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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (gap)
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (apgM)
  4. Enolase (eno)
  5. Pyruvate kinase (PF1188)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34SubstrateBy similarity1
Binding sitei114SubstrateBy similarity1
Binding sitei154SubstrateBy similarity1
Binding sitei332ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi358 – 361ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:PF1057
OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Taxonomic identifieri186497 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
Proteomesi
  • UP000001013 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460661 – 410Phosphoglycerate kinaseAdd BLAST410

Proteomic databases

PRIDEiP61883.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi186497.PF1057.

Structurei

3D structure databases

ProteinModelPortaliP61883.
SMRiP61883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 21Substrate bindingBy similarity3
Regioni57 – 60Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiarCOG00496. Archaea.
COG0126. LUCA.
HOGENOMiHOG000227108.
KOiK00927.
OMAiDMIFDIG.
OrthoDBiPOG093Z051V.

Family and domain databases

Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P61883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRLRDFEYY NRTVFLRVDL NSPMSNGKII SDARFRAVLP TIKYLIESGA
60 70 80 90 100
KVVVGTHQGK PYSEEYSTTE EHARILSELL NMHVEYVEDI FGKYARERIK
110 120 130 140 150
AMKPGEVIVL ENLRFSAEEV KNATIEECEK TFFVRKLSQV IDLVVNDAFA
160 170 180 190 200
AAHRSQPSLV GFARIKPMIM GFLMEKEVDA LTKAYESEEK PRVYVLGGAK
210 220 230 240 250
VDDSLKVAEN VLRKEKADLI LTGGLVGQLF TLAKGFDLGR ENIKFLEKKG
260 270 280 290 300
ILKYVDWAEK ILDEFYPYVR TPVDFAIDFK GERVEIDLLS DEKRLFDEYP
310 320 330 340 350
ILDIGSRTVE KYREILLKAR IIVANGPMGV FEREEFAVGT IGVFKAIGES
360 370 380 390 400
PAFSVIGGGH SIASIYKYNI TGISHISTGG GAMLTFFAGE KLPVLEALKI
410
SYEKFSNLLS
Length:410
Mass (Da):46,224
Last modified:June 7, 2004 - v1
Checksum:iD90D4172A06707E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009950 Genomic DNA. Translation: AAL81181.1.
RefSeqiWP_011012194.1. NC_003413.1.

Genome annotation databases

EnsemblBacteriaiAAL81181; AAL81181; PF1057.
GeneIDi1468923.
KEGGipfu:PF1057.
PATRICifig|186497.12.peg.1118.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPGK_PYRFU
AccessioniPrimary (citable) accession number: P61883
Secondary accession number(s): P50316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families