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Reviewed, UniProtKB/Swiss-Prot P61925 (IPKA_HUMAN)

Last modified November 3, 2009. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    cAMP-dependent protein kinase inhibitor alpha
Alternative name(s):
    cAMP-dependent protein kinase inhibitor, muscle/brain isoform
    PKI-alpha
Gene names
Name: PKIA
Synonyms: PRKACN1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length76 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Miscellaneous

The inhibitory site contains regions very similar to the hinge regions (sites that directly interact with the enzyme active site) and "pseudosubstrate site" of the regulatory chains; but, unlike these chains, PKI does not contain cAMP-binding sites. The arginine residues within the inhibitory site are essential for inhibition and recognition of the enzyme active site.

Sequence similarities

Belongs to the PKI family.

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Ontologies

Keywords
   Molecular functionProtein kinase inhibitor
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Molecular functioncAMP-dependent protein kinase inhibitor activity

Traceable author statement. Source: UniProtKB

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 7675cAMP-dependent protein kinase inhibitor alpha
PRO_0000154532

Sites

Site161Important for inhibition By similarity
Site191Important for inhibition By similarity
Site201Important for inhibition By similarity

Amino acid modifications

Modified residue21Blocked amino end (Thr) By similarity

Secondary structure

1 ... 76
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P61925-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: BDCE072810435951

FASTA767,989
        10         20         30         40         50         60 
MTDVETTYAD FIASGRTGRR NAIHDILVSS ASGNSNELAL KLAGLDINKT EGEEDAQRSS 

        70 
TEQSGEAQGE AAKSES

« Hide

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References

« Hide 'large scale' references
[1]"Inhibition of protein kinase-A by overexpression of the cloned human protein kinase inhibitor."
Olsen S.R., Uhler M.D.
Mol. Endocrinol. 5:1246-1256(1991) [PubMed: 1770951] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Knoell R.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skeletal muscle.
+Additional computationally mapped references.

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Cross-references

Sequence databases

S76965 mRNA. Translation: AAB21141.1.
AF234641 Genomic DNA. Translation: AAF40206.1.
CR457052 mRNA. Translation: CAG33333.1.
BC022265 mRNA. Translation: AAH22265.1.
IPIIPI00220907.
PIRA40468.
RefSeqNP_006814.1.
NP_862822.1.
UniGeneHs.433700

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1CMKX-ray2.90I6-26[»]
1JLUX-ray2.25S6-25[»]
1Q8TX-ray2.00B6-25[»]
1VEBX-ray2.89B6-25[»]
1XH4X-ray2.45B6-25[»]
1XH5X-ray2.05B6-25[»]
1XH6X-ray1.90B6-25[»]
1XH7X-ray2.47B6-25[»]
1XH8X-ray1.60B6-25[»]
1XH9X-ray1.64B6-25[»]
1XHAX-ray2.46B6-25[»]
1YDRX-ray2.20I6-25[»]
2C1AX-ray1.95I6-25[»]
2C1BX-ray2.00I6-25[»]
2F7EX-ray2.00I6-25[»]
2GNIX-ray2.27I6-25[»]
2JDSX-ray2.00I6-25[»]
2JDTX-ray2.15I6-25[»]
2JDVX-ray2.08I6-25[»]
2UVXX-ray2.00I6-25[»]
2UVYX-ray1.95I6-25[»]
2UVZX-ray1.94I6-25[»]
2UW0X-ray2.00I6-25[»]
2UW3X-ray2.19I6-25[»]
2UW4X-ray2.00I6-25[»]
2UW5X-ray2.14I6-25[»]
2UW6X-ray2.23I6-25[»]
2UW7X-ray2.10I6-25[»]
2UW8X-ray2.00I6-25[»]
2VNWX-ray2.09I6-25[»]
2VNYX-ray1.96I6-25[»]
2VO0X-ray1.94I6-25[»]
2VO3X-ray1.98I6-25[»]
2VO6X-ray1.97I6-25[»]
2VO7X-ray1.98I6-25[»]
ModBaseSearch...

Protein-protein interaction databases

STRINGP61925.

PTM databases

PhosphoSiteP61925.

Genome annotation databases

EnsemblENST00000352966; ENSP00000336552; ENSG00000171033; Homo sapiens. [Genome view]
ENST00000396418; ENSP00000379696; ENSG00000171033; Homo sapiens. [Genome view]
GeneID5569.
KEGGhsa:5569.
UCSCuc003yba.1. human.

Organism-specific databases

CTD5569.
GeneCardsGC08P079590.
H-InvDBHIX0007603.
HGNCHGNC:9017. PKIA.
MIM606059. gene.
PharmGKBPA33349.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP61925.
HOVERGENP61925.
OMADVESTYA.

Gene expression databases

ArrayExpressP61925.
BgeeP61925.
CleanExHS_PKIA.
GenevestigatorP61925.
GermOnlineENSG00000171033. Homo sapiens.

Family and domain databases

InterProIPR004171. cAMP_dep_PKI.
[Graphical view]
PfamPF02827. PKI. 1 hit.
[Graphical view]
PIRSFPIRSF001667. PKI. 1 hit.
ProDomPD010366. cAMP_dep_PKI. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Other Resources

NextBio21582.
SOURCESearch...

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Entry information

Entry nameIPKA_HUMAN
AccessionPrimary (citable) accession number: P61925
Secondary accession number(s): P04541, Q6IAV2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: January 23, 2007
Last modified: November 3, 2009
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents