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Protein

Flavodoxin-1

Gene

fldA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Low-potential electron donor to a number of redox enzymes (Potential). Involved in the reactivation of inactive cob(II)alamin in methionine synthase.Curated1 Publication

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciEcoCyc:FLAVODOXIN1-MONOMER.
ECOL316407:JW0671-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Flavodoxin-1
Gene namesi
Name:fldA
Ordered Locus Names:b0684, JW0671
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10318. fldA.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001716222 – 176Flavodoxin-1Add BLAST175

Proteomic databases

EPDiP61949.
PaxDbiP61949.
PRIDEiP61949.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
recXP335963EBI-550021,EBI-1129990
ydaWP760662EBI-550021,EBI-9142914

Protein-protein interaction databases

BioGridi4261909. 10 interactors.
DIPiDIP-48242N.
IntActiP61949. 29 interactors.
MINTiMINT-1239730.
STRINGi511145.b0684.

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 8Combined sources5
Beta strandi11 – 13Combined sources3
Helixi14 – 26Combined sources13
Turni28 – 30Combined sources3
Beta strandi31 – 35Combined sources5
Helixi36 – 38Combined sources3
Helixi41 – 45Combined sources5
Beta strandi48 – 53Combined sources6
Turni58 – 60Combined sources3
Helixi64 – 73Combined sources10
Beta strandi82 – 88Combined sources7
Turni91 – 96Combined sources6
Helixi100 – 109Combined sources10
Turni110 – 113Combined sources4
Beta strandi114 – 117Combined sources4
Beta strandi133 – 135Combined sources3
Beta strandi138 – 144Combined sources7
Turni146 – 148Combined sources3
Turni150 – 152Combined sources3
Helixi153 – 168Combined sources16
Helixi170 – 173Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG9X-ray1.80A/B2-176[»]
1AHNX-ray2.60A2-176[»]
2MOKNMR-A1-176[»]
ProteinModelPortaliP61949.
SMRiP61949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 165Flavodoxin-likePROSITE-ProRule annotationAdd BLAST162

Sequence similaritiesi

Belongs to the flavodoxin family.Curated
Contains 1 flavodoxin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105MHQ. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030543.
InParanoidiP61949.
KOiK03839.
OMAiASKGMAD.
PhylomeDBiP61949.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR010086. Flavodoxin_lc.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038996. FldA. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01752. flav_long. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITGIFFGS DTGNTENIAK MIQKQLGKDV ADVHDIAKSS KEDLEAYDIL
60 70 80 90 100
LLGIPTWYYG EAQCDWDDFF PTLEEIDFNG KLVALFGCGD QEDYAEYFCD
110 120 130 140 150
ALGTIRDIIE PRGATIVGHW PTAGYHFEAS KGLADDDHFV GLAIDEDRQP
160 170
ELTAERVEKW VKQISEELHL DEILNA
Length:176
Mass (Da):19,737
Last modified:January 23, 2007 - v2
Checksum:i8878DA1A8EAA55BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59426 Genomic DNA. Translation: AAA23789.1.
U00096 Genomic DNA. Translation: AAC73778.1.
AP009048 Genomic DNA. Translation: BAA35333.1.
PIRiA37319.
RefSeqiNP_415210.1. NC_000913.3.
WP_001018618.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73778; AAC73778; b0684.
BAA35333; BAA35333; BAA35333.
GeneIDi945293.
KEGGiecj:JW0671.
eco:b0684.
PATRICi32116561. VBIEscCol129921_0713.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59426 Genomic DNA. Translation: AAA23789.1.
U00096 Genomic DNA. Translation: AAC73778.1.
AP009048 Genomic DNA. Translation: BAA35333.1.
PIRiA37319.
RefSeqiNP_415210.1. NC_000913.3.
WP_001018618.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AG9X-ray1.80A/B2-176[»]
1AHNX-ray2.60A2-176[»]
2MOKNMR-A1-176[»]
ProteinModelPortaliP61949.
SMRiP61949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261909. 10 interactors.
DIPiDIP-48242N.
IntActiP61949. 29 interactors.
MINTiMINT-1239730.
STRINGi511145.b0684.

Proteomic databases

EPDiP61949.
PaxDbiP61949.
PRIDEiP61949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73778; AAC73778; b0684.
BAA35333; BAA35333; BAA35333.
GeneIDi945293.
KEGGiecj:JW0671.
eco:b0684.
PATRICi32116561. VBIEscCol129921_0713.

Organism-specific databases

EchoBASEiEB0314.
EcoGeneiEG10318. fldA.

Phylogenomic databases

eggNOGiENOG4105MHQ. Bacteria.
COG0716. LUCA.
HOGENOMiHOG000030543.
InParanoidiP61949.
KOiK03839.
OMAiASKGMAD.
PhylomeDBiP61949.

Enzyme and pathway databases

BioCyciEcoCyc:FLAVODOXIN1-MONOMER.
ECOL316407:JW0671-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP61949.
PROiP61949.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR001226. Flavodoxin_CS.
IPR010086. Flavodoxin_lc.
IPR029039. Flavoprotein-like_dom.
[Graphical view]
PfamiPF00258. Flavodoxin_1. 1 hit.
[Graphical view]
PIRSFiPIRSF038996. FldA. 1 hit.
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01752. flav_long. 1 hit.
PROSITEiPS00201. FLAVODOXIN. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFLAV_ECOLI
AccessioniPrimary (citable) accession number: P61949
Secondary accession number(s): P23243
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.