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Protein

60S ribosomal protein L37

Gene

RPL37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 23S rRNA.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi19ZincBy similarity1
Metal bindingi22ZincBy similarity1
Metal bindingi34ZincBy similarity1
Metal bindingi37ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • RNA binding Source: UniProtKB
  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

Metal-binding, RNA-binding, rRNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145592-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L37
Alternative name(s):
G1.16
Gene namesi
Name:RPL37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:10347. RPL37.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic large ribosomal subunit Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi6167.
OpenTargetsiENSG00000145592.
PharmGKBiPA34736.

Polymorphism and mutation databases

BioMutaiRPL37.
DMDMi48429090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001397052 – 9760S ribosomal protein L37Add BLAST96

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei97PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP61927.
MaxQBiP61927.
PaxDbiP61927.
PeptideAtlasiP61927.
PRIDEiP61927.
TopDownProteomicsiP61927.

PTM databases

iPTMnetiP61927.
PhosphoSitePlusiP61927.

Expressioni

Gene expression databases

BgeeiENSG00000145592.
CleanExiHS_RPL37.
ExpressionAtlasiP61927. baseline and differential.
GenevisibleiP61927. HS.

Interactioni

Protein-protein interaction databases

BioGridi112086. 31 interactors.
IntActiP61927. 11 interactors.
MINTiMINT-3022842.
STRINGi9606.ENSP00000274242.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lj1-97[»]
4V6Xelectron microscopy5.00Cj1-97[»]
5AJ0electron microscopy3.50Aj1-97[»]
ProteinModelPortaliP61927.
SMRiP61927.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L37e family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 37C4-typeSequence analysisAdd BLAST19

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
GeneTreeiENSGT00390000005254.
HOGENOMiHOG000111076.
HOVERGENiHBG004454.
InParanoidiP61927.
KOiK02922.
OrthoDBiEOG091G10FG.
PhylomeDBiP61927.
TreeFamiTF300260.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e. 1 hit.
InterProiIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomiPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61927-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGTSSFGK RRNKTHTLCR RCGSKAYHLQ KSTCGKCGYP AKRKRKYNWS
60 70 80 90
AKAKRRNTTG TGRMRHLKIV YRRFRHGFRE GTTPKPKRAA VAASSSS
Length:97
Mass (Da):11,078
Last modified:January 23, 2007 - v2
Checksum:iF565A11E983027C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65R → S in AAB47039 (PubMed:7588717).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01460681G → E.Corresponds to variant rs14898dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D23661 mRNA. Translation: BAA04888.1.
L11567 mRNA. Translation: AAA62148.1.
S79979 mRNA. Translation: AAB47039.2.
AB061834 Genomic DNA. Translation: BAB79472.1.
CR456890 mRNA. Translation: CAG33171.1.
AK311827 mRNA. Translation: BAG34769.1.
BC079477 mRNA. Translation: AAH79477.1.
BC084576 mRNA. Translation: AAH84576.1.
AB007184 Genomic DNA. Translation: BAA25843.1.
AB007183 Genomic DNA. Translation: BAA25842.1.
CCDSiCCDS3934.1.
PIRiS47646.
RefSeqiNP_000988.1. NM_000997.4.
UniGeneiHs.447582.
Hs.558601.
Hs.731513.

Genome annotation databases

EnsembliENST00000274242; ENSP00000274242; ENSG00000145592.
GeneIDi6167.
KEGGihsa:6167.
UCSCiuc021xxr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D23661 mRNA. Translation: BAA04888.1.
L11567 mRNA. Translation: AAA62148.1.
S79979 mRNA. Translation: AAB47039.2.
AB061834 Genomic DNA. Translation: BAB79472.1.
CR456890 mRNA. Translation: CAG33171.1.
AK311827 mRNA. Translation: BAG34769.1.
BC079477 mRNA. Translation: AAH79477.1.
BC084576 mRNA. Translation: AAH84576.1.
AB007184 Genomic DNA. Translation: BAA25843.1.
AB007183 Genomic DNA. Translation: BAA25842.1.
CCDSiCCDS3934.1.
PIRiS47646.
RefSeqiNP_000988.1. NM_000997.4.
UniGeneiHs.447582.
Hs.558601.
Hs.731513.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Lj1-97[»]
4V6Xelectron microscopy5.00Cj1-97[»]
5AJ0electron microscopy3.50Aj1-97[»]
ProteinModelPortaliP61927.
SMRiP61927.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112086. 31 interactors.
IntActiP61927. 11 interactors.
MINTiMINT-3022842.
STRINGi9606.ENSP00000274242.

PTM databases

iPTMnetiP61927.
PhosphoSitePlusiP61927.

Polymorphism and mutation databases

BioMutaiRPL37.
DMDMi48429090.

Proteomic databases

EPDiP61927.
MaxQBiP61927.
PaxDbiP61927.
PeptideAtlasiP61927.
PRIDEiP61927.
TopDownProteomicsiP61927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274242; ENSP00000274242; ENSG00000145592.
GeneIDi6167.
KEGGihsa:6167.
UCSCiuc021xxr.2. human.

Organism-specific databases

CTDi6167.
DisGeNETi6167.
GeneCardsiRPL37.
HGNCiHGNC:10347. RPL37.
MIMi604181. gene.
neXtProtiNX_P61927.
OpenTargetsiENSG00000145592.
PharmGKBiPA34736.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3475. Eukaryota.
COG2126. LUCA.
GeneTreeiENSGT00390000005254.
HOGENOMiHOG000111076.
HOVERGENiHBG004454.
InParanoidiP61927.
KOiK02922.
OrthoDBiEOG091G10FG.
PhylomeDBiP61927.
TreeFamiTF300260.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145592-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPL37. human.
GeneWikiiRPL37.
GenomeRNAii6167.
PROiP61927.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145592.
CleanExiHS_RPL37.
ExpressionAtlasiP61927. baseline and differential.
GenevisibleiP61927. HS.

Family and domain databases

Gene3Di2.20.25.30. 1 hit.
HAMAPiMF_00547. Ribosomal_L37e. 1 hit.
InterProiIPR011331. Ribosomal_L37ae/L37e.
IPR001569. Ribosomal_L37e.
IPR018267. Ribosomal_L37e_CS.
IPR011332. Ribosomal_zn-bd.
[Graphical view]
PfamiPF01907. Ribosomal_L37e. 1 hit.
[Graphical view]
ProDomiPD005132. Ribosomal_L37e. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF57829. SSF57829. 1 hit.
PROSITEiPS01077. RIBOSOMAL_L37E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL37_HUMAN
AccessioniPrimary (citable) accession number: P61927
Secondary accession number(s): B2R4H2
, P02403, Q6IBB4, Q99883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.