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P61912

- DUT_TREDE

UniProt

P61912 - DUT_TREDE

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene
dut, TDE_1042
Organism
Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761Substrate By similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. dUMP biosynthetic process Source: UniProtKB-UniPathway
  2. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciTDEN243275:GJ7G-1056-MONOMER.
UniPathwayiUPA00610; UER00666.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:dut
Ordered Locus Names:TDE_1042
OrganismiTreponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222)
Taxonomic identifieri243275 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeTreponema
ProteomesiUP000008212: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 144144Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotationPRO_0000182912Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243275.TDE1042.

Structurei

3D structure databases

ProteinModelPortaliP61912.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni63 – 653Substrate binding By similarity
Regioni80 – 823Substrate binding By similarity

Sequence similaritiesi

Belongs to the dUTPase family.

Phylogenomic databases

eggNOGiCOG0756.
KOiK01520.
OMAiYSRIDFE.
OrthoDBiEOG689HXK.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00116. dUTPase_bact.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR00576. dut. 1 hit.

Sequencei

Sequence statusi: Complete.

P61912-1 [UniParc]FASTAAdd to Basket

« Hide

MEVFTKLKEG ALLPEYKTSG SAGADLRALI EEPIILKPMQ RCLIPTGLSV    50
ELPKGIELQV RPRSGLALKH GITVLNTPGT VDSDYRGELA VLLINLGNED 100
FKIENGDRIA QAVIAQAIQA DFLQKDELSN TERGAGGYGS TGIA 144
Length:144
Mass (Da):15,402
Last modified:June 7, 2004 - v1
Checksum:iA3D741BD3B6E85BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017226 Genomic DNA. Translation: AAS11531.1.
RefSeqiNP_971650.1. NC_002967.9.

Genome annotation databases

EnsemblBacteriaiAAS11531; AAS11531; TDE_1042.
GeneIDi2741316.
KEGGitde:TDE1042.
PATRICi20524288. VBITreDen445_1002.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE017226 Genomic DNA. Translation: AAS11531.1 .
RefSeqi NP_971650.1. NC_002967.9.

3D structure databases

ProteinModelPortali P61912.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243275.TDE1042.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAS11531 ; AAS11531 ; TDE_1042 .
GeneIDi 2741316.
KEGGi tde:TDE1042.
PATRICi 20524288. VBITreDen445_1002.

Phylogenomic databases

eggNOGi COG0756.
KOi K01520.
OMAi YSRIDFE.
OrthoDBi EOG689HXK.

Enzyme and pathway databases

UniPathwayi UPA00610 ; UER00666 .
BioCyci TDEN243275:GJ7G-1056-MONOMER.

Family and domain databases

Gene3Di 2.70.40.10. 1 hit.
HAMAPi MF_00116. dUTPase_bact.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR008181. dUTPase_1.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 1 hit.
TIGRFAMsi TIGR00576. dut. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35405 / CIP 103919 / DSM 14222.

Entry informationi

Entry nameiDUT_TREDE
AccessioniPrimary (citable) accession number: P61912
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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