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P61894 (MDH_KLEOX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
OrganismKlebsiella oxytoca
Taxonomic identifier571 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeKlebsiella

Protein attributes

Sequence length223 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – ›223›223Malate dehydrogenase
PRO_0000113309

Regions

Nucleotide binding82 – 843NAD By similarity

Sites

Active site1421Proton acceptor By similarity
Binding site461Substrate By similarity
Binding site521Substrate By similarity
Binding site591NAD By similarity
Binding site841Substrate By similarity
Binding site1181Substrate By similarity
Binding site1921NAD By similarity

Experimental info

Non-terminal residue11
Non-terminal residue2231

Sequences

Sequence LengthMass (Da)Tools
P61894 [UniParc].

Last modified June 7, 2004. Version 1.
Checksum: D4175B9AEE52ACFB

FASTA22322,855
        10         20         30         40         50         60 
APVTPGVAVD LSHIPTDVKI KGFSGEDATP ALEGADVVLI SAGVARKPGM DRSDLFNVNA 

        70         80         90        100        110        120 
GIVKNLVQQI AKTCPQACVG IITNPVNTTV AIAAEVLKKA GVYDKNKLFG VTTLDIIRSN 

       130        140        150        160        170        180 
TFVAELKGKS SSDVEVPVIG GHSGVTILPL LSQIPGVSFS EQEVADLTKR IQNAGTEVVE 

       190        200        210        220 
AKAGGGSATL SMGQAAARFG LSLVRAMQGE KGVVECAYVE GDG 

« Hide

References

[1]"Klebsiella variicola, a novel species with clinical and plant-associated isolates."
Rosenblueth M., Martinez L., Silva J., Martinez-Romero E.
Syst. Appl. Microbiol. 27:27-35(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 13182.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY367380 Genomic DNA. Translation: AAQ72406.1.

3D structure databases

ProteinModelPortalP61894.
SMRP61894. Positions 1-223.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP61894.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMDH_KLEOX
AccessionPrimary (citable) accession number: P61894
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families