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P61895

- MDH_RAOTE

UniProt

P61895 - MDH_RAOTE

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Raoultella terrigena (Klebsiella terrigena)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1 – 11NADBy similarity
Binding sitei48 – 481SubstratePROSITE-ProRule annotation
Binding sitei54 – 541SubstratePROSITE-ProRule annotation
Binding sitei61 – 611NADBy similarity
Binding sitei86 – 861SubstratePROSITE-ProRule annotation
Binding sitei120 – 1201SubstratePROSITE-ProRule annotation
Active sitei144 – 1441Proton acceptorBy similarity
Binding sitei194 – 1941NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 863NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiRaoultella terrigena (Klebsiella terrigena)
Taxonomic identifieri577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeRaoultella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›225›225Malate dehydrogenasePRO_0000113311Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP61895.
SMRiP61895. Positions 1-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P61895-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DIAPVTPGVA VDLSHIPTDV KIKGFSGEDA TPALEGADVV LISAGVARKP
60 70 80 90 100
GMDRSDLFNV NAGIVKNLVQ QIAKTSPQAC IGIITNPVNT TVAIAAEVLK
110 120 130 140 150
KAGVYDKNKL FGVTTLDIIR SNTFVAELKG KSSSDVEVPV IGGHSGVTIL
160 170 180 190 200
PLLSQIAGVS FSEQEVADLT KRIQNAGTEV VEAKAGGGSA TLSMGQAAAR
210 220
FGLSLVRAMQ GEKGVVECAY VEGDG
Length:225
Mass (Da):23,055
Last modified:June 7, 2004 - v1
Checksum:i6E76E81267F09DD0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei225 – 2251

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367381 Genomic DNA. Translation: AAQ72407.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367381 Genomic DNA. Translation: AAQ72407.1 .

3D structure databases

ProteinModelPortali P61895.
SMRi P61895. Positions 1-225.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Klebsiella variicola, a novel species with clinical and plant-associated isolates."
    Rosenblueth M., Martinez L., Silva J., Martinez-Romero E.
    Syst. Appl. Microbiol. 27:27-35(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33257 / DSM 2687 / JCM 1687 / NBRC 14941 / NCTC 13038 / VTT-E-97854.

Entry informationi

Entry nameiMDH_RAOTE
AccessioniPrimary (citable) accession number: P61895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3