Thyroxine-binding globulin precursor - Mus musculus (Mouse)

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P61939 (THBG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 64. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Thyroxine-binding globulin

Alternative name(s):
Serpin A7
T4-binding globulin

Gene names

Name:	Serpina7
Synonyms:	Tbg

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major thyroid hormone transport protein in serum By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
PTM	Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara post-embryonic development Inferred from electronic annotation. Source: Compara regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to prostaglandin E stimulus Inferred from electronic annotation. Source: Compara response to vitamin A Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular region Inferred from Biological aspect of Ancestor. Source: RefGenome extracellular space Inferred from electronic annotation. Source: Compara
Molecular_function	hormone binding Inferred from electronic annotation. Source: Compara serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

20

By similarity

Chain

398

Thyroxine-binding globulin

PRO_0000032437

Sites

Binding site

1

Thyroxine By similarity

Binding site

1

Thyroxine By similarity

Amino acid modifications

Modified residue

1

Phosphoserine Ref.3

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P61939 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: F1BE953FA206FD72
Show »

418

47,052

        10         20         30         40         50         60 
MSVFFYLFVL VFGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA DFAFSLYRRL 

        70         80         90        100        110        120 
SVENPDLNIF FSPVSISVAL AMLSFGSGSS TQTQILEVLG FNLTDTPVTE LQQGFQHLIC 

       130        140        150        160        170        180 
SLNFPKNELE LQMGNAVFIG QQLKPLAKFL DDVKTLYETE VFSTDFSNVS AAQHKINSYV 

       190        200        210        220        230        240 
EKQTKGKIVG LIQGLKLNII MILVNYIHFR AQWANPFRVS KTEESSNFSV DKSTTVQVPM 

       250        260        270        280        290        300 
MHQLEQYYHY VDMELNCTVL QMDYSENALA LFVLPKEGHM EWVEAAMSSK TLKKWNYLLQ 

       310        320        330        340        350        360 
KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITEDSGLKLS YAFHKAVLHI 

       370        380        390        400        410 
GEEGTKEGAS PEVGSLDQQE VPPLHPVIRL DRAFLLMILE KRTRSVLFLG KLVNPTKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Moeller L.C., Liao X., Dumitrescu A.M., Rietz C., Weiss R.E., Janssen O.E., Refetoff S. Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-370, MASS SPECTROMETRY. Tissue: Melanoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY575783 mRNA. Translation: AAS88726.1. BC132100 mRNA. Translation: AAI32101.1.
IPI	IPI00410951.
UniGene	Mm.211704.
3D structure databases
ProteinModelPortal	P61939.
SMR	P61939. Positions 40-417.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000033626.
Protein family/group databases
MEROPS	I04.955.
PTM databases
PhosphoSite	P61939.
Proteomic databases
PaxDb	P61939.
PRIDE	P61939.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:3041197. Serpina7.
Phylogenomic databases
eggNOG	COG4826.
HOVERGEN	HBG005957.
InParanoid	A2RSG7.
OrthoDB	EOG4B2SX7.
Gene expression databases
ArrayExpress	P61939.
Bgee	P61939.
Genevestigator	P61939.
GermOnline	ENSMUSG00000031271. Mus musculus.
Family and domain databases
InterPro	IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	13844566.
SOURCE	Search...

Entry information

Entry name

THBG_MOUSE

Accession

Primary (citable) accession number: P61939
Secondary accession number(s): A2RSG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	June 7, 2004
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents