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P61939

- THBG_MOUSE

UniProt

P61939 - THBG_MOUSE

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Protein

Thyroxine-binding globulin

Gene

Serpina7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Major thyroid hormone transport protein in serum.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei296 – 2961ThyroxineBy similarity
Binding sitei401 – 4011ThyroxineBy similarity

GO - Molecular functioni

  1. hormone binding Source: Ensembl
  2. serine-type endopeptidase inhibitor activity Source: RefGenome

GO - Biological processi

  1. aging Source: Ensembl
  2. negative regulation of endopeptidase activity Source: RefGenome
  3. post-embryonic development Source: Ensembl
  4. regulation of proteolysis Source: RefGenome
  5. response to corticosterone Source: Ensembl
  6. response to drug Source: Ensembl
  7. response to peptide hormone Source: Ensembl
  8. response to prostaglandin E Source: Ensembl
  9. response to vitamin A Source: Ensembl
  10. thyroid hormone transport Source: Ensembl
Complete GO annotation...

Protein family/group databases

MEROPSiI04.029.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroxine-binding globulin
Alternative name(s):
Serpin A7
T4-binding globulin
Gene namesi
Name:Serpina7
Synonyms:Tbg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:3041197. Serpina7.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: RefGenome
  2. extracellular space Source: Ensembl
  3. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 418398Thyroxine-binding globulinPRO_0000032437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi39 – 391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP61939.
PRIDEiP61939.

PTM databases

PhosphoSiteiP61939.

Expressioni

Gene expression databases

BgeeiP61939.
ExpressionAtlasiP61939. baseline and differential.
GenevestigatoriP61939.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033626.

Structurei

3D structure databases

ProteinModelPortaliP61939.
SMRiP61939. Positions 40-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4826.
HOVERGENiHBG005957.
InParanoidiP61939.

Family and domain databases

InterProiIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61939-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVFFYLFVL VFGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA
60 70 80 90 100
DFAFSLYRRL SVENPDLNIF FSPVSISVAL AMLSFGSGSS TQTQILEVLG
110 120 130 140 150
FNLTDTPVTE LQQGFQHLIC SLNFPKNELE LQMGNAVFIG QQLKPLAKFL
160 170 180 190 200
DDVKTLYETE VFSTDFSNVS AAQHKINSYV EKQTKGKIVG LIQGLKLNII
210 220 230 240 250
MILVNYIHFR AQWANPFRVS KTEESSNFSV DKSTTVQVPM MHQLEQYYHY
260 270 280 290 300
VDMELNCTVL QMDYSENALA LFVLPKEGHM EWVEAAMSSK TLKKWNYLLQ
310 320 330 340 350
KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITEDSGLKLS
360 370 380 390 400
YAFHKAVLHI GEEGTKEGAS PEVGSLDQQE VPPLHPVIRL DRAFLLMILE
410
KRTRSVLFLG KLVNPTKQ
Length:418
Mass (Da):47,052
Last modified:June 7, 2004 - v1
Checksum:iF1BE953FA206FD72
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY575783 mRNA. Translation: AAS88726.1.
BC132100 mRNA. Translation: AAI32101.1.
RefSeqiXP_006528641.1. XM_006528578.1.
UniGeneiMm.211704.

Genome annotation databases

GeneIDi331535.
KEGGimmu:331535.
UCSCiuc009uka.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY575783 mRNA. Translation: AAS88726.1 .
BC132100 mRNA. Translation: AAI32101.1 .
RefSeqi XP_006528641.1. XM_006528578.1.
UniGenei Mm.211704.

3D structure databases

ProteinModelPortali P61939.
SMRi P61939. Positions 40-417.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000033626.

Protein family/group databases

MEROPSi I04.029.

PTM databases

PhosphoSitei P61939.

Proteomic databases

PaxDbi P61939.
PRIDEi P61939.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 331535.
KEGGi mmu:331535.
UCSCi uc009uka.2. mouse.

Organism-specific databases

CTDi 6906.
MGIi MGI:3041197. Serpina7.

Phylogenomic databases

eggNOGi COG4826.
HOVERGENi HBG005957.
InParanoidi P61939.

Miscellaneous databases

NextBioi 13844566.
PROi P61939.
SOURCEi Search...

Gene expression databases

Bgeei P61939.
ExpressionAtlasi P61939. baseline and differential.
Genevestigatori P61939.

Family and domain databases

InterProi IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view ]
PANTHERi PTHR11461. PTHR11461. 1 hit.
Pfami PF00079. Serpin. 1 hit.
[Graphical view ]
SMARTi SM00093. SERPIN. 1 hit.
[Graphical view ]
SUPFAMi SSF56574. SSF56574. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Moeller L.C., Liao X., Dumitrescu A.M., Rietz C., Weiss R.E., Janssen O.E., Refetoff S.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTHBG_MOUSE
AccessioniPrimary (citable) accession number: P61939
Secondary accession number(s): A2RSG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3