P61954 (GBG11_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene names

Name:	Gng11
Synonyms:	Gngt11

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	73 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.
Subunit structure	G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 By similarity.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential.
Sequence similarities	Belongs to the G protein gamma family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Molecular function	Transducer
PTM	Lipoprotein Methylation Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 70	70	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11		PRO_0000012663
	Propeptide	71 – 73	3	Removed in mature form By similarity		PRO_0000012664
Amino acid modifications
	Modified residue	70	1	Cysteine methyl ester Potential
	Lipidation	70	1	S-farnesyl cysteine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P61954 [UniParc]. Last modified June 7, 2004. Version 1. Checksum: 2B13935E3AEFB9E8	FASTA	73	8,481
	10 20 30 40 50 60 MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED 70 KNPFKEKGSC VIS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and cloning of rat G protein gamma 11 subunit." Costain W.J., Mishra R.K. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF257110 mRNA. Translation: AAF68984.1. BC097320 mRNA. Translation: AAH97320.1.
IPI	IPI00195552.
RefSeq	NP_071791.1. NM_022396.2. XP_003749746.1. XM_003749698.1.
UniGene	Rn.892.
3D structure databases
ProteinModelPortal	P61954.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000014616.
PTM databases
PhosphoSite	P61954.
Proteomic databases
PaxDb	P61954.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469. ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914.
GeneID	100912034. 64199.
KEGG	rno:100912034. rno:64199.
UCSC	RGD:621515. rat.
Organism-specific databases
CTD	2791.
RGD	621515. Gng11.
Phylogenomic databases
eggNOG	NOG250223.
GeneTree	ENSGT00530000063397.
HOGENOM	HOG000231034.
HOVERGEN	HBG014983.
InParanoid	P61954.
KO	K04546.
OMA	QPVSKCS.
OrthoDB	EOG4TMR3S.
Gene expression databases
Genevestigator	P61954.
GermOnline	ENSRNOG00000010946. Rattus norvegicus.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	612880.

Entry information

Entry name

GBG11_RAT

Accession

Primary (citable) accession number: P61954
Secondary accession number(s): P50152, Q4V8M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program