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P61954

- GBG11_RAT

UniProt

P61954 - GBG11_RAT

Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

Gng11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.By similarity

    GO - Molecular functioni

    1. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
    Gene namesi
    Name:Gng11
    Synonyms:Gngt11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi621515. Gng11.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. heterotrimeric G-protein complex Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11PRO_0000012663Add
    BLAST
    Propeptidei71 – 733Removed in mature formBy similarityPRO_0000012664

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei70 – 701Cysteine methyl esterSequence Analysis
    Lipidationi70 – 701S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PaxDbiP61954.

    PTM databases

    PhosphoSiteiP61954.

    Expressioni

    Gene expression databases

    GenevestigatoriP61954.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000014616.

    Structurei

    3D structure databases

    ProteinModelPortaliP61954.
    SMRiP61954. Positions 9-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G protein gamma family.Curated

    Phylogenomic databases

    eggNOGiNOG250223.
    GeneTreeiENSGT00530000063397.
    HOGENOMiHOG000231034.
    HOVERGENiHBG014983.
    InParanoidiP61954.
    KOiK04546.
    OMAiRQPVSKC.
    OrthoDBiEOG7H1JP7.
    PhylomeDBiP61954.
    TreeFamiTF319909.

    Family and domain databases

    Gene3Di4.10.260.10. 1 hit.
    InterProiIPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view]
    PANTHERiPTHR13809. PTHR13809. 1 hit.
    PfamiPF00631. G-gamma. 1 hit.
    [Graphical view]
    PRINTSiPR00321. GPROTEING.
    SMARTiSM00224. GGL. 1 hit.
    [Graphical view]
    SUPFAMiSSF48670. SSF48670. 1 hit.
    PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61954-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE   50
    DPLVKGIPED KNPFKEKGSC VIS 73
    Length:73
    Mass (Da):8,481
    Last modified:June 7, 2004 - v1
    Checksum:i2B13935E3AEFB9E8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF257110 mRNA. Translation: AAF68984.1.
    BC097320 mRNA. Translation: AAH97320.1.
    RefSeqiNP_071791.1. NM_022396.2.
    XP_003749746.1. XM_003749698.2.
    UniGeneiRn.892.

    Genome annotation databases

    EnsembliENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469.
    ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914.
    GeneIDi100912034.
    64199.
    KEGGirno:100912034.
    rno:64199.
    UCSCiRGD:621515. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF257110 mRNA. Translation: AAF68984.1 .
    BC097320 mRNA. Translation: AAH97320.1 .
    RefSeqi NP_071791.1. NM_022396.2.
    XP_003749746.1. XM_003749698.2.
    UniGenei Rn.892.

    3D structure databases

    ProteinModelPortali P61954.
    SMRi P61954. Positions 9-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000014616.

    PTM databases

    PhosphoSitei P61954.

    Proteomic databases

    PaxDbi P61954.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074048 ; ENSRNOP00000065818 ; ENSRNOG00000050469 .
    ENSRNOT00000075326 ; ENSRNOP00000066965 ; ENSRNOG00000047914 .
    GeneIDi 100912034.
    64199.
    KEGGi rno:100912034.
    rno:64199.
    UCSCi RGD:621515. rat.

    Organism-specific databases

    CTDi 2791.
    RGDi 621515. Gng11.

    Phylogenomic databases

    eggNOGi NOG250223.
    GeneTreei ENSGT00530000063397.
    HOGENOMi HOG000231034.
    HOVERGENi HBG014983.
    InParanoidi P61954.
    KOi K04546.
    OMAi RQPVSKC.
    OrthoDBi EOG7H1JP7.
    PhylomeDBi P61954.
    TreeFami TF319909.

    Miscellaneous databases

    NextBioi 612880.
    PROi P61954.

    Gene expression databases

    Genevestigatori P61954.

    Family and domain databases

    Gene3Di 4.10.260.10. 1 hit.
    InterProi IPR015898. G-protein_gamma-like_dom.
    IPR001770. Gprotein-gamma.
    [Graphical view ]
    PANTHERi PTHR13809. PTHR13809. 1 hit.
    Pfami PF00631. G-gamma. 1 hit.
    [Graphical view ]
    PRINTSi PR00321. GPROTEING.
    SMARTi SM00224. GGL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48670. SSF48670. 1 hit.
    PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of rat G protein gamma 11 subunit."
      Costain W.J., Mishra R.K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiGBG11_RAT
    AccessioniPrimary (citable) accession number: P61954
    Secondary accession number(s): P50152, Q4V8M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3