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P61895

- MDH_RAOTE

UniProt

P61895 - MDH_RAOTE

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Protein
Malate dehydrogenase
Gene
mdh
Organism
Raoultella terrigena (Klebsiella terrigena)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1 – 11NAD By similarity
Binding sitei48 – 481Substrate By similarity
Binding sitei54 – 541Substrate By similarity
Binding sitei61 – 611NAD By similarity
Binding sitei86 – 861Substrate By similarity
Binding sitei120 – 1201Substrate By similarity
Active sitei144 – 1441Proton acceptor By similarity
Binding sitei194 – 1941NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 863NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiRaoultella terrigena (Klebsiella terrigena)
Taxonomic identifieri577 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeRaoultella

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›225›225Malate dehydrogenase
PRO_0000113311Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP61895.
SMRiP61895. Positions 1-225.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P61895-1 [UniParc]FASTAAdd to Basket

« Hide

DIAPVTPGVA VDLSHIPTDV KIKGFSGEDA TPALEGADVV LISAGVARKP    50
GMDRSDLFNV NAGIVKNLVQ QIAKTSPQAC IGIITNPVNT TVAIAAEVLK 100
KAGVYDKNKL FGVTTLDIIR SNTFVAELKG KSSSDVEVPV IGGHSGVTIL 150
PLLSQIAGVS FSEQEVADLT KRIQNAGTEV VEAKAGGGSA TLSMGQAAAR 200
FGLSLVRAMQ GEKGVVECAY VEGDG 225
Length:225
Mass (Da):23,055
Last modified:June 7, 2004 - v1
Checksum:i6E76E81267F09DD0
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei225 – 2251

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY367381 Genomic DNA. Translation: AAQ72407.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY367381 Genomic DNA. Translation: AAQ72407.1 .

3D structure databases

ProteinModelPortali P61895.
SMRi P61895. Positions 1-225.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Klebsiella variicola, a novel species with clinical and plant-associated isolates."
    Rosenblueth M., Martinez L., Silva J., Martinez-Romero E.
    Syst. Appl. Microbiol. 27:27-35(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 33257 / DSM 2687 / JCM 1687 / NBRC 14941 / NCTC 13038 / VTT-E-97854.

Entry informationi

Entry nameiMDH_RAOTE
AccessioniPrimary (citable) accession number: P61895
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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