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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

Gng11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_231505. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_232206. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_235881. Glucagon-type ligand receptors.
REACT_255871. Glucagon signaling in metabolic regulation.
REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:Gng11
Synonyms:Gngt11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi621515. Gng11.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11PRO_0000012663Add
BLAST
Propeptidei71 – 733Removed in mature formBy similarityPRO_0000012664

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Cysteine methyl esterSequence Analysis
Lipidationi70 – 701S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP61954.

PTM databases

PhosphoSiteiP61954.

Expressioni

Gene expression databases

GenevestigatoriP61954.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014616.

Structurei

3D structure databases

ProteinModelPortaliP61954.
SMRiP61954. Positions 9-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG250223.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61954.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61954.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61954-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257110 mRNA. Translation: AAF68984.1.
BC097320 mRNA. Translation: AAH97320.1.
RefSeqiNP_071791.1. NM_022396.2.
XP_003749746.1. XM_003749698.3.
UniGeneiRn.892.

Genome annotation databases

EnsembliENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469.
ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914.
GeneIDi100912034.
64199.
KEGGirno:100912034.
rno:64199.
UCSCiRGD:621515. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257110 mRNA. Translation: AAF68984.1.
BC097320 mRNA. Translation: AAH97320.1.
RefSeqiNP_071791.1. NM_022396.2.
XP_003749746.1. XM_003749698.3.
UniGeneiRn.892.

3D structure databases

ProteinModelPortaliP61954.
SMRiP61954. Positions 9-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014616.

PTM databases

PhosphoSiteiP61954.

Proteomic databases

PaxDbiP61954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469.
ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914.
GeneIDi100912034.
64199.
KEGGirno:100912034.
rno:64199.
UCSCiRGD:621515. rat.

Organism-specific databases

CTDi2791.
RGDi621515. Gng11.

Phylogenomic databases

eggNOGiNOG250223.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61954.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61954.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_231505. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_232206. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_235881. Glucagon-type ligand receptors.
REACT_255871. Glucagon signaling in metabolic regulation.
REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

NextBioi612880.
PROiP61954.

Gene expression databases

GenevestigatoriP61954.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of rat G protein gamma 11 subunit."
    Costain W.J., Mishra R.K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGBG11_RAT
AccessioniPrimary (citable) accession number: P61954
Secondary accession number(s): P50152, Q4V8M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.