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P61954 (GBG11_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene names
Name:Gng11
Synonyms:Gngt11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length73 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.

Subunit structure

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Sequence similarities

Belongs to the G protein gamma family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Molecular functionTransducer
   PTMLipoprotein
Methylation
Prenylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentheterotrimeric G-protein complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionsignal transducer activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
PRO_0000012663
Propeptide71 – 733Removed in mature form By similarity
PRO_0000012664

Amino acid modifications

Modified residue701Cysteine methyl ester Potential
Lipidation701S-farnesyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P61954 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: 2B13935E3AEFB9E8

FASTA738,481
        10         20         30         40         50         60 
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE DPLVKGIPED 

        70 
KNPFKEKGSC VIS 

« Hide

References

« Hide 'large scale' references
[1]"Identification and cloning of rat G protein gamma 11 subunit."
Costain W.J., Mishra R.K.
Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF257110 mRNA. Translation: AAF68984.1.
BC097320 mRNA. Translation: AAH97320.1.
RefSeqNP_071791.1. NM_022396.2.
XP_003749746.1. XM_003749698.2.
UniGeneRn.892.

3D structure databases

ProteinModelPortalP61954.
SMRP61954. Positions 9-66.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000014616.

PTM databases

PhosphoSiteP61954.

Proteomic databases

PaxDbP61954.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000074048; ENSRNOP00000065818; ENSRNOG00000050469.
ENSRNOT00000075326; ENSRNOP00000066965; ENSRNOG00000047914.
GeneID100912034.
64199.
KEGGrno:100912034.
rno:64199.
UCSCRGD:621515. rat.

Organism-specific databases

CTD2791.
RGD621515. Gng11.

Phylogenomic databases

eggNOGNOG250223.
GeneTreeENSGT00530000063397.
HOGENOMHOG000231034.
HOVERGENHBG014983.
InParanoidP61954.
KOK04546.
OMARQPVSKC.
OrthoDBEOG7H1JP7.
PhylomeDBP61954.
TreeFamTF319909.

Gene expression databases

GenevestigatorP61954.

Family and domain databases

Gene3D4.10.260.10. 1 hit.
InterProIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERPTHR13809. PTHR13809. 1 hit.
PfamPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSPR00321. GPROTEING.
SMARTSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMSSF48670. SSF48670. 1 hit.
PROSITEPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio612880.
PROP61954.

Entry information

Entry nameGBG11_RAT
AccessionPrimary (citable) accession number: P61954
Secondary accession number(s): P50152, Q4V8M0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families