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Protein

Type 2 lactosamine alpha-2,3-sialyltransferase

Gene

St3gal6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 lactosamine alpha-2,3-sialyltransferase (EC:2.4.99.-)
Alternative name(s):
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
Short name:
ST3GalVI
Sialyltransferase 10
Gene namesi
Name:St3gal6
Synonyms:Siat10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1303279 St3gal6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini26 – 331LumenalSequence analysisAdd BLAST306

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493081 – 331Type 2 lactosamine alpha-2,3-sialyltransferaseAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP61943
PRIDEiP61943

PTM databases

iPTMnetiP61943
PhosphoSitePlusiP61943

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002255

Structurei

3D structure databases

SMRiP61943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
HOGENOMiHOG000000682
HOVERGENiHBG056676
InParanoidiP61943
PhylomeDBiP61943

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequencei

Sequence statusi: Complete.

P61943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGYVVAIFL SSIFLYYVLY CILWGTNGYW FPNEEMKSKN NVKNCFKKPA
60 70 80 90 100
FASLLRFPQF YPFLCKADFV KVAATYGTNN FLLPYGVKTF ESYFRSGLSK
110 120 130 140 150
LQSCDLVGQF DTVPCKRCVV VGNGGVLKNK TLGAKIDSYD VIIRMNNGPV
160 170 180 190 200
LGHEEEVGKR TTFRLFYPES VFSDPSHYDP NTTAVLVVFK PQDLRWLMEI
210 220 230 240 250
LIGKKINTDG FWKKPALKLI YKQYQIRILD PYIIREAAFQ LLRFPRVFPK
260 270 280 290 300
DQKPKHPTTG IIALTLAFHI CSEVHLAGFK YNFYTPDSPL HYYGNATMSL
310 320 330
MKKNAYHNLT AEQLFLKNLI KKKMVINLTQ N
Length:331
Mass (Da):38,145
Last modified:June 7, 2004 - v1
Checksum:iDAFCC3BB681C1C8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ626743 mRNA Translation: CAF25053.1
UniGeneiRn.32316

Genome annotation databases

UCSCiRGD:1303279 rat

Similar proteinsi

Entry informationi

Entry nameiSIA10_RAT
AccessioniPrimary (citable) accession number: P61943
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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