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P61941 (RS12_THET2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
30S ribosomal protein S12
Gene names
Name:rpsL
Synonyms:rps12
Ordered Locus Names:TT_C1333
OrganismThermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) [Complete proteome] [HAMAP]
Taxonomic identifier262724 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

With S4 and S5 plays an important role in translational accuracy By similarity. HAMAP-Rule MF_00403_B

Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit By similarity. HAMAP-Rule MF_00403_B

Subunit structure

Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex By similarity.

Sequence similarities

Belongs to the ribosomal protein S12P family.

Sequence caution

The sequence AAS81675.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
tRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentsmall ribosomal subunit

Inferred from electronic annotation. Source: InterPro

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

tRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 13213130S ribosomal protein S12 HAMAP-Rule MF_00403_B
PRO_0000146340

Amino acid modifications

Modified residue8913-methylthioaspartic acid By similarity

Secondary structure

........................... 132
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P61941 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 9943D095FAD4D9BC

FASTA13214,599
        10         20         30         40         50         60 
MPTINQLVRK GREKVRKKSK VPALKGAPFR RGVCTVVRTV TPKKPNSALR KVAKVRLTSG 

        70         80         90        100        110        120 
YEVTAYIPGE GHNLQEHSVV LIRGGRVKDL PGVRYHIVRG VYDAAGVKDR KKSRSKYGTK 

       130 
KPKEAAKTAA KK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE017221 Genomic DNA. Translation: AAS81675.1. Different initiation.
RefSeqYP_005302.1. NC_005835.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2QNHX-ray3.83m1-132[»]
2R1Gelectron microscopy-H2-125[»]
3D5AX-ray3.21L2-132[»]
3D5CX-ray3.21L2-132[»]
3F1EX-ray3.00L2-132[»]
3F1GX-ray3.00L2-132[»]
3MR8X-ray3.62L2-125[»]
3MS0X-ray3.62L2-125[»]
3PYNX-ray3.50L2-125[»]
3PYQX-ray3.50L2-125[»]
3PYSX-ray3.40L2-125[»]
3PYUX-ray3.40L2-125[»]
4KBTX-ray3.86L2-126[»]
4KBVX-ray3.86L2-126[»]
4KCYX-ray3.50L2-126[»]
4KD0X-ray3.50L2-126[»]
4KD8X-ray3.50L2-126[»]
4KDAX-ray3.50L2-126[»]
4KDGX-ray4.00L2-126[»]
4KDJX-ray4.00L2-126[»]
4KFHX-ray3.40L2-123[»]
4KFKX-ray3.40L2-123[»]
4L6KX-ray3.40L2-123[»]
4L6MX-ray3.40L2-123[»]
ProteinModelPortalP61941.
SMRP61941. Positions 2-126.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP61941.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAS81675; AAS81675; TT_C1333.
GeneID2774934.
KEGGtth:TTC1333.
PATRIC23953073. VBITheThe54392_1325.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0048.
KOK02950.
OMAGTMTPRK.
OrthoDBEOG61ZTNF.
ProtClustDBPRK05163.

Enzyme and pathway databases

BioCycTTHE262724:GCAT-1348-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00403_B. Ribosomal_S12_B.
InterProIPR012340. NA-bd_OB-fold.
IPR006032. Ribosomal_S12/S23.
IPR005679. Ribosomal_S12_bac.
[Graphical view]
PANTHERPTHR11652. PTHR11652. 1 hit.
PfamPF00164. Ribosom_S12_S23. 1 hit.
[Graphical view]
PIRSFPIRSF002133. Ribosomal_S12/S23. 1 hit.
PRINTSPR01034. RIBOSOMALS12.
SUPFAMSSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00981. rpsL_bact. 1 hit.
PROSITEPS00055. RIBOSOMAL_S12. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP61941.

Entry information

Entry nameRS12_THET2
AccessionPrimary (citable) accession number: P61941
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: January 23, 2007
Last modified: February 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references