Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P61960

- UFM1_HUMAN

UniProt

P61960 - UFM1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Ubiquitin-fold modifier 1

Gene

UFM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1.2 Publications

GO - Biological processi

  1. protein ufmylation Source: UniProtKB
  2. response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-fold modifier 1
Gene namesi
Name:UFM1
Synonyms:C13orf20
ORF Names:BM-002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20597. UFM1.

Subcellular locationi

Nucleus 1 Publication. Cytoplasm 1 Publication
Note: Predominantly nuclear. Also expressed diffusely in the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi83 – 831G → A: Confers resistance to cleavage. 1 Publication

Organism-specific databases

PharmGKBiPA134863405.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8383Ubiquitin-fold modifier 1PRO_0000042122Add
BLAST
Propeptidei84 – 852Removed in mature formPRO_0000042123

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki83 – 83Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)Sequence Analysis

Keywords - PTMi

Isopeptide bond

Proteomic databases

MaxQBiP61960.
PaxDbiP61960.
PRIDEiP61960.

PTM databases

PhosphoSiteiP61960.

Expressioni

Gene expression databases

BgeeiP61960.
CleanExiHS_UFM1.
GenevestigatoriP61960.

Organism-specific databases

HPAiHPA039758.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDK5RAP3Q96JB51EBI-1045061,EBI-718818

Protein-protein interaction databases

BioGridi119616. 48 interactions.
IntActiP61960. 6 interactions.
MINTiMINT-7005139.
STRINGi9606.ENSP00000239878.

Structurei

Secondary structure

1
85
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi4 – 118Combined sources
Beta strandi14 – 163Combined sources
Beta strandi20 – 234Combined sources
Beta strandi25 – 284Combined sources
Helixi29 – 3911Combined sources
Beta strandi44 – 5310Combined sources
Helixi63 – 697Combined sources
Beta strandi72 – 798Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WXSNMR-A1-85[»]
ProteinModelPortaliP61960.
SMRiP61960. Positions 1-85.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61960.

Family & Domainsi

Sequence similaritiesi

Belongs to the UFM1 family.Curated

Phylogenomic databases

eggNOGiNOG249065.
GeneTreeiENSGT00390000010391.
HOGENOMiHOG000238677.
HOVERGENiHBG094129.
InParanoidiP61960.
KOiK12162.
OrthoDBiEOG7Q8CQW.
PhylomeDBiP61960.
TreeFamiTF312934.

Family and domain databases

InterProiIPR029071. Ubiquitin-rel_dom.
IPR005375. UFM1.
[Graphical view]
PfamiPF03671. Ufm1. 1 hit.
[Graphical view]
PIRSFiPIRSF038027. Ubiquitin-like_Ufm1. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P61960-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII
60 70 80
TNDGIGINPA QTAGNVFLKH GSELRIIPRD RVGSC
Length:85
Mass (Da):9,118
Last modified:June 7, 2004 - v1
Checksum:iEDB2412E5E5836D8
GO
Isoform 2 (identifier: P61960-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSKVSFKITLTSDPRLPYKV → MIRAFPTTTPRSLHLFTSSTFLARALPGAFPTGACEER

Show »
Length:103
Mass (Da):10,960
Checksum:iBA4D1DE2215D5ACC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121S → W in CAA94181. 1 PublicationCurated
Sequence conflicti78 – 803PRD → LEI in CAA94181. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020MSKVS…LPYKV → MIRAFPTTTPRSLHLFTSST FLARALPGAFPTGACEER in isoform 2. 1 PublicationVSP_041186Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154404 mRNA. Translation: BAD15373.1.
AF208844 mRNA. Translation: AAF64258.1.
CR457189 mRNA. Translation: CAG33470.1.
DA664581 mRNA. No translation available.
AL356863 Genomic DNA. Translation: CAH70411.1.
AL356863 Genomic DNA. Translation: CAH70414.1.
BC005193 mRNA. Translation: AAH05193.1.
Z70222 mRNA. Translation: CAA94181.1.
CCDSiCCDS66533.1. [P61960-2]
CCDS9366.1. [P61960-1]
RefSeqiNP_001273632.1. NM_001286703.1.
NP_001273633.1. NM_001286704.1. [P61960-2]
NP_001273634.1. NM_001286705.1.
NP_001273635.1. NM_001286706.1.
NP_057701.1. NM_016617.3. [P61960-1]
UniGeneiHs.643655.

