Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

cAMP-dependent protein kinase inhibitor alpha

Gene

PKIA

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Miscellaneous

The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei16Important for inhibition1
Sitei19Important for inhibition1
Sitei20Important for inhibition1

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: CAFA
  • protein kinase A catalytic subunit binding Source: CAFA

GO - Biological processi

  • negative regulation of cAMP-dependent protein kinase activity Source: CAFA

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor alpha
Short name:
PKI-alpha
Alternative name(s):
cAMP-dependent protein kinase inhibitor, muscle/brain isoform
Gene namesi
Name:PKIA
Synonyms:PRKACN1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00001545352 – 76cAMP-dependent protein kinase inhibitor alphaAdd BLAST75

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Thr); alternate1
Modified residuei2N-acetylthreonine; alternateBy similarity1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP61926

Interactioni

GO - Molecular functioni

  • protein kinase A catalytic subunit binding Source: CAFA

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000018622

Structurei

Secondary structure

176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 12Combined sources6
Beta strandi23 – 25Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDKX-ray2.00I/J6-25[»]
1CTPX-ray2.90I6-25[»]
1FMOX-ray2.20I6-25[»]
1JBPX-ray2.20S6-25[»]
1Q8WX-ray2.20B6-25[»]
1SMHX-ray2.04B6-25[»]
1STCX-ray2.30I6-25[»]
1SVEX-ray2.49B6-25[»]
1SVGX-ray2.02B6-25[»]
2ERZX-ray2.20I6-25[»]
2F7ZX-ray3.00I6-25[»]
2GFCX-ray1.87I6-25[»]
2GNHX-ray2.05I6-25[»]
2GNLX-ray2.60I6-25[»]
3DNDX-ray2.26I6-25[»]
3DNEX-ray2.00I6-25[»]
4XW4X-ray1.82B6-25[»]
4XW5X-ray1.95B6-25[»]
4XW6X-ray1.90B6-25[»]
4YXSX-ray2.11I6-25[»]
5UZKX-ray2.30I6-23[»]
DisProtiDP00015
ProteinModelPortaliP61926
SMRiP61926
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61926

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410J11W Eukaryota
ENOG410YT4B LUCA
HOGENOMiHOG000059641
HOVERGENiHBG101093
InParanoidiP61926
KOiK15985
TreeFamiTF330809

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P61926-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVETTYAD FIASGRTGRR NAIHDILVSS ASGNSNELAL KLAGLDINKT
60 70
EGEEDAQRSS TEQSGEAQGE AAKSES
Length:76
Mass (Da):7,989
Last modified:January 23, 2007 - v2
Checksum:iBDCE072810435951
GO

Sequence databases

PIRiA01340 OKRBCI
RefSeqiXP_008253905.1, XM_008255683.2

Genome annotation databases

GeneIDi100343293
KEGGiocu:100343293

Similar proteinsi

Entry informationi

Entry nameiIPKA_RABIT
AccessioniPrimary (citable) accession number: P61926
Secondary accession number(s): P04541
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health