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P61941

- RS12_THET2

UniProt

P61941 - RS12_THET2

Protein

30S ribosomal protein S12

Gene

rpsL

Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    With S4 and S5 plays an important role in translational accuracy.By similarity
    Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity.By similarity

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro
    3. tRNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding, tRNA-binding

    Enzyme and pathway databases

    BioCyciTTHE262724:GCAT-1348-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    30S ribosomal protein S12
    Gene namesi
    Name:rpsL
    Synonyms:rps12
    Ordered Locus Names:TT_C1333
    OrganismiThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
    Taxonomic identifieri262724 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
    ProteomesiUP000000592: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. small ribosomal subunit Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 13213130S ribosomal protein S12PRO_0000146340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei89 – 8913-methylthioaspartic acidBy similarity

    Proteomic databases

    PRIDEiP61941.

    Interactioni

    Subunit structurei

    Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.By similarity

    Structurei

    Secondary structure

    1
    132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi4 – 85
    Turni24 – 263
    Beta strandi30 – 4011
    Turni43 – 453
    Beta strandi50 – 578
    Beta strandi63 – 664
    Beta strandi68 – 714
    Beta strandi79 – 824
    Beta strandi90 – 923
    Beta strandi95 – 973
    Beta strandi99 – 1013
    Beta strandi106 – 1094
    Helixi114 – 1174

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2QNHX-ray3.83m1-132[»]
    2R1Gelectron microscopy-H2-125[»]
    3D5AX-ray3.21L1-132[»]
    3D5CX-ray3.21L1-132[»]
    3F1EX-ray3.00L1-132[»]
    3F1GX-ray3.00L1-132[»]
    3MR8X-ray3.62L2-125[»]
    3MS0X-ray3.62L2-125[»]
    3PYNX-ray3.50L2-125[»]
    3PYQX-ray3.50L2-125[»]
    3PYSX-ray3.40L2-125[»]
    3PYUX-ray3.40L2-125[»]
    4KBTX-ray3.86L2-126[»]
    4KBVX-ray3.86L2-126[»]
    4KCYX-ray3.50L2-126[»]
    4KD0X-ray3.50L2-126[»]
    4KD8X-ray3.50L2-126[»]
    4KDAX-ray3.50L2-126[»]
    4KDGX-ray4.00L2-126[»]
    4KDJX-ray4.00L2-126[»]
    4KFHX-ray3.40L2-123[»]
    4KFKX-ray3.40L2-123[»]
    4KVBX-ray4.20L1-132[»]
    4L6KX-ray3.40L2-123[»]
    4L6MX-ray3.40L2-123[»]
    ProteinModelPortaliP61941.
    SMRiP61941. Positions 2-126.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP61941.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S12P family.Curated

    Phylogenomic databases

    eggNOGiCOG0048.
    KOiK02950.
    OMAiCLVISIN.
    OrthoDBiEOG61ZTNF.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00403_B. Ribosomal_S12_B.
    InterProiIPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view]
    PANTHERiPTHR11652. PTHR11652. 1 hit.
    PfamiPF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSiPR01034. RIBOSOMALS12.
    SUPFAMiSSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00981. rpsL_bact. 1 hit.
    PROSITEiPS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61941-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTINQLVRK GREKVRKKSK VPALKGAPFR RGVCTVVRTV TPKKPNSALR    50
    KVAKVRLTSG YEVTAYIPGE GHNLQEHSVV LIRGGRVKDL PGVRYHIVRG 100
    VYDAAGVKDR KKSRSKYGTK KPKEAAKTAA KK 132
    Length:132
    Mass (Da):14,599
    Last modified:January 23, 2007 - v2
    Checksum:i9943D095FAD4D9BC
    GO

    Sequence cautioni

    The sequence AAS81675.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81675.1. Different initiation.
    RefSeqiYP_005302.1. NC_005835.1.

    Genome annotation databases

    EnsemblBacteriaiAAS81675; AAS81675; TT_C1333.
    GeneIDi2774934.
    KEGGitth:TTC1333.
    PATRICi23953073. VBITheThe54392_1325.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE017221 Genomic DNA. Translation: AAS81675.1 . Different initiation.
    RefSeqi YP_005302.1. NC_005835.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2QNH X-ray 3.83 m 1-132 [» ]
    2R1G electron microscopy - H 2-125 [» ]
    3D5A X-ray 3.21 L 1-132 [» ]
    3D5C X-ray 3.21 L 1-132 [» ]
    3F1E X-ray 3.00 L 1-132 [» ]
    3F1G X-ray 3.00 L 1-132 [» ]
    3MR8 X-ray 3.62 L 2-125 [» ]
    3MS0 X-ray 3.62 L 2-125 [» ]
    3PYN X-ray 3.50 L 2-125 [» ]
    3PYQ X-ray 3.50 L 2-125 [» ]
    3PYS X-ray 3.40 L 2-125 [» ]
    3PYU X-ray 3.40 L 2-125 [» ]
    4KBT X-ray 3.86 L 2-126 [» ]
    4KBV X-ray 3.86 L 2-126 [» ]
    4KCY X-ray 3.50 L 2-126 [» ]
    4KD0 X-ray 3.50 L 2-126 [» ]
    4KD8 X-ray 3.50 L 2-126 [» ]
    4KDA X-ray 3.50 L 2-126 [» ]
    4KDG X-ray 4.00 L 2-126 [» ]
    4KDJ X-ray 4.00 L 2-126 [» ]
    4KFH X-ray 3.40 L 2-123 [» ]
    4KFK X-ray 3.40 L 2-123 [» ]
    4KVB X-ray 4.20 L 1-132 [» ]
    4L6K X-ray 3.40 L 2-123 [» ]
    4L6M X-ray 3.40 L 2-123 [» ]
    ProteinModelPortali P61941.
    SMRi P61941. Positions 2-126.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P61941.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAS81675 ; AAS81675 ; TT_C1333 .
    GeneIDi 2774934.
    KEGGi tth:TTC1333.
    PATRICi 23953073. VBITheThe54392_1325.

    Phylogenomic databases

    eggNOGi COG0048.
    KOi K02950.
    OMAi CLVISIN.
    OrthoDBi EOG61ZTNF.

    Enzyme and pathway databases

    BioCyci TTHE262724:GCAT-1348-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P61941.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00403_B. Ribosomal_S12_B.
    InterProi IPR012340. NA-bd_OB-fold.
    IPR006032. Ribosomal_S12/S23.
    IPR005679. Ribosomal_S12_bac.
    [Graphical view ]
    PANTHERi PTHR11652. PTHR11652. 1 hit.
    Pfami PF00164. Ribosom_S12_S23. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002133. Ribosomal_S12/S23. 1 hit.
    PRINTSi PR01034. RIBOSOMALS12.
    SUPFAMi SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00981. rpsL_bact. 1 hit.
    PROSITEi PS00055. RIBOSOMAL_S12. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HB27 / ATCC BAA-163 / DSM 7039.

    Entry informationi

    Entry nameiRS12_THET2
    AccessioniPrimary (citable) accession number: P61941
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3