Tissue: Mammary gland, Pancreas, Placenta and Small intestine.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Solution structure of mouse hypothetical 9.1 kDa protein, a ubiquitin-like fold."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2002) to the PDB data bank
      Cited for: STRUCTURE BY NMR.

    Entry informationi

    Entry nameiUFM1_MOUSE
    AccessioniPrimary (citable) accession number: P61961
    Secondary accession number(s): Q14346
    , Q3TLT0, Q542A7, Q9CPX2, Q9NZF2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3