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P61953

- GBG11_MOUSE

UniProt

P61953 - GBG11_MOUSE

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene
Gng11, Gngt11
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity.

GO - Molecular functioni

  1. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:Gng11
Synonyms:Gngt11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1913316. Gng11.

Subcellular locationi

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11PRO_0000012661Add
BLAST
Propeptidei71 – 733Removed in mature form By similarityPRO_0000012662

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Cysteine methyl ester Reviewed prediction
Lipidationi70 – 701S-farnesyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61953.
PaxDbiP61953.
PRIDEiP61953.

PTM databases

PhosphoSiteiP61953.

Expressioni

Gene expression databases

BgeeiP61953.
GenevestigatoriP61953.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2 By similarity.

Protein-protein interaction databases

BioGridi211189. 1 interaction.
STRINGi10090.ENSMUSP00000031670.

Structurei

3D structure databases

ProteinModelPortaliP61953.
SMRiP61953. Positions 9-66.

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.

Phylogenomic databases

eggNOGiNOG250223.
GeneTreeiENSGT00530000063397.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61953.
KOiK04546.
OMAiRQPVSKC.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61953.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61953-1 [UniParc]FASTAAdd to Basket

« Hide

MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE   50
DPLVKGIPED KNPFKEKGSC VIS 73
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002765 mRNA. Translation: BAB22340.1.
AK009529 mRNA. Translation: BAB26342.1.
BC039062 mRNA. Translation: AAH39062.1.
BC040065 mRNA. Translation: AAH40065.1.
CCDSiCCDS39419.1.
RefSeqiNP_079607.1. NM_025331.2.
UniGeneiMm.25547.

Genome annotation databases

EnsembliENSMUST00000031670; ENSMUSP00000031670; ENSMUSG00000032766.
GeneIDi66066.
KEGGimmu:66066.
UCSCiuc009avj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK002765 mRNA. Translation: BAB22340.1 .
AK009529 mRNA. Translation: BAB26342.1 .
BC039062 mRNA. Translation: AAH39062.1 .
BC040065 mRNA. Translation: AAH40065.1 .
CCDSi CCDS39419.1.
RefSeqi NP_079607.1. NM_025331.2.
UniGenei Mm.25547.

3D structure databases

ProteinModelPortali P61953.
SMRi P61953. Positions 9-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211189. 1 interaction.
STRINGi 10090.ENSMUSP00000031670.

PTM databases

PhosphoSitei P61953.

Proteomic databases

MaxQBi P61953.
PaxDbi P61953.
PRIDEi P61953.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000031670 ; ENSMUSP00000031670 ; ENSMUSG00000032766 .
GeneIDi 66066.
KEGGi mmu:66066.
UCSCi uc009avj.2. mouse.

Organism-specific databases

CTDi 2791.
MGIi MGI:1913316. Gng11.

Phylogenomic databases

eggNOGi NOG250223.
GeneTreei ENSGT00530000063397.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P61953.
KOi K04546.
OMAi RQPVSKC.
OrthoDBi EOG7H1JP7.
PhylomeDBi P61953.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_221970. Ca2+ pathway.

Miscellaneous databases

NextBioi 10997.
PROi P61953.
SOURCEi Search...

Gene expression databases

Bgeei P61953.
Genevestigatori P61953.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Tongue.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and FVB/N.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 24-30, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiGBG11_MOUSE
AccessioniPrimary (citable) accession number: P61953
Secondary accession number(s): P50152, Q4QRN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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