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P61941

- RS12_THET2

UniProt

P61941 - RS12_THET2

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Protein
30S ribosomal protein S12
Gene
rpsL, rps12, TT_C1333
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

With S4 and S5 plays an important role in translational accuracy By similarity.UniRule annotation
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
  3. tRNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding, tRNA-binding

Enzyme and pathway databases

BioCyciTTHE262724:GCAT-1348-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S12
Gene namesi
Name:rpsL
Synonyms:rps12
Ordered Locus Names:TT_C1333
OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Taxonomic identifieri262724 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
ProteomesiUP000000592: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. small ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 13213130S ribosomal protein S12UniRule annotation
PRO_0000146340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei89 – 8913-methylthioaspartic acid By similarity

Proteomic databases

PRIDEiP61941.

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 85
Turni24 – 263
Beta strandi30 – 4011
Turni43 – 453
Beta strandi50 – 578
Beta strandi63 – 664
Beta strandi68 – 714
Beta strandi79 – 824
Beta strandi90 – 923
Beta strandi95 – 973
Beta strandi99 – 1013
Beta strandi106 – 1094
Helixi114 – 1174

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2QNHX-ray3.83m1-132[»]
2R1Gelectron microscopy-H2-125[»]
3D5AX-ray3.21L1-132[»]
3D5CX-ray3.21L1-132[»]
3F1EX-ray3.00L1-132[»]
3F1GX-ray3.00L1-132[»]
3MR8X-ray3.62L2-125[»]
3MS0X-ray3.62L2-125[»]
3PYNX-ray3.50L2-125[»]
3PYQX-ray3.50L2-125[»]
3PYSX-ray3.40L2-125[»]
3PYUX-ray3.40L2-125[»]
4KBTX-ray3.86L2-126[»]
4KBVX-ray3.86L2-126[»]
4KCYX-ray3.50L2-126[»]
4KD0X-ray3.50L2-126[»]
4KD8X-ray3.50L2-126[»]
4KDAX-ray3.50L2-126[»]
4KDGX-ray4.00L2-126[»]
4KDJX-ray4.00L2-126[»]
4KFHX-ray3.40L2-123[»]
4KFKX-ray3.40L2-123[»]
4KVBX-ray4.20L1-132[»]
4L6KX-ray3.40L2-123[»]
4L6MX-ray3.40L2-123[»]
ProteinModelPortaliP61941.
SMRiP61941. Positions 2-126.

Miscellaneous databases

EvolutionaryTraceiP61941.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0048.
KOiK02950.
OMAiCLVISIN.
OrthoDBiEOG61ZTNF.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00403_B. Ribosomal_S12_B.
InterProiIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERiPTHR11652. PTHR11652. 1 hit.
PfamiPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSiPR01034. RIBOSOMALS12.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61941-1 [UniParc]FASTAAdd to Basket

« Hide

MPTINQLVRK GREKVRKKSK VPALKGAPFR RGVCTVVRTV TPKKPNSALR    50
KVAKVRLTSG YEVTAYIPGE GHNLQEHSVV LIRGGRVKDL PGVRYHIVRG 100
VYDAAGVKDR KKSRSKYGTK KPKEAAKTAA KK 132
Length:132
Mass (Da):14,599
Last modified:January 23, 2007 - v2
Checksum:i9943D095FAD4D9BC
GO

Sequence cautioni

The sequence AAS81675.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81675.1. Different initiation.
RefSeqiYP_005302.1. NC_005835.1.

Genome annotation databases

EnsemblBacteriaiAAS81675; AAS81675; TT_C1333.
GeneIDi2774934.
KEGGitth:TTC1333.
PATRICi23953073. VBITheThe54392_1325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017221 Genomic DNA. Translation: AAS81675.1 . Different initiation.
RefSeqi YP_005302.1. NC_005835.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2QNH X-ray 3.83 m 1-132 [» ]
2R1G electron microscopy - H 2-125 [» ]
3D5A X-ray 3.21 L 1-132 [» ]
3D5C X-ray 3.21 L 1-132 [» ]
3F1E X-ray 3.00 L 1-132 [» ]
3F1G X-ray 3.00 L 1-132 [» ]
3MR8 X-ray 3.62 L 2-125 [» ]
3MS0 X-ray 3.62 L 2-125 [» ]
3PYN X-ray 3.50 L 2-125 [» ]
3PYQ X-ray 3.50 L 2-125 [» ]
3PYS X-ray 3.40 L 2-125 [» ]
3PYU X-ray 3.40 L 2-125 [» ]
4KBT X-ray 3.86 L 2-126 [» ]
4KBV X-ray 3.86 L 2-126 [» ]
4KCY X-ray 3.50 L 2-126 [» ]
4KD0 X-ray 3.50 L 2-126 [» ]
4KD8 X-ray 3.50 L 2-126 [» ]
4KDA X-ray 3.50 L 2-126 [» ]
4KDG X-ray 4.00 L 2-126 [» ]
4KDJ X-ray 4.00 L 2-126 [» ]
4KFH X-ray 3.40 L 2-123 [» ]
4KFK X-ray 3.40 L 2-123 [» ]
4KVB X-ray 4.20 L 1-132 [» ]
4L6K X-ray 3.40 L 2-123 [» ]
4L6M X-ray 3.40 L 2-123 [» ]
ProteinModelPortali P61941.
SMRi P61941. Positions 2-126.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P61941.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS81675 ; AAS81675 ; TT_C1333 .
GeneIDi 2774934.
KEGGi tth:TTC1333.
PATRICi 23953073. VBITheThe54392_1325.

Phylogenomic databases

eggNOGi COG0048.
KOi K02950.
OMAi CLVISIN.
OrthoDBi EOG61ZTNF.

Enzyme and pathway databases

BioCyci TTHE262724:GCAT-1348-MONOMER.

Miscellaneous databases

EvolutionaryTracei P61941.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00403_B. Ribosomal_S12_B.
InterProi IPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view ]
PANTHERi PTHR11652. PTHR11652. 1 hit.
Pfami PF00164. Ribosom_S12_S23. 1 hit.
[Graphical view ]
PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSi PR01034. RIBOSOMALS12.
SUPFAMi SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HB27 / ATCC BAA-163 / DSM 7039.

Entry informationi

Entry nameiRS12_THET2
AccessioniPrimary (citable) accession number: P61941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi