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P61954

- GBG11_RAT

UniProt

P61954 - GBG11_RAT

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

Gng11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_231505. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_232206. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_235881. Glucagon-type ligand receptors.
REACT_255871. Glucagon signaling in metabolic regulation.
REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:Gng11
Synonyms:Gngt11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi621515. Gng11.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11PRO_0000012663Add
BLAST
Propeptidei71 – 733Removed in mature formBy similarityPRO_0000012664

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Cysteine methyl esterSequence Analysis
Lipidationi70 – 701S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP61954.

PTM databases

PhosphoSiteiP61954.

Expressioni

Gene expression databases

GenevestigatoriP61954.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014616.

Structurei

3D structure databases

ProteinModelPortaliP61954.
SMRiP61954. Positions 9-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG250223.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61954.
KOiK04546.
OMAiRQPVSKC.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61954.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61954-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257110 mRNA. Translation: AAF68984.1.
BC097320 mRNA. Translation: AAH97320.1.
RefSeqiNP_071791.1. NM_022396.2.
XP_003749746.1. XM_003749698.3.
UniGeneiRn.892.

Genome annotation databases

EnsembliENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469.
ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914.
GeneIDi100912034.
64199.
KEGGirno:100912034.
rno:64199.
UCSCiRGD:621515. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257110 mRNA. Translation: AAF68984.1 .
BC097320 mRNA. Translation: AAH97320.1 .
RefSeqi NP_071791.1. NM_022396.2.
XP_003749746.1. XM_003749698.3.
UniGenei Rn.892.

3D structure databases

ProteinModelPortali P61954.
SMRi P61954. Positions 9-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000014616.

PTM databases

PhosphoSitei P61954.

Proteomic databases

PaxDbi P61954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000074048 ; ENSRNOP00000065818 ; ENSRNOG00000050469 .
ENSRNOT00000075326 ; ENSRNOP00000066965 ; ENSRNOG00000047914 .
GeneIDi 100912034.
64199.
KEGGi rno:100912034.
rno:64199.
UCSCi RGD:621515. rat.

Organism-specific databases

CTDi 2791.
RGDi 621515. Gng11.

Phylogenomic databases

eggNOGi NOG250223.
GeneTreei ENSGT00530000063397.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P61954.
KOi K04546.
OMAi RQPVSKC.
OrthoDBi EOG7H1JP7.
PhylomeDBi P61954.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_231505. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_232206. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_235881. Glucagon-type ligand receptors.
REACT_255871. Glucagon signaling in metabolic regulation.
REACT_259181. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

NextBioi 612880.
PROi P61954.

Gene expression databases

Genevestigatori P61954.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of rat G protein gamma 11 subunit."
    Costain W.J., Mishra R.K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiGBG11_RAT
AccessioniPrimary (citable) accession number: P61954
Secondary accession number(s): P50152, Q4V8M0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3