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P61896

- MDH_KLEVA

UniProt

P61896 - MDH_KLEVA

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Klebsiella variicola
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei4 – 41NADBy similarity
Binding sitei51 – 511SubstratePROSITE-ProRule annotation
Binding sitei57 – 571SubstratePROSITE-ProRule annotation
Binding sitei64 – 641NADBy similarity
Binding sitei89 – 891SubstratePROSITE-ProRule annotation
Binding sitei123 – 1231SubstratePROSITE-ProRule annotation
Active sitei147 – 1471Proton acceptorBy similarity
Binding sitei197 – 1971NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 893NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiKlebsiella variicola
Taxonomic identifieri244366 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›232›232Malate dehydrogenasePRO_0000113312Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP61896.
SMRiP61896. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P61896-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
SLYDIAPVTP GVAVDLSHIP TDVKIKGFSG EDATPALEGA DVVLISAGVA
60 70 80 90 100
RKPGMDRSDL FNVNAGIVKN LVQQIAKTCP QACIGVITNP VNTTVAIAAE
110 120 130 140 150
VLKKAGVYDK NKLFGVTTLD IIRSNTFVAE LKGKSATEVE VPVIGGHSGV
160 170 180 190 200
TILPLLSQIP GVSFSDQEVA DLTKRIQNAG TEVVEAKAGG GSATLSMGQA
210 220 230
AARFGLSLVR AMQGEKGVVE CAYVEGDGHY AR
Length:232
Mass (Da):23,972
Last modified:June 7, 2004 - v1
Checksum:i19C78AB8CCF568E6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei232 – 2321

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY367377 Genomic DNA. Translation: AAQ72403.1.
AY367378 Genomic DNA. Translation: AAQ72404.1.
AY367379 Genomic DNA. Translation: AAQ72405.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY367377 Genomic DNA. Translation: AAQ72403.1 .
AY367378 Genomic DNA. Translation: AAQ72404.1 .
AY367379 Genomic DNA. Translation: AAQ72405.1 .

3D structure databases

ProteinModelPortali P61896.
SMRi P61896. Positions 1-232.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Klebsiella variicola, a novel species with clinical and plant-associated isolates."
    Rosenblueth M., Martinez L., Silva J., Martinez-Romero E.
    Syst. Appl. Microbiol. 27:27-35(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 6A2, 801 and F2R9.

Entry informationi

Entry nameiMDH_KLEVA
AccessioniPrimary (citable) accession number: P61896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3