Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Malate dehydrogenase

Gene

mdh

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation2 Publications

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation2 Publications1
Binding sitei81SubstrateUniRule annotation2 Publications1
Binding sitei87SubstrateUniRule annotation2 Publications1
Binding sitei94NADUniRule annotation2 Publications1
Binding sitei119SubstrateUniRule annotation2 Publications1
Binding sitei153SubstrateUniRule annotation2 Publications1
Active sitei177Proton acceptorUniRule annotation1 Publication1
Binding sitei227NADUniRule annotation2 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 13NADUniRule annotation2 Publications7
Nucleotide bindingi117 – 119NADUniRule annotation2 Publications3

GO - Molecular functioni

  • L-malate dehydrogenase activity Source: UniProtKB-HAMAP
  • malate dehydrogenase activity Source: EcoliWiki
  • oxidoreductase activity Source: EcoliWiki

GO - Biological processi

  • anaerobic respiration Source: EcoliWiki
  • fermentation Source: EcoliWiki
  • glycolytic process Source: EcoliWiki
  • malate metabolic process Source: EcoliWiki
  • tricarboxylic acid cycle Source: EcoliWiki
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciEcoCyc:MALATE-DEHASE-MONOMER.
ECOL316407:JW3205-MONOMER.
MetaCyc:MALATE-DEHASE-MONOMER.
BRENDAi1.1.1.37. 2026.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase1 PublicationUniRule annotation (EC:1.1.1.37UniRule annotation2 Publications)
Gene namesi
Name:mdh1 PublicationUniRule annotation
Ordered Locus Names:b3236, JW3205
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10576. mdh.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoliWiki
  • cytosol Source: UniProtKB
  • extrinsic component of membrane Source: EcoliWiki
  • membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi153R → C: Loss of interaction with substrate. 1 Publication1

Chemistry databases

DrugBankiDB00336. Nitrofural.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001133011 – 312Malate dehydrogenaseAdd BLAST312

Proteomic databases

EPDiP61889.
PaxDbiP61889.
PRIDEiP61889.

2D gel databases

SWISS-2DPAGEP61889.

Interactioni

Subunit structurei

Homodimer.UniRule annotation4 Publications

Protein-protein interaction databases

BioGridi4260779. 18 interactors.
DIPiDIP-35924N.
IntActiP61889. 10 interactors.
STRINGi511145.b3236.

Structurei

Secondary structure

1312
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 6Combined sources5
Turni7 – 9Combined sources3
Helixi11 – 23Combined sources13
Beta strandi28 – 33Combined sources6
Helixi39 – 47Combined sources9
Beta strandi51 – 58Combined sources8
Helixi64 – 67Combined sources4
Beta strandi71 – 75Combined sources5
Helixi87 – 108Combined sources22
Beta strandi112 – 116Combined sources5
Beta strandi118 – 120Combined sources3
Helixi121 – 134Combined sources14
Beta strandi142 – 145Combined sources4
Helixi148 – 162Combined sources15
Helixi166 – 168Combined sources3
Beta strandi173 – 175Combined sources3
Helixi179 – 181Combined sources3
Beta strandi182 – 184Combined sources3
Helixi186 – 188Combined sources3
Helixi196 – 207Combined sources12
Helixi209 – 216Combined sources8
Turni217 – 219Combined sources3
Helixi225 – 242Combined sources18
Beta strandi249 – 255Combined sources7
Beta strandi262 – 271Combined sources10
Beta strandi274 – 278Combined sources5
Helixi286 – 310Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMEmodel-A1-312[»]
1EMDX-ray1.90A1-312[»]
1IB6X-ray2.10A/B/C/D1-312[»]
1IE3X-ray2.50A/B/C/D1-312[»]
2CMDX-ray1.87A1-312[»]
2PWZX-ray2.20A/C/E/G1-312[»]
3HHPX-ray1.45A/B/C/D1-312[»]
ProteinModelPortaliP61889.
SMRiP61889.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP61889.

