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P61939 (THBG_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thyroxine-binding globulin
Alternative name(s):
Serpin A7
T4-binding globulin
Gene names
Name:Serpina7
Synonyms:Tbg
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length418 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Major thyroid hormone transport protein in serum By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the serpin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 By similarity
Chain21 – 418398Thyroxine-binding globulin
PRO_0000032437

Sites

Binding site2961Thyroxine By similarity
Binding site4011Thyroxine By similarity

Amino acid modifications

Glycosylation241N-linked (GlcNAc...) Potential
Glycosylation391N-linked (GlcNAc...) Potential
Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation1681N-linked (GlcNAc...) Potential
Glycosylation2271N-linked (GlcNAc...) Potential
Glycosylation2561N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P61939 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: F1BE953FA206FD72

FASTA41847,052
        10         20         30         40         50         60 
MSVFFYLFVL VFGLQATIHC APHNSSEGKV TTCHLPQQNA TLYKMPSINA DFAFSLYRRL 

        70         80         90        100        110        120 
SVENPDLNIF FSPVSISVAL AMLSFGSGSS TQTQILEVLG FNLTDTPVTE LQQGFQHLIC 

       130        140        150        160        170        180 
SLNFPKNELE LQMGNAVFIG QQLKPLAKFL DDVKTLYETE VFSTDFSNVS AAQHKINSYV 

       190        200        210        220        230        240 
EKQTKGKIVG LIQGLKLNII MILVNYIHFR AQWANPFRVS KTEESSNFSV DKSTTVQVPM 

       250        260        270        280        290        300 
MHQLEQYYHY VDMELNCTVL QMDYSENALA LFVLPKEGHM EWVEAAMSSK TLKKWNYLLQ 

       310        320        330        340        350        360 
KGWVELFVPK FSISATYDLG STLQKMGMRD AFAESADFPG ITEDSGLKLS YAFHKAVLHI 

       370        380        390        400        410 
GEEGTKEGAS PEVGSLDQQE VPPLHPVIRL DRAFLLMILE KRTRSVLFLG KLVNPTKQ 

« Hide

References

« Hide 'large scale' references
[1]Moeller L.C., Liao X., Dumitrescu A.M., Rietz C., Weiss R.E., Janssen O.E., Refetoff S.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY575783 mRNA. Translation: AAS88726.1.
BC132100 mRNA. Translation: AAI32101.1.
RefSeqXP_006528641.1. XM_006528578.1.
UniGeneMm.211704.

3D structure databases

ProteinModelPortalP61939.
SMRP61939. Positions 40-417.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000033626.

Protein family/group databases

MEROPSI04.955.

PTM databases

PhosphoSiteP61939.

Proteomic databases

PaxDbP61939.
PRIDEP61939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID331535.
UCSCuc009uka.2. mouse.

Organism-specific databases

MGIMGI:3041197. Serpina7.

Phylogenomic databases

eggNOGCOG4826.
HOVERGENHBG005957.
InParanoidA2RSG7.

Gene expression databases

ArrayExpressP61939.
BgeeP61939.
GenevestigatorP61939.

Family and domain databases

InterProIPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERPTHR11461. PTHR11461. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. SSF56574. 1 hit.
ProtoNetSearch...

Other

NextBio13844566.
PROP61939.
SOURCESearch...

Entry information

Entry nameTHBG_MOUSE
AccessionPrimary (citable) accession number: P61939
Secondary accession number(s): A2RSG7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot