Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P61895 (MDH_RAOTE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
OrganismRaoultella terrigena (Klebsiella terrigena)
Taxonomic identifier577 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeRaoultella

Protein attributes

Sequence length225 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›225›225Malate dehydrogenase
PRO_0000113311

Regions

Nucleotide binding84 – 863NAD By similarity

Sites

Active site1441Proton acceptor By similarity
Binding site11NAD By similarity
Binding site481Substrate By similarity
Binding site541Substrate By similarity
Binding site611NAD By similarity
Binding site861Substrate By similarity
Binding site1201Substrate By similarity
Binding site1941NAD By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2251

Sequences

Sequence LengthMass (Da)Tools
P61895 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: 6E76E81267F09DD0

FASTA22523,055
        10         20         30         40         50         60 
DIAPVTPGVA VDLSHIPTDV KIKGFSGEDA TPALEGADVV LISAGVARKP GMDRSDLFNV 

        70         80         90        100        110        120 
NAGIVKNLVQ QIAKTSPQAC IGIITNPVNT TVAIAAEVLK KAGVYDKNKL FGVTTLDIIR 

       130        140        150        160        170        180 
SNTFVAELKG KSSSDVEVPV IGGHSGVTIL PLLSQIAGVS FSEQEVADLT KRIQNAGTEV 

       190        200        210        220 
VEAKAGGGSA TLSMGQAAAR FGLSLVRAMQ GEKGVVECAY VEGDG 

« Hide

References

[1]"Klebsiella variicola, a novel species with clinical and plant-associated isolates."
Rosenblueth M., Martinez L., Silva J., Martinez-Romero E.
Syst. Appl. Microbiol. 27:27-35(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 33257 / DSM 2687 / JCM 1687 / NBRC 14941 / NCTC 13038 / VTT-E-97854.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY367381 Genomic DNA. Translation: AAQ72407.1.

3D structure databases

ProteinModelPortalP61895.
SMRP61895. Positions 1-225.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_RAOTE
AccessionPrimary (citable) accession number: P61895
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families