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
InParanoidiP61889.
KOiK00024.
OMAiVEVKGFA.
PhylomeDBiP61889.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01516. Malate_dehydrog_1. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P61889-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAVLGAAG GIGQALALLL KTQLPSGSEL SLYDIAPVTP GVAVDLSHIP
60 70 80 90 100
TAVKIKGFSG EDATPALEGA DVVLISAGVA RKPGMDRSDL FNVNAGIVKN
110 120 130 140 150
LVQQVAKTCP KACIGIITNP VNTTVAIAAE VLKKAGVYDK NKLFGVTTLD
160 170 180 190 200
IIRSNTFVAE LKGKQPGEVE VPVIGGHSGV TILPLLSQVP GVSFTEQEVA
210 220 230 240 250
DLTKRIQNAG TEVVEAKAGG GSATLSMGQA AARFGLSLVR ALQGEQGVVE
260 270 280 290 300
CAYVEGDGQY ARFFSQPLLL GKNGVEERKS IGTLSAFEQN ALEGMLDTLK
310
KDIALGEEFV NK
Length:312
Mass (Da):32,337
Last modified:June 7, 2004 - v1
Checksum:i17741A3B5AD068BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37P → S (PubMed:2993232).Curated1
Sequence conflicti70A → R (PubMed:3322223).Curated1
Sequence conflicti80A → R (PubMed:3299262).Curated1
Sequence conflicti80A → R (PubMed:3322223).Curated1
Sequence conflicti116I → N (PubMed:3322223).Curated1
Sequence conflicti144F → L (PubMed:3299262).Curated1
Sequence conflicti305 – 312LGEEFVNK → WAKSSLISN (PubMed:3322223).Curated8
Sequence conflicti307E → Q (PubMed:3299262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti71D → N in strain: EC47, EC49, EC50 and RT272. 1
Natural varianti106A → S in strain: ECOR 27 and RT082. 1
Natural varianti209A → P in strain: MB001D. 1
Natural varianti218A → R in strain: A8190, E2666-74, E830587, E851819, E3406, EC10, EC14, EC32, EC35, EC38, EC40, EC44, EC46, EC47, EC49, EC50, EC52, EC58, E64 and EC70. 1
Natural varianti232A → T in strain: ECO R37. 1
Natural varianti249V → I in strain: RT083. 1
Natural varianti289Q → K in strain: EC35, EC38, EC40, EC44, EC46, EC47 and RT272. 1
Natural varianti290N → S in strain: E2666-74, ECOR 27, ECOR 45, RL012A, RT104 and RT174. 1
Natural varianti291A → S in strain: EC35. 1
Natural varianti294G → A in strain: ECOR 45. 1
Natural varianti297D → N in strain: E830587. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00129 Genomic DNA. Translation: CAA68326.1.
M24777 Unassigned DNA. Translation: AAA16107.1.
U18997 Genomic DNA. Translation: AAA58038.1.
U00096 Genomic DNA. Translation: AAC76268.1.
AP009048 Genomic DNA. Translation: BAE77279.1.
M10417 Genomic DNA. Translation: AAA24147.1.
U04742 Genomic DNA. Translation: AAC43730.1.
U04743 Genomic DNA. Translation: AAC43731.1.
U04744 Genomic DNA. Translation: AAC43732.1.
U04745 Genomic DNA. Translation: AAC43733.1.
U04746 Genomic DNA. Translation: AAC43734.1.
U04747 Genomic DNA. Translation: AAC43735.1.
U04748 Genomic DNA. Translation: AAC43736.1.
U04749 Genomic DNA. Translation: AAC43737.1.
U04750 Genomic DNA. Translation: AAC43738.1.
U04751 Genomic DNA. Translation: AAC43739.1.
U04752 Genomic DNA. Translation: AAC43740.1.
U04753 Genomic DNA. Translation: AAC43741.1.
U04754 Genomic DNA. Translation: AAC43742.1.
U04755 Genomic DNA. Translation: AAC43743.1.
U04756 Genomic DNA. Translation: AAC43744.1.
U04757 Genomic DNA. Translation: AAC43745.1.
U04758 Genomic DNA. Translation: AAC43746.1.
U04759 Genomic DNA. Translation: AAC43747.1.
U04760 Genomic DNA. Translation: AAC43748.1.
U04770 Genomic DNA. Translation: AAC43758.1.
AF004170 Genomic DNA. Translation: AAB87003.1.
AF004171 Genomic DNA. Translation: AAB87004.1.
AF004172 Genomic DNA. Translation: AAB87005.1.
AF004173 Genomic DNA. Translation: AAB87006.1.
AF004174 Genomic DNA. Translation: AAB87007.1.
AF004175 Genomic DNA. Translation: AAB87008.1.
AF004176 Genomic DNA. Translation: AAB87009.1.
AF004177 Genomic DNA. Translation: AAB87010.1.
AF004179 Genomic DNA. Translation: AAB87012.1.
AF004180 Genomic DNA. Translation: AAB87013.1.
AF004182 Genomic DNA. Translation: AAB87015.1.
AF004183 Genomic DNA. Translation: AAB87016.1.
AF004184 Genomic DNA. Translation: AAB87017.1.
AF004186 Genomic DNA. Translation: AAB87019.1.
AF004187 Genomic DNA. Translation: AAB87020.1.
AF004188 Genomic DNA. Translation: AAB87021.1.
AF004190 Genomic DNA. Translation: AAB87023.1.
AF004191 Genomic DNA. Translation: AAB87024.1.
AF004195 Genomic DNA. Translation: AAB87028.1.
AF004196 Genomic DNA. Translation: AAB87029.1.
AF004199 Genomic DNA. Translation: AAB87032.1.
AF004200 Genomic DNA. Translation: AAB87033.1.
AF004201 Genomic DNA. Translation: AAB87034.1.
AF004202 Genomic DNA. Translation: AAB87035.1.
AF004203 Genomic DNA. Translation: AAB87036.1.
AF004204 Genomic DNA. Translation: AAB87037.1.
AF004205 Genomic DNA. Translation: AAB87038.1.
AF004206 Genomic DNA. Translation: AAB87039.1.
AF004207 Genomic DNA. Translation: AAB87040.1.
AF004208 Genomic DNA. Translation: AAB87041.1.
AF004209 Genomic DNA. Translation: AAB87042.1.
AF091758 Genomic DNA. Translation: AAF97988.1.
AF091759 Genomic DNA. Translation: AAF97989.1.
AF091760 Genomic DNA. Translation: AAF97990.1.
AF091761 Genomic DNA. Translation: AAF97991.1.
AF091762 Genomic DNA. Translation: AAF97992.1.
AF091763 Genomic DNA. Translation: AAF97993.1.
AF091764 Genomic DNA. Translation: AAF97994.1.
