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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

Gng11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer

Enzyme and pathway databases

ReactomeiR-RNO-202040 G-protein activation
R-RNO-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-RNO-392170 ADP signalling through P2Y purinoceptor 12
R-RNO-392451 G beta:gamma signalling through PI3Kgamma
R-RNO-392851 Prostacyclin signalling through prostacyclin receptor
R-RNO-400042 Adrenaline,noradrenaline inhibits insulin secretion
R-RNO-4086398 Ca2+ pathway
R-RNO-416476 G alpha (q) signalling events
R-RNO-416482 G alpha (12/13) signalling events
R-RNO-418217 G beta:gamma signalling through PLC beta
R-RNO-418555 G alpha (s) signalling events
R-RNO-418592 ADP signalling through P2Y purinoceptor 1
R-RNO-418594 G alpha (i) signalling events
R-RNO-418597 G alpha (z) signalling events
R-RNO-420092 Glucagon-type ligand receptors
R-RNO-428930 Thromboxane signalling through TP receptor
R-RNO-456926 Thrombin signalling through proteinase activated receptors (PARs)
R-RNO-500657 Presynaptic function of Kainate receptors
R-RNO-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:Gng11
Synonyms:Gngt11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi621515 Gng11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126631 – 70Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11Add BLAST70
PropeptideiPRO_000001266471 – 73Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70Cysteine methyl esterSequence analysis1
Lipidationi70S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP61954

PTM databases

PhosphoSitePlusiP61954

Expressioni

Gene expression databases

BgeeiENSRNOG00000047914
GenevisibleiP61954 RN

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066965

Structurei

3D structure databases

ProteinModelPortaliP61954
SMRiP61954
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
GeneTreeiENSGT00530000063397
HOGENOMiHOG000231034
HOVERGENiHBG014983
InParanoidiP61954
KOiK04546
OMAiMPAINIE
OrthoDBiEOG091G17J0
PhylomeDBiP61954
TreeFamiTF319909

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257110 mRNA Translation: AAF68984.1
BC097320 mRNA Translation: AAH97320.1
RefSeqiNP_071791.1, NM_022396.2
XP_003749746.1, XM_003749698.3
UniGeneiRn.892

Genome annotation databases

EnsembliENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469
ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914
GeneIDi100912034
64199
KEGGirno:100912034
rno:64199
UCSCiRGD:621515 rat

Similar proteinsi

Entry informationi

Entry nameiGBG11_RAT
AccessioniPrimary (citable) accession number: P61954
Secondary accession number(s): P50152, Q4V8M0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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