Genome annotation databases

EnsembliENST00000239878; ENSP00000239878; ENSG00000120686. [P61960-1]
ENST00000379649; ENSP00000368970; ENSG00000120686. [P61960-2]
GeneIDi51569.
KEGGihsa:51569.
UCSCiuc001uwu.3. human. [P61960-1]

Polymorphism databases

DMDMi48428799.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB154404 mRNA. Translation: BAD15373.1 .
AF208844 mRNA. Translation: AAF64258.1 .
CR457189 mRNA. Translation: CAG33470.1 .
DA664581 mRNA. No translation available.
AL356863 Genomic DNA. Translation: CAH70411.1 .
AL356863 Genomic DNA. Translation: CAH70414.1 .
BC005193 mRNA. Translation: AAH05193.1 .
Z70222 mRNA. Translation: CAA94181.1 .
CCDSi CCDS66533.1. [P61960-2 ]
CCDS9366.1. [P61960-1 ]
RefSeqi NP_001273632.1. NM_001286703.1.
NP_001273633.1. NM_001286704.1. [P61960-2 ]
NP_001273634.1. NM_001286705.1.
NP_001273635.1. NM_001286706.1.
NP_057701.1. NM_016617.3. [P61960-1 ]
UniGenei Hs.643655.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WXS NMR - A 1-85 [» ]
ProteinModelPortali P61960.
SMRi P61960. Positions 1-85.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119616. 48 interactions.
IntActi P61960. 6 interactions.
MINTi MINT-7005139.
STRINGi 9606.ENSP00000239878.

PTM databases

PhosphoSitei P61960.

Polymorphism databases

DMDMi 48428799.

Proteomic databases

MaxQBi P61960.
PaxDbi P61960.
PRIDEi P61960.

Protocols and materials databases

DNASUi 51569.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239878 ; ENSP00000239878 ; ENSG00000120686 . [P61960-1 ]
ENST00000379649 ; ENSP00000368970 ; ENSG00000120686 . [P61960-2 ]
GeneIDi 51569.
KEGGi hsa:51569.
UCSCi uc001uwu.3. human. [P61960-1 ]

Organism-specific databases

CTDi 51569.
GeneCardsi GC13P038923.
HGNCi HGNC:20597. UFM1.
HPAi HPA039758.
MIMi 610553. gene.
neXtProti NX_P61960.
PharmGKBi PA134863405.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249065.
GeneTreei ENSGT00390000010391.
HOGENOMi HOG000238677.
HOVERGENi HBG094129.
InParanoidi P61960.
KOi K12162.
OrthoDBi EOG7Q8CQW.
PhylomeDBi P61960.
TreeFami TF312934.

Miscellaneous databases

ChiTaRSi UFM1. human.
EvolutionaryTracei P61960.
GeneWikii UFM1.
GenomeRNAii 51569.
NextBioi 55392.
PROi P61960.
SOURCEi Search...

Gene expression databases

Bgeei P61960.
CleanExi HS_UFM1.
Genevestigatori P61960.

Family and domain databases

InterProi IPR029071. Ubiquitin-rel_dom.
IPR005375. UFM1.
[Graphical view ]
Pfami PF03671. Ufm1. 1 hit.
[Graphical view ]
PIRSFi PIRSF038027. Ubiquitin-like_Ufm1. 1 hit.
SUPFAMi SSF54236. SSF54236. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier."
    Komatsu M., Chiba T., Tatsumi K., Iemura S., Tanida I., Okazaki N., Ueno T., Kominami E., Natsume T., Tanaka K.
    EMBO J. 23:1977-1986(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-83.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Neuroblastoma.
  5. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  7. "Characterization of different mRNA types expressed in human brain."
    Dmitrenko V.V., Garifulin O.M., Kavsan V.M.
    Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-80 (ISOFORM 1).
    Tissue: Brain.
  8. Cited for: FUNCTION.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiUFM1_HUMAN
AccessioniPrimary (citable) accession number: P61960
Secondary accession number(s): Q14346
, Q5VXS0, Q6IAG6, Q9CPX2, Q9NZF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3