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P61896 (MDH_KLEVA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
OrganismKlebsiella variicola
Taxonomic identifier244366 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length232 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›232›232Malate dehydrogenase
PRO_0000113312

Regions

Nucleotide binding87 – 893NAD By similarity

Sites

Active site1471Proton acceptor By similarity
Binding site41NAD By similarity
Binding site511Substrate By similarity
Binding site571Substrate By similarity
Binding site641NAD By similarity
Binding site891Substrate By similarity
Binding site1231Substrate By similarity
Binding site1971NAD By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2321

Sequences

Sequence LengthMass (Da)Tools
P61896 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: 19C78AB8CCF568E6

FASTA23223,972
        10         20         30         40         50         60 
SLYDIAPVTP GVAVDLSHIP TDVKIKGFSG EDATPALEGA DVVLISAGVA RKPGMDRSDL 

        70         80         90        100        110        120 
FNVNAGIVKN LVQQIAKTCP QACIGVITNP VNTTVAIAAE VLKKAGVYDK NKLFGVTTLD 

       130        140        150        160        170        180 
IIRSNTFVAE LKGKSATEVE VPVIGGHSGV TILPLLSQIP GVSFSDQEVA DLTKRIQNAG 

       190        200        210        220        230 
TEVVEAKAGG GSATLSMGQA AARFGLSLVR AMQGEKGVVE CAYVEGDGHY AR 

« Hide

References

[1]"Klebsiella variicola, a novel species with clinical and plant-associated isolates."
Rosenblueth M., Martinez L., Silva J., Martinez-Romero E.
Syst. Appl. Microbiol. 27:27-35(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 6A2, 801 and F2R9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY367377 Genomic DNA. Translation: AAQ72403.1.
AY367378 Genomic DNA. Translation: AAQ72404.1.
AY367379 Genomic DNA. Translation: AAQ72405.1.

3D structure databases

ProteinModelPortalP61896.
SMRP61896. Positions 1-232.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_KLEVA
AccessionPrimary (citable) accession number: P61896
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families