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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

Gng11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:Gng11
Synonyms:Gngt11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1913316. Gng11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000126611 – 70Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11Add BLAST70
PropeptideiPRO_000001266271 – 73Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei70Cysteine methyl esterSequence analysis1
Lipidationi70S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61953.
PaxDbiP61953.
PRIDEiP61953.

PTM databases

PhosphoSitePlusiP61953.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032766.
GenevisibleiP61953. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211189. 1 interactor.
STRINGi10090.ENSMUSP00000031670.

Structurei

3D structure databases

ProteinModelPortaliP61953.
SMRiP61953.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61953.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG091G17J0.
PhylomeDBiP61953.
TreeFamiTF319909.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002765 mRNA. Translation: BAB22340.1.
AK009529 mRNA. Translation: BAB26342.1.
BC039062 mRNA. Translation: AAH39062.1.
BC040065 mRNA. Translation: AAH40065.1.
CCDSiCCDS39419.1.
RefSeqiNP_079607.1. NM_025331.2.
UniGeneiMm.25547.

Genome annotation databases

EnsembliENSMUST00000031670; ENSMUSP00000031670; ENSMUSG00000032766.
GeneIDi66066.
KEGGimmu:66066.
UCSCiuc009avj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002765 mRNA. Translation: BAB22340.1.
AK009529 mRNA. Translation: BAB26342.1.
BC039062 mRNA. Translation: AAH39062.1.
BC040065 mRNA. Translation: AAH40065.1.
CCDSiCCDS39419.1.
RefSeqiNP_079607.1. NM_025331.2.
UniGeneiMm.25547.

3D structure databases

ProteinModelPortaliP61953.
SMRiP61953.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211189. 1 interactor.
STRINGi10090.ENSMUSP00000031670.

PTM databases

PhosphoSitePlusiP61953.

Proteomic databases

MaxQBiP61953.
PaxDbiP61953.
PRIDEiP61953.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031670; ENSMUSP00000031670; ENSMUSG00000032766.
GeneIDi66066.
KEGGimmu:66066.
UCSCiuc009avj.2. mouse.

Organism-specific databases

CTDi2791.
MGIiMGI:1913316. Gng11.

Phylogenomic databases

eggNOGiKOG4119. Eukaryota.
ENOG41122JF. LUCA.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61953.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG091G17J0.
PhylomeDBiP61953.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-400042. Adrenaline,noradrenaline inhibits insulin secretion.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.

Miscellaneous databases

PROiP61953.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032766.
GenevisibleiP61953. MM.

Family and domain databases

CDDicd00068. GGL. 1 hit.
Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGBG11_MOUSE
AccessioniPrimary (citable) accession number: P61953
Secondary accession number(s): P50152, Q4QRN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.