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Protein

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11

Gene

GNG11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • signal transducer activity Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transducer

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_263982. Ca2+ pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11
Gene namesi
Name:GNG11
Synonyms:GNGT11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:4403. GNG11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28782.

Polymorphism and mutation databases

BioMutaiGNG11.
DMDMi48428913.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7070Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11PRO_0000012659Add
BLAST
Propeptidei71 – 733Removed in mature formPRO_0000012660

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei70 – 701Cysteine methyl esterSequence Analysis
Lipidationi70 – 701S-farnesyl cysteine1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

MaxQBiP61952.
PaxDbiP61952.
PRIDEiP61952.

PTM databases

PhosphoSiteiP61952.

Expressioni

Tissue specificityi

Abundantly expressed in all tissues tested except for brain.

Gene expression databases

BgeeiP61952.
CleanExiHS_GNG11.
ExpressionAtlasiP61952. baseline and differential.
GenevisibleiP61952. HS.

Organism-specific databases

HPAiHPA045255.

Interactioni

Subunit structurei

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with beta-1 and beta-3, but not with beta-2.

Protein-protein interaction databases

BioGridi109053. 9 interactions.
IntActiP61952. 3 interactions.
MINTiMINT-1424708.
STRINGi9606.ENSP00000248564.

Structurei

3D structure databases

ProteinModelPortaliP61952.
SMRiP61952. Positions 9-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G protein gamma family.Curated

Phylogenomic databases

eggNOGiNOG250223.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61952.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61952.
TreeFamiTF319909.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALHIEDLP EKEKLKMEVE QLRKEVKLQR QQVSKCSEEI KNYIEERSGE
60 70
DPLVKGIPED KNPFKEKGSC VIS
Length:73
Mass (Da):8,481
Last modified:June 7, 2004 - v1
Checksum:i2B13935E3AEFB9E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31384 mRNA. Translation: AAC50206.1.
AF493878 mRNA. Translation: AAM12592.1.
AC002076 Genomic DNA. Translation: AAS02020.1.
BC009709 mRNA. Translation: AAH09709.1.
CCDSiCCDS5634.1.
PIRiI39159.
RefSeqiNP_004117.1. NM_004126.3.
UniGeneiHs.83381.

Genome annotation databases

EnsembliENST00000248564; ENSP00000248564; ENSG00000127920.
GeneIDi2791.
KEGGihsa:2791.
UCSCiuc003und.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31384 mRNA. Translation: AAC50206.1.
AF493878 mRNA. Translation: AAM12592.1.
AC002076 Genomic DNA. Translation: AAS02020.1.
BC009709 mRNA. Translation: AAH09709.1.
CCDSiCCDS5634.1.
PIRiI39159.
RefSeqiNP_004117.1. NM_004126.3.
UniGeneiHs.83381.

3D structure databases

ProteinModelPortaliP61952.
SMRiP61952. Positions 9-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109053. 9 interactions.
IntActiP61952. 3 interactions.
MINTiMINT-1424708.
STRINGi9606.ENSP00000248564.

PTM databases

PhosphoSiteiP61952.

Polymorphism and mutation databases

BioMutaiGNG11.
DMDMi48428913.

Proteomic databases

MaxQBiP61952.
PaxDbiP61952.
PRIDEiP61952.

Protocols and materials databases

DNASUi2791.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000248564; ENSP00000248564; ENSG00000127920.
GeneIDi2791.
KEGGihsa:2791.
UCSCiuc003und.3. human.

Organism-specific databases

CTDi2791.
GeneCardsiGC07P093551.
HGNCiHGNC:4403. GNG11.
HPAiHPA045255.
MIMi604390. gene.
neXtProtiNX_P61952.
PharmGKBiPA28782.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG250223.
HOGENOMiHOG000231034.
HOVERGENiHBG014983.
InParanoidiP61952.
KOiK04546.
OMAiMPAINIE.
OrthoDBiEOG7H1JP7.
PhylomeDBiP61952.
TreeFamiTF319909.

Enzyme and pathway databases

ReactomeiREACT_15457. G-protein activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_18274. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
REACT_18283. G alpha (q) signalling events.
REACT_18339. Adrenaline,noradrenaline inhibits insulin secretion.
REACT_18377. Glucagon-type ligand receptors.
REACT_18407. G alpha (12/13) signalling events.
REACT_19140. ADP signalling through P2Y purinoceptor 1.
REACT_19145. G beta:gamma signalling through PLC beta.
REACT_19231. G alpha (i) signalling events.
REACT_19290. G beta:gamma signalling through PI3Kgamma.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_20647. Thromboxane signalling through TP receptor.
REACT_20653. ADP signalling through P2Y purinoceptor 12.
REACT_21254. Presynaptic function of Kainate receptors.
REACT_21384. Thrombin signalling through proteinase activated receptors (PARs).
REACT_23946. Prostacyclin signalling through prostacyclin receptor.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_263982. Ca2+ pathway.

Miscellaneous databases

GeneWikiiGNG11.
GenomeRNAii2791.
NextBioi10997.
PROiP61952.
SOURCEiSearch...

Gene expression databases

BgeeiP61952.
CleanExiHS_GNG11.
ExpressionAtlasiP61952. baseline and differential.
GenevisibleiP61952. HS.

Family and domain databases

Gene3Di4.10.260.10. 1 hit.
InterProiIPR015898. G-protein_gamma-like_dom.
IPR001770. Gprotein-gamma.
[Graphical view]
PANTHERiPTHR13809. PTHR13809. 1 hit.
PfamiPF00631. G-gamma. 1 hit.
[Graphical view]
PRINTSiPR00321. GPROTEING.
SMARTiSM00224. GGL. 1 hit.
[Graphical view]
SUPFAMiSSF48670. SSF48670. 1 hit.
PROSITEiPS50058. G_PROTEIN_GAMMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits."
    Ray K., Kunsch C., Bonner L.M., Robishaw J.D.
    J. Biol. Chem. 270:21765-21771(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ISOPRENYLATION AT CYS-70.
    Tissue: Testis.
  2. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiGBG11_HUMAN
AccessioniPrimary (citable) accession number: P61952
Secondary accession number(s): P50152
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 24, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.