AF091765 Genomic DNA. Translation: AAF97995.1.
AF091766 Genomic DNA. Translation: AAF97996.1.
AF091767 Genomic DNA. Translation: AAF97997.1.
AF091768 Genomic DNA. Translation: AAF97998.1.
AF091769 Genomic DNA. Translation: AAF97999.1.
AF091770 Genomic DNA. Translation: AAF98000.1.
AF091771 Genomic DNA. Translation: AAF98001.1.
AF091772 Genomic DNA. Translation: AAF98002.1.
AF091773 Genomic DNA. Translation: AAF98003.1.
AF091774 Genomic DNA. Translation: AAF98004.1.
AF091775 Genomic DNA. Translation: AAF98005.1.
AF091776 Genomic DNA. Translation: AAF98006.1.
AF091777 Genomic DNA. Translation: AAF98007.1.
AF091778 Genomic DNA. Translation: AAF98008.1.
PIRiF65115. DEECM.
RefSeqiNP_417703.1. NC_000913.3.
WP_001295272.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76268; AAC76268; b3236.
BAE77279; BAE77279; BAE77279.
GeneIDi947854.
KEGGiecj:JW3205.
eco:b3236.
PATRICi32121898. VBIEscCol129921_3333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00129 Genomic DNA. Translation: CAA68326.1.
M24777 Unassigned DNA. Translation: AAA16107.1.
U18997 Genomic DNA. Translation: AAA58038.1.
U00096 Genomic DNA. Translation: AAC76268.1.
AP009048 Genomic DNA. Translation: BAE77279.1.
M10417 Genomic DNA. Translation: AAA24147.1.
U04742 Genomic DNA. Translation: AAC43730.1.
U04743 Genomic DNA. Translation: AAC43731.1.
U04744 Genomic DNA. Translation: AAC43732.1.
U04745 Genomic DNA. Translation: AAC43733.1.
U04746 Genomic DNA. Translation: AAC43734.1.
U04747 Genomic DNA. Translation: AAC43735.1.
U04748 Genomic DNA. Translation: AAC43736.1.
U04749 Genomic DNA. Translation: AAC43737.1.
U04750 Genomic DNA. Translation: AAC43738.1.
U04751 Genomic DNA. Translation: AAC43739.1.
U04752 Genomic DNA. Translation: AAC43740.1.
U04753 Genomic DNA. Translation: AAC43741.1.
U04754 Genomic DNA. Translation: AAC43742.1.
U04755 Genomic DNA. Translation: AAC43743.1.
U04756 Genomic DNA. Translation: AAC43744.1.
U04757 Genomic DNA. Translation: AAC43745.1.
U04758 Genomic DNA. Translation: AAC43746.1.
U04759 Genomic DNA. Translation: AAC43747.1.
U04760 Genomic DNA. Translation: AAC43748.1.
U04770 Genomic DNA. Translation: AAC43758.1.
AF004170 Genomic DNA. Translation: AAB87003.1.
AF004171 Genomic DNA. Translation: AAB87004.1.
AF004172 Genomic DNA. Translation: AAB87005.1.
AF004173 Genomic DNA. Translation: AAB87006.1.
AF004174 Genomic DNA. Translation: AAB87007.1.
AF004175 Genomic DNA. Translation: AAB87008.1.
AF004176 Genomic DNA. Translation: AAB87009.1.
AF004177 Genomic DNA. Translation: AAB87010.1.
AF004179 Genomic DNA. Translation: AAB87012.1.
AF004180 Genomic DNA. Translation: AAB87013.1.
AF004182 Genomic DNA. Translation: AAB87015.1.
AF004183 Genomic DNA. Translation: AAB87016.1.
AF004184 Genomic DNA. Translation: AAB87017.1.
AF004186 Genomic DNA. Translation: AAB87019.1.
AF004187 Genomic DNA. Translation: AAB87020.1.
AF004188 Genomic DNA. Translation: AAB87021.1.
AF004190 Genomic DNA. Translation: AAB87023.1.
AF004191 Genomic DNA. Translation: AAB87024.1.
AF004195 Genomic DNA. Translation: AAB87028.1.
AF004196 Genomic DNA. Translation: AAB87029.1.
AF004199 Genomic DNA. Translation: AAB87032.1.
AF004200 Genomic DNA. Translation: AAB87033.1.
AF004201 Genomic DNA. Translation: AAB87034.1.
AF004202 Genomic DNA. Translation: AAB87035.1.
AF004203 Genomic DNA. Translation: AAB87036.1.
AF004204 Genomic DNA. Translation: AAB87037.1.
AF004205 Genomic DNA. Translation: AAB87038.1.
AF004206 Genomic DNA. Translation: AAB87039.1.
AF004207 Genomic DNA. Translation: AAB87040.1.
AF004208 Genomic DNA. Translation: AAB87041.1.
AF004209 Genomic DNA. Translation: AAB87042.1.
AF091758 Genomic DNA. Translation: AAF97988.1.
AF091759 Genomic DNA. Translation: AAF97989.1.
AF091760 Genomic DNA. Translation: AAF97990.1.
AF091761 Genomic DNA. Translation: AAF97991.1.
AF091762 Genomic DNA. Translation: AAF97992.1.
AF091763 Genomic DNA. Translation: AAF97993.1.
AF091764 Genomic DNA. Translation: AAF97994.1.
AF091765 Genomic DNA. Translation: AAF97995.1.
AF091766 Genomic DNA. Translation: AAF97996.1.
AF091767 Genomic DNA. Translation: AAF97997.1.
AF091768 Genomic DNA. Translation: AAF97998.1.
AF091769 Genomic DNA. Translation: AAF97999.1.
AF091770 Genomic DNA. Translation: AAF98000.1.
AF091771 Genomic DNA. Translation: AAF98001.1.
AF091772 Genomic DNA. Translation: AAF98002.1.
AF091773 Genomic DNA. Translation: AAF98003.1.
AF091774 Genomic DNA. Translation: AAF98004.1.
AF091775 Genomic DNA. Translation: AAF98005.1.
AF091776 Genomic DNA. Translation: AAF98006.1.
AF091777 Genomic DNA. Translation: AAF98007.1.
AF091778 Genomic DNA. Translation: AAF98008.1.
PIRiF65115. DEECM.
RefSeqiNP_417703.1. NC_000913.3.
WP_001295272.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CMEmodel-A1-312[»]
1EMDX-ray1.90A1-312[»]
1IB6X-ray2.10A/B/C/D1-312[»]
1IE3X-ray2.50A/B/C/D1-312[»]
2CMDX-ray1.87A1-312[»]
2PWZX-ray2.20A/C/E/G1-312[»]
3HHPX-ray1.45A/B/C/D1-312[»]
ProteinModelPortaliP61889.
SMRiP61889.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260779. 18 interactors.
DIPiDIP-35924N.
IntActiP61889. 10 interactors.
STRINGi511145.b3236.

