Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P61939

- THBG_MOUSE

UniProt

P61939 - THBG_MOUSE

Protein

Thyroxine-binding globulin

Gene

Serpina7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Major thyroid hormone transport protein in serum.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei296 – 2961ThyroxineBy similarity
    Binding sitei401 – 4011ThyroxineBy similarity

    GO - Molecular functioni

    1. hormone binding Source: Ensembl
    2. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. aging Source: Ensembl
    2. negative regulation of endopeptidase activity Source: RefGenome
    3. post-embryonic development Source: Ensembl
    4. regulation of proteolysis Source: RefGenome
    5. response to corticosterone Source: Ensembl
    6. response to drug Source: Ensembl
    7. response to peptide hormone Source: Ensembl
    8. response to prostaglandin E Source: Ensembl
    9. response to vitamin A Source: Ensembl

    Protein family/group databases

    MEROPSiI04.955.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thyroxine-binding globulin
    Alternative name(s):
    Serpin A7
    T4-binding globulin
    Gene namesi
    Name:Serpina7
    Synonyms:Tbg
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:3041197. Serpina7.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: RefGenome
    2. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 418398Thyroxine-binding globulinPRO_0000032437Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP61939.
    PRIDEiP61939.

    PTM databases

    PhosphoSiteiP61939.

    Expressioni

    Gene expression databases

    BgeeiP61939.
    GenevestigatoriP61939.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000033626.

    Structurei

    3D structure databases

    ProteinModelPortaliP61939.
    SMRiP61939. Positions 40-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    HOVERGENiHBG005957.
    InParanoidiA2RSG7.

    Family and domain databases

    InterProiIPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P61939-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVFFYLFVL VFGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA    50
    DFAFSLYRRL SVENPDLNIF FSPVSISVAL AMLSFGSGSS TQTQILEVLG 100
    FNLTDTPVTE LQQGFQHLIC SLNFPKNELE LQMGNAVFIG QQLKPLAKFL 150
    DDVKTLYETE VFSTDFSNVS AAQHKINSYV EKQTKGKIVG LIQGLKLNII 200
    MILVNYIHFR AQWANPFRVS KTEESSNFSV DKSTTVQVPM MHQLEQYYHY 250
    VDMELNCTVL QMDYSENALA LFVLPKEGHM EWVEAAMSSK TLKKWNYLLQ 300
    KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITEDSGLKLS 350
    YAFHKAVLHI GEEGTKEGAS PEVGSLDQQE VPPLHPVIRL DRAFLLMILE 400
    KRTRSVLFLG KLVNPTKQ 418
    Length:418
    Mass (Da):47,052
    Last modified:June 7, 2004 - v1
    Checksum:iF1BE953FA206FD72
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY575783 mRNA. Translation: AAS88726.1.
    BC132100 mRNA. Translation: AAI32101.1.
    RefSeqiXP_006528641.1. XM_006528578.1.
    UniGeneiMm.211704.

    Genome annotation databases

    GeneIDi331535.
    KEGGimmu:331535.
    UCSCiuc009uka.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY575783 mRNA. Translation: AAS88726.1 .
    BC132100 mRNA. Translation: AAI32101.1 .
    RefSeqi XP_006528641.1. XM_006528578.1.
    UniGenei Mm.211704.

    3D structure databases

    ProteinModelPortali P61939.
    SMRi P61939. Positions 40-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000033626.

    Protein family/group databases

    MEROPSi I04.955.

    PTM databases

    PhosphoSitei P61939.

    Proteomic databases

    PaxDbi P61939.
    PRIDEi P61939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 331535.
    KEGGi mmu:331535.
    UCSCi uc009uka.2. mouse.

    Organism-specific databases

    CTDi 6906.
    MGIi MGI:3041197. Serpina7.

    Phylogenomic databases

    eggNOGi COG4826.
    HOVERGENi HBG005957.
    InParanoidi A2RSG7.

    Miscellaneous databases

    NextBioi 13844566.
    PROi P61939.
    SOURCEi Search...

    Gene expression databases

    Bgeei P61939.
    Genevestigatori P61939.

    Family and domain databases

    InterProi IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Moeller L.C., Liao X., Dumitrescu A.M., Rietz C., Weiss R.E., Janssen O.E., Refetoff S.
      Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTHBG_MOUSE
    AccessioniPrimary (citable) accession number: P61939
    Secondary accession number(s): A2RSG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3