Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P61897

- MDH_PECCC

UniProt

P61897 - MDH_PECCC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Malate dehydrogenase

Gene

mdh

Organism
Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei3 – 31SubstratePROSITE-ProRule annotation
Binding sitei9 – 91SubstratePROSITE-ProRule annotation
Binding sitei16 – 161NADBy similarity
Binding sitei41 – 411SubstratePROSITE-ProRule annotation
Binding sitei75 – 751SubstratePROSITE-ProRule annotation
Active sitei99 – 991Proton acceptorBy similarity
Binding sitei149 – 1491NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi39 – 413NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiPectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
Taxonomic identifieri555 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›154›154Malate dehydrogenasePRO_0000113318Add
BLAST

Proteomic databases

PRIDEiP61897.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP61897.
SMRiP61897. Positions 1-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P61897-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LRRKPGMDRS DLFNVNAGIV RNLVEQIAVT CPKACIGIIT NPVNTTVAIA
60 70 80 90 100
AEVLKKAGVY DKNKLFGVTT LDIIRSNTFV AELKGKQPQD INVPVIGGHS
110 120 130 140 150
GVTILPLLSQ VPGISFSEQE VADLTKRIQN AGTEVVEAKA GGGSATLSMG

QVPG
Length:154
Mass (Da):16,149
Last modified:June 7, 2004 - v1
Checksum:i40417ECADE8C1877
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei154 – 1541

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 173VNA → LPF in strain: WPP3.
Natural varianti23 – 242LV → WH in strain: WPP3.
Natural varianti32 – 321P → R in strain: WPP3.
Natural varianti49 – 491I → M in strain: WPP7.
Natural varianti106 – 1072PL → LC in strain: WPP25.
Natural varianti111 – 1111V → D in strain: WPP25.
Natural varianti117 – 1171S → N in strain: WPP3 and WPP8.
Natural varianti133 – 1342TE → AQ in strain: WPP3.
Natural varianti137 – 1404EAKA → KPKQ in strain: WPP19.
Natural varianti137 – 1371E → K in strain: WPP3.
Natural varianti141 – 1411G → R in strain: WPP25.
Natural varianti142 – 1421G → A in strain: WPP9 and WPP10.
Natural varianti150 – 1545GQVPG → ARLPA in strain: WPP25.
Natural varianti152 – 1543VPG → AAR in strain: WPP20, WPP22 and WPP7.
Natural varianti152 – 1543VPG → AGR in strain: WPP5.
Natural varianti152 – 1532VP → AA in strain: WPP12 and WPP21.
Natural varianti152 – 1521V → A in strain: WPP24.
Natural varianti153 – 1531P → A in strain: WPP4.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY428968 Genomic DNA. Translation: AAR11889.1.
AY428969 Genomic DNA. Translation: AAR11890.1.
AY428970 Genomic DNA. Translation: AAR11891.1.
AY428971 Genomic DNA. Translation: AAR11892.1.
AY428972 Genomic DNA. Translation: AAR11893.1.
AY428973 Genomic DNA. Translation: AAR11894.1.
AY428974 Genomic DNA. Translation: AAR11895.1.
AY428975 Genomic DNA. Translation: AAR11896.1.
AY428976 Genomic DNA. Translation: AAR11897.1.
AY428977 Genomic DNA. Translation: AAR11898.1.
AY428978 Genomic DNA. Translation: AAR11899.1.
AY428979 Genomic DNA. Translation: AAR11900.1.
AY428980 Genomic DNA. Translation: AAR11901.1.
AY428981 Genomic DNA. Translation: AAR11902.1.
AY428982 Genomic DNA. Translation: AAR11903.1.
AY428983 Genomic DNA. Translation: AAR11904.1.
AY428984 Genomic DNA. Translation: AAR11905.1.
AY428985 Genomic DNA. Translation: AAR11906.1.
AY428986 Genomic DNA. Translation: AAR11907.1.
AY428987 Genomic DNA. Translation: AAR11908.1.
AY428988 Genomic DNA. Translation: AAR11909.1.
AY428989 Genomic DNA. Translation: AAR11910.1.
AY428990 Genomic DNA. Translation: AAR11911.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY428968 Genomic DNA. Translation: AAR11889.1 .
AY428969 Genomic DNA. Translation: AAR11890.1 .
AY428970 Genomic DNA. Translation: AAR11891.1 .
AY428971 Genomic DNA. Translation: AAR11892.1 .
AY428972 Genomic DNA. Translation: AAR11893.1 .
AY428973 Genomic DNA. Translation: AAR11894.1 .
AY428974 Genomic DNA. Translation: AAR11895.1 .
AY428975 Genomic DNA. Translation: AAR11896.1 .
AY428976 Genomic DNA. Translation: AAR11897.1 .
AY428977 Genomic DNA. Translation: AAR11898.1 .
AY428978 Genomic DNA. Translation: AAR11899.1 .
AY428979 Genomic DNA. Translation: AAR11900.1 .
AY428980 Genomic DNA. Translation: AAR11901.1 .
AY428981 Genomic DNA. Translation: AAR11902.1 .
AY428982 Genomic DNA. Translation: AAR11903.1 .
AY428983 Genomic DNA. Translation: AAR11904.1 .
AY428984 Genomic DNA. Translation: AAR11905.1 .
AY428985 Genomic DNA. Translation: AAR11906.1 .
AY428986 Genomic DNA. Translation: AAR11907.1 .
AY428987 Genomic DNA. Translation: AAR11908.1 .
AY428988 Genomic DNA. Translation: AAR11909.1 .
AY428989 Genomic DNA. Translation: AAR11910.1 .
AY428990 Genomic DNA. Translation: AAR11911.1 .

3D structure databases

ProteinModelPortali P61897.
SMRi P61897. Positions 1-151.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P61897.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic diversity of Erwinia carotovora subsp. carotovora and its correlation with virulence."
    Yap M.-N., Barak J.D., Charkowski A.O.
    Appl. Environ. Microbiol. 70:3013-3023(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WPP1, WPP10, WPP11, WPP12, WPP13, WPP14, WPP15, WPP17, WPP18, WPP19, WPP2, WPP20, WPP21, WPP22, WPP24, WPP25, WPP3, WPP4, WPP5, WPP6, WPP7, WPP8 and WPP9.

Entry informationi

Entry nameiMDH_PECCC
AccessioniPrimary (citable) accession number: P61897
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 1, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3