Chemistry databases

DrugBankiDB00336. Nitrofural.

2D gel databases

SWISS-2DPAGEP61889.

Proteomic databases

EPDiP61889.
PaxDbiP61889.
PRIDEiP61889.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76268; AAC76268; b3236.
BAE77279; BAE77279; BAE77279.
GeneIDi947854.
KEGGiecj:JW3205.
eco:b3236.
PATRICi32121898. VBIEscCol129921_3333.

Organism-specific databases

EchoBASEiEB0571.
EcoGeneiEG10576. mdh.

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
InParanoidiP61889.
KOiK00024.
OMAiVEVKGFA.
PhylomeDBiP61889.

Enzyme and pathway databases

BioCyciEcoCyc:MALATE-DEHASE-MONOMER.
ECOL316407:JW3205-MONOMER.
MetaCyc:MALATE-DEHASE-MONOMER.
BRENDAi1.1.1.37. 2026.

Miscellaneous databases

EvolutionaryTraceiP61889.
PROiP61889.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01516. Malate_dehydrog_1. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR023958. Malate_DH_type1_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDH_ECOLI
AccessioniPrimary (citable) accession number: P61889
Secondary accession number(s): O30401
, O30402, O30403, P06994, Q2M8X7, Q59343, Q59344, Q59345, Q59346, Q59347, Q59348, Q60133, Q60150, Q933J3, Q93R02, Q9FDQ3, Q9FDQ4, Q9FDQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1988
Last sequence update: June 7, 2004
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.