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P61897 (MDH_PECCC) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malate dehydrogenase
EC=1.1.1.37
Gene names
Name:mdh
OrganismPectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
Taxonomic identifier555 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Pectobacterium ›

Protein attributes

Sequence length154 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01516

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_01516

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›154›154Malate dehydrogenase HAMAP-Rule MF_01516
PRO_0000113318

Regions

Nucleotide binding39 – 413NAD By similarity

Sites

Active site991Proton acceptor By similarity
Binding site31Substrate By similarity
Binding site91Substrate By similarity
Binding site161NAD By similarity
Binding site411Substrate By similarity
Binding site751Substrate By similarity
Binding site1491NAD By similarity

Natural variations

Natural variant15 – 173VNA → LPF in strain: WPP3.
Natural variant23 – 242LV → WH in strain: WPP3.
Natural variant321P → R in strain: WPP3.
Natural variant491I → M in strain: WPP7.
Natural variant106 – 1072PL → LC in strain: WPP25.
Natural variant1111V → D in strain: WPP25.
Natural variant1171S → N in strain: WPP3 and WPP8.
Natural variant133 – 1342TE → AQ in strain: WPP3.
Natural variant137 – 1404EAKA → KPKQ in strain: WPP19.
Natural variant1371E → K in strain: WPP3.
Natural variant1411G → R in strain: WPP25.
Natural variant1421G → A in strain: WPP9 and WPP10.
Natural variant150 – 1545GQVPG → ARLPA in strain: WPP25.
Natural variant152 – 1543VPG → AAR in strain: WPP20, WPP22 and WPP7.
Natural variant152 – 1543VPG → AGR in strain: WPP5.
Natural variant152 – 1532VP → AA in strain: WPP12 and WPP21.
Natural variant1521V → A in strain: WPP24.
Natural variant1531P → A in strain: WPP4.

Experimental info

Non-terminal residue11
Non-terminal residue1541

Sequences

Sequence LengthMass (Da)Tools
P61897 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: 40417ECADE8C1877

FASTA15416,149
        10         20         30         40         50         60 
LRRKPGMDRS DLFNVNAGIV RNLVEQIAVT CPKACIGIIT NPVNTTVAIA AEVLKKAGVY 

        70         80         90        100        110        120 
DKNKLFGVTT LDIIRSNTFV AELKGKQPQD INVPVIGGHS GVTILPLLSQ VPGISFSEQE 

       130        140        150 
VADLTKRIQN AGTEVVEAKA GGGSATLSMG QVPG

« Hide

References

[1]"Genomic diversity of Erwinia carotovora subsp. carotovora and its correlation with virulence."
Yap M.-N., Barak J.D., Charkowski A.O.
Appl. Environ. Microbiol. 70:3013-3023(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: WPP1, WPP10, WPP11, WPP12, WPP13, WPP14, WPP15, WPP17, WPP18, WPP19, WPP2, WPP20, WPP21, WPP22, WPP24, WPP25, WPP3, WPP4, WPP5, WPP6, WPP7, WPP8 and WPP9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY428968 Genomic DNA. Translation: AAR11889.1.
AY428969 Genomic DNA. Translation: AAR11890.1.
AY428970 Genomic DNA. Translation: AAR11891.1.
AY428971 Genomic DNA. Translation: AAR11892.1.
AY428972 Genomic DNA. Translation: AAR11893.1.
AY428973 Genomic DNA. Translation: AAR11894.1.
AY428974 Genomic DNA. Translation: AAR11895.1.
AY428975 Genomic DNA. Translation: AAR11896.1.
AY428976 Genomic DNA. Translation: AAR11897.1.
AY428977 Genomic DNA. Translation: AAR11898.1.
AY428978 Genomic DNA. Translation: AAR11899.1.
AY428979 Genomic DNA. Translation: AAR11900.1.
AY428980 Genomic DNA. Translation: AAR11901.1.
AY428981 Genomic DNA. Translation: AAR11902.1.
AY428982 Genomic DNA. Translation: AAR11903.1.
AY428983 Genomic DNA. Translation: AAR11904.1.
AY428984 Genomic DNA. Translation: AAR11905.1.
AY428985 Genomic DNA. Translation: AAR11906.1.
AY428986 Genomic DNA. Translation: AAR11907.1.
AY428987 Genomic DNA. Translation: AAR11908.1.
AY428988 Genomic DNA. Translation: AAR11909.1.
AY428989 Genomic DNA. Translation: AAR11910.1.
AY428990 Genomic DNA. Translation: AAR11911.1.

3D structure databases

ProteinModelPortalP61897.
SMRP61897. Positions 1-151.
ModBaseSearch...

Proteomic databases

PRIDEP61897.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01516. Malate_dehydrog_1.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_PECCC
AccessionPrimary (citable) accession number: P61897
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: March 6, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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