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P61952

- GBG11_HUMAN

UniProt

P61952 - GBG11_HUMAN

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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

GNG11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  1. GTPase activity Source: ProtInc
  2. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. cellular response to glucagon stimulus Source: Reactome
  2. energy reserve metabolic process Source: Reactome
  3. G-protein coupled receptor signaling pathway Source: InterPro
  4. GTP catabolic process Source: GOC
  5. signal transduction Source: ProtInc
  6. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:GNG11
Synonyms:GNGT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:4403. GNG11.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. heterotrimeric G-protein complex Source: InterPro
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28782.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11PRO_0000012659Add
BLAST
Propeptidei71 – 733Removed in mature formPRO_0000012660

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Cysteine methyl esterSequence Analysis
Lipidationi70 – 701S-farnesyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61952.
PaxDbiP61952.
PRIDEiP61952.

PTM databases

PhosphoSiteiP61952.

Expressioni

Tissue specificityi

Abundantly expressed in all tissues tested except for brain.

Gene expression databases

BgeeiP61952.
CleanExiHS_GNG11.
ExpressionAtlasiP61952. baseline and differential.
GenevestigatoriP61952.

Organism-specific databases

HPAiHPA045255.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

Protein-protein interaction databases

BioGridi109053. 6 interactions.
IntActiP61952. 3 interactions.
MINTiMINT-1424708.
STRINGi9606.ENSP00000248564.

Structurei

3D structure databases

ProteinModelPortaliP61952.
SMRiP61952. Positions 9-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG250223.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61952.
KOiK04546.
OMAiLMESKIG.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61952.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61952-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31384 mRNA. Translation: AAC50206.1.
AF493878 mRNA. Translation: AAM12592.1.
AC002076 Genomic DNA. Translation: AAS02020.1.
BC009709 mRNA. Translation: AAH09709.1.
CCDSiCCDS5634.1.
PIRiI39159.
RefSeqiNP_004117.1. NM_004126.3.
UniGeneiHs.83381.

Genome annotation databases

EnsembliENST00000248564; ENSP00000248564; ENSG00000127920.
GeneIDi2791.
KEGGihsa:2791.
UCSCiuc003und.3. human.

Polymorphism databases

DMDMi48428913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U31384 mRNA. Translation: AAC50206.1 .
AF493878 mRNA. Translation: AAM12592.1 .
AC002076 Genomic DNA. Translation: AAS02020.1 .
BC009709 mRNA. Translation: AAH09709.1 .
CCDSi CCDS5634.1.
PIRi I39159.
RefSeqi NP_004117.1. NM_004126.3.
UniGenei Hs.83381.

3D structure databases

ProteinModelPortali P61952.
SMRi P61952. Positions 9-66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109053. 6 interactions.
IntActi P61952. 3 interactions.
MINTi MINT-1424708.
STRINGi 9606.ENSP00000248564.

PTM databases

PhosphoSitei P61952.

Polymorphism databases

DMDMi 48428913.

Proteomic databases

MaxQBi P61952.
PaxDbi P61952.
PRIDEi P61952.

Protocols and materials databases

DNASUi 2791.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000248564 ; ENSP00000248564 ; ENSG00000127920 .
GeneIDi 2791.
KEGGi hsa:2791.
UCSCi uc003und.3. human.

Organism-specific databases

CTDi 2791.
GeneCardsi GC07P093551.
HGNCi HGNC:4403. GNG11.
HPAi HPA045255.
MIMi 604390. gene.
neXtProti NX_P61952.
PharmGKBi PA28782.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG250223.
HOGENOMi HOG000231034.
HOVERGENi HBG014983.
InParanoidi P61952.
KOi K04546.
OMAi LMESKIG.
OrthoDBi EOG7H1JP7.
PhylomeDBi P61952.
TreeFami TF319909.

Enzyme and pathway databases

Reactomei REACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_172761. Ca2+ pathway.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Regulation of water balance by renal Aquaporins.

Miscellaneous databases

GeneWikii GNG11.
GenomeRNAii 2791.
NextBioi 10997.
PROi P61952.
SOURCEi Search...

Gene expression databases

Bgeei P61952.
CleanExi HS_GNG11.
ExpressionAtlasi P61952. baseline and differential.
Genevestigatori P61952.

Family and domain databases

Gene3Di 4.10.260.10. 1 hit.
InterProi IPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view ]
PANTHERi PTHR13809. PTHR13809. 1 hit.
Pfami PF00631. G-gamma. 1 hit.
[Graphical view ]
PRINTSi PR00321. GPROTEING.
SMARTi SM00224. GGL. 1 hit.
[Graphical view ]
SUPFAMi SSF48670. SSF48670. 1 hit.
PROSITEi PS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits."
    Ray K., Kunsch C., Bonner L.M., Robishaw J.D.
    J. Biol. Chem. 270:21765-21771(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-70.
    Tissue: Testis.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiGBG11_HUMAN
AccessioniPrimary (citable) accession number: P61952
Secondary accession number(s): P50152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3