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P61897

- MDH_PECCC

UniProt

P61897 - MDH_PECCC

Protein

Malate dehydrogenase

Gene

mdh

Organism
Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei3 – 31SubstratePROSITE-ProRule annotation
    Binding sitei9 – 91SubstratePROSITE-ProRule annotation
    Binding sitei16 – 161NADBy similarity
    Binding sitei41 – 411SubstratePROSITE-ProRule annotation
    Binding sitei75 – 751SubstratePROSITE-ProRule annotation
    Active sitei99 – 991Proton acceptorBy similarity
    Binding sitei149 – 1491NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi39 – 413NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    OrganismiPectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
    Taxonomic identifieri555 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›154›154Malate dehydrogenasePRO_0000113318Add
    BLAST

    Proteomic databases

    PRIDEiP61897.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP61897.
    SMRiP61897. Positions 1-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56327. SSF56327. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P61897-1 [UniParc]FASTAAdd to Basket

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    LRRKPGMDRS DLFNVNAGIV RNLVEQIAVT CPKACIGIIT NPVNTTVAIA    50
    AEVLKKAGVY DKNKLFGVTT LDIIRSNTFV AELKGKQPQD INVPVIGGHS 100
    GVTILPLLSQ VPGISFSEQE VADLTKRIQN AGTEVVEAKA GGGSATLSMG 150
    QVPG 154
    Length:154
    Mass (Da):16,149
    Last modified:June 7, 2004 - v1
    Checksum:i40417ECADE8C1877
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei154 – 1541

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 173VNA → LPF in strain: WPP3.
    Natural varianti23 – 242LV → WH in strain: WPP3.
    Natural varianti32 – 321P → R in strain: WPP3.
    Natural varianti49 – 491I → M in strain: WPP7.
    Natural varianti106 – 1072PL → LC in strain: WPP25.
    Natural varianti111 – 1111V → D in strain: WPP25.
    Natural varianti117 – 1171S → N in strain: WPP3 and WPP8.
    Natural varianti133 – 1342TE → AQ in strain: WPP3.
    Natural varianti137 – 1404EAKA → KPKQ in strain: WPP19.
    Natural varianti137 – 1371E → K in strain: WPP3.
    Natural varianti141 – 1411G → R in strain: WPP25.
    Natural varianti142 – 1421G → A in strain: WPP9 and WPP10.
    Natural varianti150 – 1545GQVPG → ARLPA in strain: WPP25.
    Natural varianti152 – 1543VPG → AAR in strain: WPP20, WPP22 and WPP7.
    Natural varianti152 – 1543VPG → AGR in strain: WPP5.
    Natural varianti152 – 1532VP → AA in strain: WPP12 and WPP21.
    Natural varianti152 – 1521V → A in strain: WPP24.
    Natural varianti153 – 1531P → A in strain: WPP4.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY428968 Genomic DNA. Translation: AAR11889.1.
    AY428969 Genomic DNA. Translation: AAR11890.1.
    AY428970 Genomic DNA. Translation: AAR11891.1.
    AY428971 Genomic DNA. Translation: AAR11892.1.
    AY428972 Genomic DNA. Translation: AAR11893.1.
    AY428973 Genomic DNA. Translation: AAR11894.1.
    AY428974 Genomic DNA. Translation: AAR11895.1.
    AY428975 Genomic DNA. Translation: AAR11896.1.
    AY428976 Genomic DNA. Translation: AAR11897.1.
    AY428977 Genomic DNA. Translation: AAR11898.1.
    AY428978 Genomic DNA. Translation: AAR11899.1.
    AY428979 Genomic DNA. Translation: AAR11900.1.
    AY428980 Genomic DNA. Translation: AAR11901.1.
    AY428981 Genomic DNA. Translation: AAR11902.1.
    AY428982 Genomic DNA. Translation: AAR11903.1.
    AY428983 Genomic DNA. Translation: AAR11904.1.
    AY428984 Genomic DNA. Translation: AAR11905.1.
    AY428985 Genomic DNA. Translation: AAR11906.1.
    AY428986 Genomic DNA. Translation: AAR11907.1.
    AY428987 Genomic DNA. Translation: AAR11908.1.
    AY428988 Genomic DNA. Translation: AAR11909.1.
    AY428989 Genomic DNA. Translation: AAR11910.1.
    AY428990 Genomic DNA. Translation: AAR11911.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY428968 Genomic DNA. Translation: AAR11889.1 .
    AY428969 Genomic DNA. Translation: AAR11890.1 .
    AY428970 Genomic DNA. Translation: AAR11891.1 .
    AY428971 Genomic DNA. Translation: AAR11892.1 .
    AY428972 Genomic DNA. Translation: AAR11893.1 .
    AY428973 Genomic DNA. Translation: AAR11894.1 .
    AY428974 Genomic DNA. Translation: AAR11895.1 .
    AY428975 Genomic DNA. Translation: AAR11896.1 .
    AY428976 Genomic DNA. Translation: AAR11897.1 .
    AY428977 Genomic DNA. Translation: AAR11898.1 .
    AY428978 Genomic DNA. Translation: AAR11899.1 .
    AY428979 Genomic DNA. Translation: AAR11900.1 .
    AY428980 Genomic DNA. Translation: AAR11901.1 .
    AY428981 Genomic DNA. Translation: AAR11902.1 .
    AY428982 Genomic DNA. Translation: AAR11903.1 .
    AY428983 Genomic DNA. Translation: AAR11904.1 .
    AY428984 Genomic DNA. Translation: AAR11905.1 .
    AY428985 Genomic DNA. Translation: AAR11906.1 .
    AY428986 Genomic DNA. Translation: AAR11907.1 .
    AY428987 Genomic DNA. Translation: AAR11908.1 .
    AY428988 Genomic DNA. Translation: AAR11909.1 .
    AY428989 Genomic DNA. Translation: AAR11910.1 .
    AY428990 Genomic DNA. Translation: AAR11911.1 .

    3D structure databases

    ProteinModelPortali P61897.
    SMRi P61897. Positions 1-151.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P61897.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56327. SSF56327. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic diversity of Erwinia carotovora subsp. carotovora and its correlation with virulence."
      Yap M.-N., Barak J.D., Charkowski A.O.
      Appl. Environ. Microbiol. 70:3013-3023(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WPP1, WPP10, WPP11, WPP12, WPP13, WPP14, WPP15, WPP17, WPP18, WPP19, WPP2, WPP20, WPP21, WPP22, WPP24, WPP25, WPP3, WPP4, WPP5, WPP6, WPP7, WPP8 and WPP9.

    Entry informationi

    Entry nameiMDH_PECCC
    AccessioniPrimary (citable) accession number: P61897
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3