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P61897

- MDH_PECCC

UniProt

P61897 - MDH_PECCC

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Protein
Malate dehydrogenase
Gene
mdh
Organism
Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei3 – 31Substrate By similarity
Binding sitei9 – 91Substrate By similarity
Binding sitei16 – 161NAD By similarity
Binding sitei41 – 411Substrate By similarity
Binding sitei75 – 751Substrate By similarity
Active sitei99 – 991Proton acceptor By similarity
Binding sitei149 – 1491NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 413NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiPectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
Taxonomic identifieri555 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›154›154Malate dehydrogenase
PRO_0000113318Add
BLAST

Proteomic databases

PRIDEiP61897.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP61897.
SMRiP61897. Positions 1-151.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P61897-1 [UniParc]FASTAAdd to Basket

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LRRKPGMDRS DLFNVNAGIV RNLVEQIAVT CPKACIGIIT NPVNTTVAIA    50
AEVLKKAGVY DKNKLFGVTT LDIIRSNTFV AELKGKQPQD INVPVIGGHS 100
GVTILPLLSQ VPGISFSEQE VADLTKRIQN AGTEVVEAKA GGGSATLSMG 150
QVPG 154
Length:154
Mass (Da):16,149
Last modified:June 7, 2004 - v1
Checksum:i40417ECADE8C1877
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 173VNA → LPF in strain: WPP3.
Natural varianti23 – 242LV → WH in strain: WPP3.
Natural varianti32 – 321P → R in strain: WPP3.
Natural varianti49 – 491I → M in strain: WPP7.
Natural varianti106 – 1072PL → LC in strain: WPP25.
Natural varianti111 – 1111V → D in strain: WPP25.
Natural varianti117 – 1171S → N in strain: WPP3 and WPP8.
Natural varianti133 – 1342TE → AQ in strain: WPP3.
Natural varianti137 – 1404EAKA → KPKQ in strain: WPP19.
Natural varianti137 – 1371E → K in strain: WPP3.
Natural varianti141 – 1411G → R in strain: WPP25.
Natural varianti142 – 1421G → A in strain: WPP9 and WPP10.
Natural varianti150 – 1545GQVPG → ARLPA in strain: WPP25.
Natural varianti152 – 1543VPG → AAR in strain: WPP20, WPP22 and WPP7.
Natural varianti152 – 1543VPG → AGR in strain: WPP5.
Natural varianti152 – 1532VP → AA in strain: WPP12 and WPP21.
Natural varianti152 – 1521V → A in strain: WPP24.
Natural varianti153 – 1531P → A in strain: WPP4.

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei154 – 1541

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY428968 Genomic DNA. Translation: AAR11889.1.
AY428969 Genomic DNA. Translation: AAR11890.1.
AY428970 Genomic DNA. Translation: AAR11891.1.
AY428971 Genomic DNA. Translation: AAR11892.1.
AY428972 Genomic DNA. Translation: AAR11893.1.
AY428973 Genomic DNA. Translation: AAR11894.1.
AY428974 Genomic DNA. Translation: AAR11895.1.
AY428975 Genomic DNA. Translation: AAR11896.1.
AY428976 Genomic DNA. Translation: AAR11897.1.
AY428977 Genomic DNA. Translation: AAR11898.1.
AY428978 Genomic DNA. Translation: AAR11899.1.
AY428979 Genomic DNA. Translation: AAR11900.1.
AY428980 Genomic DNA. Translation: AAR11901.1.
AY428981 Genomic DNA. Translation: AAR11902.1.
AY428982 Genomic DNA. Translation: AAR11903.1.
AY428983 Genomic DNA. Translation: AAR11904.1.
AY428984 Genomic DNA. Translation: AAR11905.1.
AY428985 Genomic DNA. Translation: AAR11906.1.
AY428986 Genomic DNA. Translation: AAR11907.1.
AY428987 Genomic DNA. Translation: AAR11908.1.
AY428988 Genomic DNA. Translation: AAR11909.1.
AY428989 Genomic DNA. Translation: AAR11910.1.
AY428990 Genomic DNA. Translation: AAR11911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY428968 Genomic DNA. Translation: AAR11889.1 .
AY428969 Genomic DNA. Translation: AAR11890.1 .
AY428970 Genomic DNA. Translation: AAR11891.1 .
AY428971 Genomic DNA. Translation: AAR11892.1 .
AY428972 Genomic DNA. Translation: AAR11893.1 .
AY428973 Genomic DNA. Translation: AAR11894.1 .
AY428974 Genomic DNA. Translation: AAR11895.1 .
AY428975 Genomic DNA. Translation: AAR11896.1 .
AY428976 Genomic DNA. Translation: AAR11897.1 .
AY428977 Genomic DNA. Translation: AAR11898.1 .
AY428978 Genomic DNA. Translation: AAR11899.1 .
AY428979 Genomic DNA. Translation: AAR11900.1 .
AY428980 Genomic DNA. Translation: AAR11901.1 .
AY428981 Genomic DNA. Translation: AAR11902.1 .
AY428982 Genomic DNA. Translation: AAR11903.1 .
AY428983 Genomic DNA. Translation: AAR11904.1 .
AY428984 Genomic DNA. Translation: AAR11905.1 .
AY428985 Genomic DNA. Translation: AAR11906.1 .
AY428986 Genomic DNA. Translation: AAR11907.1 .
AY428987 Genomic DNA. Translation: AAR11908.1 .
AY428988 Genomic DNA. Translation: AAR11909.1 .
AY428989 Genomic DNA. Translation: AAR11910.1 .
AY428990 Genomic DNA. Translation: AAR11911.1 .

3D structure databases

ProteinModelPortali P61897.
SMRi P61897. Positions 1-151.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P61897.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic diversity of Erwinia carotovora subsp. carotovora and its correlation with virulence."
    Yap M.-N., Barak J.D., Charkowski A.O.
    Appl. Environ. Microbiol. 70:3013-3023(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WPP1, WPP10, WPP11, WPP12, WPP13, WPP14, WPP15, WPP17, WPP18, WPP19, WPP2, WPP20, WPP21, WPP22, WPP24, WPP25, WPP3, WPP4, WPP5, WPP6, WPP7, WPP8 and WPP9.

Entry informationi

Entry nameiMDH_PECCC
AccessioniPrimary (citable) accession number: P61897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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