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Protein

Coatomer subunit zeta-1

Gene

Copz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity
The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.By similarity

GO - Biological processi

  1. intracellular protein transport Source: InterPro
  2. intra-Golgi vesicle-mediated transport Source: UniProtKB
  3. toxin transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_284363. COPI Mediated Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit zeta-1
Alternative name(s):
Zeta-1-coat protein
Short name:
Zeta-1 COP
Gene namesi
Name:Copz1
Synonyms:Copz
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1929063. Copz1.

Subcellular locationi

Cytoplasm By similarity. Golgi apparatus membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.By similarity

GO - Cellular componenti

  1. COPI vesicle coat Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 177177Coatomer subunit zeta-1PRO_0000193826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP61924.
PaxDbiP61924.
PRIDEiP61924.

PTM databases

PhosphoSiteiP61924.

Expressioni

Gene expression databases

BgeeiP61924.
CleanExiMM_COPZ1.
ExpressionAtlasiP61924. baseline and differential.
GenevestigatoriP61924.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.By similarity

Protein-protein interaction databases

BioGridi207987. 1 interaction.
IntActiP61924. 1 interaction.
MINTiMINT-1864573.

Structurei

3D structure databases

ProteinModelPortaliP61924.
SMRiP61924. Positions 1-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5541.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiP61924.
OMAiDGFMMDI.
OrthoDBiEOG75TMD6.
PhylomeDBiP61924.
TreeFamiTF300262.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALILEPSL YTVKAILILD NDGDRLFAKY YDDTYPSVKE QKAFEKNIFN
60 70 80 90 100
KTHRTDSEIA LLEGLTVVYK SSIDLYFYVI GSSYENELML MAVLNCLFDS
110 120 130 140 150
LSQMLRKNVE KRALLENMEG LFLAVDEIVD GGVILESDPQ QVVHRVALRG
160 170
EDVPLTEQTV SQVLQSAKEQ IKWSLLR
Length:177
Mass (Da):20,198
Last modified:June 6, 2004 - v1
Checksum:i355530D032D3A049
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037370 mRNA. Translation: BAA90303.1.
AK003302 mRNA. Translation: BAB22703.1.
BC002246 mRNA. No translation available.
BC058524 mRNA. Translation: AAH58524.1.
BC085314 mRNA. Translation: AAH85314.1.
CCDSiCCDS27901.1.
RefSeqiNP_062791.1. NM_019817.1.
UniGeneiMm.29473.

Genome annotation databases

EnsembliENSMUST00000100162; ENSMUSP00000097738; ENSMUSG00000060992.
GeneIDi56447.
KEGGimmu:56447.
UCSCiuc007xxv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037370 mRNA. Translation: BAA90303.1.
AK003302 mRNA. Translation: BAB22703.1.
BC002246 mRNA. No translation available.
BC058524 mRNA. Translation: AAH58524.1.
BC085314 mRNA. Translation: AAH85314.1.
CCDSiCCDS27901.1.
RefSeqiNP_062791.1. NM_019817.1.
UniGeneiMm.29473.

3D structure databases

ProteinModelPortaliP61924.
SMRiP61924. Positions 1-149.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207987. 1 interaction.
IntActiP61924. 1 interaction.
MINTiMINT-1864573.

PTM databases

PhosphoSiteiP61924.

Proteomic databases

MaxQBiP61924.
PaxDbiP61924.
PRIDEiP61924.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000100162; ENSMUSP00000097738; ENSMUSG00000060992.
GeneIDi56447.
KEGGimmu:56447.
UCSCiuc007xxv.1. mouse.

Organism-specific databases

CTDi22818.
MGIiMGI:1929063. Copz1.

Phylogenomic databases

eggNOGiCOG5541.
HOGENOMiHOG000214428.
HOVERGENiHBG051077.
InParanoidiP61924.
OMAiDGFMMDI.
OrthoDBiEOG75TMD6.
PhylomeDBiP61924.
TreeFamiTF300262.

Enzyme and pathway databases

ReactomeiREACT_284363. COPI Mediated Transport.

Miscellaneous databases

ChiTaRSiCopz1. mouse.
NextBioi312654.
PROiP61924.
SOURCEiSearch...

Gene expression databases

BgeeiP61924.
CleanExiMM_COPZ1.
ExpressionAtlasiP61924. baseline and differential.
GenevestigatoriP61924.

Family and domain databases

InterProiIPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Murine Copz1 gene encoding nonclathrin coat protein zeta-COP."
    Hahn Y., Chung J.H.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and C57BL/6J.
    Tissue: Brain and Embryo.

Entry informationi

Entry nameiCOPZ1_MOUSE
AccessioniPrimary (citable) accession number: P61924
Secondary accession number(s): Q9Y3C3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2004
Last sequence update: June 6, 2004
Last modified: March 31, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.